CN103212034A - 一种治疗慢性病毒性肝炎的中药组合物 - Google Patents
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Abstract
本发明公开了一种治疗慢性病毒性肝炎的中药组合物。中医认为，肝炎的病变部位主要在肝胆，病机主要是湿热毒邪导致肝胆功能失常。为此，本发明选择具有清热燥湿，活血化瘀，平肝利胆，健脾补肾的中药黄刺皮、龙胆草、马尾连、蝉翼藤、地锦草、郁金、滇獐牙菜、玉米须、白芍、春不见、茯苓、绞股蓝、枸橘，由我院制剂室制成汤剂，经临床试验，总有效率达到96.2％，明显优于对照组，而且治疗组治疗前后TBiL、ACT、AST三项指标的变化也明显好于对照组。
Description
技术领域
本发明涉及一种中药组合物，尤其涉及一种治疗慢性病毒性肝炎的中药组合物。
背景技术
慢性病毒性肝炎是肝病中的一种，具有传染性强、传播途径复杂、流行面广泛、发病率高等特点，如果不及时清除体内病毒，病毒复制会引起肝功能异常。患者临床表现食欲不振、恶心、呕吐、肝区不适、腹痛、腹泻等等，此外，随着病情的恶化，慢性病毒性肝炎患者还会出现蜘蛛痣、黄疸、肝掌等症状，慢性病毒性肝炎病程迁延，可发展为肝硬化，肝细胞癌，对人们健康危害甚大。对于慢性病毒性肝炎的治疗西药存在着很多的缺陷，申请人经过多年的临床研究证明，利用中药治疗慢性病毒性肝炎具有较好的疗效。
发明内容
本发明的目的是提供一种治疗慢性病毒性肝炎的中药组合物。中医认为，肝炎的病变部位主要在肝胆，病机主要是湿热毒邪导致肝胆功能失常。
本发明的目的是通过以下技术方案实现的，该治疗慢性病毒性肝炎的中药组合物由以下重量份的中药制成：黄刺皮5-25份、龙胆草10-15份、马尾连7-20份、蝉翼藤10-30份、地锦草6-15份、郁金7-9份、滇獐牙菜8-25份、玉米须5-8份、白芍10-20份、春不见9-18份、茯苓4-20份、绞股蓝9-13份、枸橘9-17份。
优选的，黄刺皮15份、龙胆草13份、马尾连14份、蝉翼藤20份、地锦草11份、郁金8份、滇獐牙菜12份、玉米须6份、白芍15份、春不见14份、茯苓12份、绞股蓝11份、枸橘13份。
制备方法将本发明所述的中药加水适量，急火煎开，温火煎30min。
方中：黄刺皮、龙胆草、马尾连清热燥湿，泻肝胆火，解毒；蝉翼藤、地锦草、郁金活血化瘀，清热利湿，解毒消肿，行气止痛，解郁心情，利胆退黄，凉血；滇獐牙菜、玉米须、白芍、春不见清肝利胆，除湿清热，利尿泄热，养血调经，清热解毒，平肝散结；茯苓利水渗湿，健脾安神；绞股蓝健脾补肾，化痰止咳，清热解毒；枸橘疏肝和胃，理气止痛。
临床资料
1、一般资料所有病例均为本院住院患者，诊断均符合《病毒性肝炎防治方案》，中医辨证参照《病毒性肝炎中医辨证分型标准》(试行)，所选病例均为肝胆湿热兼瘀血阻络症。将130例病例随机分为两组，治疗组65例，男40例，女25例；年龄10-65岁，平均26.8岁；病程6个月-7年，平均3.5年；对照组65例，男42例，女23例；年龄11-70岁，平均27.5岁；病程7个月-8年，平均4年两组一般情况比较，差异无显著性意义(P＜0.05)，具有可比性。
2、治疗方法治疗组服用本发明所述的中药组合物，每日一剂，早晚2次服用；对照组给予丹参注射液20mL，加入5％葡萄糖液250mL，静脉滴注，每天1次，两组均3个月为一个疗程。
3、疗效标准参照中国中医药学会内科肝病专业委员会制定的《病毒性肝炎疗效评定标准》执行：(1)临床近期治愈：湿热证与瘀血证的主要症状消失，肝脾肿大较前回缩或稳定不变，肝功能恢复正常(SB＜25.7μmol/L，ALT＜40u/L)，2周后复查仍正常。(2)临床近期基本治愈：湿热证与瘀血证的主要症状大部分消失，肝脾肿大稳定不变，肝功能接近正常(SB＜25.7μmol/L，ALT＜50u/L)，2周后复查仍在此水平。(3)好转：湿热证与瘀血证的主要症状大部分消失，肝脾肿大稳定不变(肝功能SB＜25.7μmol/L，ALT≤70u/L)。(4)无效：治疗3个月未达好转标准者。
4、治疗结果(1)两组患者治疗前后TBiL、ACT、AST三项指标的变化
见表1。
表1两组患者治疗前后TBiL、ACT、AST、三项指标的变化
治疗组治疗前后比较P＜0.05；与对照组比较P＜0.05
(2)两组治疗三个月后疗效比较见表2。
表2两组治疗三个月后疗效比较
与对照组比较P＜0.05
两组比较治疗组的临床近期治愈、总有效率，明显优于对照组具有可比性(P＜0.05)。
具体实施方式
实施例一：称取黄刺皮15g、龙胆草13g、马尾连14g、蝉翼藤20g、地锦草11g、郁金8g、滇獐牙菜12g、玉米须6g、白芍11g、春不见14g、茯苓12g、绞股蓝11g、枸橘9g。将以上中药加水适量，急火煎开，温火煎30min。
实施例二：称取黄刺皮25g、龙胆草10g、马尾连7g、蝉翼藤10g、地锦草15g、郁金7g、滇獐牙菜25g、玉米须5g、白芍10g、春不见18g、茯苓20g、绞股蓝13g、枸橘17g。将以上中药加水适量，急火煎开，温火煎30min。
实施例三：称取黄刺皮5g、龙胆草15g、马尾连20g、蝉翼藤30g、地锦草6g、郁金9g、滇獐牙菜8g、玉米须8g、白芍20g、春不见9g、茯苓4g、绞股蓝9g、枸橘9g。将以上中药加水适量，急火煎开，温火煎30min。
Claims (2)
1.一种治疗慢性病毒性肝炎的中药组合物，其特征在于该中药组合物由以下重量份的中药制成：黄刺皮5-25份、龙胆草10-15份、马尾连7-20份、蝉翼藤10-30份、地锦草6-15份、郁金7-9份、滇獐牙菜8-25份、玉米须5-8份、白芍10-20份、春不见9-18份、茯苓4-20份、绞股蓝9-13份、枸橘9-17份。
2.根据权利要求1所述的一种治疗慢性病毒性肝炎的中药组合物，其特征在于该中药组合物由以下重量份的中药制成：黄刺皮15份、龙胆草13份、马尾连14份、蝉翼藤20份、地锦草11份、郁金8份、滇獐牙菜12份、玉米须6份、白芍15份、春不见14份、茯苓12份、绞股蓝11份、枸橘13份。
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1160559A (zh) * | 1996-11-30 | 1997-10-01 | 李泽良 | 乙肝化毒丸 |
| CN1682995A (zh) * | 2005-03-07 | 2005-10-19 | 崔庆峰 | 治疗肝炎的中药制剂及其制备方法 |
| CN101757561A (zh) * | 2009-11-02 | 2010-06-30 | 泰一和浦（北京）中医药研究院有限公司 | 一种治疗慢性肝炎病症的中药组合物及其制备方法 |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1160559A (zh) * | 1996-11-30 | 1997-10-01 | 李泽良 | 乙肝化毒丸 |
| CN1682995A (zh) * | 2005-03-07 | 2005-10-19 | 崔庆峰 | 治疗肝炎的中药制剂及其制备方法 |
| CN101757561A (zh) * | 2009-11-02 | 2010-06-30 | 泰一和浦（北京）中医药研究院有限公司 | 一种治疗慢性肝炎病症的中药组合物及其制备方法 |
Non-Patent Citations (3)
| Title |
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| 李良础: "辨证论治病毒性肝炎", 《实用中医内科杂志》, vol. 27, no. 2, 28 February 2013 (2013-02-28), pages 50 - 51 * |
| 邬祥惠等: "连香冲剂治疗慢性肝炎的疗效分析", 《中成药》, no. 1, 31 December 1984 (1984-12-31), pages 17 - 18 * |
| 钟有添: "中医药治疗病毒性乙型肝炎研究进展", 《赣南医学院学报》, vol. 24, no. 2, 30 April 2004 (2004-04-30), pages 224 - 227 * |
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