CN103228229B - 具有支持和径向扩散支架的可植入细胞装置 - Google Patents

具有支持和径向扩散支架的可植入细胞装置 Download PDF

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Publication number
CN103228229B
CN103228229B CN201180057044.2A CN201180057044A CN103228229B CN 103228229 B CN103228229 B CN 103228229B CN 201180057044 A CN201180057044 A CN 201180057044A CN 103228229 B CN103228229 B CN 103228229B
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distance
chamber
distance member
filaments
support
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Expired - Fee Related
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CN201180057044.2A
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English (en)
Chinese (zh)
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CN103228229A (zh
Inventor
拉尔斯·U·沃尔伯格
詹斯·托诺伊
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Gloriana Therapeutics Sarl
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NS Gene AS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/022—Artificial gland structures using bioreactors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012—Cell encapsulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2240/001—Designing or manufacturing processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • A61K2035/128—Immunoprotecting barriers, e.g. jackets, diffusion chambers capsules, e.g. microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/64—Animal cells
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49826—Assembling or joining

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Surgery (AREA)
  • Biotechnology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN201180057044.2A 2010-09-27 2011-09-27 具有支持和径向扩散支架的可植入细胞装置 Expired - Fee Related CN103228229B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA201070410 2010-09-27
DKPA201070410 2010-09-27
US38719110P 2010-09-28 2010-09-28
US61/387,191 2010-09-28
PCT/DK2011/050360 WO2012041320A1 (en) 2010-09-27 2011-09-27 Implantable cell device with supportive and radial diffusive scaffolding

Publications (2)

Publication Number Publication Date
CN103228229A CN103228229A (zh) 2013-07-31
CN103228229B true CN103228229B (zh) 2015-11-25

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CN201180057044.2A Expired - Fee Related CN103228229B (zh) 2010-09-27 2011-09-27 具有支持和径向扩散支架的可植入细胞装置

Country Status (8)

Country Link
US (3) US9669154B2 (https=)
EP (1) EP2621403B1 (https=)
JP (1) JP5852655B2 (https=)
CN (1) CN103228229B (https=)
AU (1) AU2011307663B2 (https=)
CA (1) CA2812707C (https=)
DK (1) DK2621403T3 (https=)
WO (1) WO2012041320A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103228229B (zh) * 2010-09-27 2015-11-25 Ns基因公司 具有支持和径向扩散支架的可植入细胞装置
WO2014173441A1 (en) * 2013-04-24 2014-10-30 Nestec S.A. Encapsulation device
CA2928887C (en) * 2013-12-13 2021-07-06 Vac Stent Medtec Ag Suction stent, stent system, and method for sealing a leakage
CA2982205A1 (en) 2015-04-10 2016-10-13 David W. Andrews Methods and compositions for treating cancers and enhancing therapeutic immunity by selectively reducing immunomodulatory m2 monocytes
US10849731B2 (en) * 2016-11-08 2020-12-01 W. L. Gore & Associates, Inc. Cell encapsulation devices containing structural spacers
EP3428264A1 (en) 2017-07-12 2019-01-16 Defymed Non-foldable pouch for forming an implantable artificial organ
MX2020007844A (es) * 2018-01-24 2021-01-20 Univ Jefferson Camara de biodifusion.
CN108676769B (zh) * 2018-04-24 2022-09-23 武汉仝干医疗科技股份有限公司 一种促进肝细胞生长的无纺布支架材料及其制备方法
EP3975926A1 (en) * 2019-05-31 2022-04-06 W.L. Gore & Associates, Inc. A biocompatible membrane composite
CN113786521B (zh) * 2021-08-06 2022-07-19 深圳华源再生医学有限公司 一种组合式支架及其制备方法与应用
CN114377168B (zh) * 2022-01-26 2024-05-17 北京倍舒特妇幼用品有限公司 一种卫生巾消毒装置及其方法
EP4736896A1 (en) * 2023-06-29 2026-05-06 Mochida Pharmaceutical Co., Ltd. Biocompatible device
JP7451818B1 (ja) 2023-11-10 2024-03-18 洋之 高尾 Ｄｉｆｆｕｓｉｏｎ Ｃｈａｍｂｅｒ型人工膵島器

Citations (8)

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WO1995017526A1 (de) * 1993-12-22 1995-06-29 Prenosil, Jiri, E. Verfahren und vorrichtung zur herstellung einer zellstruktur auf einer semipermeablen membran
US5773286A (en) * 1987-11-17 1998-06-30 Cytotherapeutics, Inc. Inner supported biocompatible cell capsules
WO2000058437A1 (en) * 1999-03-31 2000-10-05 Gore Enterprise Holdings, Inc. Respiratory aids
US6426214B1 (en) * 1993-08-10 2002-07-30 Gore Enterprise Holdings, Inc. Cell encapsulating device containing a cell displacing core for maintaining cell viability
US20030124722A1 (en) * 2001-12-28 2003-07-03 Hisako Ohgawara Chamber for artificial organ
CN2830410Y (zh) * 2004-05-18 2006-10-25 中山大学附属第一医院 组织工程化周围神经移植物
WO2010057039A2 (en) * 2008-11-14 2010-05-20 Cythera, Inc. Encapsulation of pancreatic cells derived from human pluripotent stem cells

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US6303136B1 (en) 1998-04-13 2001-10-16 Neurotech S.A. Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane
US6902932B2 (en) 2001-11-16 2005-06-07 Tissue Regeneration, Inc. Helically organized silk fibroin fiber bundles for matrices in tissue engineering
US20040126405A1 (en) 2002-12-30 2004-07-01 Scimed Life Systems, Inc. Engineered scaffolds for promoting growth of cells
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EP1883446B8 (en) 2005-05-17 2017-11-15 Gloria Therapeutics Sarl An implantable therapy system for treating a living being with an active factor
CA2635534C (en) * 2005-12-30 2014-07-29 Neurotech Usa Inc. Micronized device for the delivery of biologically active molecules and methods of use thereof
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CN103228229B (zh) * 2010-09-27 2015-11-25 Ns基因公司 具有支持和径向扩散支架的可植入细胞装置

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Publication number Priority date Publication date Assignee Title
US5773286A (en) * 1987-11-17 1998-06-30 Cytotherapeutics, Inc. Inner supported biocompatible cell capsules
WO1993024627A1 (en) * 1992-06-03 1993-12-09 Case Western Reserve University Bandage for continuous application of biologicals
US6426214B1 (en) * 1993-08-10 2002-07-30 Gore Enterprise Holdings, Inc. Cell encapsulating device containing a cell displacing core for maintaining cell viability
WO1995017526A1 (de) * 1993-12-22 1995-06-29 Prenosil, Jiri, E. Verfahren und vorrichtung zur herstellung einer zellstruktur auf einer semipermeablen membran
WO2000058437A1 (en) * 1999-03-31 2000-10-05 Gore Enterprise Holdings, Inc. Respiratory aids
US20030124722A1 (en) * 2001-12-28 2003-07-03 Hisako Ohgawara Chamber for artificial organ
CN2830410Y (zh) * 2004-05-18 2006-10-25 中山大学附属第一医院 组织工程化周围神经移植物
WO2010057039A2 (en) * 2008-11-14 2010-05-20 Cythera, Inc. Encapsulation of pancreatic cells derived from human pluripotent stem cells

Also Published As

Publication number Publication date
WO2012041320A1 (en) 2012-04-05
DK2621403T3 (en) 2015-06-15
EP2621403B1 (en) 2015-03-18
JP5852655B2 (ja) 2016-02-03
EP2621403A1 (en) 2013-08-07
CA2812707A1 (en) 2012-04-05
US20210069407A1 (en) 2021-03-11
CA2812707C (en) 2020-02-18
US20170232186A1 (en) 2017-08-17
AU2011307663A1 (en) 2013-05-02
US10835664B2 (en) 2020-11-17
CN103228229A (zh) 2013-07-31
HK1183428A1 (en) 2013-12-27
JP2013537820A (ja) 2013-10-07
US9669154B2 (en) 2017-06-06
US20130261543A1 (en) 2013-10-03
AU2011307663B2 (en) 2015-05-07

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Granted publication date: 20151125