CN103223139A - 一种治疗慢性溃疡性结肠炎的中药组合物 - Google Patents
一种治疗慢性溃疡性结肠炎的中药组合物 Download PDFInfo
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Abstract
本发明涉及一种治疗慢性溃疡性结肠炎的中药组合物，其是由下列重量份的中药原料制成：党参5-20份、车前子10-40份、乌梅5-20份、黄连5-25份、当归10-40份、生地5-25份、铁苋菜5-20份、黄芩5-20份、柴胡5-25份、陈皮5-20份、五味子5-25份、秦皮5-25份、砂仁5-15份、鱼腥草5-20份、桑椹子10-30份、石榴皮5-20份。本发明的中药组合物具有疏肝补肾、化湿润燥、生津润肠、温脾止泻的功效，其治疗慢性溃疡性结肠炎疗效显著，作用可靠。
Description
技术领域
本发明涉及一种传统草药的未确定结构的医药配制品，尤其是一种治疗慢性溃疡性结肠炎的中药组合物。
背景技术
慢性溃疡性结肠炎是一种结、直肠粘膜的弥漫性炎症，其临床特点为原因不明的、时好时坏血性腹泻。症状以腹泻为主，排出含有血、脓和粘液的粪便，常伴有阵发性结肠痉挛性疼痛，并里急后重，排便后可获缓解。慢性溃疡性结肠炎可能与免疫、遗传、感染及精神因素等有关。临床上一般会采取药物抗感染的治疗措施。目前，内科治疗包括4个方面：⑴卧床休息和全身支持治疗：包括液体和电解质平衡，尤其是钾的补充，低血钾者应予纠正；⑵口服柳氮磺胺吡啶；⑶点滴皮质类固醇；⑷使用免疫抑制剂。其存在着疗效不佳的不足。如内科治疗效果不佳则会考虑手术治疗，存在着手术创伤大、费用高的不足。
中药治疗慢性溃疡性结肠炎效果比较理想。
中医认为，慢性溃疡性结肠炎多为饮食不节或感受外邪，而致湿热、积滞等邪客于肠道，与肠道气血相搏结，大肠传导失司，气血凝滞，脂膜血络损伤，血败肉腐，壅滞成脓，内溃成疡，形成本病。
根据中医理论，针对慢性溃疡性结肠炎的发病机理，进行辩证配伍组方，以生津润燥，温运化湿为治则，达到标本兼治的目的。
发明内容
为了克服现有技术中西药治疗慢性溃疡性结肠炎疗效差及手术治疗创伤大的不足，本发明提供一种配制简便、成本低、疗效显著、无副作用的治疗慢性溃疡性结肠炎的中药组合物。
本发明解决其技术问题所采用的技术方案是：一种治疗慢性溃疡性结肠炎的中药组合物，其特征在于：其是由下列重量份的中药原料制成：党参5-20份、车前子10-40份、乌梅5-20份、黄连5-25份、当归10-40份、生地5-25份、铁苋菜5-20份、黄芩5-20份、柴胡5-25份、陈皮5-20份、五味子5-25份、秦皮5-25份、砂仁5-15份、鱼腥草5-20份、桑椹子10-30份、石榴皮5-20份。
本发明的优选技术方案是：一种治疗慢性溃疡性结肠炎的中药组合物，其特征在于：其是由下列重量份的中药原料制成：党参10份、车前子30份、乌梅10份、黄连15份、当归30份、生地15份、铁苋菜12份、黄芩12份、柴胡15份、陈皮10份、五味子15 份、秦皮15份、砂仁10份、鱼腥草10份、桑椹子20份、石榴皮10份。
本发明中药组合物是在传统中医理论和临床经验指导下，精选药物组方。本发明中药组合物中：党参具有补中益气、健脾益肺的功效；车前子具有利水通淋、渗湿止泻、清肝明目、清热化痰的功效；乌梅具有敛肺温中、涩肠止泻、生津止渴的功效；黄连具有清热燥湿、泻火解毒的功效；当归具有补血活血、调经止痛，润肠通便的功效；生地具有清热凉血、养阴生津、止痛调经的功效；铁苋菜具有清热解毒、消积、止痢、止血的功效；黄芩具有清热燥湿、泻火解毒、止血安胎的功效；柴胡具有疏散退热、升阳舒肝的功效；陈皮具有理气健脾、调中利水、燥湿化痰的功效；五味子具有收敛固涩、益气生津、补肾宁心的功效；秦皮具有清热燥湿、清肝明目、收涩的功效；砂仁具有化湿开胃、温脾止泻、理气安胎的功效；鱼腥草具有清热解毒、排脓消痈、利尿通淋的功效；桑椹子具有滋阴补血、生津润肠的功效；石榴皮具有涩肠止泻、止血驱虫的功效。本发明精选药物组方，其药物组分经辩证配伍，在作用上相互佐助，共奏疏肝补肾、化湿润燥、生津润肠、温脾止泻的功效，对慢性溃疡性结肠炎的治疗达到标本兼治。
本发明组合物的组分均采用天然的中药原料，其配制简便、药源广、成本低。本发明遵循中医的处方用药原则，各种组分药物采用水煎服用。经临床应用验证，其疗效显著可靠，药性平和，未出现毒副作用，有效率达92%，治愈率69.3%。
具体实施方式
下面结合实施例对本发明作进一步说明。
实施例1
一种治疗慢性溃疡性结肠炎的中药组合物，其是由下列重量配比的中药原料制成：党参10g、车前子30g、乌梅10g、黄连15g、当归30g、生地15g、铁苋菜12g、黄芩12g、柴胡15g、陈皮10g、五味子15g、秦皮15g、砂仁10g（后下）、鱼腥草10g、桑椹子20g、石榴皮10g。
实施例2
一种治疗慢性溃疡性结肠炎的中药组合物，其是由下列重量配比的中药原料制成：党参20g、车前子10g、乌梅5g、黄连25g、当归40g、生地10g、铁苋菜10g、黄芩15g、柴胡20g、陈皮12g、五味子5g、秦皮20g、砂仁12g（后下）、鱼腥草15g、桑椹子15g、石榴皮5g。
实施例3
一种治疗慢性溃疡性结肠炎的中药组合物，其是由下列重量配比的中药原料制成：党参15g、车前子20g、乌梅12g、黄连5g、当归10g、生地25g、铁苋菜20g、黄芩5g、柴胡25g、陈皮5g、五味子10g、秦皮25g、砂仁5g（后下）、鱼腥草20g、桑椹子30g、石榴皮12g。
实施例4
一种治疗慢性溃疡性结肠炎的中药组合物，其是由下列重量配比的中药原料制成：党参5g、车前子40g、乌梅15g、黄连10g、当归25g、生地20g、铁苋菜5g、黄芩10g、柴胡10g、陈皮20g、五味子20g、秦皮5g、砂仁15g（后下）、鱼腥草5g、桑椹子25g、石榴皮15g。
实施例5
一种治疗慢性溃疡性结肠炎的中药组合物，其是由下列重量配比的中药原料制成：党参12g、车前子25g、乌梅20g、黄连20g、当归15g、生地5g、铁苋菜15g、黄芩20g、柴胡5g、陈皮15g、五味子25g、秦皮12g、砂仁9g（后下）、鱼腥草12g、桑椹子10g、石榴皮20g。
本发明实施例中的中药组合物按常规的水煎法制取药剂。具体方法如下：将组方的中药原料放入容器中，加冷水漫过药面，浸泡15～20分钟，再加水没过药面约6厘米，进行煎煮，未沸前采用武火煎煮，沸后用文火煎煮20～30分钟；第二煎煮，加水没过药面约4厘米，进行煎煮，水沸后煎煮15～20分钟。两次煎煮取汁，合并。
一种治疗慢性溃疡性结肠炎的中药组合物，临床疗效总结：
一、一般性资料：本中药组合物应用于临床观察病例75例，男49例，女26例，年龄20～65岁。
二、诊断依据：
参照1987年制定的“慢性非特异性溃疡性结肠炎诊断分型及治疗标准”。
三、用法用量：临床应用时，组合物中的组分用量根据患者的体重和年龄酌情增减。一日一剂，水煎两遍取汁约300ml，分早、晚两次服用。五剂为一疗程。
三、疗效标准：
(1)痊愈：临床症状消失，结肠镜复查黏膜正常；
(2)有效：临床症状基本消失，结肠镜复查黏膜轻度炎症反应；
(3)无效：经治疗后临床症状、内镜所见及病理检查无改善；
四、治疗效果：该临床观察病例中，服药3-6个疗程，痊愈52例，随访未见复发；有效17例，无效6例。治疗期间未发生毒副作用。
五、典型病例：
病例1：
王某，男，52岁。无明显诱因的出现腹痛、腹泻带脓血便，大便每天约5-6次，经结肠镜检查显示：溃疡性结肠炎。经临床输液、灌肠治疗后，无明显效果。服用本发明中药组合物制备的药剂2个疗程，脓血便无，腹痛、腹泻症状减轻，续服3个疗程，临床症状消失，结肠镜复查黏膜正常。随访至今无复发。
病例2：
刘某，男，45岁，泄泻日行数次、肠鸣腹痛、大便无血无浓，肠镜检查：直肠黏膜面充血，水肿，乙状结肠见多发溃疡灶。服用本发明中药组合物制备的药剂治疗2个疗程，诸症状减轻；续服3个疗程，结肠镜复查黏膜正常，临床症状完全消失，痊愈。
Claims (2)
1.一种治疗慢性溃疡性结肠炎的中药组合物，其特征在于：其是由下列重量份的中药原料制成：党参5-20份、车前子10-40份、乌梅5-20份、黄连5-25份、当归10-40份、生地5-25份、铁苋菜5-20份、黄芩5-20份、柴胡5-25份、陈皮5-20份、五味子5-25份、秦皮5-25份、砂仁5-15份、鱼腥草5-20份、桑椹子10-30份、石榴皮5-20份。
2.根据权利要求1所述的一种治疗慢性溃疡性结肠炎的中药组合物，其特征在于：其是由下列重量份的中药原料制成：党参10份、车前子30份、乌梅10份、黄连15份、当归30份、生地15份、铁苋菜12份、黄芩12份、柴胡15份、陈皮10份、五味子15 份、秦皮15份、砂仁10份、鱼腥草10份、桑椹子20份、石榴皮10份。
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| CN104825937A (zh) * | 2015-05-15 | 2015-08-12 | 宁波好口味食品有限公司 | 一种治疗慢性结肠炎的中药制剂及其制备方法 |
| CN105535498A (zh) * | 2016-01-19 | 2016-05-04 | 吕娜娜 | 一种治疗慢性溃疡性结肠炎的中药制剂 |
| CN106138504A (zh) * | 2016-08-30 | 2016-11-23 | 罗嘉辉 | 一种治疗慢性溃疡性结肠炎的中药 |
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| CN1442187A (zh) * | 2003-04-09 | 2003-09-17 | 林云毅 | 慢性非特异性溃疡性结肠炎的中药配方 |
| CN101785835A (zh) * | 2010-02-28 | 2010-07-28 | 泰一和浦（北京）中医药研究院有限公司 | 一种治疗慢性肠炎的中药组合物及其制备方法 |
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| CN104825937A (zh) * | 2015-05-15 | 2015-08-12 | 宁波好口味食品有限公司 | 一种治疗慢性结肠炎的中药制剂及其制备方法 |
| CN105535498A (zh) * | 2016-01-19 | 2016-05-04 | 吕娜娜 | 一种治疗慢性溃疡性结肠炎的中药制剂 |
| CN106138504A (zh) * | 2016-08-30 | 2016-11-23 | 罗嘉辉 | 一种治疗慢性溃疡性结肠炎的中药 |
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