CN103276468A - Preparation method of medical antibacterial polypropylene mesh containing nano silver - Google Patents
Preparation method of medical antibacterial polypropylene mesh containing nano silver Download PDFInfo
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- CN103276468A CN103276468A CN 201310187527 CN201310187527A CN103276468A CN 103276468 A CN103276468 A CN 103276468A CN 201310187527 CN201310187527 CN 201310187527 CN 201310187527 A CN201310187527 A CN 201310187527A CN 103276468 A CN103276468 A CN 103276468A
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- nano silver
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- antibacterial polypropylene
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Abstract
The invention discloses a preparation method of a medical antibacterial polypropylene mesh containing nano silver. The preparation method comprises the following steps of: (1) uniformly mixing antibacterial polypropylene master batches containing the nano silver with fiber-grade polypropylene chips, and putting the mixture into a twin-screw extruder for pelleting; (2) putting granules coming out of the twin-screw extruder into a vacuum drum dryer for drying; (3) spinning the dried granules by using a melt spinning machine to obtain as-spun fibers; (4) drafting the as-spun fibers to obtain fine fibers; and (5) plying 5-8 strands of the fine fibers, and weaving the fine fibers into the antibacterial polypropylene mesh. According to the preparation method, antibacterial agent nano silver is added into the polypropylene mesh to obtain the antibacterial polypropylene mesh containing the nano silver, so that the risk of infection after an abdominal external hernia tension-free neoplasty can be reduced, and the use of patient and social medical resources is reduced.
Description
Technical field
The present invention relates to a kind of preparation method of medical biomaterial, particularly a kind of preparation method who contains Nano Silver medical antibacterial polypropylene mesh.
Background technology
Abdominal external hernia is the common disease kind of surgery: be because the congenital or posteriori tissue of human body is weak, cause abdominal cavity interior tissue organ to protrude from body surface through weak spot, and then bring out a series of clinical symptoms.Using synthetic material that the human body weak spot is carried out " patch " formula and repair, is present modal modus operandi.
The patch material of using always both at home and abroad comprises several big kinds at present:
1, absorbable material does not comprise a, polypropylene mesh b, polyester webs sheet c, expanded PTFE net sheet
2, absorbable material comprises a, polyglycolic acid net sheet b, polylactic-co-glycolic acid net sheet c, acellular matrix material
Wherein not polyester and two kinds of net sheets of expanded PTFE in the absorbable material: all be because mesh is less, bacterium can be at the inner apposition growth of net sheet, but the immunocyte of body is difficult to enter kill bacteria, so the probability of POI is relatively large.And polypropylene mesh can allow the immunocyte of body to enter net sheet inside because mesh is relatively large, and then suppresses to be attached to the bacterial growth on the net sheet, so the POI probability is less.Though the antibacterial effect of polypropylene sticking patch is best relatively, but still might take place owing to bacterial reproduction causes infecting, and then cause operative failure.And this kind net sheet is very big in whole world use amount, even it is very little that the probability of infection takes place, the absolute number of morbidity is still very many.Therefore invention has the polypropylene mesh of antibacterial effect, has very large using value clinically, can produce bigger economy and social benefit.
Summary of the invention
For solving above technical problem, the object of the present invention is to provide a kind of preparation method who contains Nano Silver medical antibacterial polypropylene mesh.
The present invention seeks to realize like this: a kind of preparation method of antibacterial polypropylene net sheet is characterized in that: finish according to following steps:
(1), the commercially available antibiotic polypropylene master batch that contains Nano Silver and fibrous polypropylene section are mixed, enter extruding pelletization in the double screw extruder then;
(2), the pellet that will come out from double screw extruder is put into the vacuum drum drying machine and is carried out drying;
(3), dried pellet is carried out spinning with melt spinning machine and obtain as-spun fibre;
(4), as-spun fibre is carried out the drawing-off processing and obtain fine fibre;
(5) with the above-mentioned fine fibre plying of 5-8 thigh, be woven into antibacterial polypropylene net sheet then.
In technique scheme: the weight of the antibiotic polypropylene master batch of described argentiferous is the 5%-10% of the weight of fibrous polypropylene section.
In technique scheme: in the described step (2), dry temperature is 105 ℃, and the time is 12h.
In technique scheme: in the described step (4), drafting multiple is 3.2 times.
Beneficial effect: the present invention joins the antiseptic Nano Silver in the polypropylene mesh, obtains to contain the antibacterial polypropylene net sheet of Nano Silver, can reduce abdominal external hernia and not have tension force neoplasty postoperative infection risk, reduces the use of patient and social medical resource.
Below for the present invention preparation contain Nano Silver polypropylene mesh and conventional polypropylene mesh, to staphylococcus aureus standard bacterial classification 1,3, the inhibition of 7d.Can see, As time goes on, the decline of carrying out property of the bacterial concentration of argentiferous group, and carrying out property of the bacterial content rising of conventional group.(used experimental technique is the ware counting method of inclining)
Count of bacteria result (unit: 106cfu/ml)
Group 1d 3d 7d
Argentiferous group 250.85 ± 19.56 4.2 ± 0.214 0.059 ± 0.00342
Conventional group 270.85 ± 20.24 358.75 ± 27.48 631.25 ± 49.12
Two groups of data contrasts: 3d, 7d have significant difference (P＜0.05); 1d there was no significant difference (P＞0.05); Same group of different periods compare: contrast has statistical significance (P＜0.05) between argentiferous group group; Contrast has significant difference (P＜0.05) between conventional group group
The specific embodiment
Embodiment 1
A kind of preparation method of antibacterial polypropylene net sheet, finish according to following steps:
(1), the commercially available antibiotic polypropylene master batch (weight of Nano Silver and polyacrylic weight ratio are 1: 100) that contains Nano Silver and fibrous polypropylene section are mixed, enter extruding pelletization in the double screw extruder then.
The weight of the antibiotic polypropylene master batch of described argentiferous be fibrous polypropylene section weight 5%.Screw rod is respectively distinguished temperature:
| ? | One district | Two districts | Three districts | Four districts | Five districts | Six districts |
| Temperature | 180 | 195 | 195 | 205 | 210 | 210 |
The screw rod extruded velocity is: 20min
-1
(2), the pellet that will come out from double screw extruder puts into the vacuum drum drying machine and carries out drying,
105 ℃ of baking temperatures, drying time 12h.
(3), dried pellet is carried out spinning with melt spinning machine and obtain as-spun fibre;
The parameter of melt spinning machine is:
| ? | One district | Two districts | Three districts | Four districts | Measuring pump | Casing | Straight tube | Molten temperature |
| Temperature | 230 | 240 | 255 | 255 | 255 | 255 | 255 | 257 |
Winding speed: 1000m/min
Nylon finish: 15%
(4), as-spun fibre is carried out drawing-off handle and to obtain fine fibre in drawing machine, to improve the mechanical property of fiber, make fiber satisfy the requirement of braided fabric.3.2 times of drafting multiples, the parameter of drawing machine is:
The mechanical property of the polypropylene fibre after drawing-off is handled is:
(5) with 6 strands of above-mentioned fine fibres plying, be woven at Knitting Machinery then and contain Nano Silver medical antibacterial polypropylene mesh.
Embodiment 2
(1), the commercially available antibiotic polypropylene master batch (weight of Nano Silver and polyacrylic weight ratio are 1: 100) that contains Nano Silver and fibrous polypropylene section are mixed, enter extruding pelletization in the double screw extruder then.
The weight of the antibiotic polypropylene master batch of described argentiferous be fibrous polypropylene section weight 10%.
Screw rod is respectively distinguished temperature:
| ? | One district | Two districts | Three districts | Four districts | Five districts | Six districts |
| Temperature | 180 | 195 | 195 | 205 | 210 | 210 |
The screw rod extruded velocity is: 20min
-1
(2), the pellet that will come out from double screw extruder puts into the vacuum drum drying machine and carries out drying,
105 ℃ of baking temperatures, drying time 12h.
(3), dried pellet is carried out spinning with melt spinning machine and obtain as-spun fibre;
The parameter of melt spinning machine is:
| ? | One district | Two districts | Three districts | Four districts | Measuring pump | Casing | Straight tube | Molten temperature |
| Temperature | 230 | 240 | 255 | 255 | 255 | 255 | 255 | 257 |
Winding speed: 1000m/min
Nylon finish: 15%
(4), as-spun fibre is carried out drawing-off handle and to obtain fine fibre in drawing machine, to improve the mechanical property of fiber, make fiber satisfy the requirement of braided fabric.3.2 times of drafting multiples, the parameter of drawing machine is:
The mechanical property of the polypropylene fibre after drawing-off is handled is:
(5) with 8 strands of above-mentioned fine fibres plying, be woven at Knitting Machinery then and contain Nano Silver medical antibacterial polypropylene mesh.
Specific embodiments of the invention just further specify of the present invention, and the present invention is not limited to specific embodiment, everyly prepare antibacterial polypropylene net sheet according to aim of the present invention and all fall into protection scope of the present invention.
Claims (4)
1. preparation method who contains Nano Silver medical antibacterial polypropylene mesh is characterized in that: finish according to following steps:
(1), will contain the antibiotic polypropylene master batch of Nano Silver and the fibrous polypropylene section mixes, enter granulation in the double screw extruder then;
(2), the pellet that will come out from double screw extruder is put into the vacuum drum drying machine and is carried out drying;
(3), dried pellet is carried out spinning with melt spinning machine and obtain as-spun fibre;
(4), as-spun fibre is carried out the drawing-off processing and obtain fine fibre;
(5) with the above-mentioned fine fibre of 5-8 thigh plying, be woven into then and contain the nanometer silver antimicrobial polypropylene mesh.
2. according to the described preparation method who contains Nano Silver medical antibacterial polypropylene mesh of claim 1, it is characterized in that: the weight of the antibiotic polypropylene master batch of described argentiferous is the 5%-10% of the weight of fibrous polypropylene section.
3. according to the described preparation method who contains Nano Silver medical antibacterial polypropylene mesh of claim 1, it is characterized in that: in the described step (2), dry temperature is 105 ℃, and the time is 12h.
4. according to the described preparation method who contains Nano Silver medical antibacterial polypropylene mesh of claim 1, it is characterized in that: in the described step (4), drafting multiple is 3.2 times.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201310187527 CN103276468A (en) | 2013-05-20 | 2013-05-20 | Preparation method of medical antibacterial polypropylene mesh containing nano silver |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201310187527 CN103276468A (en) | 2013-05-20 | 2013-05-20 | Preparation method of medical antibacterial polypropylene mesh containing nano silver |
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| Publication Number | Publication Date |
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| CN103276468A true CN103276468A (en) | 2013-09-04 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201310187527 Pending CN103276468A (en) | 2013-05-20 | 2013-05-20 | Preparation method of medical antibacterial polypropylene mesh containing nano silver |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103893830A (en) * | 2014-03-31 | 2014-07-02 | 刘文博 | Nano-silver anti-infection hernia repair patch and preparation method thereof |
| WO2021051902A1 (en) * | 2019-09-17 | 2021-03-25 | 南通大学 | Developable composite biological mesh containing barium sulfate and preparation method therefor |
-
2013
- 2013-05-20 CN CN 201310187527 patent/CN103276468A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103893830A (en) * | 2014-03-31 | 2014-07-02 | 刘文博 | Nano-silver anti-infection hernia repair patch and preparation method thereof |
| WO2021051902A1 (en) * | 2019-09-17 | 2021-03-25 | 南通大学 | Developable composite biological mesh containing barium sulfate and preparation method therefor |
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Application publication date: 20130904 |