CN103230632B - Displacement pump - Google Patents

Displacement pump Download PDF

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Publication number
CN103230632B
CN103230632B CN201310136984.1A CN201310136984A CN103230632B CN 103230632 B CN103230632 B CN 103230632B CN 201310136984 A CN201310136984 A CN 201310136984A CN 103230632 B CN103230632 B CN 103230632B
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China
Prior art keywords
reservoir
unit
parts
fluid
equipment
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CN201310136984.1A
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CN103230632A (en
Inventor
O·约迪法特
A·内塔
Y·沙莱夫
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ROSTI AS
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ROSTI AS
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
    • F04B43/1253—Machines, pumps, or pumping installations having flexible working members having peristaltic action by using two or more rollers as squeezing elements, the rollers moving on an arc of a circle during squeezing
    • F04B43/1269—Machines, pumps, or pumping installations having flexible working members having peristaltic action by using two or more rollers as squeezing elements, the rollers moving on an arc of a circle during squeezing the rotary axes of the rollers lying in a plane perpendicular to the rotary axis of the driving motor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M2005/14208—Pressure infusion, e.g. using pumps with a programmable infusion control system, characterised by the infusion program
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A61M2005/14252—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type with needle insertion means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M2005/14268—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body with a reusable and a disposable component
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/0007—Special media to be introduced, removed or treated introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3546—Range
    • A61M2205/3569—Range sublocal, e.g. between console and disposable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3576—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver
    • A61M2205/3592—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver using telemetric means, e.g. radio or optical transmission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/04—Skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14212—Pumping with an aspiration and an expulsion action
    • A61M5/14232—Roller pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

For to delivering the system of therapeutic fluids in the patient, method and apparatus is disclosed.This equipment includes that issuing unit has drive mechanism, pumping mechanism, the reservoir of receiving therapeutic fluids, discharge port.Drive mechanism is ordered about pumping mechanism and is moved by the therapeutic fluids forward in reservoir, for being delivered in the patient through discharge port by therapeutic fluids.

Description

Displacement pump
The application is filing date on May 11st, 2008, Application No. 200880015500.5, sends out The divisional application of the application for a patent for invention of bright entitled " displacement pump ".
Cross-Reference to Related Applications
This application claims entitled " the A Positive Displacement submitted on May 11st, 2007 Pump " U.S. Provisional Application No.60/928, the priority of 815, the disclosure of this application is on the whole It is incorporated by reference herein.
The application relate to CO-PENDING/entitled " the Methods And Apparatus For that owns together Monitoring Rotation Of An Infusion Pump Driving Mechanism " United States Patent (USP) Shen Please No.XX/XXX, XXX, it requires the U.S. Provisional Application No. submitted on May 11st, 2007 The priority of 60/60/928,751；Further relate to U.S. Patent application No.XX/XXX, XXX, entitled " Fluid Delivery Device ", it requires the entitled " Fluid submitted on May 11st, 2007 Delivery Device " the priority of U.S. Provisional Application No.60/928,750.The public affairs of above-mentioned each application Open content to be incorporated by reference herein on the whole.
Technical field
The present invention generally relates to the apparatus and method of continuing medical infusion fluid.Particularly, The present invention relates to a kind of minitype portable infusion device, it can be connected to patient body and from patient Health disengages, and can accurately provide fluid.Additionally, the present invention relates to a kind of infusion pump, its There are two parts: disposable unit and parts can be used again.Disposable unit comprises thin-walled reservoir.
Background technology
The Medical Treatment of some diseases is required by medicine continuous infusion to various body parts, such as By subcutaneous injection and intravenous injection.For example, diabetics needs that infusion is not in one day Commensurability insulin is to control its blood glucose level.In recent years, on-fixed point portable insulin is defeated Note pump has occurred, as the useful replacement of the most repeatedly needle cylinder injection insulin.These pumps, to hold Continuous reference speed rate and additional drug dose deliver insulin, be developed into by patient from repeatedly from I frees in administration injection, and allows patient to maintain intimate normal daily routines.Benchmark agent Amount and boost must deliver with accurate amount according to individual prescription, because the overdosage of insulin It is all fatal with deficiency.
Some on-fixed point insulin infusion device at present can be commercially available.Most commonly, these Device has two parts: reusable part, and it comprises sending trap, controller and electronic device, and Disposable part, it comprises syringe type reservoir, with sleeve pipe and the needle assembly of puncture component and stream Body delivery tube.Generally, patient is filling insulin in reservoir, and pin and delivery tube are attached to storage The ports having of device, then inserts pump case by reservoir.By the air in reservoir, pipe and pin After blowout, patient's select location on health inserts needle assembly, puncture component and sleeve pipe, and withdraws from Puncture component.In order to avoid stimulating and infecting, subcutaneous sleeve pipe must after 2-3 days with empty reservoir one Rise and change and discarded.The example of first generation one-shot injector type reservoir and pipe is disclosed in U.S. of Hobbs State's patent No.3, United States Patent (USP) No.3 of 631,847, Kaminski, U.S. of 771,694, Stempfle State's patent No.4,657,486, and United States Patent (USP) No.4 of Skakoon, 544,369.These devices Drive mechanism is screw drive type plunger, controls the sequencing campaign of cylinder piston.
Providing gear is also had to be disclosed United States Patent (USP) No.4,498,843 of Schneider and Wolff United States Patent (USP) No.4,715,786, including wriggling displacement pump.These devices are to multiple injection every day Mode be made that improvement, however, they still suffer from some shortcomings.Major defect is device Large scale and weight, this is to be caused by syringe and the structure of the drive mechanism of piston and relatively large size 's.This relatively cumbersome device needs to be loaded in the pocket of patient or is attached to belt.So, Fluid delivery is longer, typically longer than 60cm, in order to allow pin to insert at the distant sites of health.This The uncomfortable heavy device a bit with long tube is abandoned by most of diabetes insulin user, because The daily action of they interference patients, such as, sleep and swim.Additionally, at the health of ten how old patients Upper scar is also unacceptable.Additionally, delivery tube makes some optional insertion sites at a distance As buttocks, arm and leg are left out.
In order to avoid the negative effect of long delivery tube, the new ideas pump of the second filial generation is suggested.This conception of species Including the device of the be attached at skin of remote control, it includes housing, and the basal surface of housing is adapted to connect Touch the skin of patient, the reservoir being arranged in housing, and it is adapted to the injection that connects with reservoir Pin.These devices that can be attached at skin should be abandoned every 2-3 days, is similar to operational pump Infusion.These devices are at least disclosed United States Patent (USP) No.5 of Sage, and 957,895, Connelly United States Patent (USP) No.6,589,229, and United States Patent (USP) No.6 of Flaherty, 740,059.Can attach Other structure in the pump of skin is disclosed in United States Patent (USP) No.6,723,072 and the Mason of Flaherty United States Patent (USP) No.6,485,461.These devices there is also some limitation: they volumes are big and high Expensive, the reason of their high price is high manufacturing cost and accessory cost, and user must be every 2- Within 3 days, abandon whole device, wherein comprise relatively costly parts, such as drive mechanism and other electronics device Part.
Such as, existing various types of tradition pumping mechanism is used in infusion device.Pumping mechanism One example is syringe type, and wherein, fluid is removed cylindrical shape reservoir by motor-driven plunger. The motor that processor controls allows fluid granting and the fluid granting as required of pre-programmed.
Such syringe type mechanism is discussed in the following United States Patent (USP) such as relating to first generation pump: United States Patent (USP) No.3 of Kamen, United States Patent (USP) No.4 of 858,581, Siposs, 435,173, Fenton United States Patent (USP) No.4, United States Patent (USP) No.5 of 652,260, Strisathapat, 954,697.Syringe type Reservoir is also described in the U.S. patents and patent applications relating to second filial generation pump: the U.S. of Flaherty The U.S. Patent application No.2005/0251097 of patent No.6,656,159 and O'Neill.
Regrettably, the second filial generation can be attached at the infusion device of skin and there is significant drawbacks, including Following and other shortcoming:
？They are heavy to be typically pipe part for huge-syringe type reservoir, therefore accommodate such as The medicine of 3ml, they otherwise longer and there is minor diameter (that is, 60mm length × 8mm internal diameter), Shorter and there is major diameter (that is, 17mm length × 15mm internal diameter).This is all portable pancreases The major obstacle that island element infusion device runs into when diabetics, can paste especially for the second filial generation For investing the insulin pump of skin.
？Their manufacture and change expensive-(electronic device drives machine to comprise relatively costly parts Structure etc.) whole device should abandon for every 3 days.
？Reservoir filling may require using additional syringe to come from the then filling of vial withdrawn fluid Pump reservoir.
？They can not be removed-there is a case in which, i.e. patient wishes that pulling down pump (such as, exists When shower, Saunas, sexual life etc.), but, conventional pump does not allow this pulling down.
？Sleeve pipe is rigidly secured in pump case, and therefore, user can not select casing length and change Become and insert angle.
？Waste insulin-in the case of installation position mistake (such as, scar tissue, bleed, Sleeve pipe kink etc.), whole device, including the insulin reservoir being filled, it is necessary to be abandoned, this meeting The insulin causing costliness is wasted.
Summary of the invention
In some embodiments, the present invention is to overcome the defect in above-mentioned conventional apparatus to provide one Minitype portable fluid dispensing apparatus able to programme (hereinafter referred to as " provides joint " or " issuing unit ", therefore Term " unit " is the most mixed with " joint "), described device does not have long exterior tube Part and can any desired site on health be attached to patient (with depart from patient).Real at some Executing in mode, the present invention is simple and the most expensive granting joint, and it has two parts: disposable Parts and parts can be used again.After can connecting with parts and disposable unit, whole device has thin again Profile and relatively small footprint area (that is, light and handy) on a patient body.At some embodiments In, the present invention relates to a kind of granting joint, it can be with safe and reliable and that user is friendly side Formula is connected to (or reconnecting to) patient body and departs from patient body.Connect (or again connect Connect or disengage) both do not interfere with the parts provided in joint, also will not injure surrounding body tissue.
In some embodiments, the present invention relates to a kind of granting joint, it delivers stream through soft tube Body is in the patient, and the insertion of its middle sleeve both can realize by hand, it is possible to use special inserter It is automatically obtained.In some embodiments, fluid may utilize soft tube and is delivered, and sleeve pipe can Insert with any desired angle.Additionally, the length of sleeve pipe can be customized to meet the needs of patient.
In some embodiments, the present invention relates to a kind of granting joint, be used for delivering fluid to patient Internal, its center tap has two parts: disposable unit, it has some and easily manufactures and assemble And cheap part, and parts can be used again.In some embodiments, disposable unit includes pin Cartridge type reservoir, it is configured to jerrycan, to maintain thin contour.In some embodiments, Syringe type reservoir can be from vial withdrawn fluid.Additionally, disposable unit and can again with parts it Between sealing after connection do not affect the function of device.
In some embodiments, the present invention relates to a kind of device, it can deliver therapeutic fluids and arrive In health.The fluid delivery device of the present invention includes 3 unit: issuing unit, can be attached at skin Pin unit, and RCU.Issuing unit can be connected to the described pin unit that can be attached at skin Departing from from it, RCU and issuing unit communication are to allow programming, user input, data acquisition Collection.
In some embodiments, issuing unit includes drive mechanism, pumping mechanism, reservoir and row Go out port.Discharge port allows issuing unit is connected to pin unit and disengages from it.Discharge port sets Having connecting element (such as, connect tube chamber), it can puncture self-seal type rubber interval body, described between Spacer seals discharge port.Connect tube chamber and allow to set up fluid communication between issuing unit and pin unit. Issuing unit can be configured to single-piece.In some embodiments, issuing unit includes that at least one is store Storage, pipe, battery, drive mechanism and pumping mechanism, electronic device, and other accessory, example As, clogging sensor.
In some embodiments, issuing unit can also be configured to two-piece unit, and it has can be again With parts and disposable unit, wherein:
A. can include drive mechanism and pumping mechanism, electronic device with parts again, and other is relatively costly Parts such as clogging sensor.
B. disposable unit includes not expensive components, for example, at least one reservoir, manages, and battery, Described battery can be powered until reservoir empty, is typically used a few days.
In some embodiments, pin unit includes following elements:
A. sleeve pipe and puncture component.Puncture component will be removed after the insertion.
B. saddle-it is flat sheet, has the adhesion layer towards skin, and side is carried thereon Connecting elements to allow connection to issuing unit and to disengage from it.Insert sleeve pipe time, saddle by Skin is remained adhered in adhesion layer.Saddle anchoring casing pipe, and allow connection to issuing unit.Saddle Portion can be rigidly connected to sleeve pipe and be connected to standpipe connection, or can be independent separate part.
C. standpipe connection (well)-it is tubular projections, from saddle upwards projection, right to allow The discharge port of quasi-issuing unit, and be suitable to be connected to as required between pin and issuing unit, with Just fluid is correctly delivered to health.
In some embodiments, RCU includes being programmed for fluid flow, controlling to send out Put unit, data acquisition and the component of instruction (such as, display).
In some embodiments, the issuing unit of the present invention can also be provided with suitable input link, Such as, for sending the button of flowing instruction.
In some embodiments, issuing unit includes two parts: reusable and disposable. Described disposable unit includes reservoir, battery, and discharge port；Electronics device can be included again with parts Part, drive mechanism, and pumping mechanism.Reservoir has the cross section of general flat profile.Such Cross section can be the most avette, oval or rectangle.Utilize this configuration, whole disposable portion Part the thinnest (for example, less than 15mm).Reservoir is equipped with moveable piston formula plunger A part for syringe.The discharge port of reservoir such as connects tube chamber by tubulose connector and is connected to send out Put the discharge port of unit.The discharge port of reservoir is configured to and is sized to accurately assemble To standard drug vial stopper.Reservoir filling is to be engaged with the rubbery stopper of bottle by discharge port And realize.Connect tube chamber and puncture rubbery stopper, thus when bottle is by turned upside down so that By the rearward movement of plunger, medicine is extracted from bottle.
By the disposable unit being filled with and the connection that parts can be used again, can be again with the electronics in parts Device battery in being located at disposable unit (it will be understood by those skilled in the art that it can is single-unit Battery) receive electric energy.Based on programming and/or deliver order based on the fluid that is actually needed, drive machine Structure is activated and can promote piston.Issuing unit disengages from pin unit and reconnects can Perform according to the decision-making of patient.
Therefore, a purpose of some embodiments of the present invention is to provide a kind of method, system and dress Put, in medical science infusion fluid to health.
One purpose of some embodiments of the present invention is to provide a kind of for lasting medical science infusion Device, it is with controlled speed injecting fluid into the human body.
One purpose of some embodiments of the present invention is to provide a kind of device for medical science infusion, It comprises issuing unit, this issuing unit slim body, does not has outer tube, and can be attached to body Any position of body.
One purpose of some embodiments of the present invention is to provide a kind of device for medical science infusion, It comprises issuing unit, and this issuing unit includes at least one reservoir and discharge port, this outlet side The in direct fluid communication that mouth can reach and can be attached between the pin unit of skin.
One purpose of some embodiments of the present invention is to provide a kind of device for medical science infusion, It comprises the pin unit that can be attached at skin.The described pin unit being attached at skin includes subcutaneous sleeve pipe And standpipe connection, described standpipe connection allow subcutaneous location in the health of issuing unit and patient it Between set up fluid communication.
One purpose of some embodiments of the present invention is to provide a kind of issuing unit, and it can be by structure Make as single-piece unit, or be configured to have and can use parts and the two-piece unit of disposable unit again. Electronic device, drive mechanism and pumping mechanism and other relatively costly parts can be comprised such as again with parts, For detecting the sensor of blocking；Disposable unit comprises reservoir and discharge port.Battery can fill In disposable unit and/or can be again with in parts.
One purpose of some embodiments of the present invention is to provide a kind of device, and it uses and can disengage With the issuing unit reconnected.
One purpose of some embodiments of the present invention is to provide a kind of infusion device, and it comprises three Unit～RCU, issuing unit and pin unit.Wherein issuing unit or so-called joint can be connected Be connected to pin unit/from pin list disengage, wherein pin unit may be attached to skin.Infusion programming can be by remote control Unit or realized by least one control knob of being arranged on joint.
One purpose of some embodiments of the present invention is to provide a kind of infusion device, and it comprises granting Unit, described issuing unit can be connected to pin unit and depart from pin unit.Pin unit includes that skin is suitable Answering property saddle, this saddle is equipped with sleeve pipe and standpipe connection.
One purpose of some embodiments of the present invention is to provide a kind of infusion device, and it comprises granting Unit, described issuing unit can be connected to skin compliance saddle and depart from this saddle.Comprise sleeve pipe Can be inserted in skin by saddle with the pin unit of standpipe connection.
One purpose of some embodiments of the present invention is to provide a kind of infusion device, and it comprises by extremely Lack the issuing unit of a parts composition and there is another unit (pin of saddle, standpipe connection and sleeve pipe Unit).Saddle has the adhesion layer allowing to adhere to skin in its bottom side, and attachment member is arranged on On on the upside of it, to allow issuing unit is connected to saddle.Standpipe connection is connected to sleeve pipe on the downside of it, And side has rubber interval body (that is, silicone, chlorobutyl rubber) thereon.
The discharge port of issuing unit is provided with short connecting element, and it has and connects in issuing unit and vertical tube The sharp hollow end of fluid communication between Kou.This connecting element, is hereinafter also referred to as " connects tube chamber ", it is allowed to rubber interval body is carried out multiple puncture, and between reservoir and sleeve pipe, sets up fluid even Logical.
One purpose of some embodiments of the present invention is to provide a kind of method, and it allows by flexibility Soft percutaneous sleeve pipe infusion fluid in the health of patient.Sleeve pipe can be manually or by special bullet Spring loads inserter and inserts in patient body.
One purpose of some embodiments of the present invention is to provide a kind of method, and it allows by adhering to Component, by saddle patch symbol to patient skin surface, therefore provides the fixing of sleeve pipe and for dispatch hist The anchoring base portion of unit.
The another object of some embodiments of the present invention is to provide a kind of method, and it makes issuing unit Can be connected to pin unit and disengage from it, the discharge port of issuing unit is connected to standpipe connection, sends out Put joint housing and be connected to saddle, and puncture rubber interval body by connecting tube chamber.
The another object of some embodiments of the present invention is to provide a kind of safe, simple, reliable and makes The method that user is friendly, for issuing unit being connected to patient and departing from from it, maintains health simultaneously With the damage avoided patient and/or infusion device.
Accompanying drawing explanation
Describe embodiments of the present invention below with reference to accompanying drawings in detail, in the accompanying drawings with identical accompanying drawing Labelling represents corresponding parts.
Fig. 1 shows exemplary fluid dispensing apparatus according to certain embodiments of the present invention, its bag Include issuing unit and RCU.
Fig. 2 a-b shows that exemplary single-piece according to certain embodiments of the present invention and two-piece type are sent out Put unit.
It is exemplarily that issuing unit is straight that Fig. 3 a-c shows according to certain embodiments of the present invention Attachment is connected to health.
Fig. 4 a-c shows that the pin unit used according to certain embodiments of the present invention exemplarily will Issuing unit patch accords with the skin to patient.
Fig. 5 a-b shows the exemplary operation of issuing unit according to certain embodiments of the present invention Pattern.
Fig. 6 a-b show according to certain embodiments of the present invention include showing of they internal parts Example single-piece and two-piece type issuing unit.
Fig. 7 a-c shows and uses infusion exemplarily to exist according to certain embodiments of the present invention Fluid communication is set up between issuing unit and sleeve pipe.
Fig. 8 a-b show according to certain embodiments of the present invention there is the exemplary of standpipe connection Issuing unit.
Fig. 9 a-b show according to certain embodiments of the present invention for making together with standpipe connection Exemplary puncture box and puncture component.
Figure 10 a-d shows that use according to certain embodiments of the present invention is shown in the perpendicular of Fig. 8 a-b The exemplary grommet of interface tube is inserted.
Figure 11 a-d shows exemplary pin unit according to certain embodiments of the present invention.
Figure 12 a-b shows that use according to certain embodiments of the present invention has saddle and punctures box The exemplary grommet of the pin unit of part is inserted.
Figure 13 a-c shows that exemplary issuing unit according to certain embodiments of the present invention connects Disengage to pin unit with from it.
Figure 14 a-b shows the example with circular cross section according to certain embodiments of the present invention Property reservoir.
Figure 15 a-b show according to certain embodiments of the present invention there is showing of oval cross section Example reservoir.
Figure 16 a-b shows the example with oval cross-section according to certain embodiments of the present invention Property reservoir.
Figure 17 a-b shows having by four curve limits according to certain embodiments of the present invention The exemplary reservoir of cross section.
Figure 18 a-b shows disposable unit according to certain embodiments of the present invention, including Exemplary syringe type reservoir.
Figure 19 a-f shows exemplary reservoir filling according to certain embodiments of the present invention and opens Use program.
Figure 20 a-b shows the exemplary storage using adapter according to certain embodiments of the present invention Storage filling.
Figure 21 a-e shows disposable unit according to certain embodiments of the present invention and can use portion again The exemplary connection of part, wherein plunger is shared by described reusable parts and disposable unit.
Figure 22 a-c shows disposable unit according to certain embodiments of the present invention and can use portion again The exemplary connection of part, during wherein plunger is placed in disposable unit.
Figure 23 a-b shows issuing unit according to certain embodiments of the present invention, its have for The exemplary drive mechanism of plunger displacement, this drive mechanism is equipped with screw rod and nut.
Figure 24 a-b shows issuing unit according to certain embodiments of the present invention, its have for The exemplary drive mechanism of plunger displacement, this drive mechanism is equipped with screw rod, nut and driving spring.
Figure 25 a-b shows issuing unit according to certain embodiments of the present invention, its have for The exemplary drive mechanism of plunger displacement, this drive mechanism is equipped with screw rod, nut and lever arm.
Figure 26 a-c shows issuing unit according to certain embodiments of the present invention, and it has example Property drive nut and plunger.
Figure 27 a-b show according to certain embodiments of the present invention can be again with parts and disposable The example seal realized when parts connect, it uses packing ring such as o-ring.
Figure 28 a-b show according to certain embodiments of the present invention can be again with parts and disposable The another exemplary realized when parts connect seals.
Figure 29 a-d shows issuing unit according to certain embodiments of the present invention, and it has can be again With parts and the disposable unit being configured to semi-ring surface form.
Figure 30 a-b shows issuing unit according to certain embodiments of the present invention, and it has can be again With parts and disposable unit, wherein reservoir is configured to segment.
Detailed description of the invention
In order to overcome the limitation of legacy system, and in order to avoid price limit with in order to extend patient Customization capability, the third generation can be attached at the granting joint of skin and be suggested.One example of this device Be described in CO-PENDING/the U.S. Patent application No.11/397,115 that owns together and international monopoly Shen Please No.PCT/IL 06/001276, the disclosure of above-mentioned application is incorporated by reference this Shen on the whole Please.In such a device, issuing unit includes two parts:
-parts can be used again, including driving and pumping mechanism, electronic device, relative with other high Your parts；And
-disposable unit, including not expensive components, such as reservoir, pipe and battery.
This concept provides a kind of low-cost type scheme, and allows the purposes of expansion instrument, such as, Use the reservoir of various sizes.An improvement to the pump of the be attached at skin with two parts Be described in CO-PENDING/the U.S. Patent application No.60/876 that owns together, 679, United States Patent (USP) Shen Please No.12/004,837, and international patent application No.PCT/IL 07/001578, the public affairs of above-mentioned application Open content to be incorporated by reference herein on the whole.In those references, for connecting and take apart can The method of the pump being attached at skin comes forth.Described method use saddle, its by initial adherence in skin, Then sleeve pipe is inserted in health by saddle.Therefore two-piece type pump can connect based on patient's decision-making Disengage to saddle and from saddle.
This concept allows multiduty operator scheme, inserts including craft and automatic casing, it is allowed to make With the sleeve pipe of various length, and sleeve pipe is allowed to insert with various insertion angles.
Instant invention overcomes the many disadvantages in legacy system, and retouch referring to Fig. 1-30b State.
Fig. 1-5b shows exemplary fluid dispensing apparatus (1) according to certain embodiments of the present invention With the various options for being attached to patient body.Fig. 1 shows device (1), for controlling Treatment fluidic medical is infused in the patient.Device (1) includes issuing unit (10) and RCU (40).Issuing unit (10) communicates with RCU (40), and RCU can send order, Receive and process the instruction from issuing unit (10), etc..RCU (40) can include showing Show device and multiple button so that control unit (10) and the operation of (40).Unit (10) and (40) Can be with wireless, wired, special line, radio frequency or any other type of communication.Unit (40) Can be personal computer, notebook computer, iPod, PDA, mobile phone, remote controller, or any its The device that it is suitable.
Fig. 2 a-b shows the additional detail of issuing unit (10).Issuing unit can include single-piece (as It is shown in Fig. 2 a) or two parts (as shown in Fig. 2 b).Two-piece type issuing unit (10) includes can be again With parts (100) and disposable unit (200), wherein disposable unit (200) includes outlet side Mouth (210).One-piece unit (10) can also include discharge port (210).Some embodiment party In formula, issuing unit (10) includes the discharge port (210) being positioned at its lower surface.Discharge port (210) It is in fluid communication with the reservoir (not shown) being arranged in unit (10), and allows fluid opening Drip during with, and therapeutic fluids is delivered in the patient.
Fig. 3 a-c show according to certain embodiments of the present invention exemplarily by patch accord with dispatch hist Unit (10) to patient skin (5).Fig. 3 a shows removal binding agent protective layer (13).Binding agent Protective layer (13) can be arranged in the bottom of unit (10), and once layer (13) is removed, Unit (10) can be directly attached to the skin (5) of patient.Fig. 3 b shows issuing unit (10) Adhere to skin (5).Fig. 3 c shows that issuing unit (10) has been adhered to skin (5).Ability Field technique personnel are appreciated that unit (10) can be directly attached to skin (5) or pass through intermediate layer / device adheres to skin.
In some embodiments, as shown in Fig. 4 a-c, pin unit (20) can be with initial adherence in skin Skin (5).Then, decision-making based on patient, issuing unit (10) can be connected to (with the most de- From) pin unit (20).Fig. 4 a shows the pin unit (20) adhering to patient body.Fig. 4 b shows Go out and issuing unit (10) has been connected to pin unit (20).Fig. 4 c shows issuing unit (10) Have been connected to pin unit (20) and be ready for may be used for operation.
Fig. 5 a-b shows the various of issuing unit (10) according to certain embodiments of the present invention Operator scheme.Patient by using RCU (40) (as shown in Fig. 5 a) or can be arranged by use One or more button (15) (as shown in Fig. 5 b) in issuing unit (10) operates issuing unit (10).By utilizing RCU (40) or button (15) input order, unit (10) is permissible Implementing various function, such as, granting fluid, in the patient, produces the feedback about fluid delivering amount, Produce various alarm, etc..
Fig. 6 a-b shows issuing unit or " connector unit " (10) of exemplary be attached at skin, It uses syringe type pump, is used for providing fluid in the patient.Fig. 6 a shows single-piece issuing unit (10).Unit (10) include housing, housing comprise reservoir (220), fluid delivery (230), Discharge port (210), power supply (such as, one or more battery) (240), electronic device components (130), Drive mechanism (120) and manual button (15).Reservoir (220) through delivery tube (230) with Discharge port (210) is in fluid communication, and allows therapeutic fluids through discharge port (210) Deliver (such as, insulin) in the patient.In order to pump fluid to fluid from reservoir (220) In delivery tube (230), plunger (110) is provided in reservoir (220), and can be towards stream Body delivery tube (230) promotes fluid.Plunger (110) is connected to drive mechanism (120), and it drives Plunger (110) moves in reservoir (220).Drive mechanism (120) includes that motor is (such as, Motor, DC motor, SMA actuator or the like) and be used for driving driving of plunger (110) Moving gear.Drive mechanism is controlled by electronic device (130), and this electronic device can include controller, place Reason device, transceiver and other electron component.Power supply (240) provides electric energy to electronic device (130) With drive mechanism (120), it is used for receiving/sending order, and for driving in reservoir (220) Dynamic plunger (110).Unit (10) can use remote controller (40) (not shown) and/or use setting One or more button (15) in issuing unit (10) is programmed.Button (15) can connect/ Switching units (10), it is provided that infusion/granting instruction, causes transmission/reception order, etc..
Fig. 6 b shows exemplary two-piece type issuing unit according to certain embodiments of the present invention (10), it has and can use parts (100) and disposable unit (200) again.Unit (10) uses Pumping mechanism such as displacement pump.The unit (10) being shown in Fig. 6 b includes and the unit (10) being shown in Fig. 6 a In similar parts.But, some parts are placed in can be used in parts (100) again, other parts It is placed in disposable unit (200).
Can again with parts (100) include drive mechanism (120) (such as, motor, one or more gear Deng), electronic device (130), at least one button (15), and various electric connector.Disposable portion Part (200) includes the reservoir (220) being provided with plunger (110), power source means (240), fluid Delivery tube (230), and discharge port (210).In some embodiments, plunger (110) is permissible It is placed in and can use in parts (100) again, or by sharing with parts and disposable unit again.Pass through Use remote controller (40) (not shown) and/or use be arranged on can use again on parts (100) or Multiple buttons (15), infusion programming is capable of.By can use again parts (100) connect (as Shown in arrow) to disposable unit (200), it is possible to carry out fluid granting.Such two-piece type A kind of embodiment of unit be disclosed in CO-PENDING/the U.S. Patent application No. that owns together 11/397,115 and international patent application No.PCT/IL 06/001276, the disclosure of above-mentioned application is whole It is incorporated by reference herein on body.The operation of the two-piece unit (10) being shown in Fig. 6 b is similar to It is shown in the operation of the unit (10) of Fig. 6 a.
Fig. 7 a-13c shows that use issuing unit (10) according to certain embodiments of the present invention exists Fluid reservoir (220) and in the patient between set up the exemplary approach of fluid communication.
Fig. 7 a-c shows exemplary infusion (50) according to certain embodiments of the present invention, For delivering therapeutic fluids (such as, insulin) in the patient.As shown in Fig. 7 a-c, infusion External member (50) is arranged in the hull outside of issuing unit (10).Infusion (50) includes connecting Pipe (52), set hub (54), sleeve pipe (330) and puncture component (320).Connecting tube (52) is connected to Overlap hub (54) and be in fluid communication with sleeve pipe (330).Set hub (54) allows puncture component (320) Insertion in sleeve pipe (330).By puncture component (320) is passed sleeve pipe (330), puncture component (320) patient skin (5) (being not illustrated in Fig. 7 a) can be punctured and allow sleeve pipe (330) to insert skin Lower portion (that is, is positioned at below patient skin).Set hub (54) can also include adhesion layer (57), It can adhere to skin (5), in order to during fluid delivers, set hub (54) is anchored on skin Skin.Following permission fluid delivers through infusion (50), and connecting tube (52) connects (or insertion) To discharge port (210).Discharge port (210) can be provided with adapter such as, and luer is locking Adapter, for setting up reliable and/or sealing between infusion (50) and issuing unit (10) Connect.By connecting tube (52) is inserted discharge port (210), reservoir (220) and sleeve pipe (330) Fluid communication with each other, and therapeutic fluids can be passed through sleeve pipe (330) from reservoir (220) Deliver in the patient.
Fig. 7 b shows that issuing unit (10) is attached directly to skin (5) and is connected to infusion set Part (50), as previously discussed.As it can be seen, puncture component (320) has already passed through set hub (54) With sleeve pipe (330), and puncture patient skin (5), to allow sleeve pipe (330) and puncture component (320) project in subcutaneous location.Puncture component (330) can include piercing portions (such as, sword Body etc.), it can puncture patient skin and therefore allow sleeve pipe (330) to insert.Puncturing Part (320) is arranged under the state in set hub (54) and sleeve pipe (330), and fluid can not be delivered to Patient.
Fig. 7 c shows and is connected to infusion (50) recalling puncture component (320) unit afterwards (10). Once puncture component is withdrawn, and fluid communication is set up in sleeve pipe (330) and the storage of issuing unit (10) Between device (220), and fluid can be delivered to patient.
Fig. 8 a-10d shows the reality of issuing unit (10) according to certain embodiments of the present invention Execute example, wherein, standpipe connection (60) with by reservoir (220) and wearing that sleeve pipe (330) is connected Thorn box (62) is used together.One illustrative embodiments of this system be disclosed in CO-PENDING/ The U.S. Provisional Application No.60/833 owned together, 110 and 60/837,877, and international patent application PCT/IL 07/000932, the disclosure of above-mentioned application is incorporated by reference herein on the whole.
Fig. 8 a shows exemplary two-piece type issuing unit (10).As before, issuing unit (10) Including can again with parts (100) and for and the disposable unit (200) that can be connected with parts (100) again. Can again with parts (100) include plunger (110), drive mechanism (120) (such as, motor, gear, With other parts), electronic device (130), button (15), by each electronic device (130) parts with The connecting lead wire that battery (240) connects.Disposable unit (200) includes battery (240), storage Device (220), fluid delivery (230), discharge port (210).As before, reservoir (220) It is in fluid communication with discharge port (210) through fluid delivery (230).Discharge port (210) is entered One step includes standpipe connection (60), and it is through fluid delivery/tubular connector (230) and reservoir (220) fluid communication.Standpipe connection (60) is provided with opening (64), punctures box (320) and sleeve pipe (330) this opening (this state is not illustrated in Fig. 8 a) can be passed.
By using lock bolt, buckle structure or other suitable structure any, parts (100) can be used again Can be connected to each other with disposable unit (200).In some embodiments, gastight seal (97) can be placed between parts (100) and (200), to prevent dirt or other outside unit Part enters.As being further illustrated in Fig. 8 a, the plug portion of plunger (110) (its by fluid towards discharge Port (210) promotes) it is contained in reservoir (220), the shaft portion of plunger (110) is by part Be arranged in and can use again in parts (100) and disposable unit (200).The axle portion of plunger (110) Divide the drive mechanism (120) being connected to for impeller-hub part, and be configured to be suitable at parts (100) and move between (200).Such as, during reservoir filling operation, plunger (110) Shaft portion moved back along the direction leaving reservoir (220)；And in the process of the program of granting In, the shaft portion of plunger (110) is by mobile towards reservoir (220), thus pushes fluid into stream In body delivery tube (230) and discharge port (210).
The standpipe connection (60) that Fig. 8 b is disposed upon in disposable unit (200) is along in Fig. 8 a The sectional view that line A-A' is made.As shown in Fig. 8 b, standpipe connection (60) and fluid delivery (230) Fluid communication.In some embodiments, fluid delivery (230) can be connected to connecting tube (231). Connecting tube (231) is in fluid communication with opening (64).Once puncture box (320) by from opening (64) Removing, fluid can flow through connecting tube (231) from fluid delivery (230), and enters opening (64) and towards discharge port (210) flow, in order to be delivered to patient.Connecting tube (231) and Connection between fluid delivery (230) is to be tightly connected, its stop fluid delivery (230) from Adapter (231) slippage and any leakage of fluid or dirt enter opening (64).Real at some Executing in mode, opening (64) can also include interval body parts, and it is eliminating puncture component (320) After seal up opening (64).Interval body also can stop dirt to enter standpipe connection (60) and the letting out of fluid Dew.
Fig. 9 a shows exemplary puncture box (62) according to certain embodiments of the present invention.Puncture Box (62) includes body part (63), sleeve pipe (330), self-seal type interval body (313), punctures Part (320).Puncture component (320) can be configured to sword body (321), has sharp distal tip and grasping Portion (322).Puncture component (320) is adapted to puncture the surface (being not illustrated in Fig. 9 a) of skin (5). Puncture component (320) passes interval body (313) and sleeve pipe (330).Interval body (313) seals up to be worn Path (comprising sleeve pipe (330)) in the body part (63) of thorn box (62).Once puncture component (320) Being removed by the path from body part (63), interval body (313) seals up described path.Fig. 9 a Show that interval body (313) seals described path.Fig. 9 b shows that puncture component (320) is placed In puncturing box (62).
Figure 10 a-d shows the special inserter of use according to certain embodiments of the present invention (70) The exemplary insertion carried out and percutaneous placement sleeve pipe (330).The exemplary embodiment party of inserter (70) Formula be disclosed CO-PENDING/the U.S. Provisional Application No.60/861 that owns together, 345, above-mentioned Shen Disclosure please is incorporated by reference herein on the whole.
Figure 10 a is standpipe connection (60) and the sectional view of inserter (70), wherein inserter (70) It is loaded puncture box (62).Inserter (70) include housing (71), spring-actuated mechanism (73), Release button (74), puncture component keep platform (76), projection (72a) and (72b).Release button (74) be connected to spring-actuated mechanism (73), and allow to discharge spring-actuated mechanism (73) so that In general's puncture box (62) insertion standpipe connection (60) (and utilize puncture component (320) pierce skin (5)).Projection (72) is connected to housing (71), and is configured to be suitable to and standpipe connection (60) Respective recesses (66a) and (66b) coordinate.Standpipe connection (60) is inserted puncturing box (62) During, projection (72) and the depression (66) stability needed for housing (71) provides.As Being shown in Figure 10 a, housing (71) is loaded puncture box (62) (with puncture component (320) and sleeve pipe (330) Together), and spring-actuated mechanism (73) is in compressive state (such as, spring is compressed).Protect The platform (76) that maintains an equal level fastens the puncture box (62) inserted before standpipe connection (60).
Inserting standpipe connection (60) to puncture box (62), user/patient is by projection (72) Align with depression (66), and facing to standpipe connection (60) rugged housing (71).Then, make User/patient presses the button (74), and spring-actuated mechanism (73) is released.Once spring opens Motivation structure is released, and punctures box (62) and is just inserted in standpipe connection (60), and puncture component (320) Pierce patient skin.Along with pierce skin (5), it is loaded in the sleeve pipe (330) punctured in box (62) Insert in patient's subcutaneous location.Once skin (5) is by pierce, and spring-actuated mechanism (73) is compressed, And puncture component (320) is by from puncturing box (62) removal.Once puncture component (320) is removed, Puncture box (62) to keep being deposited in standpipe connection (60) together with sleeve pipe (330).Real at some Execute in mode, use spring-actuated mechanism, puncture box (62) and puncture component (320) is inserted simultaneously into Or insert in tandem.Said process shows in Figure 10 b-c.
Once puncture box (62) to be positioned in standpipe connection (60), and sleeve pipe (330) Being deposited in skin (5) subcutaneous location below, inserter (70) is removed, as shown in figure 10d.Through puncturing box (62), fluid communication is set up at fluid delivery (230) and sleeve pipe (330) Between.Self-seal type interval body (313) provides the sealing punctured needed for box (62), in order to anti-fluid stopping The leakage of body and dirt enter.
Figure 11 a-13c shows exemplary issuing unit according to certain embodiments of the present invention (10), it utilizes pin unit (20) to be connected to skin (5).The exemplary enforcement of pin unit (20) Mode be disclosed in detail in CO-PENDING/the U.S. Patent application No.60/876 that owns together, 679, on The disclosure stating application is incorporated by reference herein on the whole.
In some embodiments, pin unit (20) (also referred to as saddle unit) includes two parts:
1. saddle, it is provided with:
A. saddle.
2. puncture box parts (also referred to as sleeve pipe housing unit), comprising:
A. standpipe connection；
B. sleeve pipe；With
C. puncture component.
Figure 11 a is the side view of exemplary saddle (21) according to certain embodiments of the present invention. Saddle (21) includes saddle (300), connects lock bolt (306a-d), opening (307), anchoring lock Door bolt (302a-d).Anchoring latches (302) is arranged around the periphery of saddle (300), and will provide Unit (10) is fastened to saddle (21).Connect lock bolt (306) to arrange around opening (307), and Box parts (22) (being shown in Figure 11 D) will be punctured and be fastened to saddle (300).In some embodiments, Lock bolt (302) and (306) are respectively in lock bolt and issuing unit (10) and puncture box parts (22) Between produce snap-lock structure.
Figure 11 b-c is illustrated in top view and the perspective view of the saddle (21) of Figure 11 a.Implement at some In mode, saddle (300) can include protuberance border, and it allows the issuing unit (10) to inserting to carry For further stability.
Figure 11 d shows puncture box parts (22), and it is similar to puncture box (62) previously discussed, And including some similar component.Parts (22) include standpipe connection (310), lateral recesses (316a -d), interval body (313), sleeve pipe (330), puncture component (320).Depression (316) is corresponding to lock Door bolt (306), and be configured to be suitable to puncture when box parts (22) are connected to saddle (21) with Lock bolt (306) coordinates, thus will puncture box parts (22) and be anchored to saddle (21).Assembling shape State, puncture component (320) passes standpipe connection (310) and the sleeve pipe (330) of parts (22).Between Spacer (313) seals up standpipe connection (310), to prevent fluid leakage and/or dirt from entering.
Figure 12 a-b shows saddle (21) according to certain embodiments of the present invention and punctures box portion The exemplary connection of part (22).After saddle (21) is adhered to patient skin (5), parts (21) it is connected, as shown in Figure 12 a with (22).Use binding agent or other component any, attached Can realize to skin (5).It will be understood by those skilled in the art that and will be attached to skin (5) Before, the adhesion layer on saddle (21) is facing to skin (5).Once saddle (21) is secured to Skin (5), and before issuing unit (10) connects, set up through puncturing box parts (22) Lead to the entrance of patient subcutaneous location.Return to Figure 12 a, use lock bolt (306) and depression (316) Combination, puncture box parts (22) can realize to the connection of saddle (21).People in the art Member is appreciated that the mode of other connection member (21) and (22) is also feasible.Once parts (21) and (22) are secured to each other, puncture component (322) punctures skin (5), and allows set Pipe (330) inserts in subcutaneous location.
After inserting sleeve pipe (330), puncture component (320) can be removed.Figure 12 b shows and wears Thorn part (320) is removed from puncturing box parts (22).After puncture component (320) is removed, saddle (21) remain adhered to skin (5), and sleeve pipe (330) remains inserted in health.Between self-seal type Spacer (313) seals up standpipe connection (310), and allows the connection tube chamber of issuing unit (10) (being not illustrated in Figure 12 b) repeats to puncture interval body (313), in order to deliver with sleeve pipe (330) and fluid Pipe (230) (not shown) sets up fluid communication.Therefore, issuing unit (10) can as required with Arbitrarily repeatedly it is connected to pin unit (20) and departs from pin unit.Self-seal type interval body (313) prevents The leakage of provided fluid and dirt enter.
Figure 13 a shows that issuing unit (10) according to certain embodiments of the present invention is to pin unit (20) exemplary connection.In order to be connected with pin unit (20), issuing unit also includes connecting tube Chamber (250).Connect tube chamber (250) to be in fluid communication with reservoir (220).Connect tube chamber (250) It is further arranged as near discharge port (210).In some embodiments, discharge port (210) It is configured to the depression in the housing of issuing unit (10), in order to allow reception to be placed in saddle (300) Opening (307) (see Fig. 9 a-12d) in puncture box parts (22).When issuing unit (10) Reach tight with pin unit (20) adjacent time, connect tube chamber (250) and puncture the self sealss of standpipe connection Rubber interval body (313), and between tube chamber (250) and sleeve pipe (330), set up the stream of sealing Body connects, thus allows to be in fluid communication between sleeve pipe (330) and reservoir (220).For sending out Putting unit (10) and be fastened to saddle (21), issuing unit (10) includes recess (12a-d), it Be configured to the anchoring latches (302a-d) be suitable to pin unit (20) and coordinate.Issuing unit (10) The connection to pin unit (20) represent with the arrow in Figure 13 a.Figure 13 b shows issuing unit (10) pin unit (20) (and issuing unit is in operator scheme) it is attached to.People in the art Member be appreciated that the connection to pin unit (20) of issuing unit (10) can use any other Component is set up.
Figure 13 c shows that the lock bolt (302) by pulling back elastically deformable pulls down issuing unit (10).Then, issuing unit (10) is pulled along the direction leaving pin unit (20), such as figure Shown in arrow in 13c.After removing issuing unit, pin unit (20) continues to remain adhered to skin Skin (5), and sleeve pipe (330) is continually maintained in subcutaneous location.Self-seal type interval body (313) After removing issuing unit (10), holding seals standpipe connection (310) securely, thus anti-fluid stopping The leakage of body and/or dirt enter.
Figure 14 a-16b shows exemplary reservoir (220) according to certain embodiments of the present invention. Figure 14 a-b shows that exemplary reservoir (220) has circular cross section.Figure 15 a-b shows Exemplary reservoir (220) has oval cross-section.Figure 16 a-b shows exemplary reservoir (220) If having the cross section limited by stem curve (such as, 4-curve, 8-curve).
Figure 14 a shows cylinder-shaped reservoir device (220), and it has plunger (110).Reservoir (220) Including the hollow housing surrounded by storage wall.The open at one end of reservoir (220), other end closing, To prevent fluid leakage.The open end of reservoir is blocked by plunger (110), thus prevents fluid from spacious Beginning reveals.As it was previously stated, before and after plunger (110) is configured to be suitable in reservoir (220) Slide, to force fluid to be discharged from the discharge port (210) being arranged on reservoir (220) housing. For example, reservoir (220) can accommodate the fluid of maximum 2 cubic centimetres (cc).It has length Degree (V) (for example, it is possible to about 18mm), internal diameter (D) (such as, about 12mm), and Wall thickness (t) (such as, about 1mm).In some embodiments, the height of plunger is of about 14mm. Figure 14 b is the sectional view of reservoir (220).This sectional view is the direction B marked in Figure 14 a -B ' is made.
Figure 15 a shows avette (or oval) reservoir (220) with plunger (110).Figure 15b is the sectional view of reservoir (220).This sectional view is along Figure 15 b acceptance of the bid outgoing direction C-C ' Made.Some advantages of elliptical or oval shape reservoir (220) are to reduce the thickness of reservoir Degree, and therefore allow whole unit (10) (not shown) to have tiny profile.
Figure 16 a shows the reservoir (220) with oval cross section.As before, storage Device (220) is provided with plunger (110).Figure 16 b shows the sectional view of reservoir (220).This cuts open View is that the direction E-E ' marked in Figure 16 a is made.As before, plunger (110) There is the cross section with the internal engagement of reservoir (220).
The ellipse and the oval structures that are shown in Figure 15 a-16b cause reservoir (220) to have thin contour, Its thickness is of about 10mm.The length of such reservoir can be store in the rank of about 20mm The capacity of storage can be the fluid of maximum 2cc.It will be understood by those skilled in the art that equipped with this The issuing unit (10) planting elliptical or oval shape reservoir also can have thin contour, thus carries to patient For comfortable and light and handy pump unit.
Figure 17 a-b shows many shaped forms reservoir (220) according to certain embodiments of the present invention. Figure 17 a is the perspective view of many shaped forms reservoir (220), and Figure 17 b is illustrated in the reservoir of Figure 17 a The sectional view made along line F-F'.Reservoir (220) is further equipped with plunger (110).As shown in Figure 17 a-b, four curves of the cross section of reservoir (220) are by limiting.Two of which curve (top Curve 2001 and bottom curve 2003) there is radius R1, two other curve (side curve 2002 With 2004) there is radius R2.Connection between every two adjacent curves is smooth.This many curves Type reservoir (220) provides additional rigidity to reservoir (220), also allows for maintaining storage simultaneously The thin contour of storage (220).It will be understood by those skilled in the art that reservoir (220) can be by four Its shape of curve limit more than bar, and every curve can have different radius, length and width Degree.
It will be understood by those skilled in the art that issuing unit (10) can multiple reservoirs (220), its In each reservoir can have different shape, design and sizes, as shown in Figure 14 a-17b.
Figure 18 a-19f show reservoir (220) filling according to certain embodiments of the present invention and Enable program.Specifically, Figure 18 a-19e shows the disposable unit (200) in filling operation, Figure 19 f shows the disposable unit 200 in the program of enabling.
As shown in Figure 18 a, disposable unit (200) include having plunger (110) reservoir (220), Fluid delivery/tubulose connects (230), battery (240), discharge port (210).These parts Configuration and connection are described above.As further illustrated in Figure 18 a, disposable unit (200) (and therefore issuing unit (10)) can have elliptical or oval shape profile.Figure 18 b is illustrated in The transverse sectional view of the disposable unit (200) of Figure 18 a.As being further illustrated in Figure 18 b, disposably The discharge port (210) of parts (200) includes connecting tube chamber (250).Connect tube chamber (250) warp Cross fluid delivery (230) to be in fluid communication with reservoir (220).As it was previously stated, connect tube chamber (250) Allow to be in fluid communication between reservoir (220) and the parts being connected to tube chamber (250).This In the case of, tube chamber (250) is used for from cartridge delivery fluid to reservoir (220).In filling Before reservoir (220), plunger (110) is driven fully in reservoir (220), thus plunger Axle be located substantially entirely in reservoir, as shown in Figure 18 a-b.
Therapeutic fluids container (6) (such as, comprising insulin) is connected at discharge port (210) place It is connected to disposable unit (200), as shown in Figure 19 a-b.Specifically, tube chamber (250) thorn is connected The interval body (7) of broken container, thus allow fluid from container (6) transmission to reservoir (220).Logical Cross and pull the axle of plunger (110) and therefore produce the suction by fluid extracts from container (6) and make With, fluid is extracted out from container (6), as shown in Figure 19 c-e.It is filled with the stream of reservoir (220) The amount of body (that is, insulin) can customize according to the needs of patient, i.e. for child, is used for The required dosage of whole day is relatively small, therefore can the part of a filling reservoir (220)；And it is right In adult, the whole volume of reservoir (220) can be used.Therefore, by means of reservoir with disposable The previously described configuration of parts, it is no longer necessary to the reservoir (220) of custom-made is provided, and several Fluid will not be wasted.In some embodiments, patient/user can be observed in filling operation It is filled with the fluid of reservoir (220).
Figure 19 f shows that exemplary reservoir (220) according to certain embodiments of the present invention enables Program.The program of enabling is designed to after removing container (6) to clean out and any is likely to accumulate in reservoir (220) air in.By disposable unit (200) being maintained at stand up position and pushing away forward Hydraulic plunger (110), until fluid (8) drips from discharge port (210), can clean out bubble.
In some embodiments, reservoir (220) can be placed in be held in external shell In secondary property parts.Such housing can be made of clear material at least in part, to allow patient even Monitor the fluid level/composition in reservoir (220) continuously.
In some embodiments, it is possible to use minor adaptations (213) realizes reservoir (220) Filling operation, as shown in Figure 20 a-b.Figure 20 a shows example adaptor (213), its bag Include two contrary ports: a port (211) is used for connecting container (6), another port (211') For connecting with reservoir (220).Port (211) includes pin (215), its by with container (6) Connect and puncture the interval body (7) of container.Adapter (213) farther includes rubber interval body (217), It seals up port (211').When adapter (213) is connected to discharge port (210), interval The connected tube chamber (250) of body (217) punctures, in order to for the purpose of fluid transmission.Figure 20 b shows Go out adapter (213) to disposable unit (200) and the connection of container (6).As it can be seen, Container (6) is connected to the port (211) of adapter (213), and the port (211') of adapter (213) It is connected to the port (210) of disposable unit (200).The most above-mentioned connection is done, and treatment is flowed Body will be transmitted and reservoir (220) by adapter (213) from container (6), thus to storage Storage (220) fluid-filling.The filling journey that filling operation is discussed with reference to Figure 18 a-19e before being similar to Sequence.In some embodiments, reservoir (220) can use and be connected to inlet port and (be not illustrated in Figure 20 a-b) auxiliary needle cylinder carry out filling.
After being filled with reservoir (220), parts (100) and disposable unit (200) can be used again Can be connected to each other, thus produce issuing unit (10), as previously discussed.Issuing unit (10) Can then be attached to patient skin, as it can be seen, such as shown in Figure 13 a-c.
Figure 21 a-e and 22a-c show according to certain embodiments of the present invention exemplary disposably Parts (200) and can use parts (100) again, wherein the bar (110b) of plunger (110) is arranged in In both parts.As shown in Figure 21 a, plunger (110) includes stopper head (110a) and plunger rod (110b).Stopper head (110a) is connected to plunger rod (110b).Plunger rod (110b) is connected to Drive mechanism (120), this drive mechanism allows plunger (110) can use parts (100) and again Move between secondary property parts (200).The motion of plunger rod (110b) causes stopper head (110a) to exist Motion in reservoir (220).Plunger rod (110b) can be connected to be arranged in drive mechanism (120) In driving gear (not shown).Additionally, the motion of plunger (110) can pass through PCB (130) Controlling, this PCB sends suitable order to drive mechanism (120).The motion of plunger (110) Scheme/speed (such as, basic dose measures) can be delivered with adding based on specific fluid.
In some embodiments, issuing unit (10) can also include auxiliary rod (110c), its energy Enough it is used for filling reservoir (220), as shown in Figure 21 a.Once can use parts and disposable unit again Be disengaged from, in order to for filling reservoir purpose (such as, user/patient receive instruction or Judge the basic overhead of reservoir), plunger rod (110b) can automatically or manually depart from plunger Head (110a), and auxiliary rod (110c) may be coupled to stopper head (110a).Auxiliary rod (110c) Can pass through buckle structure, by bar (110c) is threaded onto stopper head (110a) or use any its Component that it is suitable and be connected to stopper head (110a).
Figure 21 b shows that disposable unit (200) departs from can use parts (100), and auxiliary rod again (110c) it is connected to stopper head (110a), and reservoir (220) is filled with therapeutic fluids. For filling reservoir, user/patient take before with reference to similar program described by Figure 18 a-19e. In this embodiment kind, user pulls auxiliary rod along the direction leaving reservoir (220) (110c), as shown in the arrow in Figure 21 b.Along with user pulls auxiliary rod (110c), fluid Extracted from container (6) (being not illustrated in Figure 21 b).Once filling operation is done, auxiliary rod (110c) I.e. departed from from stopper head (110a) and removed from disposable unit (200), as shown in Figure 21 c. Additionally, by filling reservoir (220), stopper head (110a) can arrive can again with parts and once At fillet between property parts.
Once auxiliary rod (110c) is removed, and can be connected to that with parts and disposable unit again This, as shown in Figure 21 d.By the connection of both parts, the far-end of plunger rod (110b) (deviates from Drive mechanism and the one end close to stopper head (110a)) it is fixed in stopper head (110a)；And it is near End (being connected to one end of drive mechanism (120)) engages with drive mechanism (120).From PCB (130), after receiving suitable order and being powered by battery (240), drive mechanism (120) is drawn Play plunger rod (110b) forward in reservoir (220) to move.Figure 21 e shows and is operating Issuing unit (10).By application drive mechanism (120), plunger (110) is in reservoir (220) Moved, and fluid is promoted towards discharge port (210), thus cause delivering a fluid to patient. As it was previously stated, this delivery can be real with various dosage (such as, boost, basic dose etc.) Existing, and can be by user/patient, computer, remote controller (40) (not shown) and/or any Other device is programmed in PCB (130).
Figure 22 a-c shows another exemplary issuing unit according to certain embodiments of the present invention (10), it has two parts.In this embodiment, plunger (110) is placed in disposably In parts (200), and can use the drive mechanism (120) parts (100) again from being arranged in Disengage.Figure 22 a shows the issuing unit (10) before connection member (100) and (200). The plunger (110) being shown in Figure 22 a-c includes the portion identical with the plunger (110) being shown in Figure 21 a-e Part.It is connected to each other referring to Figure 22 a, stopper head (110a) and plunger rod (110b), and all Being placed in disposable unit (200), wherein, stopper head (110a) is disposed in reservoir (220) Inner side, plunger rod (110b) is disposed in reservoir (220) outside.Reservoir (220) is permissible Utilize before being similar to reference to the program filling described by Figure 18 a-19e.In this case, use Person/patient can pull plunger rod (110b) so that filling reservoir (220), rather than attached auxiliary rod (110c)。
Once parts (100) and (200) are connected to each other and reservoir (220) is filled with, Plunger rod (110b) can engage with drive mechanism (120).Such joint can be buckled by card Structure, screw thread, socket arrangement or use other suitable mode any to realize.As battery (240), PCB (130) after one or more electrical connection and between other electron component is established, drive mechanism (120) Can apply power to plunger rod (110b), plunger rod applies power to stopper head (110a) the most again, Thus fluid is released from reservoir (220) and promotes towards discharge port (210), as shown in figure 22b。
Figure 22 c shows the further operation of issuing unit (10).Along with plunger (110) is along just Move to sending direction, the fluid in reservoir (220) through fluid delivery (230) towards row Go out port (210) flowing, thus deliver fluid to patient.The filling of reservoir and emptying can be continuous Be repeated (or based on regulation number of times be repeated).
Figure 23 a-26c show according to certain embodiments of the present invention utilize drive mechanism (120) The exemplary alternative of the plunger (110) moved.Figure 23 a be have link together can be again Top view in cross-section by the issuing unit (10) of parts (100) and disposable unit (200).Single Unit (10) includes plunger (110), and it is provided with screw rod (110b) and is connected to screw rod (110b) Nut (114).Nut (114) is arranged in can be again with in parts (100) and fixed, i.e. It is not mobile along axis (1000).Screw rod (110b) and nut (114) are along axis (1000) Align, as shown in Figure 23 a.Screw rod (110b) can be with the side of rotary motion in nut (114) Formula moves.Nut (114) is further connected to gear (116), and its middle gear (116) is to drive A part for mechanism (120).Gear (116) is further equipped with at least one internal cogwheel.Tooth Wheel (116) is driven by motor (118) (such as, DC motor, motor etc.), and motor is also A part for drive mechanism (120).In some embodiments, gear (116) by axle or is appointed The component that what it allows motor (118) driven gear (116) to rotate is connected to motor (118).
Figure 23 b shows that plunger (110) is by mobile along axis (1000).In motor (118) Operating process in, motor (118) swing pinion (116).The rotary motion quilt of gear (116) It is delivered to be connected to the internal cogwheel of nut (114), causes nut (114) to rotate.Due to screw rod (110b) inserting in nut (114), therefore the rotation of nut (114) causes screw rod (110b) Rotate, and along axis (1000) translation bar (110b) and therefore translate plunger (110). This translational motion of plunger (110) by the fluid in reservoir (220) towards discharge port (210) Mobile.In some embodiments, nut (114) can serve as internal cogwheel, thus reduces gear (116) number of components in.It will be understood by those skilled in the art that motor (118) can be along any Direction rotates, and therefore causes nut (114) along (the rotation side according to motor (118), various directions To) rotate.So, screw rod (110b) can rotate along corresponding direction and along axis (1000) Anterior-posterior translation, causes plunger (110) to be movable into and out reservoir (220).As it was previously stated, it is such Motion is controlled by PCB (130) (not shown) powered by battery (240), and can be based in advance The scheme of programming automatically controls or hand control (such as, by pressing the button (15)).
Figure 24 a shows another exemplary issuing unit (10) according to certain embodiments of the present invention. Issuing unit (10) includes drive mechanism (120), and it has and is loaded with driving spring (113) and (113') Screw rod (110b) and the nut (114) that driven by motor (118) and gear (116).One In a little embodiments, nut (114) can be arranged in disposable unit (200), and can By one or many can be connected to the connection between parts (100) and disposable unit (200) again Individual gear (116).Alternatively, in nut (114) can be arranged in and can use parts (100) again. Being similar to be shown in the embodiment of Figure 23 a-b, nut (114) is fixed and not along axis (1000) Mobile.Nut (114) is further connected to one or more gear (116) rotated by motor (118). The rotary motion of one or more gear (116) is passed to nut (114) (through nut (114) On engaging tooth and one or more gear (116) between interaction).Driving spring (113), (113') It is arranged between nut (114) and stopper head (110a), and moves in reservoir (220) Time apply additional power to stopper head (110a).When reservoir (220) is filled with or still expires, Spring (113) is in compressive state.
Figure 24 b shows the issuing unit (10) being in fluid granting program.Motor (118) revolves Turning one or more gear (116), this causes the rotation of nut (114).The rotation of nut (114) Causing screw rod (110b) to rotate, so, screw rod translates along axis (1000).Along with screw rod (110b) Translating forward, driving spring (113), (113') expand and apply additional power at stopper head (110a) On.The additional power of application can make by motor (118) produce for by plunger (110) in storage The moment that device (220) translates reduces.
Figure 25 a-b shows the another exemplary issuing unit (10) with drive mechanism (120). Drive mechanism (120) includes one or more gear (116), nut (114), auxiliary nut (114a) (114b), four articulated jibs (119), bars (110b), screw rods (110d).Drive mechanism (120) Motor (118) drive one or more gear (116) to rotate, this causes the most again nut (114) Rotate.Nut (114) is connected to screw rod (110d).Screw rod (110d) along with nut (114) Identical direction rotates.Auxiliary nut (114a) and (114b) by screw threads for fastening to screw rod (110d), That is, nut (114a) and (114b) is configured to be suitable to along with bar (110d) rotation along spiral shell Bar (110d) anterior-posterior translation.Screw rod (110d) includes screw thread, itself and nut (114a) and (114b) Screw thread interact.Screw threaded arrangement on nut (114a) and (114b) is reciprocal side To, to allow nut (114a) and (114b), along bar, (110d puts down in directions opposite each other Move.Articulated jib (119) at the pivoting articulation (115) being arranged on screw rod (110d) opposition side and Another pivoting articulation (115') place is fastened to bar (110b) in articulated manner, as shown in Figure 25 a.
Nut (114a) and (114b) are also coupled to arm (119), thus are that arm (119) forms hinge The pivot connect.Therefore, arm (119) has four articulation pivot, at nut (114a) and (114b) Translational motion during allow arm (119) vertically and horizontally.As it was previously stated, when nut (114) When being rotated by motor (118) and one or more gear (116), nut (114) rotary screw (110d), So that nut (114a) linearly moves along screw rod (110d).Nut (114b) is also along spiral shell Bar (110d) translates, as shown in Figure 25 b.
Therefore, when nut (114a) and (114b) are closer to each other, joint (115), (115') Move in directions opposite each other along axis (1000), thus force plunger rod (110b) to be transported Dynamic, and therefore plunger (110) moves towards discharge port (210) and mobile reservoir (220) In fluid.In some embodiments, plunger (110) is forced in the reverse rotation of nut (114) Adverse movement is made along the direction leaving discharge port (210).The adverse movement of nut (114) is drawn Play pivot (115) and (115') moves towards each other along axis (1000).This configuration reduces The drive mechanism (120) total length along axis (1000), thus reduce issuing unit (10) Total length.
What Figure 26 a-c showed another exemplary embodiment has disposable unit (200) and can be again By the issuing unit (10) of parts (100), wherein, screw rod (110b) can be included with parts (110) again With the driving nut (125) being connected to screw rod (110b).Disposable unit (200) includes plunger (110) With the L-shaped bar with connection end (115).L-shaped bar (110) includes one longer section, and it is vertical In another shorter section.Screw rod (125) includes lateral recesses (1-25a), and it is configured to receive L The connection end (115) of shape bar, as shown in Figure 26 a-b.Nut (125) is driven to include screw thread, its quilt It is configured and adapted to and is arranged in the threaded engagement on bar (110b).Therefore, at screw rod (110b) In rotary course (motor (118) and (116) by drive mechanism (120) cause), drive spiral shell Female (125) translate along screw rod (110b).
In operation, nut (125) is driven to cause plunger along screw rod (110b) rectilinear translation Head (110a) displacement simultaneously, therefore by the fluid in reservoir (220) towards discharge port (210) Push, as shown in Figure 26 c.L-shaped bar allows more compactly to arrange each spatial component, and this can reduce sends out Put the size of unit.
Figure 27 a-28b shows the disposable unit (200) of issuing unit (10) and can use portion again Two embodiments of the sealing structure between part (100).In Figure 27 a-b illustrated embodiment, Only realize sealing after parts (100) and disposable unit (200) can be used again to connect, and each When parts are in " discrete " state, it is not limited in waterproof case.Embodiment party in Figure 28 a-b In formula, each parts have the seal casinghousing of himself.
Figure 27 a is can to use parts (100) and disposable unit (200) section view before proceeding again Figure.In this embodiment, disposable unit (200) includes at least one packing ring (205) (example As, elastomeric O-rings), it is attached to the housing of disposable unit (200).At some embodiments In, one or more packing ring (205) can be attached to can use parts (100) again, or can be attached to Both parts.Once can be joined together with parts (100) and disposable unit (200) again, Described parts are sealed by one or more packing ring (205), thus prevent internal part impaired and Enter moisture, dirt or other undesirable granule, as shown in Figure 27 b.
Figure 28 a shows the parts of two " discrete " each other, and each parts are sealed in special shell respectively In body.Disposable unit (200) comprises two sharp battery connection part (242) and (242'), Their outside projections and include sharp end portion.Two self sealss partitions can be comprised again with parts (100) And (142') (142), for sealed cell connecting portion, and pleated corrugated tube (117), it is used for receiving Plunger rod (110b) and it is sealed.Figure 28 b shows two parts being connected to.Electricity Pond connecting portion (242) and (242') puncture corresponding partition (142) and (142'), thus at electricity Pond (240) (being placed in disposable unit (200)), PCB (130) and electronic component (dispose Can use in parts (100) again) between set up electrical connection.Plunger rod (110b) is by corrugated tube (117) Seal and cover and mobile plunger head (110a).
Figure 29 a-30b shows have disposable unit (200) and can use sending out of parts (100) again Put the another exemplary embodiment of unit (10).
Figure 29 a shows reservoir (220), and it is configured to the form of semi-ring surface.Shown storage The cross section of storage (220) can be shaped form oval, avette, many or any other is the most horizontal Cross section.The shape of reservoir and cross section determine the configuration of other parts such as plunger, housing etc.. Figure 29 b-d shows the applicable cases of the reservoir (220) being shown in Figure 29 a.
Figure 29 b shows two parts, and each parts are configured to the form of half anchor ring.Disposable portion Part (200) has semi-ring surface type reservoir (220), battery (240) and discharge port (210). Drive mechanism (120) (such as, motor and gear) can be included again with parts (100), plunger (110), PCB (130) and other relatively costly parts, such as, clogging sensor (not shown).Blocking passes The illustrative embodiments of sensor be disclosed own together/14 days February in 2007 of CO-PENDING The U.S. Patent application No.11/706 submitted to, 606, and the U.S. of December in 2007 submission on the 21st is special Profit application No.11/963,481, the disclosure of above-mentioned application is incorporated by reference this Shen on the whole Please.Drive mechanism (120) farther includes motor (118), worm screw (134), the second gear (135), With circular gear (137).Circular gear (137) is pivotably connected to can use parts (100) again Housing.Motor (118) rotary worm (134), worm screw rotates the most again the second gear (135). Along with gear (135) rotates, its engaging tooth interacts with the tooth of circular gear (137), thus Force gear (137) pivot section on parts (100) can used again to rotate around it.Due to post Plug (110) is connected to gear (137), and the circus movement of gear (137) causes plunger (110) to exist Reservoir moves in (220).Owing to gear (137) is circular, and reservoir (220) is also Circular, therefore gear (137) is by the curve movement along reservoir (220), thus by fluid Mobile, as shown in Figure 29 c-d towards discharge port (210).The repercussion campaign of gear (135) is permitted Permitted the adverse movement of gear (137), along with plunger (110) along leaving reservoir (220) The motion in direction.
Figure 30 a-b shows the another exemplary embodiment of issuing unit (10), the most disposably Parts (200) including: reservoir (220), and it is configured to segment (such as, quadrant), Plunger (110), it is constituted in the way of being similar to windshield wiper blade, battery (240), and outlet side Mouth (210).Can include with parts (100) again: drive mechanism (120), electronic device (130), Button (15), and other additional parts such as clogging sensor (not shown).Drive mechanism includes Motor (118), worm screw (141), the first gear (143), and the second gear (145).Motor (118) Rotary worm (141), this is by between worm screw (141) and the engaging tooth of the first gear (143) Interact and cause the rotation of the first gear (143).First gear (143) in turn further through Interaction between the tooth of each gear and cause the rotation of the second gear (145).Plunger (110) It is connected to the second gear (145), and rotates along with the rotation of gear (145).Due to plunger (110) It is configured to bar, pushing away towards discharge port (210) in therefore it will be arranged in reservoir (220) Dynamic.Figure 30 b shows the issuing unit (10) being in operator scheme, wherein plunger (110) along Direction (2000) is mobile, to be promoted towards discharge port (210) from reservoir (220) by fluid.
Although describing particular implementation here in detail, but they be only the most in an illustrative manner for The purpose disclosed is given, and is not meant to that the respective range to limiting in claim is construed as limiting. Particularly, inventor it is envisioned that in without departing from claim limit spirit and scope of the invention On the premise of, various replacement can be made, replace, revise.Other side, advantage and amendment are recognized For comprising within the scope of the claims.Proposed claim represent invention disclosed herein Representative aspect.The invention of other failed call protection is it is further envisaged that out.Inventor retains by rear The continuous claim proposed protects these rights invented.
The all patents quoted in the application and the disclosure of pending patent application are on the whole with the side of quoting Formula is incorporated herein.
The method of the present invention and the illustrative embodiments of parts are here described.Institute as local in other Pointing out, the description of these illustrative embodiments is merely for the explanatory purpose rather than restricted 's.Other embodiment is feasible and is covered by the present invention.Based on the technology enlightenment comprised here, Technical staff in one or more correlative technology field is clearly understood that such embodiment.Cause This, the coverage rate of the present invention and scope are not limited to any previously described illustrative embodiments, But only limited by claim and equivalent thereof.

Claims (18)

1. for therapeutic fluids being delivered to an equipment in the patient, including:
Issuing unit, it has the reservoir that accommodate therapeutic fluids；
Puncturing box, it has for puncture component inserted into the patient and sleeve pipe；
RCU, for communicating with described issuing unit, and is used for sending instruction so that convection cell Flowing is programmed, controls described issuing unit, data acquisition and data and show；
Wherein, described issuing unit can be attached directly patient body, or can be connected to paste Invest the pin unit of skin and the pin unit of skin can be attached at described in departing from；
Described equipment farther includes standpipe connection, and wherein, described standpipe connection passes through tubular connector Connecting with described reservoir fluid, and include opening, described puncture box and described sleeve pipe are through described Opening.
Equipment the most according to claim 1, wherein, described issuing unit farther includes drive mechanism And discharge port, described discharge port includes described standpipe connection；
Described drive mechanism causes the therapeutic fluids being contained in described reservoir towards described discharge port Mobile；
Wherein, described discharge port is configured to be suitably connected to described pin unit and depart from described pin Unit, thus fluid communication can be set up between reservoir and sleeve pipe through connecting tube chamber.
Equipment the most according to claim 2, wherein, described issuing unit farther includes:
Can use parts again, it includes at least some of, the electronic component of described drive mechanism, for controlling Make at least one button of the operation of described issuing unit；
Disposable unit, it includes described reservoir；And
Power source means, it electrically connect at least one described electronic component, for using portion again described Part and described disposable unit are powered when connecting.
Equipment the most according to claim 3, wherein, described issuing unit farther includes: air-tightness Sealing member, between it is placed in disposable unit and can use again, to prevent dirt from entering.
5. according to the equipment any one of claim 2 to 4, wherein, described issuing unit is further Including fluid delivery, standpipe connection is in fluid communication with fluid delivery；Fluid delivery is connected to Adapter, connecting tube and open fluid communication；Once puncturing box to be removed from opening, fluid can be from fluid Delivery tube flows through connecting tube, and enters opening and flow towards discharge port, in order to be delivered to Patient.
Equipment the most according to claim 5, wherein, the connection between connecting tube and fluid delivery is Being tightly connected, it stops fluid delivery to slip from adapter and any leakage of fluid or dirt enter Enter opening.
7. according to the equipment any one of Claims 1-4, wherein, opening also includes being spaced body Part, it seals up opening after eliminating puncture component, and interval body parts also can stop dirt to enter vertical tube Interface and the leakage of fluid.
Equipment the most according to claim 7, wherein, interval body seals up in the body part puncturing box Path, described path comprises described sleeve pipe；Once puncture component is removed by the path from body part, Interval body seals up described path.
9. according to the equipment any one of Claims 1-4, wherein, described puncture component is sword body, There is sharp distal tip and grasping part, and be adapted to puncture patient skin surface.
Equipment the most according to claim 3, wherein, described disposable unit farther includes plunger.
11. equipment according to claim 10, wherein, described plunger include being received within described can Again with the plunger rod in parts and the stopper head being arranged in described disposable unit；
Described stopper head is arranged in the reservoir being placed in described disposable unit；
Described plunger rod is connected to described drive mechanism, and described disposable unit and described can be again Be partially positioned in when being connected with parts described can again with in parts and be partially positioned in described disposably In parts；
Described stopper head by the described therapeutic fluids in described reservoir towards described discharge port forward Mobile.
12. according to the equipment any one of Claims 1-4, farther includes special purpose spring and loads Inserter, wherein inserter is loaded puncture box, and sleeve pipe can be loaded by described special purpose spring Inserter inserts in patient body.
13. equipment according to claim 12, wherein, described inserter has housing, and projection connects In housing, and it is configured to the respective recesses be suitable to standpipe connection and coordinates；Insert perpendicular puncturing box During interface tube, projection and depression stability needed for housing provides.
14. equipment according to claim 12, wherein, once puncture box and have been positioned in vertical tube and connect In mouthful, and sleeve pipe has been deposited in the subcutaneous location below skin, and inserter is removed.
15. according to the equipment any one of Claims 1-4, and wherein, described reservoir has non- Circular cross section.
16. equipment according to claim 15, wherein, described reservoir has selected from set below Cross section: avette, oval, rectangle, many shaped forms.
17. equipment according to claim 3, wherein, by using parts and described again by described Secondary property parts connect, and realize described fluid granting.
18. according to the equipment any one of Claims 1-4, and wherein, described RCU is selected from Set below: personal computer, notebook computer, iPod, PDA, mobile phone, remote controller.
CN201310136984.1A 2007-05-11 2008-05-11 Displacement pump Active CN103230632B (en)

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US92881507P 2007-05-11 2007-05-11
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US60/928,750 2007-05-11
US60/928,815 2007-05-11
US60/928,751 2007-05-11

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Families Citing this family (142)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6850788B2 (en) 2002-03-25 2005-02-01 Masimo Corporation Physiological measurement communications adapter
CA2523267C (en) 2003-04-23 2013-09-03 Biovalve Technologies, Inc. Hydraulically actuated pump for long duration medicament administration
US9089636B2 (en) 2004-07-02 2015-07-28 Valeritas, Inc. Methods and devices for delivering GLP-1 and uses thereof
US9687186B2 (en) 2005-07-21 2017-06-27 Steadymed Ltd. Drug delivery device
IL175460A (en) 2006-05-07 2011-05-31 Doron Aurbach Drug delivery device
NZ567390A (en) * 2005-11-18 2010-01-29 Automatic Tech Au Pty Ltd Device for monitoring motion of a movable closure
US7887508B2 (en) 2006-03-14 2011-02-15 The University Of Southern California MEMS device and method for delivery of therapeutic agents
KR101361376B1 (en) 2006-03-30 2014-02-10 발레리타스 인코포레이티드 Multi-cartridge fluid delivery device
US8435211B2 (en) * 2006-07-24 2013-05-07 Medingo Ltd. Systems, devices and methods for fluid/drug delivery
US9138534B2 (en) 2007-05-11 2015-09-22 Roche Diabetes Care, Inc. Positive displacement pump
EP2165320A2 (en) * 2007-06-22 2010-03-24 Medingo Ltd. Communications for medicinal fluid delivery system
EP2183006B1 (en) 2007-07-20 2019-02-13 Roche Diabetes Care GmbH Manually operable portable infusion device
DK2178583T3 (en) 2007-07-20 2014-02-24 Roche Diagnostics Gmbh Distribution device with bleeding
JP2010535057A (en) * 2007-08-01 2010-11-18 メディンゴ・リミテッド Portable infusion device with means for monitoring and controlling fluid delivery
US8147446B2 (en) 2007-08-01 2012-04-03 Medingo Ltd. Detachable portable infusion device
US9173997B2 (en) 2007-10-02 2015-11-03 Medimop Medical Projects Ltd. External drug pump
WO2009066287A2 (en) 2007-11-21 2009-05-28 Medingo Ltd. Hypodermic optical monitoring of bodily analyte
MX2010006840A (en) 2007-12-20 2010-08-12 Univ Southern California Apparatus and methods for delivering therapeutic agents.
WO2009081399A1 (en) 2007-12-21 2009-07-02 Medingo Ltd. Devices and methods for powering a medical device
US8641672B2 (en) * 2008-03-10 2014-02-04 Roche Diagnostics Operations Inc. Infusion and sensing device with battery charging and data transferring mechanisms
WO2009113075A1 (en) 2008-03-12 2009-09-17 Medingo Ltd. Devices and methods for improving accuracy of fluid delivery
JP5506780B2 (en) 2008-04-09 2014-05-28 エフ．ホフマン−ラ ロシュ アーゲー System, apparatus and method for delivering fluid
EP2323716B1 (en) 2008-05-08 2015-03-04 MiniPumps, LLC Drug-delivery pumps
US9333297B2 (en) 2008-05-08 2016-05-10 Minipumps, Llc Drug-delivery pump with intelligent control
MX2010012213A (en) 2008-05-08 2011-05-03 Minipumps Llc Implantable pumps and cannulas therefor.
US8052645B2 (en) 2008-07-23 2011-11-08 Avant Medical Corp. System and method for an injection using a syringe needle
CA3142745A1 (en) 2008-05-20 2009-11-26 Avant Medical Corp. Autoinjector system
US8177749B2 (en) 2008-05-20 2012-05-15 Avant Medical Corp. Cassette for a hidden injection needle
IT1391274B1 (en) * 2008-08-08 2011-12-01 Medica S R L Ab IRRIGATION AND SUCTION SYSTEM, IN PARTICULAR FOR LAPAROSCOPIC SURGERY
JP5298699B2 (en) 2008-08-20 2013-09-25 セイコーエプソン株式会社 Control unit, tube unit, micro pump
JP5282508B2 (en) 2008-09-29 2013-09-04 セイコーエプソン株式会社 Control unit, tube unit, micro pump
WO2010044088A1 (en) 2008-10-16 2010-04-22 Medingo Ltd. Method and system for adaptive communication transmission
US8728034B2 (en) 2008-11-11 2014-05-20 Roche Diagnostics Operations Inc. Modular fluid delivery device with quick-release / connect mechanism for drive screw
JP5195368B2 (en) * 2008-12-05 2013-05-08 セイコーエプソン株式会社 Tube unit, control unit, micro pump
EP2391408B1 (en) 2008-12-31 2018-01-17 Roche Diabetes Care GmbH Portable medical fluid delivery device with drive screw articulated with reservoir plunger
US8197454B2 (en) 2009-02-21 2012-06-12 Incumed, Llc Fluid cartridges and partially implantable medical devices for use with same
US9370619B2 (en) * 2009-02-21 2016-06-21 Incumed, Llc Partially implantable medical devices and delivery/manifold tube for use with same
US9125981B2 (en) * 2009-02-21 2015-09-08 Incumed, Llc Fluid cartridges including a power source and partially implantable medical devices for use with same
US8292604B2 (en) * 2009-05-01 2012-10-23 Xerox Corporation Peristaltic pump
WO2010146579A1 (en) 2009-06-14 2010-12-23 Medingo Ltd. Devices and methods for malfunctions recognition in a therapeutic dispensing device
DK2453972T3 (en) * 2009-07-16 2014-02-03 Medingo Ltd DEVICE FOR EXACT INFUSION OF FLUIDS
CN102576385B (en) 2009-08-18 2016-02-24 迷你泵有限责任公司 There is the electrolytic drug discharge pump of adaptive control
EP3470100B1 (en) * 2009-12-16 2022-08-17 Becton, Dickinson and Company Self-injection device
WO2011075100A1 (en) 2009-12-16 2011-06-23 Becton, Dickinson And Company Self-injection device
US10391241B2 (en) 2010-01-22 2019-08-27 Deka Products Limited Partnership Syringe pump having a pressure sensor assembly
US9295778B2 (en) 2011-12-21 2016-03-29 Deka Products Limited Partnership Syringe pump
US9789247B2 (en) 2011-12-21 2017-10-17 Deka Products Limited Partnership Syringe pump, and related method and system
US9744300B2 (en) 2011-12-21 2017-08-29 Deka Products Limited Partnership Syringe pump and related method
US8674288B2 (en) * 2010-03-24 2014-03-18 Medtronic Minimed, Inc. Motor assembly sensor capture systems and methods
US9498573B2 (en) 2010-09-24 2016-11-22 Perqflo, Llc Infusion pumps
US9216249B2 (en) 2010-09-24 2015-12-22 Perqflo, Llc Infusion pumps
US8430849B2 (en) 2010-09-24 2013-04-30 Perqflo, Llc Infusion pumps and plunger pusher position-responsive cartridge lock for infusion pumps
US8915879B2 (en) 2010-09-24 2014-12-23 Perqflo, Llc Infusion pumps
JP2013541976A (en) * 2010-09-27 2013-11-21 ステディメッド， エルティーディー． Size efficient drug delivery device
EP2438938A1 (en) * 2010-10-11 2012-04-11 PharmaSens AG Syringe type pump
US8905972B2 (en) 2010-11-20 2014-12-09 Perqflo, Llc Infusion pumps
WO2012094641A2 (en) 2011-01-06 2012-07-12 Thoratec Corporation Percutaneous heart pump
EP2672946A2 (en) * 2011-02-13 2013-12-18 The Regents of The University of California Fluid delivery system
CA3021845C (en) 2011-04-20 2022-03-29 Amgen Inc. Autoinjector apparatus
CA2845379C (en) 2011-09-02 2019-08-06 Unitract Syringe Pty Ltd Insertion mechanism for a drug delivery pump
WO2013040154A1 (en) * 2011-09-15 2013-03-21 Helm Robert E Jr Catheter-dressing systems with integrated flushing mechanisms
WO2013076557A1 (en) 2011-11-21 2013-05-30 Kongsberg Automotive Ab Linear actuator assembly
US10722645B2 (en) 2011-12-21 2020-07-28 Deka Products Limited Partnership Syringe pump, and related method and system
US11217340B2 (en) 2011-12-21 2022-01-04 Deka Products Limited Partnership Syringe pump having a pressure sensor assembly
EP2825225B1 (en) 2012-03-15 2018-05-09 Steadymed Ltd. Enhanced infusion-site pain-reduction for drug-delivery devices
ES2715311T3 (en) 2012-03-19 2019-06-03 Steadymed Ltd Fluid connection mechanism for patch type pumps
US8603026B2 (en) 2012-03-20 2013-12-10 Medtronic Minimed, Inc. Dynamic pulse-width modulation motor control and medical device incorporating same
US8603027B2 (en) * 2012-03-20 2013-12-10 Medtronic Minimed, Inc. Occlusion detection using pulse-width modulation and medical device incorporating same
US8523803B1 (en) 2012-03-20 2013-09-03 Medtronic Minimed, Inc. Motor health monitoring and medical device incorporating same
USD898908S1 (en) 2012-04-20 2020-10-13 Amgen Inc. Pharmaceutical product cassette for an injection device
USD808010S1 (en) 2012-04-20 2018-01-16 Amgen Inc. Injection device
EP4218887A1 (en) 2012-05-14 2023-08-02 Tc1 Llc Mechanical circulatory support device for stabilizing a patient after cardiogenic shock
US8721517B2 (en) 2012-05-14 2014-05-13 Thoratec Corporation Impeller for catheter pump
US9872947B2 (en) 2012-05-14 2018-01-23 Tc1 Llc Sheath system for catheter pump
EP2674177B1 (en) * 2012-06-14 2021-06-30 Stevanato Group S.P.A. Medicament infusion device
US9358329B2 (en) 2012-07-03 2016-06-07 Thoratec Corporation Catheter pump
EP2890431B1 (en) * 2012-08-29 2016-12-21 Unitract Syringe Pty Ltd Controlled delivery drive mechanisms for drug delivery pumps
US10232155B2 (en) * 2012-11-26 2019-03-19 Kci Licensing, Inc. Combined solution pump and storage system for use with a reduced-pressure treatment system
US20140228757A1 (en) * 2013-02-11 2014-08-14 Medrad, Inc. Bent syringes and devices including same
US11033728B2 (en) 2013-03-13 2021-06-15 Tc1 Llc Fluid handling system
EP4122520A1 (en) 2013-03-13 2023-01-25 Tc1 Llc Fluid handling system
USD746975S1 (en) 2013-03-14 2016-01-05 Thoratec Corporation Catheter pump console
JP6336564B2 (en) 2013-03-15 2018-06-06 アムゲン・インコーポレーテッド Drug cassette, auto-injector, and auto-injector system
US9308302B2 (en) 2013-03-15 2016-04-12 Thoratec Corporation Catheter pump assembly including a stator
TWI580452B (en) 2013-03-15 2017-05-01 安美基公司 Cassette for an injector, injector, and method of using an apparatus comprising an autoinjector and a cassette
EP3797810A1 (en) 2013-03-15 2021-03-31 Tc1 Llc Catheter pump assembly including a stator
EP3003426B1 (en) * 2013-05-30 2021-03-10 SHL Medical AG Device for dispensing a fluid to a patient
EP4144390A3 (en) 2013-06-18 2023-07-12 Enable Injections, Inc. Vial transfer and injection apparatus and method
US20140378903A1 (en) * 2013-06-21 2014-12-25 Animas Corporation Manually actuated infusion device and dose counter
CN105813537B (en) * 2013-12-26 2018-04-10 奥林巴斯株式会社 pneumoperitoneum device
US10556059B2 (en) * 2013-12-31 2020-02-11 Biogen Ma Inc. Infusion pump drive with compression spring
EP3131615B1 (en) 2014-04-15 2021-06-09 Tc1 Llc Sensors for catheter pumps
US10350349B2 (en) 2014-05-20 2019-07-16 Cequr Sa Medicine delivery device with restricted access filling port
EP3183024B1 (en) 2014-08-18 2019-09-18 Tc1 Llc Guide features for percutaneous catheter pump
CA2960306A1 (en) 2014-09-22 2016-03-31 Becton, Dickinson And Company Plate with integral fluid path channels
MX2017004005A (en) 2014-09-29 2017-06-08 Unitract Syringe Pty Ltd Rigid needle insertion mechanism for a drug delivery pump.
US10159786B2 (en) 2014-09-30 2018-12-25 Perqflo, Llc Hybrid ambulatory infusion pumps
EP3212253B1 (en) 2014-10-28 2019-03-13 Ferrosan Medical Devices A/S Time controlled periodic infusion
US9770543B2 (en) 2015-01-22 2017-09-26 Tc1 Llc Reduced rotational mass motor assembly for catheter pump
CA2974324A1 (en) * 2015-01-28 2016-08-04 Zita S. Netzel Drug delivery methods and systems
EP3258989B1 (en) 2015-02-18 2020-01-01 Medtronic Minimed, Inc. Ambulatory infusion pump with static and dynamic seals
WO2016132937A1 (en) * 2015-02-20 2016-08-25 テルモ株式会社 Liquid drug administration device
US10463847B2 (en) 2015-06-11 2019-11-05 Steadymed Ltd. Infusion set
CN209137590U (en) 2015-09-21 2019-07-23 贝克顿·迪金森公司 Noggin piece and drug delivery device in drug delivery device
US10576207B2 (en) 2015-10-09 2020-03-03 West Pharma. Services IL, Ltd. Angled syringe patch injector
CN108430536B (en) 2015-10-09 2022-04-08 西医药服务以色列分公司 Method of filling a custom syringe
CN109219456B (en) 2016-01-21 2020-05-15 西医药服务以色列有限公司 Force containment in autoinjectors
JP6885960B2 (en) 2016-01-21 2021-06-16 ウェスト ファーマ サービシーズ イスラエル リミテッド Drug delivery device with visual indicators
EP3405229A1 (en) 2016-01-21 2018-11-28 West Pharma. Services Il, Ltd. Needle insertion and retraction mechanism
CN105597185A (en) * 2016-01-26 2016-05-25 北京英诺达医疗科技有限公司 Excessive injection preventing device and method for injection pump
US10940264B2 (en) 2016-02-12 2021-03-09 Medtronic Minimed, Inc. Ambulatory infusion pumps and assemblies for use with same
US11389597B2 (en) 2016-03-16 2022-07-19 West Pharma. Services IL, Ltd. Staged telescopic screw assembly having different visual indicators
US11389588B2 (en) 2016-05-02 2022-07-19 Amgen Inc. Syringe adapter and guide for filling an on-body injector
TWI746569B (en) * 2016-06-08 2021-11-21 瑞士商瑞健醫療股份有限公司 Dosiergerat, injektionsvorrichtung und verwendung
CN109475684B (en) * 2016-07-14 2022-02-01 赛诺菲 Medicament delivery system
US11160970B2 (en) 2016-07-21 2021-11-02 Tc1 Llc Fluid seals for catheter pump motor assembly
WO2018017683A1 (en) 2016-07-21 2018-01-25 Thoratec Corporation Gas-filled chamber for catheter pump motor assembly
CN109562229B (en) 2016-08-01 2021-07-13 西医药服务以色列有限公司 Anti-rotation medicine barrel pin
CN109045427B (en) * 2016-10-03 2021-06-25 捷普科技（上海）有限公司 Medicament dispenser
JP2018071495A (en) * 2016-11-02 2018-05-10 サントリーホールディングス株式会社 Pump mechanism and beverage dispenser
WO2018096149A1 (en) 2016-11-28 2018-05-31 Idorsia Pharmaceuticals Ltd Device for dispensing a substance
CA3049529A1 (en) 2017-01-06 2018-07-12 Chrono Therapeutics Inc. Transdermal drug delivery devices and methods
ES2924095T3 (en) * 2017-01-31 2022-10-04 Hoffmann La Roche Method and auxiliary device for removing gas and/or gas bubbles from a liquid medicament stored in a reservoir
USD853583S1 (en) 2017-03-29 2019-07-09 Becton, Dickinson And Company Hand-held device housing
JP6921997B2 (en) 2017-05-30 2021-08-18 ウェスト ファーマ サービシーズ イスラエル リミテッド Modular drive train for wearable syringes
US20180355859A1 (en) * 2017-06-08 2018-12-13 Taiko Investment Co.,Ltd. Meter-type magnetic pump and a light interrupting module thereof
KR102510743B1 (en) * 2017-07-07 2023-03-15 뉴로덤 엘티디 Device for subcutaneous delivery of fluid medicament
US20230123806A1 (en) 2017-07-07 2023-04-20 Neuroderm, Ltd. Device for subcutaneous delivery of fluid medicament
GB201712184D0 (en) * 2017-07-28 2017-09-13 Owen Mumford Ltd Medicament delivery device
IT201700108005A1 (en) 2017-09-27 2019-03-27 Medirio Sa MEDICAL INFUSION DEVICE
CN108194333B (en) * 2017-12-08 2019-12-24 江苏南京白马现代农业高新技术产业园有限公司 Peristaltic pump for eliminating pulsation by utilizing protrusions
EP3793639A1 (en) * 2018-05-15 2021-03-24 Sanofi Drive unit for a liquid handling device and liquid handling device
JP7420797B2 (en) 2018-05-29 2024-01-23 モーニングサイド ベンチャー インベストメンツ リミテッド Drug delivery methods and systems
KR102638062B1 (en) * 2019-03-22 2024-02-21 제벡스, 아이엔씨. Method for delivering residual liquid within enteral or other infusion device
US11642454B2 (en) 2019-06-06 2023-05-09 Medtronic Minimed, Inc. Fluid infusion systems
CN111053956A (en) * 2019-12-24 2020-04-24 微泰医疗器械(杭州)有限公司 Dosing device and dosing pump system
US11166601B1 (en) * 2020-08-20 2021-11-09 Faner Aroma Product Co., Ltd. Cleaning agent supply device
US11497847B1 (en) 2021-02-19 2022-11-15 Fresenius Kabi Deutschland Gmbh Wearable injector with adhesive substrate
US11406755B1 (en) 2021-02-19 2022-08-09 Fresenius Kabi Deutschland Gmbh Sensing fluid flow irregularities in an on-body injector
US11504470B1 (en) * 2021-04-30 2022-11-22 Fresenius Kabi Deutschland Gmbh Deformable drug reservoir for wearable drug delivery device
EP4351679A1 (en) * 2021-06-10 2024-04-17 Becton Dickinson and Company Medication delivery system, patch pump and medicament delivery device
US20230414864A1 (en) * 2022-06-28 2023-12-28 Insulet Corporation Methods and systems for optical-based fluid control in a fluid delivery system

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2168080A (en) * 1939-01-19 1939-08-01 William C Allen Collapsible tube dispenser
US3017883A (en) * 1957-08-12 1962-01-23 Becton Dickinson Co Venoclysis assembly
US3151616A (en) * 1962-07-25 1964-10-06 Paul M Selfon Automatic transfusion apparatus
US3631847A (en) * 1966-03-04 1972-01-04 James C Hobbs Method and apparatus for injecting fluid into the vascular system
US3771694A (en) 1972-07-07 1973-11-13 A Kaminski Infusion pump
US3858581A (en) * 1973-07-02 1975-01-07 Dean Kamen Medication injection device
US3884228A (en) * 1974-02-26 1975-05-20 Lynkeus Corp Intravenous feeding system
AT336372B (en) * 1974-12-20 1977-05-10 Evg Entwicklung Verwert Ges FEED DEVICE FOR ROD OR STRIP-SHAPED MATERIAL
US4234104A (en) * 1978-06-02 1980-11-18 Apuzzo Jr Louis J Toothpaste dispenser having a slip clutch drive mechanism
IN151725B (en) * 1978-09-15 1983-07-16 Runciman Susan Ines C
JPS56113084A (en) * 1980-02-12 1981-09-05 Terumo Corp Pulsation preventing method and device for peristaltic finger pump
US4396385A (en) * 1980-12-05 1983-08-02 Baxter Travenol Laboratories, Inc. Flow metering apparatus for a fluid infusion system
US4525164A (en) 1981-04-24 1985-06-25 Biotek, Inc. Wearable medication infusion system with arcuated reservoir
US4435173A (en) * 1982-03-05 1984-03-06 Delta Medical Industries Variable rate syringe pump for insulin delivery
US4498843A (en) * 1982-08-02 1985-02-12 Schneider Philip H Insulin infusion pump
US4552561A (en) * 1982-12-23 1985-11-12 Alza Corporation Body mounted pump housing and pump assembly employing the same
GB8312069D0 (en) * 1983-05-03 1983-06-08 Peritronic Medical Ind Plc Peristaltic pumps
WO1985000523A1 (en) * 1983-07-18 1985-02-14 Baxter Travenol Laboratories, Inc. Solution container having integral power source
US4544369A (en) 1983-11-22 1985-10-01 C. R. Bard, Inc. Battery operated miniature syringe infusion pump
US4657486A (en) 1984-01-13 1987-04-14 Stempfle Julius E Portable infusion device
DE3420865C1 (en) 1984-06-05 1985-08-29 B. Braun Melsungen Ag, 3508 Melsungen Infusion syringe pump
US4715786A (en) * 1984-12-14 1987-12-29 Cole-Parmer Instrument Company Control method and apparatus for peristaltic fluid pump
US4652260A (en) 1985-03-11 1987-03-24 Strato Medical Corporation Infusion device
US5000739A (en) * 1988-07-12 1991-03-19 Pinewood Medical, Inc. Programmable infusion pump
GB2238479B (en) 1989-12-20 1994-04-06 Chen A Tien Drip infusion set
US5048725A (en) * 1990-12-03 1991-09-17 Peterson Mildred I Wall mountable toothpaste dispenser with magnetic tube-winder holding means
US5322511A (en) * 1992-04-21 1994-06-21 Sterling Winthrop Inc. Portable hand-held power injector
US5562615A (en) * 1994-02-28 1996-10-08 Corpak, Inc. Free flow detector for an enternal feeding pump
WO1996025186A2 (en) * 1995-02-07 1996-08-22 Gensia, Inc. Feedback controlled drug delivery system
US5775540A (en) * 1995-03-01 1998-07-07 Greenberg; Robert M. Collapsible tube dispenser aid
US5692645A (en) * 1995-06-22 1997-12-02 Choon Woo Ryu Flexible tube dispensing apparatus
GB2304584A (en) 1995-08-23 1997-03-26 Graham Cameron Grant Infusion device comprising a collapsible bag and a movable wall
US5976109A (en) * 1996-04-30 1999-11-02 Medtronic, Inc. Apparatus for drug infusion implanted within a living body
GB2319079B (en) * 1996-10-29 2000-07-12 Baxter Int Infusion pump monitoring encoder/decoder
US5957895A (en) 1998-02-20 1999-09-28 Becton Dickinson And Company Low-profile automatic injection device with self-emptying reservoir
US5954697A (en) 1998-03-02 1999-09-21 Srisathapat; Chad Threaded nut syringe plunger for use with a medication infusion pump
US7621893B2 (en) * 1998-10-29 2009-11-24 Medtronic Minimed, Inc. Methods and apparatuses for detecting occlusions in an ambulatory infusion pump
US6375638B2 (en) * 1999-02-12 2002-04-23 Medtronic Minimed, Inc. Incremental motion pump mechanisms powered by shape memory alloy wire or the like
US6659978B1 (en) * 1999-10-04 2003-12-09 Seiko Instruments Inc. Portable dosing apparatus
US6726655B1 (en) * 1999-11-05 2004-04-27 Tandem Medical Medication delivery system
US6485471B1 (en) 2000-03-03 2002-11-26 Roche Diagnostics Corporation Bellowed fluid delivery apparatus
US6485461B1 (en) * 2000-04-04 2002-11-26 Insulet, Inc. Disposable infusion device
US6589229B1 (en) 2000-07-31 2003-07-08 Becton, Dickinson And Company Wearable, self-contained drug infusion device
DK1335764T3 (en) * 2000-09-08 2007-10-01 Insulet Corp Patient infusion apparatus and system
US6749587B2 (en) 2001-02-22 2004-06-15 Insulet Corporation Modular infusion device and method
JP3688592B2 (en) * 2001-03-08 2005-08-31 Ｓｍｃ株式会社 Unlocked state holding mechanism
US8934968B2 (en) * 2001-08-03 2015-01-13 Cardiac Pacemakers, Inc. Neurostimulation and coronary artery disease treatment
US20060122577A1 (en) * 2001-09-26 2006-06-08 Poulsen Jens U Modular drug delivery system
EP2239669B8 (en) * 2001-12-31 2015-12-09 B. Braun Medical, Inc. Pharmaceutical compounding information management system
US7041082B2 (en) * 2002-02-28 2006-05-09 Smiths Medical Md, Inc. Syringe pump control systems and methods
US7052251B2 (en) * 2002-04-22 2006-05-30 Medtronic Minimed, Inc. Shape memory alloy wire driven positive displacement micropump with pulsatile output
US6656159B2 (en) 2002-04-23 2003-12-02 Insulet Corporation Dispenser for patient infusion device
US6723072B2 (en) * 2002-06-06 2004-04-20 Insulet Corporation Plunger assembly for patient infusion device
US7144384B2 (en) * 2002-09-30 2006-12-05 Insulet Corporation Dispenser components and methods for patient infusion device
JP2006511262A (en) * 2002-12-23 2006-04-06 エム２・メディカル・アクティーゼルスカブ Flexible piston rod
JP2006522658A (en) * 2003-04-08 2006-10-05 メドラッド インコーポレーテッド Fluid transport system, fluid transport device, and method for transporting hazardous fluid
DE10327254B4 (en) * 2003-06-17 2010-01-28 Disetronic Licensing Ag Modular infusion pump
KR20060099520A (en) * 2003-10-21 2006-09-19 노보 노르디스크 에이/에스 Medical skin mountable device
US7309326B2 (en) * 2003-11-18 2007-12-18 Icu Medical, Inc. Infusion set
JP4663656B2 (en) * 2003-12-30 2011-04-06 ディセトロニック・ライセンシング・アクチェンゲゼルシャフト Insertion device for infusion set
WO2005072794A2 (en) * 2004-01-29 2005-08-11 M 2 Medical A/S Disposable medicine dispensing device
WO2006108809A1 (en) * 2005-04-13 2006-10-19 Novo Nordisk A/S Medical skin mountable device and system
US7905868B2 (en) * 2006-08-23 2011-03-15 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US20080097291A1 (en) * 2006-08-23 2008-04-24 Hanson Ian B Infusion pumps and methods and delivery devices and methods with same
US7569050B2 (en) * 2005-05-06 2009-08-04 Medtronic Minimed, Inc. Infusion device and method with drive device in infusion device and method with drive device in separable durable housing portion
US8137314B2 (en) * 2006-08-23 2012-03-20 Medtronic Minimed, Inc. Infusion medium delivery device and method with compressible or curved reservoir or conduit
US8277415B2 (en) * 2006-08-23 2012-10-02 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US8840586B2 (en) * 2006-08-23 2014-09-23 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US7935104B2 (en) * 2005-11-07 2011-05-03 Medingo, Ltd. Systems and methods for sustained medical infusion and devices related thereto
US8435211B2 (en) 2006-07-24 2013-05-07 Medingo Ltd. Systems, devices and methods for fluid/drug delivery
US7794434B2 (en) * 2006-08-23 2010-09-14 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
JP4899784B2 (en) * 2006-10-25 2012-03-21 セイコーエプソン株式会社 Fluid transport device
EP2099384B1 (en) 2006-11-28 2018-09-05 Roche Diabetes Care GmbH An insertion device and method for inserting a subcutaneously insertable element into a body
FI3632488T3 (en) * 2006-12-22 2023-05-25 Roche Diabetes Care Gmbh Device for sustained delivery of a therapeutic fluid
US8679062B2 (en) * 2007-04-10 2014-03-25 Roche Diagnostics Operations Inc. Apparatus and method for pumping fluid
US9138534B2 (en) 2007-05-11 2015-09-22 Roche Diabetes Care, Inc. Positive displacement pump
JP5506780B2 (en) 2008-04-09 2014-05-28 エフ．ホフマン−ラ ロシュ アーゲー System, apparatus and method for delivering fluid

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EP2155289A2 (en) 2010-02-24
US20150352276A1 (en) 2015-12-10
US20100137802A1 (en) 2010-06-03
EP2155295A2 (en) 2010-02-24
US20100130932A1 (en) 2010-05-27
JP5536641B2 (en) 2014-07-02
CN101687075A (en) 2010-03-31
CN103230632A (en) 2013-08-07
US20100130931A1 (en) 2010-05-27
US9138534B2 (en) 2015-09-22
AU2008249567A1 (en) 2008-11-20
US10398831B2 (en) 2019-09-03
WO2008139458A3 (en) 2009-03-05
CN101687075B (en) 2013-04-10
US9173993B2 (en) 2015-11-03
WO2008139460A3 (en) 2009-03-12
JP2010526633A (en) 2010-08-05
WO2008139460A2 (en) 2008-11-20
WO2008139459A1 (en) 2008-11-20
WO2008139458A2 (en) 2008-11-20
EP3388096A1 (en) 2018-10-17

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