CN103285948A - Chip-type electroosmotic pump - Google Patents
Chip-type electroosmotic pump Download PDFInfo
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- CN103285948A CN103285948A CN2013102036677A CN201310203667A CN103285948A CN 103285948 A CN103285948 A CN 103285948A CN 2013102036677 A CN2013102036677 A CN 2013102036677A CN 201310203667 A CN201310203667 A CN 201310203667A CN 103285948 A CN103285948 A CN 103285948A
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Abstract
The invention aims at designing a Y-shaped chip-type electroosmotic pump with two packed columns. A left channel and a right channel are respectively filled with fillers with positive charges and negative charges. When the electroosmotic pump is in work, an electric field only exists in the two packed column-type channels, and an intermediate intersected buffering area and a functional unit which is connected with the intermediate intersected buffering area are free from the interference of the electric field. According to the chip-type electroosmotic pump, the precise control of the flow speed between 1nL/min to 1000nL/min can be realized, and the output pressure range is between 0.1KPa and 2KPa. The electroosmotic pump also has the following characteristics that (1) multiple Y-shaped electroosmotic pumps can be integrated in a micro-fluidic chip; (2) by further integrating an external channel and other functional units of the micro-fluidic chip, such as a micro-reactor and a biological sensor, the chemical and biological components can be rapidly reacted and detected online in real time.
Description
Technical field
The present invention relates to a kind of little electroosmotic pump, particularly a kind of chip type electroosmotic pump.Mainly be applicable to the liquid driven of micrometeor system, particularly infuse at the trace in micro-fluidic chip, clinical medicine field.
Background technology
Electroosmotic pump utilizes the little distinctive electroosmosis of chip microchannel size to carry out fluid and drives control, convenient and flexible operation and easy of integration in chip, thereby become one of microfluidic control technology most widely used in the micro-fluidic chip research.Also there are some problems in the use of little electroosmotic pump, the problem of other parts being disturbed as the electroosmotic pump electric field, the problem that improves flow velocity and pressure under the situation that does not improve operating voltage etc.At present, the electric field interference problem mainly is to take method that the electroosmotic pump unit is separated with the main channel, the one, the electroosmotic pump unit is placed downstream, main channel or upstream, but this method can cause the bubble of generation to enter the main channel, causes pump to quit work; Another kind method then is the one or both sides that the pump unit placed the main channel, and what have also completely cuts off bubble by the method for making the salt bridge node.The method of a plurality of parallel channels parallel connections is mainly adopted in the raising of flow velocity, namely increases the electroosmotic pump channel cross-sectional area under the situation that does not reduce linear velocity, thereby increases flow velocity; The raising of pressure, the then normal methods such as reducing the pump channel degree of depth, increase pump channel length that adopts.
Summary of the invention
At the weak point of electroosmotic pump in the above-mentioned micro-fluidic chip application, the objective of the invention is to design a kind of Y core chip electroosmotic pump with two kinds of packed columns, left and right passage is filled with the filler with positive and negative electric charge respectively.When electroosmotic pump was worked, electric field existed only in two and fills the pillar passages, and middle cross buffering area and continuous functional unit thereof then do not have electric field to be disturbed.And fill the pillar electroosmotic pump, can improve electroosmotic pump efficient greatly.
For achieving the above object, the invention provides a kind of chip type electroosmotic pump, this electroosmotic pump is made of filling pillar electroosmotic pump and the buffering area that crosses of two Junction on bend aheads.
Chip type electroosmotic pump provided by the present invention, the material of described chip are glass, silicon, quartz, Merlon, polymethyl methacrylate, dimethyl silicone polymer etc.
Chip type electroosmotic pump provided by the present invention, described filling pillar electroosmotic pump is the passage of 10～3000 microns of internal diameters, inside is full of filler.
Chip type electroosmotic pump provided by the present invention, the filler in the described packed column are selected a kind of in silica gel, ion exchange resin, polymer microsphere, inorganic sphere or amorphous filler, the interior moulding filler for use, and particle diameter is 50～5000 nanometers.Filler in the packed column of described two Junction on bend aheads is respectively with two kinds of opposite electric charges.
Chip type electroosmotic pump provided by the present invention, the described buffering area that crosses can be connected with other functional units on the micro-fluidic chip, and the fluid that is used for micro-fluidic chip drives.
Description of drawings
Fig. 1. the structural representation of a kind of chip type electroosmotic pump provided by the invention.Wherein, A is for filling pillar electroosmotic pump 1; B fills pillar electroosmotic pump 2; C is the filler of oppositely charged; D is the buffering area that crosses; E is the external passage of electroosmotic pump.
Specific embodiments
The following examples will give further instruction to the present invention in conjunction with Figure of description.
A kind of micro-fluidic chip formula of embodiment electroosmotic pump
As shown in Figure 1, a kind of chip type electroosmotic pump provided by the invention, filling pillar electroosmotic pump A, B and the buffering area D that crosses by two Junction on bend aheads constitute, wherein fill among pillar electroosmotic pump A and the B, being filled with the filler C of oppositely charged respectively, can be the glass microsphere of the different charged species of finishing.The size characteristic of passage and filler is specific as follows: A, B channel width and the degree of depth are respectively 200 microns and 100 microns; The size characteristic of glass microsphere is 5 microns of particle diameters; The width of the import and export of packed column passage and the degree of depth are respectively 50 microns and 5 microns of microns, form a cofferdam type structure, and glass microsphere is limited in the packed column.The buffering area that crosses is 300 microns border circular areas, is connected with external passage E.
When using chip type electroosmotic pump provided by the invention, toward the electroosmotic pump chip in, fill it up with buffer solution earlier, add two opposite electric fields in the exits of two filling pillar passages then.
When the left side apply anodal electric field, when the right applies the negative pole electric field, the EOF direction of filling pillar electroosmotic pump A and B is from intersection and flows to corresponding outlet, under this state, the fluid among the external passage E will drivenly move toward the electroosmotic pump direction.And the fluid components among the external passage E is not disturbed by electric field.
When the left side apply the negative pole electric field, when the right applies anodal electric field, the EOF direction of filling pillar electroosmotic pump A and B is from corresponding outlet and flows to intersection, under this state, the fluid among the external passage E will drivenly move toward the opposite direction of electroosmotic pump.And the fluid components among the external passage E is not disturbed by electric field yet.
Chip type electroosmotic pump provided by the invention can be realized other flow velocity accuracy controlling of 1～1000nL/min level, and the output pressure scope is 0.1～2KPa.In addition, this electroosmotic pump also has following characteristics: (1) can a plurality of Y type electroosmotic pumps integrated in micro-fluidic chip; (2) can be further integrated by other functional units such as microreactor, the biology sensor etc. of external passage and micro-fluidic chip, thus realize chemistry, biological components online, in real time, react fast and detect.
Claims (6)
1. a chip type electroosmotic pump is characterized in that, this electroosmotic pump is made of filling pillar electroosmotic pump and the buffering area that crosses of two Junction on bend aheads.
2. according to the described a kind of chip type electroosmotic pump of claim 1, it is characterized in that the material of described chip is glass, silicon, quartz, Merlon, polymethyl methacrylate, dimethyl silicone polymer etc.
3. according to the described a kind of chip type electroosmotic pump of claim 1, it is characterized in that described filling pillar electroosmotic pump is the passage of 10～3000 microns of internal diameters, inside is full of filler.
4. according to claim 1 and 3 described a kind of chip type electroosmotic pumps, it is characterized in that, filler in the described packed column is selected a kind of in silica gel, ion exchange resin, polymer microsphere, inorganic sphere or amorphous filler, the interior moulding filler for use, and particle diameter is 50～5000 nanometers.
5. according to the described a kind of chip type electroosmotic pump of claim 1, it is characterized in that the filler in the packed column of described two Junction on bend aheads is respectively with two kinds of opposite electric charges.
6. according to the described a kind of chip type electroosmotic pump of claim 1, it is characterized in that the described buffering area that crosses can be connected with other functional units on the micro-fluidic chip, the fluid that is used for micro-fluidic chip drives.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013102036677A CN103285948A (en) | 2013-05-27 | 2013-05-27 | Chip-type electroosmotic pump |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013102036677A CN103285948A (en) | 2013-05-27 | 2013-05-27 | Chip-type electroosmotic pump |
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| CN103285948A true CN103285948A (en) | 2013-09-11 |
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| CN2013102036677A Pending CN103285948A (en) | 2013-05-27 | 2013-05-27 | Chip-type electroosmotic pump |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109529962A (en) * | 2019-01-18 | 2019-03-29 | 江苏医联生物科技有限公司 | The method of film electroosmotic pump and its detection pressure and flow velocity based on microchannel plate |
| CN113410120A (en) * | 2021-05-28 | 2021-09-17 | 清华大学深圳国际研究生院 | Method and device for generating spray ions |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030068229A1 (en) * | 2001-10-05 | 2003-04-10 | Tihiro Ohkawa | Fiber filled electro-osmotic pump |
| US20110011735A1 (en) * | 2009-07-17 | 2011-01-20 | Canon Kabushiki Kaisha | Fluid structure control device |
-
2013
- 2013-05-27 CN CN2013102036677A patent/CN103285948A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030068229A1 (en) * | 2001-10-05 | 2003-04-10 | Tihiro Ohkawa | Fiber filled electro-osmotic pump |
| US20110011735A1 (en) * | 2009-07-17 | 2011-01-20 | Canon Kabushiki Kaisha | Fluid structure control device |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109529962A (en) * | 2019-01-18 | 2019-03-29 | 江苏医联生物科技有限公司 | The method of film electroosmotic pump and its detection pressure and flow velocity based on microchannel plate |
| CN113410120A (en) * | 2021-05-28 | 2021-09-17 | 清华大学深圳国际研究生院 | Method and device for generating spray ions |
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| DD01 | Delivery of document by public notice |
Addressee: Suzhou YoungChip Chip Technology Co., Ltd. Document name: Notification of Passing Preliminary Examination of the Application for Invention |
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Addressee: Ye Jiaming Document name: Notification of Publication and of Entering the Substantive Examination Stage of the Application for Invention |
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Addressee: Suzhou YoungChip Chip Technology Co., Ltd. Document name: the First Notification of an Office Action |
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Application publication date: 20130911 |