CN103251859B - One treats dermopathic pharmaceutical composition - Google Patents
One treats dermopathic pharmaceutical composition Download PDFInfo
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- CN103251859B CN103251859B CN201310080895.XA CN201310080895A CN103251859B CN 103251859 B CN103251859 B CN 103251859B CN 201310080895 A CN201310080895 A CN 201310080895A CN 103251859 B CN103251859 B CN 103251859B
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Abstract
The invention discloses a kind for the treatment of or alleviate dermopathic pharmaceutical composition, being made up of the Chinese medicine such as Radix Rehmanniae, Folium Isatidis, the dosage forms such as pill, tablet, capsule can being prepared into according to clinical needs.This pharmaceutical composition has very excellent treatment or mitigation for psoriasis.
Description
Technical field
The invention discloses a kind for the treatment of or alleviate dermopathic pharmaceutical composition, being made up of the Chinese medicine such as Radix Rehmanniae, Folium Isatidis, the dosage forms such as pill, tablet, capsule can being prepared into according to clinical needs.This pharmaceutical composition has very excellent treatment or mitigation for psoriasis.
Background technology
Dermatosis is one of the commonly encountered diseases, frequently-occurring disease that have a strong impact on people ' s health, after referring to that skin (comprising hair and first) is subject to the impact of internal and external factor, its form, 26S Proteasome Structure and Function all change, and produce pathological process, and the various clinical priority performance of corresponding generation.Common dermatosis has psoriasis (psoriasis), vitiligo, rosacea, impetigo, pyogenic baeceria infection, cicatrix, tinea, ichthyosis, bromhidrosis, comedo, folliculitis, alopecia areata, alopecia, clavus, freckle, pompholyx, acarid dermatitis, eczema, urticaria, tinea unguium, scleroderma, skin pruritus, depilation, chloasma etc.Because the dermopathic definite pathogenic factor of majority is not yet clear, current treating for skin disease all can only temporary relief of symptoms, can't effect a radical cure or prevent recurrence.
Wherein, psoriasis is that a kind of common chronic inflammatory skin is sick, and the traditional Chinese medical science has another name called “ Bai Mange ", among the people have title " psoriasis ", belongs to typical difficult miscellaneous diseases.Psoriasis can by multiple motivating factor, and as wound, infection, medicine etc. all may bring out this disease in susceptible individual, quite a few patient is then unknown cause morbidity.Typical cutaneous manifestations is the red speckle that boundary clearly has silvery white squama, and the lighter can show as the patella ulnaris position speckle of several silver coin size, and severe one also can be got involved by whole skin, has a strong impact on the life of patient with self-confident.Doctor trained in Western medicine generally adopts the chemotherapy such as immunosuppressant or corticosteroid hormone to this disease, and therapeutic effect is poor, and namely drug withdrawal recurs, even therefore exacerbation of symptoms.The traditional Chinese medical science it is generally acknowledged that psoriatic main pathogenesis is that heat in blood poison is contained, and asthenia of qi and blood wind-dryness etc. causes, reported in literature treat the method for the treatment of of this disease and prescription also more, but mostly also be temporary relief symptom, and need Long-term taking medicine.
Summary of the invention
The invention provides a kind of pharmaceutical composition, effectively can alleviate and even effect a radical cure dermatosis.It is better that the present invention is used for psoriatic therapeutic effect, especially psoriasis vulgaris heat in blood wind-dryness syndrome.This pharmaceutical composition is made up of the component of following weight proportioning:
Radix Rehmanniae 30-110 part, Folium Isatidis 30-150 part, Radix Scrophulariae 15-90 part, Radix Salviae Miltiorrhizae 15-150 part, Radix Paeoniae Rubra 30-80 part, Rhizoma Smilacis Glabrae 70-150 part.
Preferred pharmaceutical composition is made up of the component of following weight proportioning:
Radix Rehmanniae 60-90 part, Folium Isatidis 80-130 part, Radix Scrophulariae 50-80 part, Radix Salviae Miltiorrhizae 80-130 part, Radix Paeoniae Rubra 50-70 part, Rhizoma Smilacis Glabrae 80-130 part.
Most preferred pharmaceutical composition is made up of the component of following weight proportioning:
Radix Rehmanniae 80 parts, Folium Isatidis 110 parts, Radix Scrophulariae 70 parts, Radix Salviae Miltiorrhizae 100 parts, Radix Paeoniae Rubra 60 parts, Rhizoma Smilacis Glabrae 90 parts.
In addition, the basis of aforementioned pharmaceutical compositions can also increase as one sees fit the component of following weight proportioning:
Fructus Forsythiae 40-90 part, Cortex Moutan 50-90 part, Rhizoma Polygoni Cuspidati 30-90 part, Carapax et Plastrum Testudinis 40-100 part, Cortex Dictamni 30-100 part, Radix Glycyrrhizae 20-70 part.
Wherein, the preferred weight proportioning of above-mentioned increased component is:
Fructus Forsythiae 50-80 part, Cortex Moutan 60-80 part, Rhizoma Polygoni Cuspidati 40-70 part, Carapax et Plastrum Testudinis 60-90 part, Cortex Dictamni 50-90 part, Radix Glycyrrhizae 30-60 part.
The most preferably weight proportion of above-mentioned increased component is:
Fructus Forsythiae 60 parts, Cortex Moutan 70 parts, Rhizoma Polygoni Cuspidati 50 parts, Carapax et Plastrum Testudinis 80 parts, Cortex Dictamni 80 parts, 40 parts, Radix Glycyrrhizae.
In addition, according to the dialectical difference of individual patients, can also be carried out some to above-mentioned prescription and adjust flexibly, include but not limited to: increase or alleviate part or all of prescription consumption; Delete constituent part; Increase or replace some clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling or the Chinese medicine that nourishes blood.Certainly, these adjustment all should be included within the present invention.
Pharmaceutical composition of the present invention can be prepared as various dosage form, includes but not limited to: decoction, tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, ointment, plaster, cream, spray, drop.Research shows, pharmaceutical composition of the present invention can be oral, also can external, or orally combines with external, all has good clinical effectiveness.
Wherein, the preferred dosage form of pharmaceutical composition of the present invention is pill, and preparation method is comparatively simple, and taking convenience, utilization ratio of drug is higher.Its preparation method comprises the following steps:
(1) mixed powder is broken into fine powder, sieves, mixing;
(2) general with water is piller;
(3) dry;
(4) subpackage;
(5) sterilizing, to obtain final product.
Content of the present invention also comprises the application that this pharmaceutical composition is treated in preparation or improved in dermopathic medicine, the application being preferably preparation treatment or alleviating in psoriatic medicine.
The present invention is described further by the following examples.
Detailed description of the invention
Embodiment 1
Prescription: Radix Rehmanniae 80g, Folium Isatidis 110g, Radix Scrophulariae 70g, Radix Salviae Miltiorrhizae 100g, Radix Paeoniae Rubra 60g, Rhizoma Smilacis Glabrae 90g.
Preparation: take the above-mentioned prescription prepared slices of Chinese crude drugs, pulverizes after mixing as fine powder, sieves, mixing, and with water pill, dry, subpackage, namely sterilizing obtains pill.
Usage and dosage: oral, each 6g, two ~ tri-times on the one.
Embodiment 2
Prescription: Radix Rehmanniae 60g, Folium Isatidis 130, Radix Scrophulariae 50, Radix Salviae Miltiorrhizae 130, Radix Paeoniae Rubra 50, Rhizoma Smilacis Glabrae 130.
Preparation: take the above-mentioned prescription prepared slices of Chinese crude drugs, pulverizes after mixing as fine powder, sieves, mixing, and with water pill, dry, subpackage, namely sterilizing obtains pill.
Usage and dosage: oral, each 6g, two ~ tri-times on the one.
Embodiment 3
Prescription: Radix Rehmanniae 90g, Folium Isatidis 80g, Radix Scrophulariae 80g, Radix Salviae Miltiorrhizae 80g, Radix Paeoniae Rubra 70g, Rhizoma Smilacis Glabrae 80g.
Preparation: take the above-mentioned prescription prepared slices of Chinese crude drugs, be placed in container, add 2 times of water, heating extraction 1 hour, filters to obtain Aqueous extracts.Repeatedly extract 3 times, merge extractive liquid, is concentrated into 2000ml and get final product.
Usage and dosage: oral, each 100ml, twice on the one.External, directly smears illing skin, one day one ~ twice.
Embodiment 4
Radix Rehmanniae 30g, Folium Isatidis 150g, Radix Scrophulariae 15g, Radix Salviae Miltiorrhizae 150g, Radix Paeoniae Rubra 30g, Rhizoma Smilacis Glabrae 150g.
Preparation: take the above-mentioned prescription prepared slices of Chinese crude drugs, pulverizes after mixing as fine powder, sieves, mixing, and with water pill, dry, subpackage, namely sterilizing obtains pill.
Usage and dosage: oral, each 6g, two ~ tri-times on the one.
Embodiment 5
Radix Rehmanniae 110g, Folium Isatidis 30g, Radix Scrophulariae 90g, Radix Salviae Miltiorrhizae 15g, Radix Paeoniae Rubra 80g, Rhizoma Smilacis Glabrae 70g.
Preparation: take the above-mentioned prescription prepared slices of Chinese crude drugs, pulverizes after mixing as fine powder, sieves, mixing, and with water pill, dry, subpackage, namely sterilizing obtains pill.
Usage and dosage: oral, each 6g, two ~ tri-times on the one.
Embodiment 6
Radix Rehmanniae 80g, Folium Isatidis 110g, Radix Scrophulariae 70g, Radix Salviae Miltiorrhizae 100g, Radix Paeoniae Rubra 60g, Rhizoma Smilacis Glabrae 90g, Fructus Forsythiae 60g, Cortex Moutan 70g, Rhizoma Polygoni Cuspidati 50g, Carapax et Plastrum Testudinis 80g, Cortex Dictamni 80g, Radix Glycyrrhizae 40g.
Preparation: take the above-mentioned prescription prepared slices of Chinese crude drugs, pulverizes after mixing as fine powder, sieves, mixing, and with water pill, dry, subpackage, namely sterilizing obtains pill.
Usage and dosage: oral, each 6g, two ~ tri-times on the one.
Embodiment 7
Radix Rehmanniae 60g, Folium Isatidis 80g, Radix Scrophulariae 80g, Radix Salviae Miltiorrhizae 100g, Radix Paeoniae Rubra 70g, Rhizoma Smilacis Glabrae 90g, Fructus Forsythiae 50g, Cortex Moutan 60g, Rhizoma Polygoni Cuspidati 50g, Carapax et Plastrum Testudinis 80g, Cortex Dictamni 50g, Radix Glycyrrhizae 30g.
Preparation: take the above-mentioned prescription prepared slices of Chinese crude drugs, pulverizes after mixing as fine powder, sieves, mixing, and with water pill, dry, subpackage, namely sterilizing obtains pill.
Usage and dosage: oral, each 6g, two ~ tri-times on the one.
Embodiment 8
Radix Rehmanniae 90g, Folium Isatidis 110g, Radix Scrophulariae 70g, Radix Salviae Miltiorrhizae 80g, Radix Paeoniae Rubra 60g, Rhizoma Smilacis Glabrae 130g, Fructus Forsythiae 80g, Cortex Moutan 80g, Rhizoma Polygoni Cuspidati 70g, Carapax et Plastrum Testudinis 60g, Cortex Dictamni 90g, Radix Glycyrrhizae 40g.
Preparation: take the above-mentioned prescription prepared slices of Chinese crude drugs, pulverizes after mixing as fine powder, sieves, mixing, and with water pill, dry, subpackage, namely sterilizing obtains pill.
Usage and dosage: oral, each 6g, two ~ tri-times on the one.
Embodiment 9
Radix Rehmanniae 80g, Folium Isatidis 130g, Radix Scrophulariae 50g, Radix Salviae Miltiorrhizae 130g, Radix Paeoniae Rubra 50g, Rhizoma Smilacis Glabrae 80g, Fructus Forsythiae 60g, Cortex Moutan 70g, Rhizoma Polygoni Cuspidati 40g, Carapax et Plastrum Testudinis 90g, Cortex Dictamni 80g, Radix Glycyrrhizae 60g.
Preparation: take the above-mentioned prescription prepared slices of Chinese crude drugs, pulverizes after mixing as fine powder, sieves, mixing, and with water pill, dry, subpackage, namely sterilizing obtains pill.
Usage and dosage: oral, each 6g, two ~ tri-times on the one.
Embodiment 10
Radix Rehmanniae 30g, Folium Isatidis 150g, Radix Scrophulariae 15g, Radix Salviae Miltiorrhizae 150g, Radix Paeoniae Rubra 80g, Rhizoma Smilacis Glabrae 70g, Fructus Forsythiae 90g, Cortex Moutan 50g, Rhizoma Polygoni Cuspidati 30g, Carapax et Plastrum Testudinis 40g, Cortex Dictamni 100g, Radix Glycyrrhizae 70g.
Preparation: take the above-mentioned prescription prepared slices of Chinese crude drugs, pulverizes after mixing as fine powder, sieves, mixing, and with water pill, dry, subpackage, namely sterilizing obtains pill.
Usage and dosage: oral, each 6g, two ~ tri-times on the one.
Embodiment 11
Radix Rehmanniae 110g, Folium Isatidis 30g, Radix Scrophulariae 90g, Radix Salviae Miltiorrhizae 15g, Radix Paeoniae Rubra 30g, Rhizoma Smilacis Glabrae 150g, Fructus Forsythiae 40g, Cortex Moutan 90g, Rhizoma Polygoni Cuspidati 90g, Carapax et Plastrum Testudinis 100g, Cortex Dictamni 30g, Radix Glycyrrhizae 20g.
Preparation: take the above-mentioned prescription prepared slices of Chinese crude drugs, pulverizes after mixing as fine powder, sieves, mixing, and with water pill, dry, subpackage, namely sterilizing obtains pill.
Usage and dosage: oral, each 6g, two ~ tri-times on the one.
Embodiment 12
Inventor has carried out a series of animal experiment research to pharmaceutical preparation prepared by above-described embodiment 1-11.
Experiment one, medicine of the present invention are on the mitotic impact of mouse oestrogen phase vagina epithelium
Get the female healthy mice of body weight (22 ± 2) g 156, random point 13 groups, often organize 12.Wherein only, every day 1 time, continuous 3d, makes it be in the estrogen phase to 5 groups of lumbar injection diethylstilbestrol 0.12mg/.Wherein 1 group is blank group, gives normal saline; 1 group is positive controls, gives methotrexate (4mg/kg); All the other groups give the experimental drug of embodiment 1 ~ 11 respectively.Every day gastric infusion 1 time, continuous 3d.After last medicine, 2h lumbar injection colchicine 2mg/kg, puts to death mice after 6h.Get its vagina tissue, fix with 10% formalin, HE dyes, and count the mitosis number of 300 vagina epithelium basal cells under light microscopic, its percentage rate is mitotic index (%), and data see the following form.Result shows, the present invention has obvious inhibitory action (P < 0.05) to mouse oestrogen phase vaginal epithelial cell mitosis.
| Group | Mitotic index (%) |
| Embodiment 1 | 13.51±3.43 |
| Embodiment 2 | 14.11±4.04 |
| Embodiment 3 | 14.03±3.89 |
| Embodiment 4 | 15.66±4.22 |
| Embodiment 5 | 15.35±4.02 |
| Embodiment 6 | 11.02±4.12 |
| Embodiment 7 | 11.11±5.01 |
| Embodiment 8 | 11.23±4.98 |
| Embodiment 9 | 11.32±5.02 |
| Embodiment 10 | 15.45±5.11 |
| Embodiment 11 | 15.70±3.97 |
| Blank | 22.01±4.83 |
| Positive control | 14.90±4.68 |
The impact that experiment two, medicine of the present invention grow mouse tail epidermal granular cell
Get healthy mice 156, male and female half and half, be divided into 13 groups at random, often organize 12.Positive control drug gives methotrexate group, and blank group gives the normal saline of same volume, and all the other groups give the embodiment of the present invention 1 ~ 11 medicine, and every day, gastric infusion 1 time, amounted to 14 times.After last medicine, 2h puts to death whole mice, gets apart from Mus root of the tail portion 118cm place skin of back one rectangular, fixes with 10% formalin, and HE dyes, and under light microscopic, (400 ×) count the scale percent containing granular cell of embarking on journey continuously in every 100 scales.Experimental result sees the following form.Result shows, medicine of the present invention generates mouse tail epidermal granular cell has obvious facilitation (with matched group than P < 0.05).
| Group | Granular cell number (%) |
| Embodiment 1 | 11.0±2.6 |
| Embodiment 2 | 10.7±2.8 |
| Embodiment 3 | 10.3±3.4 |
| Embodiment 4 | 9.8±2.9 |
| Embodiment 5 | 10.0±3.3 |
| Embodiment 6 | 11.8±2.8 |
| Embodiment 7 | 11.9±3.2 |
| Embodiment 8 | 11.6±2.7 |
| Embodiment 9 | 11.7±3.0 |
| Embodiment 10 | 9.9±2.8 |
| Embodiment 11 | 9.8±3.6 |
| Blank | 5.8±2.1 |
| Positive control | 10.5±2.2 |
Claims (10)
1. treat a dermopathic pharmaceutical composition, be made up of the component of following weight proportioning:
Radix Rehmanniae 30-110 part, Folium Isatidis 30-150 part, Radix Scrophulariae 15-90 part, Radix Salviae Miltiorrhizae 15-150 part, Radix Paeoniae Rubra 30-80 part, Rhizoma Smilacis Glabrae 70-150 part.
2. pharmaceutical composition as described in claim 1, is characterized in that, be made up of the component of following weight proportioning:
Radix Rehmanniae 60-90 part, Folium Isatidis 80-130 part, Radix Scrophulariae 50-80 part, Radix Salviae Miltiorrhizae 80-130 part, Radix Paeoniae Rubra 50-70 part, Rhizoma Smilacis Glabrae 80-130 part.
3. pharmaceutical composition as described in claim 1, is characterized in that, be made up of the component of following weight proportioning:
Radix Rehmanniae 80 parts, Folium Isatidis 110 parts, Radix Scrophulariae 70 parts, Radix Salviae Miltiorrhizae 100 parts, Radix Paeoniae Rubra 60 parts, Rhizoma Smilacis Glabrae 90 parts.
4. treat a dermopathic pharmaceutical composition, be made up of the component of following weight proportioning:
Radix Rehmanniae 30-110 part, Folium Isatidis 30-150 part, Radix Scrophulariae 15-90 part, Radix Salviae Miltiorrhizae 15-150 part, Radix Paeoniae Rubra 30-80 part, Rhizoma Smilacis Glabrae 70-150 part, Fructus Forsythiae 40-90 part, Cortex Moutan 50-90 part, Rhizoma Polygoni Cuspidati 30-90 part, Carapax et Plastrum Testudinis 40-100 part, Cortex Dictamni 30-100 part, Radix Glycyrrhizae 20-70 part.
5. pharmaceutical composition as described in claim 4, is characterized in that, be made up of the component of following weight proportioning:
Radix Rehmanniae 60-90 part, Folium Isatidis 80-130 part, Radix Scrophulariae 50-80 part, Radix Salviae Miltiorrhizae 80-130 part, Radix Paeoniae Rubra 50-70 part, Rhizoma Smilacis Glabrae 80-130 part, Fructus Forsythiae 50-80 part, Cortex Moutan 60-80 part, Rhizoma Polygoni Cuspidati 40-70 part, Carapax et Plastrum Testudinis 60-90 part, Cortex Dictamni 50-90 part, Radix Glycyrrhizae 30-60 part.
6. pharmaceutical composition as described in claim 4, is characterized in that, be made up of the component of following weight proportioning:
Radix Rehmanniae 80 parts, Folium Isatidis 110 parts, Radix Scrophulariae 70 parts, Radix Salviae Miltiorrhizae 100 parts, Radix Paeoniae Rubra 60 parts, Rhizoma Smilacis Glabrae 90 parts, Fructus Forsythiae 60 parts, Cortex Moutan 70 parts, Rhizoma Polygoni Cuspidati 50 parts, Carapax et Plastrum Testudinis 80 parts, Cortex Dictamni 80 parts, 40 parts, Radix Glycyrrhizae.
7. the pharmaceutical composition as described in claim 1 or 4, it is characterized in that, it is prepared as tablet, capsule, oral liquid, sucks agent, granule, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, cream, spray, drop.
8. pharmaceutical composition as claimed in claim 7, is pill.
9. the preparation method of pharmaceutical composition as claimed in claim 8, comprises the following steps:
(1) mixed powder is broken into fine powder, sieves, mixing;
(2) general with water is piller;
(3) dry;
(4) subpackage;
(5) sterilizing, to obtain final product.
10. the application that the pharmaceutical composition described in claim 1 or 4 is treated in preparation or improved in psoriatic medicine.
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| CN201310080895.XA CN103251859B (en) | 2013-03-08 | 2013-03-08 | One treats dermopathic pharmaceutical composition |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104288618B (en) * | 2014-10-16 | 2017-07-21 | 史飞 | A kind of Chinese medicine composition for treating children's psoriasis vulgaris |
| CN108310289A (en) * | 2018-05-15 | 2018-07-24 | 陈忠 | A kind of pharmaceutical composition for treating psoriasis |
| CN112402522B (en) * | 2021-01-15 | 2021-11-23 | 江苏省中医药研究院 | Chinese herbal medicine oil for externally treating psoriasis |
| CN115531470B (en) * | 2022-10-20 | 2024-03-01 | 南方医科大学皮肤病医院（广东省皮肤病医院、广东省皮肤性病防治中心、中国麻风防治研究中心） | External washing formula for psoriasis in rest period and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530581A (en) * | 2008-03-10 | 2009-09-16 | 王林祥 | Drug for treating psoriasis |
| CN102106937A (en) * | 2011-02-23 | 2011-06-29 | 徐海彬 | Medicament for treating psoriasis |
| CN102416127A (en) * | 2011-12-09 | 2012-04-18 | 崔国志 | Chinese medicinal powder for treating psoriasis |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530581A (en) * | 2008-03-10 | 2009-09-16 | 王林祥 | Drug for treating psoriasis |
| CN102106937A (en) * | 2011-02-23 | 2011-06-29 | 徐海彬 | Medicament for treating psoriasis |
| CN102416127A (en) * | 2011-12-09 | 2012-04-18 | 崔国志 | Chinese medicinal powder for treating psoriasis |
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