CN103282031A - 包含甲状腺激素的新药物组合物以及它们的治疗应用 - Google Patents

包含甲状腺激素的新药物组合物以及它们的治疗应用 Download PDF

Info

Publication number
CN103282031A
CN103282031A CN2008800215379A CN200880021537A CN103282031A CN 103282031 A CN103282031 A CN 103282031A CN 2008800215379 A CN2008800215379 A CN 2008800215379A CN 200880021537 A CN200880021537 A CN 200880021537A CN 103282031 A CN103282031 A CN 103282031A
Authority
CN
China
Prior art keywords
rats treated
rats
treated
hormone
results
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2008800215379A
Other languages
English (en)
Chinese (zh)
Inventor
X·勒韦尔夫
N·塔勒沃
R·法维耶
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Joseph fourier university
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Joseph fourier university
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Joseph fourier university, Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Joseph fourier university
Publication of CN103282031A publication Critical patent/CN103282031A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2008800215379A 2007-05-16 2008-05-16 包含甲状腺激素的新药物组合物以及它们的治疗应用 Pending CN103282031A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07290635A EP1992341A1 (en) 2007-05-16 2007-05-16 New pharmaceutical compositions comprising a thyroid hormon and their therapeutic use
EP07290635.7 2007-05-16
PCT/EP2008/056076 WO2008138995A1 (en) 2007-05-16 2008-05-16 New pharmaceutical compositions comprising a thyroid hormon and their therapeutic use

Publications (1)

Publication Number Publication Date
CN103282031A true CN103282031A (zh) 2013-09-04

Family

ID=38562932

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008800215379A Pending CN103282031A (zh) 2007-05-16 2008-05-16 包含甲状腺激素的新药物组合物以及它们的治疗应用

Country Status (7)

Country Link
US (1) US20110064773A1 (enExample)
EP (2) EP1992341A1 (enExample)
JP (1) JP2010526858A (enExample)
CN (1) CN103282031A (enExample)
BR (1) BRPI0811636A2 (enExample)
CA (1) CA2687385A1 (enExample)
WO (1) WO2008138995A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108037276A (zh) * 2017-11-28 2018-05-15 泰州泽成生物技术有限公司 磁微粒化学发光法测定rT3含量的试剂盒及其检测方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20110713A1 (it) 2011-04-29 2012-10-30 Bracco Imaging Spa Processo per la preparazione di un derivato solfatato di3,5-diiodo-o-[3-iodofenil]-l-tirosina
ITMI20022394A1 (it) 2002-11-13 2004-05-14 Bracco Spa Uso di triiodotironina 3-solfato come farmaco ad attivita' tireomimetica e relative formulazioni farmaceutiche.
US20130005814A1 (en) * 2011-07-01 2013-01-03 Thomas Najarian Methods and compositions for facilitating weight loss by administration of thyroid hormones
WO2016140714A1 (en) * 2015-03-05 2016-09-09 The General Hospital Corporation Novel compositions and uses of metformin agents
CN115734784A (zh) * 2020-05-21 2023-03-03 平衡治療有限責任公司 用于控制甲状腺激素水平的微针装置
CN116270581A (zh) * 2023-02-28 2023-06-23 山东大学 碘塞罗宁在制备治疗动脉粥样硬化药物中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221911B1 (en) * 1995-06-07 2001-04-24 Karo Bio Ab Uses for thyroid hormone compounds or thyroid hormone-like compounds
WO2005009433A1 (en) * 2003-07-24 2005-02-03 Fernando Goglia Use of 3,5 diiodothyronine as regulators of lipid metabolism

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010526857A (ja) * 2007-05-16 2010-08-05 ユニヴェルシテ ジョセフ フーリエ ジヨードチロニンを含んでなる新規な医薬組成物及びその治療的使用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221911B1 (en) * 1995-06-07 2001-04-24 Karo Bio Ab Uses for thyroid hormone compounds or thyroid hormone-like compounds
WO2005009433A1 (en) * 2003-07-24 2005-02-03 Fernando Goglia Use of 3,5 diiodothyronine as regulators of lipid metabolism

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CETTOUR-ROSE P ET AL: "triiodothyronine does not alter thyroxine-induced inhibition of thyrotropin secretion in hypothyroid rats.", 《EUROPEAN JOURNAL OF ENDOCRINOLOGY》 *
ERIC S. TIEN ET AL.: "he Nuclear Receptor Constitutively Active/Androstane Receptor Regulates Type 1 Deiodinase and Thyroid Hormone Activity in the Regenerating Mouse Liver", 《 THE JOURNAL OF PHARMACOLOGY AND EXPRIMENTAL THERAPEUTICS》 *
LAN YANG CHENG ET AL.: "Film Autoradiography Identifies Unique Features of [125I]3,3’5’-(Reverse) Triiodothyronine Transport From Blood to Brain", 《JOURNAL OF NEUROPHYSIOLOGY》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108037276A (zh) * 2017-11-28 2018-05-15 泰州泽成生物技术有限公司 磁微粒化学发光法测定rT3含量的试剂盒及其检测方法

Also Published As

Publication number Publication date
US20110064773A1 (en) 2011-03-17
WO2008138995A1 (en) 2008-11-20
EP1992341A1 (en) 2008-11-19
JP2010526858A (ja) 2010-08-05
EP2068859A1 (en) 2009-06-17
CA2687385A1 (en) 2008-11-20
BRPI0811636A2 (pt) 2014-11-11

Similar Documents

Publication Publication Date Title
Vallon Glucose transporters in the kidney in health and disease
Jiang et al. Diabetic-induced alterations in hepatic glucose and lipid metabolism: the role of type 1 and type 2 diabetes mellitus
Ferrannini Sodium-glucose co-transporters and their inhibition: clinical physiology
Wilson Regulation of vitamin C transport
Goldfine et al. Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes
Owen et al. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
Poucheret et al. Vanadium and diabetes
Goldwaser et al. Insulin-like effects of vanadium: basic and clinical implications
Casirola et al. α-Glucosidase inhibitors prevent diet-induced increases in intestinal sugar transport in diabetic mice
Fujita et al. Nutrient signalling in the regulation of human muscle protein synthesis
Morakinyo et al. Magnesium upregulates insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide-induced type-2 diabetic rats
Yang et al. Insulin stimulates Akt translocation to mitochondria: implications on dysregulation of mitochondrial oxidative phosphorylation in diabetic myocardium
CN103282031A (zh) 包含甲状腺激素的新药物组合物以及它们的治疗应用
Papazoglou et al. Hypothalamic serotonin–insulin signaling cross-talk and alterations in a type 2 diabetic model
Otlivanchik et al. Perifornical hypothalamic orexin and serotonin modulate the counterregulatory response to hypoglycemic and glucoprivic stimuli
Watała et al. Anti-diabetic effects of 1-methylnicotinamide (MNA) in streptozocin-induced diabetes in rats
Casaer et al. Bench-to-bedside review: metabolism and nutrition
Ybarra et al. Glycemia-lowering effect of cobalt chloride in the diabetic rat: increased GLUT1 mRNA expression
Tessari Changes in protein, carbohydrate, and fat metabolism with aging: possible role of insulin
Finocchietto et al. Control of muscle mitochondria by insulin entails activation of Akt2-mtNOS pathway: implications for the metabolic syndrome
US20110028554A1 (en) pharmaceutical compositions comprising diiodothyronine and their therapeutic use
Bhatnagar et al. Regulation of vascular smooth muscle cell growth by aldose reductase
Vazquez et al. Regulation of leucine catabolism by caloric sources. Role of glucose and lipid in nitrogen sparing during nitrogen deprivation.
Nair Metabolic effects of chromium—Potential molecular mechanisms
Wahba et al. Telmisartan and/or vitamin D3 ameliorate skeletal muscle injury in a rat model of metabolic syndrome: A new insight into PPAR-γ/AT1 receptor/GLUT4 axis

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20130904