CN103223064A - Ovarian cyst-relieving enema and preparation method thereof - Google Patents
Ovarian cyst-relieving enema and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an ovarian cyst-relieving enema and a preparation method thereof. The ovarian cyst-relieving enema comprises 10 to 15 parts of seaweed, 12 to 15 parts of kelp, 6 to 10 parts of cassia twig, 10 to 15 parts of poria cocos, 10 to 15 parts of talc, 20 to 30 parts of plantain seed, 10 to 15 parts of turtle shell, 30 to 40 parts of raw oyster shell, 5 to 8 parts of beautiful sweetgum fruit, 20 to 35 parts of red sage root, 15 to 20 parts of red peony root, 10 to 12 parts of rhizoma alismatis, 5 to 8 parts of cassia bark and 10 to 12 parts of lychee seed. The ovarian cyst-relieving enema is a pure Chinese medicine enema fixing preparation. The enteroclysis method adopting the ovarian cyst-relieving enema is a novel method of traditional Chinese medicine external treatment on ovarian cyst, and supplies a gap of research and development of an external fixing agent-form enema at home and abroad. A pharmacological experiment proves that reactive oxygen metabolic disturbance is a main pathogenesis of ovarian cyst. A toxicity experiment proves that the ovarian cyst-relieving enema is safe and has no toxic and side effect. A clinical study proves that the ovarian cyst-relieving enema has obvious and good effects and is simple, convenient and cheap.
Description
Technical field
The present invention relates to a kind of external therapy of Chinese herb preparation for the treatment of gynaecopathia, be specially a kind of external (controlling) Chinese medicine preparation for the treatment of ovarian cyst.
Background technology
Ovarian cyst is gynecological clinic commonly encountered diseases, frequently-occurring disease, also is the difficult disease of gynecological, and the traditional Chinese medical science belongs to " mass in the abdomen " ， “ mass in the abdomen " etc. category.Show that according to China's Epidemiological study China's child-bearing period ovarian cyst sickness rate accounts for about 20%, and is ascendant trend year by year.
At present mainly based on operation, there are shortcomings such as postoperative edge of a knife cicatrix, easily recurrence, abdominal discomfort to the treatment of ovarian cyst in doctor trained in Western medicine, and the patient fears operation, bears higher surgery cost.Although means such as interventional therapy have appearred under laparoscopic surgery, B ultrasonic, the X line in the continuous innovation of medical skill, still there is risk in the art, postoperative accompanying infection, easy drawback such as recurrence, costly, still can not popularization and application.Remain further safer, effective, the economic treatment technology of research and development.
Chinese medicine has been obtained than much progress in the treatment of ovarian cyst in recent years, and demonstrates advantage.The traditional Chinese medical science is many based on treatment by oral administration of medicines, and differentiation of symptoms and signs for classification of syndrome treatment commonly used has obtained certain curative effect.According to documents and materials, less to the external therapy of ovarian cyst, particularly the treatment of primary disease still there is not the fixedly preparation of clear and definite dosage form, at pharmaceutical preparation technology, toxicity, pharmacology aspect still do not have and probe into.
Summary of the invention
Purpose of the present invention is to remedy the deficiencies in the prior art, and a kind of simple, convenient, cheap, good effect is provided, and is evident in efficacy, the pure Chinese medicinal preparation of economical and practical treatment ovarian cyst---Hua Disorder enema.
A kind ofization Disorder enema is characterized in that: comprise following parts by weight of Chinese traditional medicine crude drug: Sargassum 10-15 part, Thallus Laminariae (Thallus Eckloniae) 12-15 part, Ramulus Cinnamomi 6-10 part, Poria 10-15 part, Talcum 10-15 part, Semen Plantaginis 20-30 part, Carapax Trionycis 10-15 part, Concha Ostreae 30-40 part, Fructus Liquidambaris 5-8 part, Radix Salviae Miltiorrhizae 20-35 part, Radix Paeoniae Rubra 15-20 part, Rhizoma Alismatis 10-12 part, Cortex Cinnamomi 5-8 part, Semen Litchi 10-12 part.
Described a kind ofization Disorder enema is characterized in that: described raw material of Chinese medicine medicine parts by weight: 12 parts of Sargassums, 12 parts of Thallus Laminariae (Thallus Eckloniae)s, 8 parts of Ramulus Cinnamomi, 10 parts in Poria, 12 parts in Talcum, 30 parts of Semen Plantaginiss, 12 parts of Carapax Trionycis, 30 parts of Concha Ostreae, 6 parts of Fructus Liquidambaris, 30 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Paeoniae Rubra, 10 parts of Rhizoma Alismatis, 6 parts of Cortex Cinnamomis, 10 parts of Semen Litchis.
A kind of technology of making describedization Disorder enema comprises the steps: to take by weighing by weight the prepared slices of Chinese crude drugs that pharmacopeia requires in meeting;
⑴ pulverized 40 mesh sieves with Semen Litchi, soaked into 24 hours with 50% ethanol, adorns the diafiltration tube then, with the diafiltration of 2ml/min speed, collects percolate, standby;
⑵ extract Ramulus Cinnamomi, cinnamomic volatile oil with the way of distillation, and the water suspension of getting described volatile oil content and be 1-5wt% is standby;
⑶ decoct with water twice with Semen Litchi diafiltration slag and Ramulus Cinnamomi, cinnamomic bottoms and all the other 11 flavor medical materials, filters respectively, adds 8 times of water gagings of described crude drug weight for the first time, adds 6 times of water gagings of described crude drug weight for the second time, decocted 2 hours at every turn, filters;
⑷ extract filtrate with Semen Litchi percolate, Ramulus Cinnamomi and Cortex Cinnamomi volatile oil water suspension and twice decocting mixes and puts into vacuum concentrator, being evaporated to 1000-1500 part below 60 ℃, filters and be distributed into every bottle of 100ml, must of the present inventionization Disorder enema.
Advantage of the present invention is: the fixed dosage form that a kind of pure herbal enema agent is provided---Hua Disorder enema, adopt enema method treatment ovarian cyst, and start external treatment with Chinese medicine primary disease new method, filled up the research and development blank of domestic and international external treatment fixed dosage form enema.Analyze the main pathogeny that the active oxygen metabolism disorder is an ovarian cyst through pharmacological evaluation, showing of toxicological experiment Disorder enema safe without toxic side effect, clinical research shows evident in efficacy, has simple, convenient, cheap, the good effect, characteristics.
Description of drawings
Fig. 1 is the active change curves of different treatment phase patient SOD; Wherein, abscissa be administration time (my god), vertical coordinate is a SOD changing value in the body.
Fig. 2 is the active change curves of different treatment phase patient CTA; Wherein, abscissa be the course of treatment (my god), vertical coordinate is CTA activity value (mmol H
2O
2/ mlIIImin).
Fig. 3 is the active change curves of different treatment phase patient gSH-Px; Wherein, abscissa be the course of treatment (my god), vertical coordinate is a GSH-Px activity change value (u/g.pr).
Fig. 4 is the change curve of different treatment phase patient gSH content; Wherein, abscissa be the course of treatment (my god), vertical coordinate is GSH changes of contents value (umol/ml III).
Fig. 5 is the change curve of different treatment phase patient MDA content; Wherein, abscissa be the course of treatment (my god), vertical coordinate is the lipoperoxide relative amount.
Fig. 6 is the change curves of different treatment phase patient's malonaldehyde to MDA content; Abscissa be the course of treatment (my god), vertical coordinate is a mda content.
Fig. 7 Shiization Disorder enema suppresses the curve chart of the reductive effect of NBT; Abscissa is dosage (mg) among the figure, and vertical coordinate is NBT percent reduction (%).
Fig. 8 Shiization Disorder enema is removed the experimental result curve chart of 0H; Abscissa is dosage (mg) among the figure, and vertical coordinate is Cyto oxygenation efficiency (%).
Fig. 9 Shiization Disorder enema suppresses the effect curves figure of lipid peroxidation; Abscissa is dosage (mg) among the figure, and vertical coordinate is IPO generation (mmol/h).
The specific embodiment
Solution of the present invention is based on understanding and the treatment of motherland's medical science to ovarian cyst.Ovarian cyst belongs to the traditional Chinese medical science and " gathers ", " mass in the abdomen " ， “ mass in the abdomen ", wait category." a Ling Shu Miraculous Pivot or Divine Axis watery distension piece of writing " cloud: " how about the cold visitor is outside intestinal for mass in the abdomen, fights with defending gas phase, and gas must not be flourish; because of direct bearing is arranged, addiction and interior work, bad odor has been; give birth in the polyp, its beginning gives birth to also, and is big as ovum gallinaceum; big with benefit slightly, becomes enlarged abdomen like that of pregnant woman to it, person of a specified duration from the year; the then heavily fortified point of pressing; what push away then moves, regular menstrual cycle, this its time is also ..." and " Ye Shi woman section card control " say: " phlegm-damp resistance born of the same parents card can go out the expectorant of existing mass in the abdomen ... all by insufficiency of the spleen mistake fortune, wetly gather into expectorant, hinder in collaterals of the uterus the trouble of long-pending Er Cheng mass in the abdomen." according to above theory as can be known, the main pathogenesis of primary disease is that phlegm-damp stagnates, treatment when reduce phlegm with warming YANG, invigorating the spleen for eliminating dampness, hard masses softening and resolving, blood-activating and qi-promoting, dredging the meridian.
Fang Zhongyong Semen Plantaginis, Rhizoma Alismatis, Poria are the product of promoting diuresis to clear away damp pathogen, and the water that can eliminate cyst is wet, help the product of the big heat of Cortex Cinnamomi slightly, to reach the usefulness of warming uterus for dispelling cold, add with Ramulus Cinnamomi to walk and do not keep the latent bent part of current meridians.It is thin strongly fragrant stagnant with broken knot to join the Semen Litchi circulation of qi promoting, amounts to warm catharsis Jiao's purpose.The married woman is this with blood, and the capable then gas of blood is smooth, so with the product of nourshing blood and promoting blood circulation such as Radix Salviae Miltiorrhizae wonderful reason is also arranged.Add Concha Ostreae, Carapax Trionycis, Sargassum hard masses softening and resolving, with the cyst that disappears, with the through sick institute of the current venation priming of Fructus Liquidambaris, all medicines share, and effect is remarkable.
Described medicine can be made enema, decoction.
Embodiment 1:
By officinal following traditional Chinese medicine raw medicine in meeting: Sargassum 12 grams, Thallus Laminariae (Thallus Eckloniae) 12 grams, Ramulus Cinnamomi 8 grams, Poria 10 grams, Talcum 12 grams, Semen Plantaginis 30 grams, Carapax Trionycis 12 grams, Concha Ostreae 30 grams, Fructus Liquidambaris 6 grams, Radix Salviae Miltiorrhizae 30 grams, Radix Paeoniae Rubra 15 grams, Rhizoma Alismatis 10 grams, Cortex Cinnamomi 6 grams, Semen Litchi 10 grams are standby.
⑴ pulverized 40 mesh sieves with Semen Litchi, soaked into 24 hours with 50% ethanol, adorns the diafiltration tube then, with the diafiltration of 2ml/min speed, collects percolate, standby;
⑵ extract Ramulus Cinnamomi, cinnamomic volatile oil with the way of distillation, and the water suspension of getting described volatile oil content and be 1-5wt% is standby; When this water suspension leaves standstill water below, volatile oil floats on the water surface.
⑶ decoct with water twice with Semen Litchi diafiltration slag and Ramulus Cinnamomi, cinnamomic bottoms and all the other 11 flavor medical materials, and filter, and adds 8 times of water gagings of described crude drug weight for the first time, adds 6 times of water gagings of described crude drug weight for the second time, decocted 2 hours at every turn;
⑷ mix with the Cortex Cinnamomi volatile oil water suspension Semen Litchi percolate, Ramulus Cinnamomi and put into vacuum concentrator with the filtrate of twice decocting extraction, be evaporated to 1200 ml below 60 ℃, filters and be distributed into every bottle of 100ml, gets of the present inventionization Disorder enema.
Sooner or later coloclysis once, each coloclysis 100ml.
ToxicityExperiment: the research of using the embodiment of the invention 1 made medicine that mouse toxicity is tested
Observe the influence of medicine of the present invention, to estimate its safety to mice.
[Experimental facilities and method]
Laboratory animal:
White mice (Kunming system) male and female half and half of 40 18-30 gram through the adaptability raising after 10 days, are weighed and are divided into two groups at random, half and half, one group of contrast of every group of male and female, one group of administration.
Route of administration:
Press body weight through lumbar injection “ization Disorder enema " 1.8-2.5ml.
[experimental result]
1, overall condition:
Compare with matched group in first week after the administration, the administration mice mental status, appetite are all relatively poor, particularly the administration initial stage.Along with time lengthening, it is normal that the spirit of administration treated animal, appetite are recovered gradually later on.
2, death condition:
Whole experimental period, dead 5 of matched group, dead 6 of administration group.
3, body weight situation mice body weight g (X ± SD): (seeing the following form)
Statistical procedures: P〉0.05, two groups of there was no significant differences are described.
[experiment conclusion
]According to above-mentioned experimental result, think that this enema to mice safety, does not have tangible toxicity.
Clinical pharmacology observes 1: the pharmacological research of the ovarian cyst patient being removed the active oxygen ability with the embodiment of the invention 1 made medicine.
[material and method]
Material and processing:
By different course before the administration, cure different time, regularly adopt four ovarian cyst patients (35 years old mean age) venous blood on an empty stomach, and with four normal artificial contrasts.Add the dilution of a certain proportion of water in the anticoagulation, haemolysis is used to measure glutathion (gSH) content, malonaldehyde (represent lipid oxidation thing＜90), the activity of fat hydroperoxides, catalase (CAT), glutathion peroxidase (gSH-Px) activity.Anticoagulation is centrifugal, as to get red blood cell determination superoxide dismutase (SOD) activity.
Method:
GSH content, gSH-Px activity are used the DTNB colorimetry, LPO TBA colorimetry, CAT TICL4 colorimetry, fat hydroperoxides KI oxidation colorimetry, SOD NBT reduction ratio color method.
Interpretation of result:
1, “ization Disorder enema " to the influence of patient's oxygen scavenging activity enzyme.
Enzymes such as SOD, CAT, gSH-Px are referred to as the oxygen scavenging activity enzyme, and SOD can remove 0
- 2, CAT, gSH-Px can remove H
20
2, gSH-Px can remove the fat hydroperoxides, and their active height directly affects the size of active o content.Following chart 1,2,3 has been listed the patient in difference treatment phase three kinds of active variations of enzyme, and by these data as can be known, before the administration, three kinds of enzymatic activitys of patient all are not lower than normal person's value.When treatment during first course of treatment, three kinds of enzymatic activitys begin to rise, SOD particularly, its value has surpassed normal person's value, to the 3rd the course of treatment enzymatic activity reach the highest, and surpass normal person's value, cure the back enzymatic activity and descend and be worth near the normal person.
2, “ization Disorder enema " to the influence of patient gSH.
GSH is the important substance of removing in the human body in the active oxygen non-enzyme system, is again the substrate of gSH-Px.We have formulated the patient at the difference gSH content (as Fig. 4) of treatment phase for this reason. as shown in Figure 4, do not giving
During medicine, gSH content is higher, and after beginning was during administration, its content descended suddenly, then progressively rises, and during to healing, returns to normal person's level.
3, “ization Disorder enema " to the influence of patient's level of lipid
Active o content raises, and the human body level of lipid is raise, i.e. intermediate product fat hydroperoxides (ROOH) and comprise the end-product content rising of malonaldehyde.By we result (Fig. 5,6) as can be known, during administration, patient's fat hydroperoxides and mda content all are not higher than the normal person, when the beginning administration, and this content constantly descends, and during to healing, has been lower than normal person's level.
Conclusion
The active oxygen metabolism disorder is the important pathogeny of ovarian cyst, “ization Disorder enema " major reason of curing ovarian cyst is “ization Disorder enema " can improve oxygen scavenging activity enzyme ground activity by a relatively large margin, particularly outstanding to the SOD active function.“ization Disorder enema in addition " also can improve the content of gSH.Because removing the enzyme system and the non-enzyme system function of active oxygen all significantly strengthens.Thereby active oxygen is eliminated very soon, has reduced the injury of pair cell, ovarian cyst reduces thereupon, disappears at last.
Clinical pharmacology observes 2: the embodiment of the invention 1 made medicine is removed the pharmacological research of oxygen-derived free radicals to the ovarian cyst patient:
Method:
Remove 0
- 2Effect, be 0 with ultraviolet irradiation riboflavin
- 2The source is 0 with the NBT percent reduction
- 2Productive rate.Remove the 0H effect, with Cu
2+-ascorbic acid is the 0H source, is the 0H productive rate with the cytochrome C oxygenation efficiency.Suppress lipid peroxidation, with Fe
2+--H
20
2System produces 0H.Under 30 ℃ of conditions, make its effect Semen arachidis hypogaeae homogenate 30 minutes, with the spectrophotometry mda content, represent lipid peroxide contents then with it.
The result:
(1), describedization Disorder irritates agent liquid and removes 0
- 2Effect
Fig. 7 ，ization Disorder enema as can be known can suppress the NBT reduction, and this liquor strength is big more in the system, and inhibitory action is strong more.This explanation, this enema have removes 0
- 2Effect, working concentration is big more, removes 0
- 2Act on strong more.Be equivalent to the SOD unit of activity with every gram crude drug and represent this enema concentration 0
- 2Ability, then its value 1849 ± 162(u/g)
(2), “ization Disorder enema " effect of removing 0H
As shown in Figure 8, after adding " changing the Disorder enema " in the reaction system, reduced the oxygenation efficiency of cytochrome C, and this coloclysis liquid measure is big more in the system, cytochrome C oxygenation efficiency amplitude is big more.“ization Disorder enema is described " have the effect of removing 0H, dose is big more, and removing 0H effect is strong more.
(3), “ization Disorder enema " suppress the effect of lipid peroxidation
When at Fe-H
20
2Add the Semen arachidis hypogaeae homogenate in the system of generation 0H, 30 ℃ of insulations recorded in this system and have produced malonaldehyde after 30 minutes, illustrated that this reaction system can be used as 0H and causes the reaction model that unsaturated fatty acid is oxidized to lipid peroxide.After adding this enema in this system, system produces content of MDA and reduces (Fig. 9).This explanation " is changed the Disorder enema " can suppress lipid peroxidation, and by following diagram data as can be known, this enema consumption is big more, and it is strong more to suppress the snperoxiaized effect of fat.
[conclusion]
Experimental result shows, “ization Disorder enema " can remove 0
- 2, 0H be that solvent refluxing extracts because " change Disorder enema " preparation is 50% ethanol, protein degeneration already in the preparation is so have reason to think that the material that " changing the Disorder enema " removes oxygen-derived free radicals is non-protein ingredient.
Clinical pharmacology observes 3
:
“ization Disorder enema in ovarian cyst patient's body " composition directly removes the experimentation of active oxygen.
Material:
By different course before the administration, cure different time, regularly adopt four ovarian cyst phlegm-damp type patients (35 years old mean age) venous blood on an empty stomach, and with four normal artificial contrasts.Add the dilution of a certain proportion of water in the anticoagulation, haemolysis is used to measure glutathion (gSH) content, malonaldehyde (represent lipid oxidation thing＜90), the activity of fat hydroperoxides, catalase (CAT), glutathion peroxidase (gSH-Px) activity.Anticoagulation is centrifugal, as to get red blood cell determination superoxide dismutase (SOD) activity.
Method
After some anticoagulations are diluted with water to 100 times, in the boiling water-bath 10 minutes, to kill enzymatic activity such as SOD.Get 50ml and use the DTNB colorimetry with gSH content, gSH-PX activity, LPO TBA colorimetry, CAT TICL4 colorimetry, the fat hydroperoxides remove 0 with KI oxidation colorimetry, SOD with NBT reduction colorimetric method for determining
- 2Ability, other gets serum and measures Vc content in the serum with the reduction high ferro.
The result
1, non-protein substance removes 0 among the different treatment phase patients serums
- 2Ability
Remove 0 in the normal human blood
- 2, material mainly contains SOD and Vc, SOD in boiling water bath 10 minutes be inactivation.Non-protein substance removes 0 in the different treatment phase blood samples of patients of the measured in solution of our protein deactivation
- 2Ability.The results are shown in down Figure 10.As seen from the figure, along with the increase of treatment time, non-protein substance removes 0 in the blood samples of patients
- 2Ability improve constantly.
We think, above-mentioned variation have two, one, remove 0 in the blood
- 2Material-Vc content increase, or, make reaction because gSH content increases.
Ascorbic acid+20
- 2+ 2H+ → deoxidation ascorbic acid+H
20
2, deoxidation ascorbic acid+gSH, ascorbic acid+gSSg speeds up, and has increased the utilization rate of ascorbic acid.The 2nd, Hua Disorder enema composition directly eliminates 0
- 2
2, the VC content among the different treatment phase patients serums
In order to inquire into VC content to removing 0
- 2The influence of ability, the VC that we have measured among the different treatment phase patients serums contains scale.
VC contains scale among the different treatment phase patients serums
| The treatment phase (my god) | VC content (mg/100ml serum) |
| 0 | 0.8±0.08 |
| 10 | 0.96±0.05 |
| 20 | 0.09±0.04 |
| 30 | 0.93±0.04 |
By data in the table as can be known, no significant difference between each group (p〉0.05), illustrate that the patient uses “ization Disorder enema " after, VC content does not have remarkable increase in the blood, and non-protein substance removes 0
- 2The increase of ability is not that the rising of VC content causes.
In addition, from blood samples of patients the gSH changes of contents as can be known, patient gSH content is not higher during medication, gSH content descends after the beginning medication, then just progressively raises, but does not exceed not drug level.In view of the above, we think that the probability that the patient recycles VC and speeds up is minimum.
[conclusion]
The above analysis result, we as can be known, the patient removes 0 at non-protein substance of treatment phase
- 2The raising of ability mainly is because of the intravital “ization Disorder of patient enema " composition directly removes 0
- 2Effect.
So “ization Disorder enema " improve the effect that the patient removes the active oxygen ability two aspects are arranged, the one, medicine can improve the vigor of patient removing active oxygen enzyme system itself, and the 2nd, medicine can directly be removed active oxygen.“ization Disorder enema " effect by these two aspects removes and reaches therapeutic purposes.
Clinical pharmacology observes 4
:
The clinical research of Drug therapy ovarian cyst of the present invention (phlegm-damp stagnate type).
Experimental data
This is organized 100 examples and all derives from March, 2009-2010 year Jinzhong City institute of traditional Chinese medicine TCM Gynecology outpatient service in October and ward and belong to the stagnate patient of type of phlegm-damp through being diagnosed as ovarian cyst.Age reckling 22 years old, the maximum 47 years old, married 80 examples of having educated, married 15 examples of not educating, unmarried 5 examples of not educating, normal 53 examples of menstrual cycle, 30 examples in advance, later stages 11 example, successively irregular 6 examples are through measuring normal 52 examples, through measuring many 17 examples, hypomenorrhea 31 examples, ovarian cyst maximum gauge are 8.8x7.8cm, and minimum diameter is 3.5x3.5cm.
Therapeutic Method:
With medicine 100ml of the present invention, insert anus 20cm with disposal urinary catheter, this liquid is splashed into anus with 37 ℃ temperature with (40-50 drip/minute), every day 2 times, intermenstrual period is stopped using, and three weeks were a course of treatment, observed 1-3 the course of treatment.
Criterion of therapeutical effect:
Cure: ovarian cyst is through gynecologial examination, and the ultrasound diagnosis cyst disappears, clinical symptom disappearance.
Produce effects: ovarian cyst is through gynecologial examination, and the ultrasound diagnosis cyst is dwindled more than 1/2, and clinical symptoms partly or entirely disappears.
Effectively: ovarian cyst is through gynecologial examination, the ultrasound diagnosis cyst dwindle 1/3 or administration after cyst continue person more than 2 months, clinical symptoms partly disappears or alleviates.
Invalid: symptom does not have improvement, and cyst is not seen obviously and dwindled.
Treatment back comprehensive therapeutic effect situation:
This organizes 100 routine patients, treatment back recovery from illness 80 examples, and effective 20 examples, invalid 0 example, cure rate reaches 80%, and total effective rate reaches 100%.
Model case:
Case 1:Lee XX, woman, 32 years old, cashier, people from Yuci
First visit on May 22 in 2009 is examined in the main cause WomanHealth health check-up row gynecological, finds that right ovary has the capsule of the about 6cmx5cm thing that swells, and for asking further diagnosis and treatment, goes to a doctor then in my the section's outpatient service of my institute.Point out right attachment area to visit and the echoless of the about 5.6cmx4.9cm of a size reflects through ultrasound diagnosis, the border is clear, and peplos is arranged.Meet the diagnosis of ovarian cyst.The patient is menstrual cycle 30 days usually, conduct 5 days, and medium through measuring, color is dark red, and with lower abdomen dull pain, fatigue and weakness is received the peace of can sleeping, and two just transfer, and red tongue with thin fur is white, deep pulse.The patient is the capable left ovary excision in 2002 once.Give " changing the Disorder enema " retention-enema treatment today, treat 1.5 courses of treatment, June 26 in 2009 examined in the Nikkei gynecological and do not touch the right ovary cyst, parallel B ultrasonic check, and the uterus double accessory shows no obvious abnormalities, and follows up a case by regular visits to not recurrence in 2 years.
Case 2: Xue XX, woman, 47 years old, teacher, people from Linfen
First visit on April 7 in 2009, main cause " menostaxis March " is gone to a doctor and is examined in my gate, and the patient is menstrual cycle 28 days usually, passed through 6 days, and measured mediumly, color is scarlet, menostaxis to 10 occur surplus day because of work strain nearly March, amount is few, and color is purple dark, accompanies the black clot, receive the peace of to sleep, two just transfer, and red tongue with thin fur is white, weak pulse.Anteversion of uterus, palace body size (8.0x6.0x5.2cm) are shown in the ultrasound diagnosis of suggestion row; flesh layer echo is even, no abnormality seen echo group, the about 0.6cm of interior thickness; left side attachment shows no obvious abnormalities; the right side attachment area can be visited and the no echo area of the about 5.1x2.9cm of a size, meets the diagnosis of ovarian cyst, gives " change Disorder enema " retention-enema treatment; after treat 1 course of treatment; give B ultrasonic on April 27th, 2009 and check, point out the uterus double accessory to show no obvious abnormalities, follow up a case by regular visits to and do not see recurrence in 2 years.
Case 3:Ma, woman, 29 years old, civil servant, people from Yuci
First visit on July 20 in 2009, main cause " through rare in water 3 years, increase the weight of half a year " goes to a doctor and examines in my gate, patient menstruation 40-150 days usually, and once repeatedly oral Progesterone can be risen, and nearly half a year, oral Progesterone failed to gather effects, my section of going to a doctor today then.The suggestion ultrasound diagnosis, show the about 0.3cm of intrauterine thickness, adnexa zone, a left side can be visited and the about 4.6x3.2cm echoless enclosed mass of size, the border is clear, meets the diagnosis of ovarian cyst, gives " changing the Disorder enema " retention-enema treatment; after treating 1 course of treatment; in check on August 10th, 2009 B ultrasonic, and prompting uterus double accessory shows no obvious abnormalities, and follows up a case by regular visits to and does not see recurrence in 1 year.
Case 4:Zhao so-and-so, woman, 33 years old, nurse, people from Pingyao
JIUYUE in 2009 first visit on the 9th, because of " right attachment area cyst " found in the health check-up of last month unit, the suggestion operative treatment, because of being reluctant operation, my gate of going to a doctor today is then examined.The patient is the menstrual cycle rule usually, and no significant discomfort was passed through 6 days on LMP:2009 August 20, measures mediumly, and color is scarlet, no clot, lower abdomen dull pain.In capable B ultrasonic prompting on August 27: the no echo area of the visible 5x4.6cm of right attachment area, the border is clear, meets the diagnosis of ovarian cyst, give “ization Disorder enema " retention-enema treatment; after treating for two weeks, patient B is onlapped to look into and is shown uterus double accessory no abnormality seen, and right adnexal cyst disappears.
Case 6.:Zhao, woman, 27 years old, self-employed entrepreneurs, people from Yuci
First visit on July 31 in 2009, main cause " lower abdomen dull pain companion waist is stranded " my section of going to a doctor, once oral voluntarily " FUKE QIANJIN PIAN " slightly alleviated, and for asking further diagnosis and treatment, satisfies my section of going to a doctor today.Inscribe disease opinion: irascible temperament usually, lower abdomen dull pain is liked warm pain relieved by pressing, profuse leukorrhea, the color white matter is rare, and waist is stranded, and receives the peace of can sleeping, clear urine in large amounts, constipation with dry stool, the red tongue tongue is bored with in vain, stringy and hesitant pulse.The LMP:7 month 19.Tcm diagnosis: lower abdominal pain, dialectical genus cold and stagnate type.B ultrasonic is looked in suggestion, prompting: the about 0.6cm of intrauterine thickness, and the no echo area of the visible 6.8x4.6cm of right attachment area, douglas cul-de-sac can reach the opaque dark area of fluid of 1.3cm, prompting ovarian cyst, pelvic hydrops.Giving Disorder enema retention-enema treatment, the back lower abdomen dull pain alleviation of one week of coloclysis.After treating 1.5 courses of treatment, give the B ultrasonic check, prompting uterus double accessory no abnormality seen, the prompting cyst disappears, and follows up a case by regular visits to and does not see recurrence in 2 years.
Case 7:The week certain, woman, 30 years old, workman, Taigu County people
First visit on July 13 in 2009, the patient goes to a doctor because of " surplus dripping January not to the utmost through water ", once goes to a doctor in local county hospital, gives oral " Herba Clinopodii Tabellae " and fails to stop blooding, and satisfies my institute of going to a doctor today.Inscribe disease opinion: not to the utmost dripping through water, amount is few, and color is dark red, presss from both sides little clot, and matter is thick, does not have stomachache, soreness of the waist and knees, and weak asthenia, shallow complexion, anorexia dormancy peace, red tongue with thin fur is white, thready and weak pulse.Tcm diagnosis: metrorrhagia (qi stagnation and blood stasis type) suggestion B ultrasonic shows: the about 1.1cm of intrauterine thickness, the no echo area of left side attachment area visible " 4.8x3.9cm ", the border is clear, the visible size of right attachment area is the no echo area of " 5.2x3.4cm " approximately, the border is clear, diagnosis: endometrial thickness, bilateral ovaries cyst.After giving oral 5 doses of Chinese medicines, clean through water, changed Disorder enema retention-enema treatment ovarian cyst on July 19th, 2009, give the B ultrasonic check after treating 1.5 courses of treatment, prompting uterus double accessory no abnormality seen, prompting ovarian cyst disappears, and follows up a case by regular visits to and does not see recurrence in 2 years.
Case 8:Pacify certain, woman, 42 years old, peasant, people from Shouyang County
First visit on June 8 in 2010, the main suit " gradually lacks 2 years through amount ", and once oral voluntarily " Herba Leonuri granule " do not gather effects, my institute of going to a doctor today then.Inscribe disease opinion: gradually few through amount, color is dark red, dysphoria with feverish sensation in the chest palms and soles, and idol has vague pain and uneasy over the lower abdomen, and the leukorrhagia amount is few, and the red tongue tongue is few, thready pulse.The Lmp6 month 7, the suggestion B ultrasonic shows: the about 0.7cm of intrauterine thickness, and the no echo area of the visible 5x5cm of right side attachment area, the border is clear.Diagnosis: through the water yield few (caused by liver and kidney deficiency); Ovarian cyst.Give oral 3 doses of Chinese medicines after amount before increases, giving Disorder enema retention-enema treatment after clean, treated for 3 weeks after, suggestion check B ultrasonic, prompting double accessory no abnormality seen, the disappearance of prompting cyst is followed up a case by regular visits to and was not seen recurrence in 1 year half.
Case 9:Korea Spro so-and-so, woman, 46 years old, teacher, people from Yuci
First visit on April 2 in 2009, the patient advises operative treatment because of a week preceding unit health examination discovery right ovary cyst (6.5x5.2cm), the patient is reluctant to be treated surgically, and desires to ask expectant treatment, satisfies my institute of going to a doctor today.Inscribe disease opinion: patient's lower abdominal distention pain usually is indistinct, and waist is stranded, weak asthenia, and profuse leukorrhea, color is white, and matter is sticky, red tongue with yellowish and greasy fur, thready and hesitant pulse.The retention enema of giving Disorder enema, treatment 3 week back check cysts (4.2x3.9cm) are continued enema treatment, and about 5 weeks back check B ultrasonic prompting cysts disappear, and follow up a case by regular visits to not see recurrence in 1 year half.
Case 10:Stone so-and-so, woman, 30 years old, accounting, people from Yuci
First visit on June 26 in 2009, the main suit: " lacking March through the water lead " do not give any treatment, satisfies my institute of going to a doctor today, inscribe disease opinion: do not have obvious inducement and shift to an earlier date 8-10 days through water nearly March, and the companion measures few, and color is dark red, the leukorrhagia amount is few, and the color white matter is rare, emaciated physique, the anorexia xerostomia, the red tongue tongue is few, thready and weak pulse, the LMP:6 month 21, passed through 3 days, measure about less 20ml, color is dark red, and matter is thick, does not have stomachache.Diagnosis: through the water yield few (caused by liver and kidney deficiency type).The suggestion B ultrasonic shows: the about 0.3cm of intrauterine thickness, right adnexal cyst is pointed out in the no echo area of the about 6.2x5.4cm of the visible size of right side attachment area.Giving Disorder enema retention-enema treatment, enema treatment was checked after 5 weeks, prompting double accessory no abnormality seen echo.Follow up a case by regular visits to and do not see recurrence in 1 year.
Claims (3)
1. change the Disorder enema for one kind, it is characterized in that: comprise following parts by weight of Chinese traditional medicine crude drug: Sargassum 10-15 part, Thallus Laminariae (Thallus Eckloniae) 12-15 part, Ramulus Cinnamomi 6-10 part, Poria 10-15 part, Talcum 10-15 part, Semen Plantaginis 20-30 part, Carapax Trionycis 10-15 part, Concha Ostreae 30-40 part, Fructus Liquidambaris 5-8 part, Radix Salviae Miltiorrhizae 20-35 part, Radix Paeoniae Rubra 15-20 part, Rhizoma Alismatis 10-12 part, Cortex Cinnamomi 5-8 part, Semen Litchi 10-12 part.
2. according to claim 1ization Disorder enema is characterized in that: described raw material of Chinese medicine medicine parts by weight: 12 parts of Sargassums, 12 parts of Thallus Laminariae (Thallus Eckloniae)s, 8 parts of Ramulus Cinnamomi, 10 parts in Poria, 12 parts in Talcum, 30 parts of Semen Plantaginiss, 12 parts of Carapax Trionycis, 30 parts of Concha Ostreae, 6 parts of Fructus Liquidambaris, 30 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Paeoniae Rubra, 10 parts of Rhizoma Alismatis, 6 parts of Cortex Cinnamomis, 10 parts of Semen Litchis.
3. a technology of making claim 1 or 2 describedization Disorder enemas comprises the steps: to take by weighing by weight the prepared slices of Chinese crude drugs that pharmacopeia requires in meeting;
⑴ pulverized 40 mesh sieves with Semen Litchi, soaked into 24 hours with 50% ethanol, adorns the diafiltration tube then, with the diafiltration of 2ml/min speed, collects percolate, standby;
⑵ extract Ramulus Cinnamomi, cinnamomic volatile oil with the way of distillation, and the water suspension of getting described volatile oil content and be 1-5wt% is standby;
⑶ decoct with water twice with Semen Litchi diafiltration slag and Ramulus Cinnamomi, cinnamomic bottoms and all the other 11 flavor medical materials, filters respectively, adds 8 times of water gagings of described crude drug weight for the first time, adds 6 times of water gagings of described crude drug weight for the second time, decocted 2 hours at every turn, filters;
⑷ extract filtrate with Semen Litchi percolate, Ramulus Cinnamomi and Cortex Cinnamomi volatile oil water suspension and twice decocting mixes and puts into vacuum concentrator, be evaporated to 1000-1500 parts below 60 ℃, filter and be distributed into every bottle of 100ml, get of the present inventionization Disorder enema.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1032295A (en) * | 1988-02-22 | 1989-04-12 | 黑龙江省中医学院中药厂 | The grand manufacture method of sharp liver |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1032295A (en) * | 1988-02-22 | 1989-04-12 | 黑龙江省中医学院中药厂 | The grand manufacture method of sharp liver |
Non-Patent Citations (2)
| Title |
|---|
| 卢翠云，等: "卵巢囊肿的中医药治疗概况", 《中医药学刊》, vol. 24, no. 4, 30 April 2006 (2006-04-30), pages 712 - 713 * |
| 王金权，等: "王氏化癥灌肠液治疗卵巢囊肿100例", 《中医杂志》, vol. 52, no. 24, 31 December 2011 (2011-12-31) * |
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