CN103254050A - Process for extracting curcumin - Google Patents
Process for extracting curcumin Download PDFInfo
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- CN103254050A CN103254050A CN201310141337XA CN201310141337A CN103254050A CN 103254050 A CN103254050 A CN 103254050A CN 201310141337X A CN201310141337X A CN 201310141337XA CN 201310141337 A CN201310141337 A CN 201310141337A CN 103254050 A CN103254050 A CN 103254050A
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- extraction
- curcumine
- ginger
- carbon dioxide
- curcumin
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention provides a process for extracting curcumin by a carbon dioxide supercritical extraction method. According to the process, curcumin is extracted from ginger by taking a supercritical carbon dioxide liquid as an extractant and 95% ethanol as an entrainer. The method adopted is simple in flow and convenient to operate. Separation is realized at the same time in the extraction process, and the method has no bad effect on production personnel and the environment. The yield and purity of curcumin are high.
Description
Technical field
The present invention relates to a kind of plant constituent extraction and separation method, specifically refer to a kind of extraction and separation method of turmeric effective ingredient curcumin.
Background technology
Curcumine (Curcumin) is a kind of xanthein that obtains that extracts from rhizome such as zingiberaceous plant turmeric.Be acid polyphenols, main chain is unsaturated aliphatic and aromatic group.Be typically used as meat-based food tinting material and acid base indicator, have anti-inflammatory, pharmacological action such as anti-oxidant simultaneously.DEVELOPMENT PROSPECT with medicine widely or food aspect.For this reason, the quality of the preparation of curcumine and extraction and separation technology is subjected to increasing attention.
Prior art is to be carried out condensation and got by Vanillin and methyl ethyl diketone to the preparation of curcumine.Take anhydrous ethyl acetate dissolving Vanillin, the complex compound that adds tributyl borate then and generated by methyl ethyl diketone, boron trioxide drips n-Butyl Amine 99 again, drips off and stirs 4-5h, and placement is spent the night.The 0.4N hydrochloric acid that adds 60 ℃ next day continues to stir 1h, and with 50 ℃ of water bath heat preservations, makes to react completely.Divide the water layer of dereaction resultant, wash with water 3-4 time, leach curcumine, obtain crude product 2-3 time with the ethyl acetate washing, get product with ethyl alcohol recrystallization.But in building-up process, unavoidably can produce related substance, and be retained in the middle of the product, remove related substance and have certain difficulty, badly influence quality product.
Prior art also can be extracted from turmeric by enzyme process or HPLC method and obtain.The mode of just going is: yellow ginger washes with water, pulverizes, after fermentation and the acid hydrolysis, and centrifugation solids (hydrolyzate) and acidic aqueous solution extract the curcumine that is dissolved in the aqueous solution with N-BUTYL ACETATE from the aqueous solution; Be contained in curcumine in the solids (hydrolyzate) with N-BUTYL ACETATE extraction again, be about to curcumine and separate through returning extraction.Through further handling, can obtain the curcumine product.
CN200710304013 discloses a kind of extraction and separation method of turmeric effective ingredient curcumin, belonging to the separation of Chinese medicine extracts active ingredients and technology uses, the extraction and separation method of this compound of curcumine, its process comprises: turmeric is pulverized, add that buck is cold to be carried, filter, through macroporous resin column chromatography, use the alcohol-water gradient elution, collect elutriant, reduction vaporization concentrates, vacuum-drying namely obtains effective ingredient curcumin.
The product that from turmeric, directly extracts, the product of the condensation prepared of comparing, the impurity in the product mainly are the impurity little to the human influence that plant itself contains, so product has higher security, purposes is also relatively extensively.
But above-mentioned technology extraction cost is higher, and the material of employing can't be accomplished to recycle, and can produce harm to environment.
Summary of the invention
In order to overcome the deficiency of said extracted mode, the invention provides the extraction process that a kind of carbon dioxide supercritical extraction method prepares curcumine, be to adopt CO 2 fluid under the supercritical state as extraction agent, the extraction and separation technology of extraction curcumine from ginger.Flow process is simple, and is easy to operate, realize to separate simultaneously in extraction process, producers and environment are had no adverse effects, and the yield of the curcumine that obtains and purity is higher.
For achieving the above object, the present invention is achieved in that
Earlier ginger is carried out pre-treatment---ginger is carried out drying, then dried Rhizoma Zingiberis Recens powder is broken into fragment.After the ginger pre-treatment, it is carried out supercritical carbon dioxide extraction, at last the carbonic acid gas of the target extract that contains is reduced pressure to resolve and separate, the component that parses is curcumine.
The condition of carbon dioxide upercritical fluid extraction is: pressure 10-50MPa, temperature 30-90 ℃, time 60-150 minute, 95% ethanol is entrainment agent, the ethanol mass ratio of ginger fragment and extraction agent carbonic acid gas and entrainment agent 95% is followed successively by 1-1.5:15-50:0.5-1.5, extract is resolved in decompression, the dry curcumine that gets.
Condition the best of carbon dioxide upercritical fluid extraction is: the ethanol mass ratio of ginger fragment and extraction agent carbonic acid gas and entrainment agent 95% is followed successively by 1:30:1.5, and extracting pressure is 30MPa, and extraction temperature is 50 ℃, and the extraction time is 120 minutes.
The present invention has following positive effect: by the curcumine method in the above carbon dioxide upercritical fluid extraction ginger, improve the yield of curcumine, the extraction yield can reach 85%, and purity reaches 96%.The almost non-toxic property of extracted products solvent, production technique are low in the pollution of the environment.In addition, present method treasury is got, separation of double action scope one, does not have the phase transition process of material, does not need heat, and is easy to operate, simplified technical process greatly, not only saved power consumption, reduced production cost, and production safety is reliable.
Embodiment:
The present invention is described in further detail below in conjunction with embodiment.
Embodiment 1
The drying treatment of 1kg and the ginger fragment pulverized being dropped in the extractor 95% ethanol consumption is 50kg, and the consumption of carbonic acid gas is 1.0kg, is 50MPa at pressure, and extraction temperature is to carry out supercritical carbon dioxide extraction under 30 ℃ the condition, and the time is 60 minutes.Extract is resolved in decompression, the dry curcumine that gets.Yield is 80%, and purity is 94%.
Embodiment 2
The drying treatment of 1kg and the ginger fragment pulverized being dropped in the extractor 95% ethanol consumption is 15kg, and the consumption of carbonic acid gas is 1.0kg, is 50MPa at pressure, and extraction temperature is to carry out supercritical carbon dioxide extraction under 40 ℃ the condition, and the time is 150 minutes.Extract is resolved in decompression, the dry curcumine that gets.Yield is 75%, and purity is 94%.
Embodiment 3
The drying treatment of 1kg and the ginger fragment pulverized being dropped in the extractor 95% ethanol consumption is 15kg, and the consumption of carbonic acid gas is 1.0kg, is 50MPa at pressure, and extraction temperature is to carry out supercritical carbon dioxide extraction under 60 ℃ the condition, and the time is 60 minutes.Extract is resolved in decompression, the dry curcumine that gets.Yield is 74%, and purity is 92%.
Embodiment 4
The drying treatment of 1kg and the ginger fragment pulverized being dropped in the extractor 95% ethanol consumption is 30kg, and the consumption of carbonic acid gas is 1.5kg, is 30MPa at pressure, and extraction temperature is to carry out supercritical carbon dioxide extraction under 50 ℃ the condition, and the time is 120 minutes.Extract is resolved in decompression, the dry curcumine that gets.Yield is 85%, and purity is 96%.
Above-mentioned embodiment and embodiment be not as the restriction to technical scheme of the present invention.
Claims (2)
1. the extraction process of a curcumine is characterized in that step is as follows:
1) with ginger drying, pulverizing in flakes;
2) carbon dioxide upercritical fluid extraction: pressure 10-50MPa, temperature 30-90 ℃, time 60-150 minute, 95% ethanol is entrainment agent, the ethanol mass ratio of ginger fragment and extraction agent carbonic acid gas and entrainment agent 95% is followed successively by 1-1.5:15-50:0.5-1.5, extract is resolved in decompression, the dry curcumine that gets.
2. the extraction process of curcumine according to claim 1, it is characterized in that, the condition of carbon dioxide upercritical fluid extraction is that the ethanol mass ratio of ginger fragment and extraction agent carbonic acid gas and entrainment agent 95% is followed successively by 1:30:1.5, extracting pressure is 30MPa, extraction temperature is 50 ℃, and the extraction time is 120 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310141337XA CN103254050A (en) | 2013-04-23 | 2013-04-23 | Process for extracting curcumin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310141337XA CN103254050A (en) | 2013-04-23 | 2013-04-23 | Process for extracting curcumin |
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| CN103254050A true CN103254050A (en) | 2013-08-21 |
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| CN201310141337XA Withdrawn CN103254050A (en) | 2013-04-23 | 2013-04-23 | Process for extracting curcumin |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103565819A (en) * | 2013-10-18 | 2014-02-12 | 上海科爱生物技术有限公司 | Composition for inhibiting tumor stem cells |
| CN105669409A (en) * | 2016-01-12 | 2016-06-15 | 郭月玲 | Curcumin extraction method |
| CN110240541A (en) * | 2019-07-08 | 2019-09-17 | 哈尔滨工业大学 | It is a kind of to use vacuum couplings ultrasonic wave-supercritical CO2The method of extraction extraction curcumin |
| CN112999173A (en) * | 2021-04-13 | 2021-06-22 | 云南氪莱铂科技有限公司 | Preparation method of functional heating smoke body and heating non-combustible cigarette |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101259247A (en) * | 2008-04-22 | 2008-09-10 | 美晨集团股份有限公司 | Method for continuously extracting various active ingredient in turmeric |
-
2013
- 2013-04-23 CN CN201310141337XA patent/CN103254050A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101259247A (en) * | 2008-04-22 | 2008-09-10 | 美晨集团股份有限公司 | Method for continuously extracting various active ingredient in turmeric |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103565819A (en) * | 2013-10-18 | 2014-02-12 | 上海科爱生物技术有限公司 | Composition for inhibiting tumor stem cells |
| CN105669409A (en) * | 2016-01-12 | 2016-06-15 | 郭月玲 | Curcumin extraction method |
| CN105669409B (en) * | 2016-01-12 | 2018-01-05 | 郭月玲 | A kind of curcumin extracting method |
| CN110240541A (en) * | 2019-07-08 | 2019-09-17 | 哈尔滨工业大学 | It is a kind of to use vacuum couplings ultrasonic wave-supercritical CO2The method of extraction extraction curcumin |
| CN112999173A (en) * | 2021-04-13 | 2021-06-22 | 云南氪莱铂科技有限公司 | Preparation method of functional heating smoke body and heating non-combustible cigarette |
| CN112999173B (en) * | 2021-04-13 | 2022-06-14 | 云南氪莱铂科技有限公司 | Preparation method of functional heating smoke body and heating non-combustible cigarette |
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Application publication date: 20130821 |