CN103275345A - Hemostatic sponge and preparation method thereof - Google Patents
Hemostatic sponge and preparation method thereof Download PDFInfo
- Publication number
- CN103275345A CN103275345A CN2013101669121A CN201310166912A CN103275345A CN 103275345 A CN103275345 A CN 103275345A CN 2013101669121 A CN2013101669121 A CN 2013101669121A CN 201310166912 A CN201310166912 A CN 201310166912A CN 103275345 A CN103275345 A CN 103275345A
- Authority
- CN
- China
- Prior art keywords
- preparation
- starch
- tissue
- modified starch
- styptic sponge
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The invention relates to hemostatic sponge and applications of the hemostatic sponge. The hemostatic sponge is prepared from the modified starch in the prior art, which is re-modified and subjected to ray irradiation. The hemostatic sponge is excellent in water absorption effect, safe and stable, and is biocompatible and can be directly applied to bloody wound surfaces.
Description
Technical field
The present invention relates to sponge of a kind of hemostasis and preparation method thereof, particularly styptic sponge a kind of biocompatibility, that can be directly used in the blood surface of a wound and preparation method thereof.
Background technology
Hemorrhage is the phenomenon of easy appearance in accident and the medical procedure, and therefore a large amount of hemorrhage entail dangers to people's life security need in time stop blooding at the hemorrhage surface of a wound.
Along with the development of medical science, hemostatic material is of a great variety, and with regard to biocompatibility, biocompatible hemostatic material commonly used has: gelatin class hemostatic materials such as absorbability gelfoam, collagen protein sponge; SURGICEL, oxidized regenerated cellulose class hemostatic material; Natural biological polysaccharide hemostatic materials such as chitosan/chitin kind, starch polysaccharide etc.
Content of the present invention relates to the hemostatic material of starch polysaccharide, and the patent application that this field is relevant is as follows:
CN200710141944.0 denaturated starch absorbable hemostatic material and preparation method thereof, the CN200710199682.3 biocompatibility modified starch sponges, the modified starch material of CN200810032631.6 biocompatible hemostatic, anti, promoting healing, surgery sealing, modified starch that CN200810033239.3 is biocompatibility pre-gelatinized and preparation method thereof, CN200810009706.9 denaturated starch absorbable hemostatic material and preparation method thereof, CN200910045995.2 biocompatible hemostatic and promotion knitting material and preparation method thereof.
More than 6 patent applications, described content is roughly the same, is same applicant or contriver.The purposes of partially denaturing starch aspect hemostasis disclosed in the above-mentioned patent, and several specific modified starches have been proposed, as the hydroxypropyl Staragel 90V of the modified starch of cationic starch, epichlorohydrin cross-linked starch, carboxymethyl starch, hydroxyethylamyle, pre-gelatinization, pre-gelatinization, vinylformic acid-carboxymethyl starch graft copolymer etc., but its specific nature and detailed applications are not described.
The applicant has carried out systematic study to above-mentioned all kinds of modified starches, finds that the modified starch water absorbent rate in the above-mentioned patent application is low, and unstable properties can not satisfy the demand of clinical hemostasis.Therefore the applicant has carried out following processing to modified starch of the prior art: modified starch of the prior art is carried out sex change again be prepared into through the modified starch after the sex change repeatedly, and carry out radiation exposure and handle in this process.The applicant after with radiation exposure modified starch being handled, surprised discovery, it can also improve water absorbent rate and the rate of water absorption of modified starch.The applicant discovers through repeated experiments repeatedly, and the styptic sponge that the technical scheme by the application obtains can significantly improve its water-absorbent, has fabulous application prospect.The applicant has also filtered out preferred processing parameter by experiment simultaneously, its preparation more stable, and safety more benefits suitability for industrialized production.
Summary of the invention
An object of the present invention is to provide a kind of new styptic sponge, this material good water absorption, safety, stable performance, it is low to have overcome in the prior art modified starch water-absorbent, shortcomings such as preparation instability.
Another object of the present invention is to provide the preparation method of described styptic sponge, the objective of the invention is to be achieved through the following technical solutions:
A kind of preparation method of styptic sponge is characterized in that: may further comprise the steps:
1) the modified starch raw material is carried out etherificate, crosslinked, esterification is repeatedly made new modified starch after the sex change,
2) drying, freeze-drying under the low temperature obtains styptic sponge.
Preferably, the modified starch raw material in the step 1 is one or more the combination in pre-gelatinized starch, denaturated starch by acid, dextrin, Sumstar 190, esterification starch, etherification starch, cross-linking starch, graft starch, the composite modified starch.
Preferably, before step 1, among or add the radiation exposure treatment step afterwards.
Preferably, the wavelength of ray is 0.01nm-400 μ m.
Preferably, ray is X ray.
Preferably, ray is infrared rays or ultraviolet ray.
Preferably, gamma intensity is 0.8keV-1.5keV.
Preferably, radiation power is 400-600W.
Preferably, the x radiation x time is 8-12min.
Another technical scheme of the present invention designs the purposes of the styptic sponge for preparing by method of the present invention:
The hemostatic material that the blood surface of a wound is arranged for the preparation of people, Mammals, birds, Reptilia.
The blood surface of a wound is arranged or be used for hemostatic material under surgical operation, emergency care of trauma, laryngoscope, endoscope, the chamber mirror for the preparation of body surface, in-vivo tissue organ and body cavity inner tissue or organ.
For the preparation of the material that promotes organization healing.
Preferably, described tissue comprises sub-dermal soft tissue, muscle tissue, osseous tissue, cerebral tissue, nervous tissue, liver,kidney,spleen.
In the material that sticks together for the preparation of the tissue that prevents wound or organ and its hetero-organization on every side or organ.
The applicant finds that method of the present invention has following characteristics after having carried out a series of conditional filtering tests:
Beneficial effect of the present invention:
1. method of the present invention has no requirement to the kind of modified starch, the modified starch of seeing commonly used may be used to present method in the prior art, its water absorbent rate of the styptic sponge for preparing and rate of water absorption have tangible performance advantage all far above modified starch sponges of the prior art.For example compare with control group, water absorbent rate on average improves more than 35%, and rate of water absorption improves more than 1 times, and tangible performance advantage is arranged.
The radiation exposure step can be positioned at before the modified starch denaturation process, among or afterwards, as long as in the preparation whole process of modified starch, used the radiation exposure step, all can improve water absorbent rate and the rate of water absorption of the new modified starch of acquisition.
3. the kind of ray is very wide in range, and the ray of wavelength between 0.01nm-400 μ m all can be used for the present invention.
4. the present invention is by carrying out sex change again to existing modified starch, and in addition radiation exposure is handled, further broken up the structure of starch molecule, significantly improved its water absorbing properties, and selected preferred processing parameter by a large amount of testing sieves, make the styptic sponge for preparing be better than like product of the prior art at water absorbing properties, wide application prospect is arranged.Convenient, preparation more stable that styptic sponge of the present invention prepares, safety more benefits suitability for industrialized production.
Embodiment
Below in conjunction with embodiment the present invention is further described in detail, the embodiment that provides is only in order to illustrate the present invention, rather than in order to limit the scope of the invention.
Embodiment 1:
With the hydroxypropyl Staragel 90V through chemical reagent such as propylene oxide, phosphoric acid carry out etherificate, crosslinked, esterification is repeatedly made new modified starch after the sex change, again this modified starch slurry is placed under the x-ray bombardment, irradiation 12min, X ray intensity is 0.8KeV, suction filtration is with alcohol washing, drying, be lyophilize 15 hours under 15 handkerchiefs at-45 ℃, vacuum tightness, obtain styptic sponge 1.
Embodiment 2:
Hydroxypropyl Staragel 90V slurry is placed under the x-ray bombardment, irradiation 12min, X ray intensity is 1.5KeV, suction filtration, with alcohol washing, drying, again through chemical reagent such as propylene oxide, phosphoric acid carry out etherificate, crosslinked, esterification is repeatedly made new modified starch after the sex change, be lyophilize 15 hours under 15 handkerchiefs at-45 ℃, vacuum tightness, obtain styptic sponge 2.
Embodiment 3:
With hydroxyethylamyle through chemical reagent such as propylene oxide, phosphoric acid carry out etherificate, crosslinked, esterification is repeatedly made new modified starch after the sex change, again this modified starch slurry is placed under the x-ray bombardment, irradiation 8min, X ray intensity is 0.8KeV, suction filtration is with alcohol washing, drying, be lyophilize 15 hours under 15 handkerchiefs at-45 ℃, vacuum tightness, obtain styptic sponge 3.
Embodiment 4:
The hydroxyethylamyle slurry is placed under the x-ray bombardment, irradiation 8min, X ray intensity is 1.5KeV, suction filtration, with alcohol washing, drying, again through chemical reagent such as propylene oxide, phosphoric acid carry out etherificate, crosslinked, esterification is repeatedly made new modified starch after the sex change, be lyophilize 15 hours under 15 handkerchiefs at-45 ℃, vacuum tightness, obtain styptic sponge 4.
Embodiment 5:
With carboxymethyl starch through chemical reagent such as propylene oxide, phosphoric acid carry out etherificate, crosslinked, esterification is repeatedly made new modified starch after the sex change, again this modified starch slurry is placed under the x-ray bombardment, irradiation 12min, X ray intensity is 1.5KeV, suction filtration is with alcohol washing, drying, be lyophilize 15 hours under 15 handkerchiefs at-45 ℃, vacuum tightness, obtain styptic sponge 5.
Embodiment 6:
The carboxymethyl starch slurry is placed under the x-ray bombardment, irradiation 8min, X ray intensity is 0.8KeV, suction filtration, with alcohol washing, drying, again through chemical reagent such as propylene oxide, phosphoric acid carry out etherificate, crosslinked, esterification is repeatedly made new modified starch after the sex change, be lyophilize 15 hours under 15 handkerchiefs at-45 ℃, vacuum tightness, obtain styptic sponge 6.
Embodiment 7:
With cationic starch through chemical reagent such as propylene oxide, phosphoric acid carry out etherificate, crosslinked, esterification is repeatedly made new modified starch after the sex change, again this modified starch slurry is placed under the uviolizing, irradiation 8min, irradiation power is 400W, suction filtration is with alcohol washing, drying, be lyophilize 15 hours under 15 handkerchiefs at-45 ℃, vacuum tightness, obtain styptic sponge 7.
Embodiment 8:
The cationic starch slurry is placed under the uviolizing, irradiation 12min, irradiation power is 600W, suction filtration, with alcohol washing, drying, again through chemical reagent such as propylene oxide, phosphoric acid carry out etherificate, crosslinked, esterification is repeatedly made new modified starch after the sex change, be lyophilize 15 hours under 15 handkerchiefs at-45 ℃, vacuum tightness, obtain styptic sponge 8.
Embodiment 9:
With the hydroxypropyl Staragel 90V through chemical reagent such as propylene oxide, phosphoric acid carry out etherificate, crosslinked, esterification is repeatedly made new modified starch after the sex change, again this modified starch slurry is placed under the uviolizing, irradiation 8min, irradiation power is 400W, suction filtration is with alcohol washing, drying, be lyophilize 15 hours under 15 handkerchiefs at-45 ℃, vacuum tightness, obtain styptic sponge 9.
Embodiment 10:
Hydroxypropyl Staragel 90V slurry is placed under the uviolizing, irradiation 8min, irradiation power is 600W, suction filtration, with alcohol washing, drying, again through chemical reagent such as propylene oxide, phosphoric acid carry out etherificate, crosslinked, esterification is repeatedly made new modified starch after the sex change, be lyophilize 15 hours under 15 handkerchiefs at-45 ℃, vacuum tightness, obtain styptic sponge 10.
Embodiment 11:
With hydroxyethylamyle through chemical reagent such as propylene oxide, phosphoric acid carry out etherificate, crosslinked, esterification is repeatedly made new modified starch after the sex change, again this modified starch slurry is placed under the uviolizing, irradiation 8min, irradiation power is 400W, suction filtration is with alcohol washing, drying, be lyophilize 15 hours under 15 handkerchiefs at-45 ℃, vacuum tightness, obtain styptic sponge 11.
Embodiment 12:
The hydroxyethylamyle slurry is placed under the infrared ray radiation, irradiation 8min, irradiation power is 400W, suction filtration, with alcohol washing, drying, again through chemical reagent such as propylene oxide, phosphoric acid carry out etherificate, crosslinked, esterification is repeatedly made new modified starch after the sex change, be lyophilize 15 hours under 15 handkerchiefs at-45 ℃, vacuum tightness, obtain styptic sponge 12.
Embodiment 13:
With carboxymethyl starch through chemical reagent such as propylene oxide, phosphoric acid carry out etherificate, crosslinked, esterification is repeatedly made new modified starch after the sex change, again this modified starch slurry is placed under the infrared ray radiation, irradiation 12min, irradiation power is 600W, suction filtration is with alcohol washing, drying, be lyophilize 15 hours under 15 handkerchiefs at-45 ℃, vacuum tightness, obtain styptic sponge 13.
Embodiment 14:
The carboxymethyl starch slurry is placed under the infrared ray radiation, irradiation 12min, irradiation power is 600W, suction filtration, with alcohol washing, drying, again through chemical reagent such as propylene oxide, phosphoric acid carry out etherificate, crosslinked, esterification is repeatedly made new modified starch after the sex change, be lyophilize 15 hours under 15 handkerchiefs at-45 ℃, vacuum tightness, obtain styptic sponge 14.
Embodiment 15:
With cationic starch through chemical reagent such as propylene oxide, phosphoric acid carry out etherificate, crosslinked, esterification is repeatedly made new modified starch after the sex change, again this modified starch slurry is placed under the infrared ray radiation, irradiation 12min, irradiation power is 400W, suction filtration is with alcohol washing, drying, be lyophilize 15 hours under 15 handkerchiefs at-45 ℃, vacuum tightness, obtain styptic sponge 15.
Embodiment 16:
The cationic starch slurry is placed under the infrared ray radiation, irradiation 2min, irradiation power is 400W, suction filtration, with alcohol washing, drying, again through chemical reagent such as propylene oxide, phosphoric acid carry out etherificate, crosslinked, esterification is repeatedly made new modified starch after the sex change, be lyophilize 15 hours under 15 handkerchiefs at-45 ℃, vacuum tightness, obtain styptic sponge 16.
Embodiment 17 control group experimental designs
Method according to the embodiment 1,3,4,5 of patent cn200710199682.3 prepares styptic sponge A respectively, C, D, E, group in contrast.
The water absorbent rate of embodiment 18 styptic sponges and the detection of rate of water absorption
Multiplying power that sponge sucks in water adopts centrifugal determination, is about to about 0.025g sponge as in the 2ml water, and balance 10min puts into whizzer then, under the 500rpm rotating speed, takes out after centrifugal 10 minutes, weighs and calculates the raffinate amount, and each sample test is removed mean value 6 times.
The rate of water absorption of sponge is observed by the German Dataphysics OCA40Micro of company video contact angle measurement.
Experimental result: the styptic sponge A that the 16 kinds of hemostasis starch that makes by embodiment 1-16 method and embodiment 17 control groups obtain, C, D, its water absorbent rate of E and rate of water absorption contrast are as shown in the table:
Table 2
Interpretation:
Can draw following conclusion by above experimental data:
1. method of the present invention has no requirement to the kind of modified starch, the modified starch of seeing commonly used may be used to present method in the prior art, its water absorbent rate of the styptic sponge for preparing and rate of water absorption have tangible performance advantage all far above modified starch sponges of the prior art.For example compare with control group, water absorbent rate on average improves more than 30%, and rate of water absorption improves more than 1 times, and tangible performance advantage is arranged.
The radiation exposure step can be positioned at before the modified starch denaturation process, among or afterwards, as long as in the preparation whole process of modified starch, used the radiation exposure step, all can improve water absorbent rate and the rate of water absorption of the new modified starch of acquisition.
3. the kind of ray is very wide in range, and the ray of wavelength between 0.01nm-400 μ m all can be used for the present invention.
Embodiment 4 modified starch styptic sponges are to the haemostatic effect of the hemorrhage model of liver
Test method:
Cut liver placenta percreta area 1.5cm * 2.5cm in the pig liver surface with scalpel, the surface of a wound degree of depth is 0.25cm, makes the hemorrhage surface of a wound, and the styptic sponge of employing has: styptic sponge 1-90, the styptic sponge that control group adopts has styptic sponge A, C, D, E.
Respectively the above-mentioned surface of a wound is stopped blooding.After hemorrhage, immediately styptic sponge is placed on the wound and also exerts pressure in sponge with medical surgical gloves or hemostatic gauze, blocking blood flow unclamps gloves or gauze behind 1～2min gently, observe haemostatic effect, gloves and gauze whether adhesion sponge and sludged blood, cause again hemorrhage when opening.Need not after the hemostasis modified starch sponges is taken away or removed, get final product but do suitable infiltration flushing with physiological saline.
Test-results:
Styptic sponge 1-16 haemostatic effect is fine, and easy to use.All styptic sponges are met and are sucked blood immediately behind blood and form the sponge-sludged blood colloid of viscosity with blood, all can control the hemorrhage of the liver surface of a wound effectively within 1 minute, and styptic sponge A, C, D, E just can control hemorrhage in the time more than 1.5 minutes.Styptic sponge 1-90 and liver wound tissue tight adhesion promote blood coagulation, and sludged blood does not stick together with the gauze dressing of pressing, and can not cause again hemorrhage.
Claims (15)
1. the preparation method of a styptic sponge is characterized in that: may further comprise the steps:
1) the modified starch raw material is carried out etherificate, crosslinked, esterification is repeatedly made new modified starch after the sex change,
2) drying, freeze-drying under the low temperature obtains styptic sponge.
2. preparation method as claimed in claim 1 is characterized in that: the modified starch raw material in the step 1 is one or more the combination in pre-gelatinized starch, denaturated starch by acid, dextrin, Sumstar 190, esterification starch, etherification starch, cross-linking starch, graft starch, the composite modified starch.
3. as the described preparation method of claim 1-2, it is characterized in that: before step 1, among or add the radiation exposure treatment step afterwards.
4. preparation method as claimed in claim 3, it is characterized in that: the wavelength of ray is 0.01nm-400 μ m.
5. as the described preparation method of claim 3-4, it is characterized in that: ray is X ray.
6. as the described preparation method of claim 3-5, it is characterized in that: ray is infrared rays or ultraviolet ray.
7. preparation method as claimed in claim 5, it is characterized in that: gamma intensity is 0.8keV-1.5keV.
8. preparation method as claimed in claim 6, it is characterized in that: radiation power is 400-600W.
9. as the described preparation method of claim 3-8, it is characterized in that: the x radiation x time is 8-12min.
10. the styptic sponge for preparing of the described method of claim 1-9.
11. the purposes of the styptic sponge of claim 10, its feature exists: the hemostatic material that the blood surface of a wound is arranged for the preparation of people, Mammals, birds, Reptilia.
12. the purposes of the styptic sponge of claim 10, its feature exists: the blood surface of a wound is arranged or be used for hemostatic material under surgical operation, emergency care of trauma, laryngoscope, endoscope, the chamber mirror for the preparation of body surface, in-vivo tissue organ and body cavity inner tissue or organ.
13. the purposes of the styptic sponge of claim 10 is characterized in that: for the preparation of promoting tissue material more.
14. the purposes of the styptic sponge of claim 13 is characterized in that: described tissue comprises sub-dermal soft tissue, muscle tissue, osseous tissue, cerebral tissue, nervous tissue, liver,kidney,spleen.
15. the purposes of the styptic sponge of claim 10 is characterized in that: in the material that sticks together for the preparation of the tissue that prevents wound or organ and its hetero-organization on every side or organ.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310166912.1A CN103275345B (en) | 2013-05-08 | 2013-05-08 | A kind of sthptic sponge and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310166912.1A CN103275345B (en) | 2013-05-08 | 2013-05-08 | A kind of sthptic sponge and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103275345A true CN103275345A (en) | 2013-09-04 |
| CN103275345B CN103275345B (en) | 2016-08-10 |
Family
ID=49057981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310166912.1A Active CN103275345B (en) | 2013-05-08 | 2013-05-08 | A kind of sthptic sponge and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103275345B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103265719A (en) * | 2013-05-08 | 2013-08-28 | 江苏德威兰医疗器械有限公司 | Hemostasis sponge and preparation method thereof |
| CN103275344A (en) * | 2013-05-08 | 2013-09-04 | 江苏德威兰医疗器械有限公司 | Hemostatic sponge and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101455857A (en) * | 2007-12-11 | 2009-06-17 | 美国淀粉医疗公司 | Biocompatibility modified starch sponges |
| CN101497670A (en) * | 2008-01-29 | 2009-08-05 | 纪欣 | Biocompatibility pre-gelatinized modified starch and preparation thereof |
| CN103265719A (en) * | 2013-05-08 | 2013-08-28 | 江苏德威兰医疗器械有限公司 | Hemostasis sponge and preparation method thereof |
| CN103275344A (en) * | 2013-05-08 | 2013-09-04 | 江苏德威兰医疗器械有限公司 | Hemostatic sponge and preparation method thereof |
-
2013
- 2013-05-08 CN CN201310166912.1A patent/CN103275345B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101455857A (en) * | 2007-12-11 | 2009-06-17 | 美国淀粉医疗公司 | Biocompatibility modified starch sponges |
| CN101497670A (en) * | 2008-01-29 | 2009-08-05 | 纪欣 | Biocompatibility pre-gelatinized modified starch and preparation thereof |
| CN103265719A (en) * | 2013-05-08 | 2013-08-28 | 江苏德威兰医疗器械有限公司 | Hemostasis sponge and preparation method thereof |
| CN103275344A (en) * | 2013-05-08 | 2013-09-04 | 江苏德威兰医疗器械有限公司 | Hemostatic sponge and preparation method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103265719A (en) * | 2013-05-08 | 2013-08-28 | 江苏德威兰医疗器械有限公司 | Hemostasis sponge and preparation method thereof |
| CN103275344A (en) * | 2013-05-08 | 2013-09-04 | 江苏德威兰医疗器械有限公司 | Hemostatic sponge and preparation method thereof |
| CN103275344B (en) * | 2013-05-08 | 2016-08-10 | 江苏德威兰医疗器械有限公司 | A kind of sthptic sponge and preparation method thereof |
| CN103265719B (en) * | 2013-05-08 | 2016-08-10 | 江苏德威兰医疗器械有限公司 | A kind of sthptic sponge and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103275345B (en) | 2016-08-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103265641B (en) | A kind of hemostatic starch and preparation method thereof | |
| US10195312B2 (en) | Modified starch material of biocompatible hemostasis | |
| CN106456823B (en) | Medical product and method of manufacturing the same | |
| EP2203053B1 (en) | Modified starch material of biocompatible hemostasis | |
| WO2009076873A1 (en) | A biocompatible denatured starch sponge material | |
| CN103333261B (en) | A kind of hemostatic starch and preparation method thereof | |
| CN107233612B (en) | Irradiation crosslinking hemostatic gel material and preparation method thereof | |
| CN103224568A (en) | Bleeding stopping starch and preparation method thereof | |
| CN106822987B (en) | A kind of preparation method of the porous ball hemostatic material of chitin-alginic acid salt | |
| CN103265719B (en) | A kind of sthptic sponge and preparation method thereof | |
| CN103275344A (en) | Hemostatic sponge and preparation method thereof | |
| CN113908330B (en) | Preparation method of composite gel with photothermal antibacterial hemostatic characteristics, product and application thereof | |
| CN103275345A (en) | Hemostatic sponge and preparation method thereof | |
| CN103265640B (en) | A kind of hemostatic starch and preparation method thereof | |
| CN110448714B (en) | Moisture-absorbing and bacteriostatic chitosan/sodium alginate interwoven dressing and preparation method thereof | |
| CN109125795B (en) | Polysaccharide hemostatic composition and preparation method and application thereof | |
| CN103224645A (en) | Bleeding stopping sponge and preparation method thereof | |
| KR100459494B1 (en) | Method for the preparation of hydrogels for wound dressings | |
| CN103319744B (en) | A kind of sthptic sponge and preparation method thereof | |
| CN108066809A (en) | A kind of antibacterial styptic sponge | |
| US20240042095A1 (en) | Composition for treating wound comprising dermal tissue-derived extracellular matrix and method for preparing same | |
| CN107596433B (en) | Preparation method of hemostatic powder with rapid liquid absorption and hemostatic properties | |
| CN103319615B (en) | A kind of hemostatic starch and preparation method thereof | |
| CN103319615A (en) | Hemostasis starch and preparation method thereof | |
| Lao et al. | Hemostasis Effect of Absorbable Regenerative Oxidized Cellulose Materials in Colorectal Cancer Surgery |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20150401 Address after: 225300 Jiangsu city of Taizhou province China pharmaceutical Road East, Xinyang City Road on the north side (G34 building) Applicant after: Jiangsu Deweilan Medical Instrument Co., Ltd. Applicant after: Zhou Xiao Address before: 225300 Jiangsu city of Taizhou province China pharmaceutical Road East, Xinyang City Road on the north side (G34 building) Applicant before: Jiangsu Deweilan Medical Instrument Co., Ltd. Applicant before: Liu Bozhi Applicant before: Zhou Xiao |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address | ||
| CP03 | Change of name, title or address |
Address after: 225300 Taizhou City, Jiangsu Province, China Medicine Chengkou Tai Road East, Xinyang Road North (G34) Workshop Area, First to Fourth Floors Co-patentee after: Zhou Xiao Patentee after: Jiangsu Deweilan medical equipment Limited by Share Ltd Address before: 225300 Jiangsu city of Taizhou province China pharmaceutical Road East, Xinyang City Road on the north side (G34 building) Co-patentee before: Zhou Xiao Patentee before: Jiangsu Deweilan Medical Instrument Co., Ltd. |