CN103228229B - 具有支持和径向扩散支架的可植入细胞装置 - Google Patents

具有支持和径向扩散支架的可植入细胞装置 Download PDF

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Publication number
CN103228229B
CN103228229B CN201180057044.2A CN201180057044A CN103228229B CN 103228229 B CN103228229 B CN 103228229B CN 201180057044 A CN201180057044 A CN 201180057044A CN 103228229 B CN103228229 B CN 103228229B
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distance
chamber
distance member
filaments
support
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Expired - Fee Related
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CN201180057044.2A
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English (en)
Chinese (zh)
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CN103228229A (zh
Inventor
拉尔斯·U·沃尔伯格
詹斯·托诺伊
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Gloriana Therapeutics Sarl
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NS Gene AS
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/022—Artificial gland structures using bioreactors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012—Cell encapsulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2240/001—Designing or manufacturing processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • A61K2035/128—Immunoprotecting barriers, e.g. jackets, diffusion chambers capsules, e.g. microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/64—Animal cells
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49826—Assembling or joining

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN201180057044.2A 2010-09-27 2011-09-27 具有支持和径向扩散支架的可植入细胞装置 Expired - Fee Related CN103228229B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA201070410 2010-09-27
DKPA201070410 2010-09-27
US38719110P 2010-09-28 2010-09-28
US61/387,191 2010-09-28
PCT/DK2011/050360 WO2012041320A1 (en) 2010-09-27 2011-09-27 Implantable cell device with supportive and radial diffusive scaffolding

Publications (2)

Publication Number Publication Date
CN103228229A CN103228229A (zh) 2013-07-31
CN103228229B true CN103228229B (zh) 2015-11-25

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CN201180057044.2A Expired - Fee Related CN103228229B (zh) 2010-09-27 2011-09-27 具有支持和径向扩散支架的可植入细胞装置

Country Status (8)

Country Link
US (3) US9669154B2 (enExample)
EP (1) EP2621403B1 (enExample)
JP (1) JP5852655B2 (enExample)
CN (1) CN103228229B (enExample)
AU (1) AU2011307663B2 (enExample)
CA (1) CA2812707C (enExample)
DK (1) DK2621403T3 (enExample)
WO (1) WO2012041320A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012041320A1 (en) * 2010-09-27 2012-04-05 Nsgene A/S Implantable cell device with supportive and radial diffusive scaffolding
JP6325649B2 (ja) 2013-04-24 2018-05-16 ネステク ソシエテ アノニム カプセル化デバイス
CN105916467B (zh) * 2013-12-13 2019-11-08 Vac支架米德迪尔股份公司 用于密封泄漏的抽吸支架、支架系统和方法
JP6957035B2 (ja) 2015-04-10 2021-11-02 トーマス・ジェファーソン・ユニバーシティ 対象への移植用の免疫原性拡散チャンバおよびその調製方法
US10849731B2 (en) * 2016-11-08 2020-12-01 W. L. Gore & Associates, Inc. Cell encapsulation devices containing structural spacers
EP3428264A1 (en) 2017-07-12 2019-01-16 Defymed Non-foldable pouch for forming an implantable artificial organ
CN112204140A (zh) * 2018-01-24 2021-01-08 托马斯杰弗逊大学 生物扩散室
CN108676769B (zh) * 2018-04-24 2022-09-23 武汉仝干医疗科技股份有限公司 一种促进肝细胞生长的无纺布支架材料及其制备方法
EP3975926A1 (en) * 2019-05-31 2022-04-06 W.L. Gore & Associates, Inc. A biocompatible membrane composite
CN113786521B (zh) * 2021-08-06 2022-07-19 深圳华源再生医学有限公司 一种组合式支架及其制备方法与应用
CN114377168B (zh) * 2022-01-26 2024-05-17 北京倍舒特妇幼用品有限公司 一种卫生巾消毒装置及其方法
JPWO2025005218A1 (enExample) * 2023-06-29 2025-01-02
JP7451818B1 (ja) 2023-11-10 2024-03-18 洋之 高尾 Ｄｉｆｆｕｓｉｏｎ Ｃｈａｍｂｅｒ型人工膵島器

Citations (8)

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WO1993024627A1 (en) * 1992-06-03 1993-12-09 Case Western Reserve University Bandage for continuous application of biologicals
WO1995017526A1 (de) * 1993-12-22 1995-06-29 Prenosil, Jiri, E. Verfahren und vorrichtung zur herstellung einer zellstruktur auf einer semipermeablen membran
US5773286A (en) * 1987-11-17 1998-06-30 Cytotherapeutics, Inc. Inner supported biocompatible cell capsules
WO2000058437A1 (en) * 1999-03-31 2000-10-05 Gore Enterprise Holdings, Inc. Respiratory aids
US6426214B1 (en) * 1993-08-10 2002-07-30 Gore Enterprise Holdings, Inc. Cell encapsulating device containing a cell displacing core for maintaining cell viability
US20030124722A1 (en) * 2001-12-28 2003-07-03 Hisako Ohgawara Chamber for artificial organ
CN2830410Y (zh) * 2004-05-18 2006-10-25 中山大学附属第一医院 组织工程化周围神经移植物
WO2010057039A2 (en) * 2008-11-14 2010-05-20 Cythera, Inc. Encapsulation of pancreatic cells derived from human pluripotent stem cells

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US5786216A (en) 1987-11-17 1998-07-28 Cytotherapeutics, Inc. Inner-supported, biocompatible cell capsules
US5156844A (en) 1987-11-17 1992-10-20 Brown University Research Foundation Neurological therapy system
US5106627A (en) 1987-11-17 1992-04-21 Brown University Research Foundation Neurological therapy devices
AU688776B2 (en) 1993-06-23 1998-03-19 Brown University Research Foundation Method and apparatus for sealing implantable, membrane encapsulation devices
US5681740A (en) 1995-06-05 1997-10-28 Cytotherapeutics, Inc. Apparatus and method for storage and transporation of bioartificial organs
US5855613A (en) * 1995-10-13 1999-01-05 Islet Sheet Medical, Inc. Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change
US5904144A (en) 1996-03-22 1999-05-18 Cytotherapeutics, Inc. Method for treating ophthalmic diseases
US6042909A (en) 1997-09-03 2000-03-28 Circe Biomedical, Inc. Encapsulation device
US6303136B1 (en) 1998-04-13 2001-10-16 Neurotech S.A. Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane
US6902932B2 (en) 2001-11-16 2005-06-07 Tissue Regeneration, Inc. Helically organized silk fibroin fiber bundles for matrices in tissue engineering
US20040126405A1 (en) 2002-12-30 2004-07-01 Scimed Life Systems, Inc. Engineered scaffolds for promoting growth of cells
WO2006026730A2 (en) 2004-08-30 2006-03-09 Iken Tissue Therapeutics, Inc. Cultured three dimensional tissues and uses thereof
WO2006122551A2 (en) 2005-05-17 2006-11-23 Nsgene A/S An implantable therapy system for treating a living being with an active factor
EP1971288B1 (en) 2005-12-30 2013-02-13 Neurotech USA, Inc. Micronized device for the delivery of biologically active molecules and methods of use thereof
WO2009149205A2 (en) 2008-06-03 2009-12-10 Neurotech Usa, Inc. Cell lines that secrete soluble vegf receptors and uses thereof
WO2012041320A1 (en) * 2010-09-27 2012-04-05 Nsgene A/S Implantable cell device with supportive and radial diffusive scaffolding

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5773286A (en) * 1987-11-17 1998-06-30 Cytotherapeutics, Inc. Inner supported biocompatible cell capsules
WO1993024627A1 (en) * 1992-06-03 1993-12-09 Case Western Reserve University Bandage for continuous application of biologicals
US6426214B1 (en) * 1993-08-10 2002-07-30 Gore Enterprise Holdings, Inc. Cell encapsulating device containing a cell displacing core for maintaining cell viability
WO1995017526A1 (de) * 1993-12-22 1995-06-29 Prenosil, Jiri, E. Verfahren und vorrichtung zur herstellung einer zellstruktur auf einer semipermeablen membran
WO2000058437A1 (en) * 1999-03-31 2000-10-05 Gore Enterprise Holdings, Inc. Respiratory aids
US20030124722A1 (en) * 2001-12-28 2003-07-03 Hisako Ohgawara Chamber for artificial organ
CN2830410Y (zh) * 2004-05-18 2006-10-25 中山大学附属第一医院 组织工程化周围神经移植物
WO2010057039A2 (en) * 2008-11-14 2010-05-20 Cythera, Inc. Encapsulation of pancreatic cells derived from human pluripotent stem cells

Also Published As

Publication number Publication date
DK2621403T3 (en) 2015-06-15
AU2011307663A1 (en) 2013-05-02
US20210069407A1 (en) 2021-03-11
AU2011307663B2 (en) 2015-05-07
EP2621403B1 (en) 2015-03-18
US20130261543A1 (en) 2013-10-03
HK1183428A1 (en) 2013-12-27
CN103228229A (zh) 2013-07-31
US9669154B2 (en) 2017-06-06
EP2621403A1 (en) 2013-08-07
JP5852655B2 (ja) 2016-02-03
US20170232186A1 (en) 2017-08-17
JP2013537820A (ja) 2013-10-07
US10835664B2 (en) 2020-11-17
CA2812707C (en) 2020-02-18
WO2012041320A1 (en) 2012-04-05
CA2812707A1 (en) 2012-04-05

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Effective date of registration: 20170324

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Patentee after: Gloriana Therapeutics S.A.R.L.

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Patentee before: Ns Gene Corp.

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Granted publication date: 20151125