CN103270176A - 发现药物基因组生物标志物的方法 - Google Patents

发现药物基因组生物标志物的方法 Download PDF

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CN103270176A
CN103270176A CN201280002881XA CN201280002881A CN103270176A CN 103270176 A CN103270176 A CN 103270176A CN 201280002881X A CN201280002881X A CN 201280002881XA CN 201280002881 A CN201280002881 A CN 201280002881A CN 103270176 A CN103270176 A CN 103270176A
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genotyping
sample
genome
genomic dna
algorithm
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罗文�
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Suoyuan Biomedicine Hangzhou Co ltd
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Suoyuan Biomedicine Hangzhou Co ltd
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/40—Population genetics; Linkage disequilibrium
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Life Sciences & Earth Sciences (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
CN201280002881XA 2011-01-31 2012-01-30 发现药物基因组生物标志物的方法 Pending CN103270176A (zh)

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US201161437788P 2011-01-31 2011-01-31
US61/437,788 2011-01-31
PCT/US2012/023195 WO2012106267A1 (en) 2011-01-31 2012-01-30 Method for discovering pharmacogenomic biomarkers

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US (2) US20140031242A1 (https=)
EP (1) EP2707498B1 (https=)
JP (3) JP2014506459A (https=)
KR (1) KR102006417B1 (https=)
CN (2) CN103270176A (https=)
AU (1) AU2012212499A1 (https=)
CA (1) CA2826109A1 (https=)
IL (1) IL227696A0 (https=)
MX (1) MX2013008846A (https=)
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WO (1) WO2012106267A1 (https=)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108108592A (zh) * 2017-12-29 2018-06-01 北京聚道科技有限公司 一种用于遗传变异致病性打分的机器学习模型的构建方法
CN109074425A (zh) * 2016-05-11 2018-12-21 国际商业机器公司 预测个体化癌转移途径，转移生物学介质和转移阻滞治疗
CN109872792A (zh) * 2019-04-16 2019-06-11 北京中佰耀因医药科技有限公司 一种用于指导精准用药的基因检测智能报告系统
CN109979545A (zh) * 2019-04-16 2019-07-05 北京中佰耀因医药科技有限公司 一种含样本状态信息管理模块的精准用药智能报告系统
CN109994176A (zh) * 2019-04-16 2019-07-09 北京中佰耀因医药科技有限公司 一种含样本类型信息管理模块的精准用药智能报告系统
CN109994180A (zh) * 2019-04-16 2019-07-09 北京中佰耀因医药科技有限公司 一种含基因位点信息管理模块的精准用药智能报告系统
CN109994156A (zh) * 2019-04-16 2019-07-09 北京中佰耀因医药科技有限公司 一种含报告模板信息管理模块的精准用药智能报告系统
CN110010200A (zh) * 2019-04-16 2019-07-12 长沙三济生物科技有限公司 一种基因身份识别系统
CN110010222A (zh) * 2019-04-16 2019-07-12 长沙三济生物科技有限公司 一种基于精准用药知识库的基因身份识别系统

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104965998B (zh) * 2015-05-29 2017-09-15 华中农业大学 多靶标药物和/或药物组合的筛选方法
KR102415328B1 (ko) * 2015-12-03 2022-06-30 삼성전자주식회사 전기적 특성을 개선할 수 있는 에스램 소자 및 이를 포함하는 로직 소자
US20180294158A1 (en) * 2015-12-04 2018-10-11 The Silanna Group Pty Ltd Semiconductor on insulator substrate
JOP20190025A1 (ar) 2016-09-01 2019-02-19 Denovo Biopharma Llc طرق وتركيبة لتوقع نشاط إنزاستورين
US10886040B2 (en) 2016-11-01 2021-01-05 Sumitomo Electric Industries, Ltd. Superconducting wire
EP4106872A4 (en) 2020-03-06 2024-04-10 Denovo Biopharma LLC Compositions and methods for assessing the efficacy of inhibitors of neurotransmitter transporters
WO2023069116A1 (en) * 2021-10-22 2023-04-27 Illumina, Inc. Genotyping methods and systems
US12518859B2 (en) * 2023-07-26 2026-01-06 Helix, Inc. Systems and methods for providing test results of gene sequencing data on a recurring basis
CN119832990B (zh) * 2024-12-19 2025-09-16 公安部第一研究所 一种利用slsqp分析二混dna的混合比例方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101191143A (zh) * 2006-11-22 2008-06-04 上海生物芯片有限公司 无需核酸标记的基因芯片及其检测方法和应用
US7790396B1 (en) * 2009-12-23 2010-09-07 Suregene, Llc Methods and compositions for the treatment of psychotic disorders through the identification of the SULT4A1-1 haplotype

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101191143A (zh) * 2006-11-22 2008-06-04 上海生物芯片有限公司 无需核酸标记的基因芯片及其检测方法和应用
US7790396B1 (en) * 2009-12-23 2010-09-07 Suregene, Llc Methods and compositions for the treatment of psychotic disorders through the identification of the SULT4A1-1 haplotype

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JONATHAN B SINGER等: "A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury", 《NATURE GENETICS》 *
SIMON MEAD等: "Genetic risk factors for variant Creutzfeldt–Jakob disease: a genome-wide association study", 《LANCET NEUROL》 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109074425A (zh) * 2016-05-11 2018-12-21 国际商业机器公司 预测个体化癌转移途径，转移生物学介质和转移阻滞治疗
CN108108592A (zh) * 2017-12-29 2018-06-01 北京聚道科技有限公司 一种用于遗传变异致病性打分的机器学习模型的构建方法
CN108108592B (zh) * 2017-12-29 2020-06-16 北京聚道科技有限公司 一种用于遗传变异致病性打分的机器学习模型的构建方法
CN109872792A (zh) * 2019-04-16 2019-06-11 北京中佰耀因医药科技有限公司 一种用于指导精准用药的基因检测智能报告系统
CN109979545A (zh) * 2019-04-16 2019-07-05 北京中佰耀因医药科技有限公司 一种含样本状态信息管理模块的精准用药智能报告系统
CN109994176A (zh) * 2019-04-16 2019-07-09 北京中佰耀因医药科技有限公司 一种含样本类型信息管理模块的精准用药智能报告系统
CN109994180A (zh) * 2019-04-16 2019-07-09 北京中佰耀因医药科技有限公司 一种含基因位点信息管理模块的精准用药智能报告系统
CN109994156A (zh) * 2019-04-16 2019-07-09 北京中佰耀因医药科技有限公司 一种含报告模板信息管理模块的精准用药智能报告系统
CN110010200A (zh) * 2019-04-16 2019-07-12 长沙三济生物科技有限公司 一种基因身份识别系统
CN110010222A (zh) * 2019-04-16 2019-07-12 长沙三济生物科技有限公司 一种基于精准用药知识库的基因身份识别系统

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Publication number Publication date
EP2707498B1 (en) 2018-01-17
JP2016214257A (ja) 2016-12-22
JP6440658B2 (ja) 2018-12-19
IL227696A0 (en) 2013-09-30
AU2012212499A1 (en) 2013-08-22
CA2826109A1 (en) 2012-08-09
SG192202A1 (en) 2013-08-30
JP2014506459A (ja) 2014-03-17
KR20140040700A (ko) 2014-04-03
JP2018148930A (ja) 2018-09-27
CN107475371A (zh) 2017-12-15
CN107475371B (zh) 2021-06-11
US20210108266A1 (en) 2021-04-15
MX2013008846A (es) 2014-02-11
US20140031242A1 (en) 2014-01-30
WO2012106267A1 (en) 2012-08-09
EP2707498A1 (en) 2014-03-19
KR102006417B1 (ko) 2019-08-01

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