CN103272163B - Traditional Chinese medicine composition for cleaning nasal cavity and application thereof - Google Patents
Traditional Chinese medicine composition for cleaning nasal cavity and application thereof Download PDFInfo
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- CN103272163B CN103272163B CN201310198039.4A CN201310198039A CN103272163B CN 103272163 B CN103272163 B CN 103272163B CN 201310198039 A CN201310198039 A CN 201310198039A CN 103272163 B CN103272163 B CN 103272163B
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Abstract
The invention provides a traditional Chinese medicine composition for cleaning a nasal cavity. The traditional Chinese medicine composition is mainly prepared from black false hellebore, mint, borneol, musk, realgar, fructus amomi, agilawood, elecampane, galangal, clove, cortex cinnamomi and adina rubella hance. A traditional Chinese medicine composition preparation is in the form of powder and water decoction spray. As a schneiderian membrane is stimulated to sneeze, bacterial viruses, inhaled dusts and nicotine remained after smoking in the nasal cavity are eliminated from a body along with nasal excreta, the traditional Chinese medicine composition has the effects of relieving pains, diminishing inflammation and inhibiting bacteria and regulating immunity so as to achieve the purposes of cleaning the nasal cavity, keeping the nasal cavity wet and improving the self-cleaning function of the nasal cavity, and can be used for preparing a medicament for cleaning the nasal cavity, keeping the nasal cavity wet and improving the self-cleaning function of the nasal cavity.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to a kind of Chinese medicine composition of clean nasal cavity, and the application in the medicine of the clean nasal cavity of preparation, maintenance nasal cavity moistening, enhancing nasal cavity self-cleaning function.
Background technology
Nose is positioned at face center, is the start-up portion of respiratory tract, and the organs such as eye, ear, pharynx, oral cavity, cranium brain around distribute.Nose is that human body carries out one of metabolic vitals, is again to prevent pathogenic microorganism, dust, the first line of defence that foul etc. are invaded.
Nose is the gateway of breathing, and nasal cavity has nasal mucosa, mucous gland and abundant blood capillary, and mucous gland can be secreted mucus.These structures can make the air that sucks nasal cavity become warm, moistening, reduce the stimulation to respiratory tract, and respiratory tract is had to protective effect.Must mouth breathing when heart nasal cavity stops up, now the effect comfort such as the heating of nasal cavity, humidification disappears, and the infection of pharyngitis, laryngitis and lower respiratory tract etc. easily occurs
one of child, due to the long-term mouth breathing of important nasal obstruction, can cause lower jaw abnormality.
Nose is the gateway of breathing, and is also one of door infecting, and nasal cavity is resident various microorganisms, when skin of nose mucosa is impaired, just easily infects
nose and eye, ear, cranium brain anatomical position are close, and nasal infection also can cause the complication of eye, ear, cranium brain.On nasolacrimal duct, connect lachrymal sac, be opened on inferior nasal meatus front upper place downwards, eye communicates whereby with nose.If lacrimal ductule is abnormal or lacrimal ductule to obstruction of naso lacrimal duct or narrow, can make tear not discharge; Nasal obstruction also can make tear can not enter nasal cavity, causes and sends out epiphora.The pharyngeal opening of auditory tube of nasopharynx sidewall, fits in concha nasalis inferior rear end approximately 1～1.5cm place.Therefore cause nasal obstruction when concha nasalis inferior swelling or plumpness, also can affect pharyngotympanic tube ventilation and drain, and occur ear's symptoms such as tinnitus and auditory dysesthesia; Nasal infection can cause salpingitis, and makes infection extend to middle ear by pharyngotympanic tube, causes otitis media.Nasal infection, particularly flu, is to cause the modal reason of acute otitis media.At the bottom of nasal cavity and Ethmoid roof are anterior cranial fossa, at the bottom of sphenoid sinus roof and sidewall are middle cranial fossa, sinus frontalis rear wall is anterior cranial fossa antetheca.This close anatomical relationship of nose and paranasal sinuses and cranium brain, easily causes nasal intracranial complication, as Nao Mo Yan ﹑ orbital cellulitis etc.; By blood, can cause cavernous sinus infection, serious happiness person can be blind, even threat to life.Do not come
Due to environmental pollution and air quality decline, the illness of nasal cavity or respiratory tract increases rapidly in recent years, and patient group increases sharply, and traces it to its cause, closely related with the dysfunction of nasal cavity.Add the particularity of nasal cavity anatomical position, the infection of nasal cavity easily causes the severe complication of respiratory tract, eye, ear, cranium brain.Hereat, clean, the health care of nasal cavity, safeguard that its normal physiological function is most important, more and more receives the concern in medical research field.
Summary of the invention
First object of the present invention is to provide a kind of Chinese medicine composition of clean nasal cavity, by the raw material of following weight portion proportioning, is made: Rhizoma et radix veratri (Radix Rhizoma Veratri) 5.0-7.0, Herba Menthae 0.5-1.0, Borneolum Syntheticum 1-2.0, Moschus 0.3-0.5, Realgar 0.5-1.0, Fructus Amomi 0.2-0.5, Lignum Aquilariae Resinatum 0.2-0.5, Radix Aucklandiae 0.2-0.5, southern Rhizoma Zingiberis Recens 0.2-0.5, Flos Caryophylli 0.5-1.0, Cortex Cinnamomi 0.2-0.5, Radix Gei japonici 1.0-2.0.
The preferred compositions of above-mentioned formula is: Rhizoma et radix veratri (Radix Rhizoma Veratri) 5.5, Fructus Amomi 2.0, Lignum Aquilariae Resinatum 2.0, the Radix Aucklandiae 2.0, southern Rhizoma Zingiberis Recens 2.0, Radix Gei japonici 1.0, Flos Caryophylli 0.5, Herba Menthae 1.0, Borneolum Syntheticum 1.0, Moschus 0.3, Cortex Cinnamomi 0.2, Realgar 1.0.
Second object of the present invention is to provide a kind of Chinese medicine composition of clean nasal cavity, by the raw material of following weight portion proportioning, made: Fructus Amomi 5.0-8.0, Lignum Aquilariae Resinatum 5.0-8.0, Radix Aucklandiae 5.0-8.0, southern Rhizoma Zingiberis Recens 3.0-5.0, Flos Caryophylli 10.0-20.0, Herba Menthae 10.0-15.0, Borneolum Syntheticum 10.0-15.0, Moschus 3-5, Cortex Cinnamomi 5.0-10.0.
The preferred compositions of above-mentioned formula is: Fructus Amomi 8.0, Lignum Aquilariae Resinatum 8.0, the Radix Aucklandiae 5.0, southern Rhizoma Zingiberis Recens 3.0, Flos Caryophylli 15.0, Herba Menthae 10.0, Borneolum Syntheticum 10.0, Moschus 5, Cortex Cinnamomi 5.0.
A further object of the present invention is to provide Chinese medicine composition described above application in the medicine of the clean nasal cavity of preparation, maintenance nasal cavity moistening, enhancing nasal cavity self-cleaning function.Pharmaceutical dosage forms prepared by Chinese medicine composition described in above-mentioned purpose one (containing preferred compositions) is powder, and the pharmaceutical dosage forms that prepared by Chinese medicine composition (containing preferred compositions) described in above-mentioned purpose two is decocting liquid spray.
The mechanism of medicine of the present invention is: by stimulating nasal mucosa to cause sneeze, the bacterial virus in nasal cavity, breathe the dust of coming in and excrete with nasal cavity Excreta because of the residual nicotine of smoking.Effective ingredient used in medicine is: Rhizoma et radix veratri (Radix Rhizoma Veratri), Fructus Amomi, Lignum Aquilariae Resinatum, the Radix Aucklandiae, southern Rhizoma Zingiberis Recens, Radix Gei japonici, Flos Caryophylli, Herba Menthae, Borneolum Syntheticum, Moschus, Cortex Cinnamomi etc.Rhizoma et radix veratri (Radix Rhizoma Veratri) enters Liver Channel, and mucosa is had to local strong stimulation, can cause sneeze, has antifungic action; Cortex Cinnamomi, Fructus Amomi Xin Wenre, return taste warp, energy removing dampness circulation of qi promoting, promoting the flow of QI-blood by warming the meridian; The Radix Aucklandiae, the pungent temperature of Flos Caryophylli property, returns spleen, stomach warp, and energy warming middle-JIAO to promote flow of QI, has antiinflammatory bactericidal action; South Jiang Xinre, returns spleen, stomach warp, can promoting the circulation of QI to relieve pain eliminate the phlegm, and has bacteriostasis; Radix Gei japonici hardship is cool, and energy heat clearing and damp drying, removing toxic substances, have bacteriostasis; Borneolum Syntheticum, Moschus are pungent, GUIXIN warp, the refreshment of having one's ideas straightened out, have pain relieving, antiinflammatory antibacterial, regulate immunization.Powder and the water decoction same use of spraying, can antibacterial anti-inflammatory, clean all kinds of abnormal secretion things of nasal cavity mucous membrane surface, thoroughly clean nasal cavity, keep nasal cavity moistening, strengthen nasal cavity " self-cleaning function ", even improve " immunity " of nasal cavity.
The specific embodiment
With embodiment, the invention will be further described below, but the present invention is not limited to these embodiment.
Each raw material of embodiment 1:(is all with weight portion proportioning)
Rhizoma et radix veratri (Radix Rhizoma Veratri) 5.5, Fructus Amomi 2.0, Lignum Aquilariae Resinatum 2.0, the Radix Aucklandiae 2.0, southern Rhizoma Zingiberis Recens 2.0, Radix Gei japonici 1.0, Flos Caryophylli 0.5, Herba Menthae 1.0, Borneolum Syntheticum 1.0, Moschus 0.3, Cortex Cinnamomi 0.2, Realgar 1.0.
The preparation technology of medicine of the present invention (powder): each raw material grinds superfine powder, sterilization, canned after with weight proportion.
Each raw material of embodiment 2:(is all with weight portion proportioning)
Fructus Amomi 8.0, Lignum Aquilariae Resinatum 8.0, the Radix Aucklandiae 5.0, southern Rhizoma Zingiberis Recens 3.0, Flos Caryophylli 15.0, Herba Menthae 10.0, Borneolum Syntheticum 10.0, Moschus 5, Cortex Cinnamomi 5.0.
The preparation technology of medicine of the present invention (water decoction): each raw material decocts with water and is prepared as after decocting liquid with weight proportion, coarse filtration, fine filtering, sterilizing, canned.
Embodiment 3: zoopery
For effect of the present invention is described, applicant has carried out zoopery by product of the present invention, specific as follows:
1, the grouping of laboratory animal and administration: healthy wild-type mice, body weight (23 ± 2) g, male, clean level, is divided into matched group and administration group at random.Matched group nasal spray normal saline, administration group nasal cavity first gives a little powder of the present invention, afterwards nasal spray water decoction of the present invention; Every day 2 times, continuous 7 days.
Experiment mice is divided into 2 groups at random, and the situation of specifically dividing into groups is in Table 1.
2, the impact of the present invention on laboratory animal body weight: weigh after every morning administration.
Matched group and administration group laboratory animal body weight do not have significant change (in Table 2)
3, the present invention is on laboratory animal sneeze and scratch the impact of nose number of times: every morning is to the sneeze in observation post administration 10 min and scratch nose number of times.
After the administration of administration group laboratory animal, in second day 10 min, sneeze number declines, and within 2-7 days, is stable state, there is no significant change (in Table 3); The nose number of times of scratching after the administration of administration group laboratory animal in 10 min does not have significant change (in Table 3) in 7 days.
4, blood smear is observed quantity of leucocyte: administration is after 7 days, and eye socket is got blood smear, Giemsa staining, the leukocytic number of light Microscopic observation.
The leukocyte number of laboratory animal blood smear administration group and matched group does not have significant difference (in Table 4).
5, antiinflammatory action: eye socket is got after blood, 100% dimethylbenzene 50 uL are coated with and give the left ear of laboratory animal, and auris dextra gives 50 uL normal saline, after 1 h, put to death laboratory animal, with card punch preparation experiment animal auricle, weigh immediately, using swelling and inhibitory rate of intumesce as inflammation index.
The swelling of administration group laboratory animal auricle is lower than the swelling of matched group laboratory animal auricle, and inhibitory rate of intumesce is that 21.277%(is in Table 5).
6, spleen, thymus index: laboratory animal is taken out rapidly complete spleen, thymus after putting to death, and with electronic balance, claims thymus, spleen weight in wet base, and thymus, spleen weight index represent with thymus in every 10 g body weight or the shared weight of spleen (mg/10 g).
The spleen of administration group laboratory animal, thymus index are compared with matched group does not have significant change (in Table 6).
Embodiment 4: clinical case
1, Qi, man, 43 years old, coal miner.Rhinitis 3 years, nose difficult breathing of itching, smoke and dust environment work.Use the powder of this invention and water decoction spraying, nasal cavity first gives a little powder of the present invention simultaneously, nasal spray water decoction of the present invention afterwards, 2 times/day.After 1 month, all symptoms take a turn for the better.In adhering to using.
2, Guo, female, 58 years old, peasant.Rhinitis for many years, sneeze, flowing water tears, bilateral nostril is stopped up, with aversion to cold aversion to wind, headache, general weakness.Use the powder of this invention and water decoction spraying, nasal cavity first gives a little powder of the present invention simultaneously, nasal spray water decoction of the present invention afterwards, 2 times/day.After 7 days, nose ventilation, watery nasal discharge obviously reduces; Use after 15 days the readme aversion to wind sense of being afraid of cold to alleviate, adhere to using euosmia 3 months.Now use once in a while and keep nasal cavity cleaning.
3, easily certain, man, 12 years old, student.Because flu causes allergic rhinitis 1 year, often there is sneeze, snivel, nasal obstruction symptom, more so, sleep poor night.Use the powder of this invention and water decoction spraying, nasal cavity first gives a little powder of the present invention simultaneously, nasal spray water decoction of the present invention afterwards, 2 times/day.Use 3 days sneeze, snivels to alleviate; Use 7 days left nare substantially to ventilate; Use and sleep stable at night in 15 days; Use symptom after 1 month all to disappear.Now adhere to using to keep nasal cavity cleaning.
Claims (4)
1. the Chinese medicine composition of a clean nasal cavity, it is characterized in that, by the raw material of following weight portion proportioning, made: Rhizoma et radix veratri (Radix Rhizoma Veratri) 5.5, Fructus Amomi 2.0, Lignum Aquilariae Resinatum 2.0, the Radix Aucklandiae 2.0, southern Rhizoma Zingiberis Recens 2.0, Radix Gei japonici 1.0, Flos Caryophylli 0.5, Herba Menthae 1.0, Borneolum Syntheticum 1.0, Moschus 0.3, Cortex Cinnamomi 0.2, Realgar 1.0.
2. a Chinese medicine composition for clean nasal cavity, is characterized in that, by the raw material of following weight portion proportioning, is made: Fructus Amomi 8.0, Lignum Aquilariae Resinatum 8.0, the Radix Aucklandiae 5.0, southern Rhizoma Zingiberis Recens 3.0, Flos Caryophylli 15.0, Herba Menthae 10.0, Borneolum Syntheticum 10.0, Moschus 5, Cortex Cinnamomi 5.0.
3. the application of the Chinese medicine composition of a kind of clean nasal cavity according to claim 1 and 2 in the medicine of the clean nasal cavity of preparation, maintenance nasal cavity moistening, enhancing nasal cavity self-cleaning function.
4. the application of the Chinese medicine composition of a kind of clean nasal cavity according to claim 3 in the medicine of the clean nasal cavity of preparation, maintenance nasal cavity moistening, enhancing nasal cavity self-cleaning function, it is characterized in that, the pharmaceutical dosage forms that described in claim 1 prepared by Chinese medicine composition is powder, and the pharmaceutical dosage forms that prepared by Chinese medicine composition described in claim 2 is decocting liquid spray.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310198039.4A CN103272163B (en) | 2013-05-26 | 2013-05-26 | Traditional Chinese medicine composition for cleaning nasal cavity and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310198039.4A CN103272163B (en) | 2013-05-26 | 2013-05-26 | Traditional Chinese medicine composition for cleaning nasal cavity and application thereof |
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| Publication Number | Publication Date |
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| CN103272163A CN103272163A (en) | 2013-09-04 |
| CN103272163B true CN103272163B (en) | 2014-11-19 |
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| CN201310198039.4A Active CN103272163B (en) | 2013-05-26 | 2013-05-26 | Traditional Chinese medicine composition for cleaning nasal cavity and application thereof |
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