CN103212002A - Medicine for treating liver cancer and preparation method thereof - Google Patents
Medicine for treating liver cancer and preparation method thereof Download PDFInfo
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Abstract
The invention provides a medicine for treating liver cancer and a preparation method thereof. The medicine is a dropping pill which is made from balanophora involucrata hook.f, aspongopus, air potato, bighead atractylodes rhizome, oldenlandia diffusa, radix sophorae flavescentis, radix trichosanthis, rhizoma smilacis glabrae, astragalus mongholicus and the like. The medicine mainly functions in soothing the liver, resolving the depression, promoting the blood circulation, detoxifying and strengthening the spleen and stomach, and can be clinically used for treating liver cancer.
Description
Technical field
The present invention relates to a kind of medicine that is used for the treatment of hepatocarcinoma and preparation method thereof, belong to the pharmaceutical preparations technology field.
Background technology
Hepatocarcinoma is one of China's common cancer.The early stage onset of clinical manifestation is quite concealment often, does not have tangible sings and symptoms, often finds by the detection or the generaI investigation of alpha-fetoprotein.Common sympton has hepatic region intermittence or rest pain, the upper abdomen distension, loss of appetite, the epigastrium lump is the enlargement of carrying out property, General Symptoms is become thin, is generated heat, diarrhoea, jaundice, and complication has hemorrhage, the secondary infection etc. of breaking of digestive tract hemorrhage, hepatic coma, liver tuberosity.
Liver neoplasm is divided constitutional and Secondary cases.The constitutional liver neoplasm has pernicious and optimum branch again.Pernicious or the benign tumor of constitutional liver all betides its blast cell, i.e. the parenchymal liver cells of liver, and epithelial duct, the stroma of support, or come from two or more tissue among this three.Primary malignant tumor, major part is primary hepatocarcinoma (PHC).It can be divided into the mixed carcinoma of liver that derives from hepatocellular hepatocarcinoma (HCC) and derive from the cholangiocellular carcinoma of epithelial duct and derive from the two, wherein is HCC more than 90%.The Secondary cases liver neoplasm is pernicious, is to transfer to liver by the carcinoma of other internal organs, or property transfer in the liver of secondary, therefore, be referred to as secondary liver cancer again.The primary benign tumor of liver sees that with hemangioma, cystic disease other are rare or rare more.
Primary disease belongs to categories such as " disease is long-pending ", " the liver rump ", " mass at the hypochondrium ", " tympanites ", " jaundice " more in tcm clinical practice.Motherland's medical science is thought depressed emotion, functional activity of QI being not smooth, and the liver failing to maintain the normal flow of QI, so see the upper abdomen distending pain, the stomach poor appetite moves back, greasy fur, stringy and thready pulse; Qi depression to blood stasis, blood is capable to be obstructed, accumulate over a long period, thus see the side of body under have long-pending, the distending pain discomfort, fatigue and weakness, darkish complexion is become thin, greasy fur, purplish tongue, thready and hesitant pulse; Insufficiency of the spleen resulting in production of dampness, the damp-stagnancy heat-transformation is accumulate in the pyretic toxicity, so see jaundice, heating, bleeding from the gum; Tympanites, yellow and greasy fur and do wiry and frequent pulse.
Primary hepatocarcinoma is because early symptom is hidden, and late period, disease progression was rapid, thereby people are referred to as it " king in the cancer ".In addition, before forming hepatocarcinoma, basic hepatitis histories such as viral hepatitis, alcoholic liver disease, liver cirrhosis are often arranged, thereby medication is careless slightly, especially adopts " treating the poisonous disease with poisonous drugs " medicine then might increase the weight of liver injury, cause the passive situation that makes the matter worse.
Then being because body is weakened body resistance in Chinese traditional treatment, then is because due to the invasion and attack of cancer poison, so treatment must accomplish that " setting upright " is double mutually with " anticancer " outside.In close relations in view of liver and taste, should attach most importance to taste so set upright, spleen with fortune for strong, stomach with logical be benefit.Simultaneously, the cancer poison is to be special evil poison, and its poison should be separated and should not attack.But treat both liver function protectings like this, the cancer poison is disarmed, excrete.Otherwise, adopt the plan of " treating the poisonous disease with poisonous drugs ", often cause " poison of drug, cancer poison " two poison to be met, " cancer poison " occur and remove as yet, and hurt sb.'s feelings the earlier passive situation of body of poison of drug.
So both had the effect that improves the health immunologic function in the treatment, had the cancer of dismission poison again, the good result of liver function protecting.Difference in view of hepatocarcinoma stadium, tumor size, metastasis degree, overall health of patients, primary disease late period particularly, the state of an illness is changeful especially, the ingredient and the immuning tissue in the health of improving immunologic function on the one hand have stronger affinity, excite the immunologic mechanism of health better, dispel the cancer poison, control cancer metastasis and diffusion; Clear up the ingredient of cancer poison on the other hand and point to cancerous cell more accurately, bring into play therapeutical effect better.
China is onset of liver cancer big country, and M ﹠ M accounts for the whole world 45%.The morbidity and the hepatitis of hepatocarcinoma are closely related, and is also relevant with bad life style such as excessive drinkings.In case suffer from hepatocarcinoma, treatment difficulty height, poor prognosis.Bring misery and family burden for people's life.Hepatocarcinoma occupies second of cancer at the sickness rate of our country, and China's hepatocarcinoma accounts for 45% of whole world PLC mortality rate and incidence rate, near half, so our national liver cancer research level also takes the lead in the world.Contain a plurality of antineoplastic components in the drug prescription of the present invention, not only can improve the radical rate of early hepatocarcinoma, and can allow the advanced liver cancer patient prolong life cycle, improve life quality, even reach alleviation fully for a long time.
Summary of the invention
The object of the invention is to provide a kind of steady quality, and curative effect is reliable, the medicine of the treatment primary hepatocarcinoma that bioavailability is high.
Medicine of the present invention is made up of medical materials such as Balanophora dioica R Br ex Royle, Herba Hedyotidis Diffusae, Aspongopus, Rhizoma Dioscoreae Bulbiferae, the Rhizoma Atractylodis Macrocephalae, Radix Sophorae Flavescentis, Radix Trichosanthis, Rhizoma Smilacis Glabraes, has soothing liver-QI for relieving depression, promoting blood circulation and detoxication, the effect of raising immunity.Use stagnation of QI due to depression of the liver, the primary hepatocarcinoma due to the malicious stasis of blood mutual resistance.We have used for many years clinically, and it is evident in efficacy.In this prescription the monarch drug Balanophora dioica R Br ex Royle be Yunnan exclusive, be grown in the Balanophora dioica R Br ex Royle in 2800 meters high mountains of height above sea level, the Balanophora dioica R Br ex Royle strengthening yang and invigorating kidney, spleen invigorating is regulated the flow of vital energy, to separate the pent-up of liver.The Herba Hedyotidis Diffusae heat-clearing and toxic substances removing, diuresis of blood circulation promoting is used for hepatitis, tumor.Modern pharmacology studies have shown that the immunity that Herba Hedyotidis Diffusae can enhancing body, suppresses the growth of tumor cell, with Balanophora dioica R Br ex Royle be monarch drug altogether.Ministerial drug, Rhizoma Dioscoreae Bulbiferae removing toxic substances and promoting subsidence of swelling, dissipating phlegm and resolving masses, cooling blood for hemostasis.Be used for tuberculous lymphadenitis, pertussis, cancerous protuberance etc.The ministerial drug Aspongopus, promoting the circulation of QI to relieve pain, warming the kidney to invigorate YANG, soothing the liver separating, can transfer incoordination between the liver and stomach or cold strongly fragrant in breast due to Jiao go through side of body gastral cavilty distending pain etc.The ministerial drug Rhizoma Atractylodis Macrocephalae, warm in nature and dry, gas is not fragrant scurries, the little suffering of bitter but slightly sweet taste, kind strengthening the spleen and stomach, expectorant water, stopping leak rushes down, and controls insufficiency of the spleen expanding, and spleen is wet to be done yearningly, and the weak quadruped locomotion of spleen is unable, even ache.The ministerial drug Radix Sophorae Flavescentis, main stagnation of QI in chest and abdomen, lump in the abdomen, jaundice, drowning has the heeltap, relieves oedema or abdominal distension through diuresis or purgation, and removes carbuncle, invigorating middle warmer, arresting lacrimation makes eye bright." matrine in the modern pharmacology proof Radix Sophorae Flavescentis has active anticancer; find under the dosage of equal antitumor action; mitomycin can make and lose weight; matrine but can make weight increase. and the chemotherapeutic index of oxymatrine is 7.8 times of mitomycin. and help that to move back the five internal organs with Radix Trichosanthis hot and suffocating; " book on Chinese herbal medicine converge speech " record: only this agent can relieving stagnation; fall phlegm-fire, and can control it again.The Rhizoma Smilacis Glabrae detoxifcation, dehumidifying, sharp joint.But Radix Astragali tonifying liver gas, the liver-yang that shakes, rescue liver and take off, the merit optimum of QI invigorating is tonifying liver gas good medicine, with the original magical effect that People of the same tastes and habits like to be together of tonifying liver, and the asthenia person decreases kidney more, the Radix Astragali can big tonifying the lung gas with source on the kidney tonifying water, make the prosperous self energy unboiled water of gas.The Radix Astragali can also be strengthened the merit and the eliminating blood stasis to promote regeneration of blood of invigorating the spleen and regulating the stomach, makes temper healthy and vigorous and QI and blood biochemistry is active.The shared promoting blood circulation and detoxication that rises altogether of all medicines, dispersing the stagnated live-QI to relieve the stagnation of QI, the effect of strengthening the spleen and stomach.
Medicine of the present invention is made by the crude drug that comprises following parts by weight ratio:
Balanophora dioica R Br ex Royle 800-1500 part Herba Hedyotidis Diffusae 400-600 part Aspongopus 300-700 part
Rhizoma Dioscoreae Bulbiferae 400-600 part Rhizoma Atractylodis Macrocephalae 600-800 part Radix Sophorae Flavescentis 100-300 part
Radix Trichosanthis 150-350 part Rhizoma Smilacis Glabrae 100-200 part Radix Astragali 300-500 part
The raw material medicines in portions by weight ratio that medicine of the present invention comprises preferably be:
Balanophora dioica R Br ex Royle 1000-1300 part Herba Hedyotidis Diffusae 450-500 part Aspongopus 400-500 part
Rhizoma Dioscoreae Bulbiferae 450-500 part Rhizoma Atractylodis Macrocephalae 650-700 part Radix Sophorae Flavescentis 150-250 part
Radix Trichosanthis 180-300 part Rhizoma Smilacis Glabrae 100-150 part Radix Astragali 400-500 part
Also be preferably:
450 parts of 480 portions of Aspongopuss of 1200 parts of Herba Hedyotidis Diffusaes of Balanophora dioica R Br ex Royle
220 parts of 680 parts of Radix Sophorae Flavescentiss of 480 parts of Rhizoma Atractylodis Macrocephalaes of Rhizoma Dioscoreae Bulbiferae
450 parts of 130 parts of Radixs Astragali of 220 parts of Rhizoma Smilacis Glabraes of Radix Trichosanthis
Chinese medicine preferred for this invention can be had the Chinese medicine of same or similar effect to replace, and these medical materials all can be concocted according to the method for records such as " national Chinese medicine processing standard ", " Chinese medicine voluminous dictionary ", and the curative effect of medication of the present invention of the medical material preparation after the process of preparing Chinese medicine is identical.
Medicine of the present invention can also adopt the application process of Chinese medicine, as fries in shallow oil soup and take, and grinds to loosing and swallows or water delivery service, also can produce same curative effect.
Another object of the present invention provides the preparation method of this medicine, and this medicine is made by the following step:
(1) Balanophora dioica R Br ex Royle, Rhizoma Dioscoreae Bulbiferae, the Rhizoma Atractylodis Macrocephalae, Radix Trichosanthis, Rhizoma Smilacis Glabrae, astragalus membranaceus powder are broken into coarse powder, decoct with water each 1.5 hours three times, collecting decoction left standstill 12 hours, filtered, filtrate decompression is concentrated into the clear paste that relative density is 1.20 (55 ℃), is spray dried to dried cream powder, and is standby;
(2) Herba Hedyotidis Diffusae, Radix Sophorae Flavescentis add the 50%-70% alcohol heating reflux and extract, and extracting solution filters, and filtrate decompression concentrates, and is spray dried to dried cream powder, and is standby;
(3) Aspongopus adds the extraction of 50%-70% alcohol heating reflux, and extracting solution filters, and concentrating under reduced pressure is standby.
(4) get above-mentioned two kinds of dried cream powders, add above-mentioned Aspongopus clear paste again, promptly get total mixture, join Macrogol 2000: the Macrogol 4000 weight ratio is in 2: 1 the fused solution, (Macrogol 4000: ratio polyethylene glycol 6000=2: 1) is to stir at 1: 1, and melting mixing liquid is moved on to dropping-pill machine system for medicine and substrate; The temperature of water dropper remains on 60-90 ℃, and condensing agent is selected liquid paraffin or dimethicone, or the mixture of the two, condensation temperature 3-5 ℃, drips and makes drop pill.
Be to confirm the curative effect of medicine of the present invention, the drop pill according to the method preparation of embodiment 1, carried out following research:
Clinical verification
Observe the curative effect of drop pill treatment late primary liver cancer of the present invention.Method is divided into 2 groups at random with 90 routine Patients with Primary, and matched group gives compound recipe Balanophora dioica R Br ex Royle granule therapy, and the treatment group is given drop pill of the present invention, then the variation of two groups of patients ' life qualities of paired observation, life cycle, AFP.The matched group effective percentage is 51% as a result, and treatment group effective percentage is 86%, two group relatively significant difference (P＜0.01); Quality of life and life cycle, relatively the treatment group was all apparently higher than matched group (P＜0.05); AFP treatment group has downward trend, and matched group has rising trend, but two groups are compared there was no significant difference (P＞0.05).
Model case
The Wang, the man, 48 years old, epigastric discomfort in JIUYUE, 2009 sense, at local hospitalize DeGrain, in December, 2009 CT examination is shown primary hepatocarcinoma.Go to a doctor in March, 2010, and big belly was hidden discomfort from during disease was seen, idol has dull pain, xerostomia, and bitter taste, poor appetite is slept and is felt unwell, and stool is normal, dark tongue quality yellow, greasy and thin fur, stringy and thready pulse.Have a medical check-up: cardiopulmonary (), abdomen is soft, in go up the discomfort of abdominal pressure, no flesh is defended counter looking into the distance bitterly.Lab testing: AFP230, GPT126.Give drop pill of the present invention, take that patient's abdominal distention alleviates after one month, stomach has been received and has been increased, and continuously uses preceding method.Treat after 3 months check CT and show primary hepatocarcinoma, do not see obvious increase soon with anter is relatively more swollen.The patient continues to take Chinese medicine, follows up a case by regular visits to full 2 years.
Zhang, the man, 58 years old, the Hok-lo, the primary hepatocarcinoma IV phase, lymphonodi coeliaci shifts, and lung shifts.Jaundice, a large amount of ascites are become thin, lower limbs edema, weak, the side of body is pain down, poor appetite is looked into AFP＞1000mg/L, ALB 20.6g/L, about 6cm * the 5cm of CT prompting liver right lower lobe tumor focus maximum diameter, oral medicine of the present invention, each 1.5g, every day 2 times, serve on February after symptom obviously alleviate check AFP 651.3mg/L, ALB 34.7g/L, the about 4cm * 4cm of CT prompting tumor.
Liu, woman, 59 years old, people from Luoyang, Henan, the primary hepatocarcinoma I phase, become thin, weak, poor appetite, the distending pain in the hypochondrium discomfort, anemia is looked into RBC 3.0 * 1012/L, HGB 85g/L, AFP＞584.2mg/L, the about 1cm * 0.8cm of CT prompting right lobe of liver tumor focus maximum diameter, oral medicine of the present invention, each 1.5g, every day 2 times, serve on April after remission, the check result of laboratory test is all normal, and CT prompting tumor disappears, and patient's life span is above 4 years.
The side certain, man, 41 years old, people from Xingtai, chronic hepatitis is arranged, liver cirrhosis, a small amount of ascites, in June, 2010, have a medical check-up because of uncomfortable liver area and to find two tumors of right lobe of liver, size is 6.5x5.7cm, 3.5x3.0cm, AFP8700ng/L, give this medicine each 1.5g, every day 2 times, back ultrasonic contrast and nuclear-magnetism show that tumor does not have enhancing, AFP drops to 174ng/l, check nuclear enhanced CT does not have enhancing after January, and AFP reduces to 2.3ng/l, family's recuperation now, life can not only be taken care of oneself, and can also participate in the work of the light middle intensity in rural area.
Huang, woman, 57 years old, people from Zhengzhou, Henan, primary hepatocarcinoma late period, lymphonodi coeliaci shifts, and lung shifts, anemia, purpura, a large amount of ascites, lower limbs edema, poor appetite is become thin, look into RBC 2.7 * 1012/L, PLT 36 * 109/L, HGB 62g/L, AFP＞1000mg/L, ALB 22.4g/L, CT do not carry and fill the air occupy-place in the liver, the visible a plurality of occupancy tuberositys in abdominal cavity, the maximum 3.2cm * 2.4cm, oral medicine of the present invention, each 1.5g, every day 2 times, serve on January after symptom obviously alleviate.
The Wang, man, 46 years old, people from Jinan, Shandong.Epigastrium dull pain discomfort, poor appetite, become thin, liver pain, epigastrium laid one's hand on enclosed mass 15 days, alpha-fetoprotein (AFP) 12500ng, B ultrasonic, CT examination show " left liver occupy-place ", go to a doctor on April 24th, 2009.Pathological replacement is: " hepatocellular carcinoma penetrates Glisson's capsule, looks in the blood vessel and sees cancer embolus ".Obey medicine of the present invention, each 1.5g, every day 2 times, after two months, AFP reduces to normally, and the life work is as usual, follows up a case by regular visits to full 2 years.
Zhang, man, 70 years old, people from Zhengzhou, Henan, primary hepatocarcinoma late period, lymphonodi coeliaci shifts, lung shifts, jaundice, a large amount of ascites, become thin, lower limbs edema, the side of body is pain down, weak, poor appetite is looked into TBIL 168.6 μ mol/L, AFP＞1000mg/L, ALB 25.5g/L fills the air occupy-place in the CT prompting liver, the visible a plurality of occupancy tuberositys in abdominal cavity, oral medicine of the present invention, each 1.5g, every day 2 times, symptom obviously alleviates after serveing on January, looks into TBIL 73.2 μ mol/L, AFP＞826.5mg/L, ALB34.1g/L followed up a case by regular visits to full 1 year.
Can find out clearly that by above-mentioned data the present invention can produce the effect of dissipate retraction, relief of symptoms to hepatocarcinoma, prolongs patient's life, alleviate patient's misery, be the innovation on the treatment liver-cancer medicine, have actual clinical meaning and exploitation to be worth, economic and social benefit is huge.
Claims (6)
1. a treatment is used for the treatment of the medicine of hepatocarcinoma, it is characterized in that this medicine made by the crude drug that comprises following weight portion ratio:
Balanophora dioica R Br ex Royle 800-1500 part Herba Hedyotidis Diffusae 400-600 part Aspongopus 300-700 part
Rhizoma Dioscoreae Bulbiferae 400-600 part Rhizoma Atractylodis Macrocephalae 400-600 part Radix Sophorae Flavescentis 100-300 part
Radix Trichosanthis 150-350 part Rhizoma Smilacis Glabrae 100-200 part Radix Astragali 300-500 part
2. medicine according to claim 1, the weight portion ratio of its crude drug is:
Balanophora dioica R Br ex Royle 1000-1300 part Herba Hedyotidis Diffusae 450-500 part Aspongopus 400-500 part
Rhizoma Dioscoreae Bulbiferae 450-500 part Rhizoma Atractylodis Macrocephalae 450-500 part Radix Sophorae Flavescentis 150-250 part
Radix Trichosanthis 180-300 part Rhizoma Smilacis Glabrae 100-150 part Radix Astragali 400-500 part
3. medicine according to claim 1, the weight portion ratio of its crude drug is:
450 parts of 480 portions of Aspongopuss of 1200 parts of Herba Hedyotidis Diffusaes of Balanophora dioica R Br ex Royle
220 parts of 480 parts of Radix Sophorae Flavescentiss of 480 parts of Rhizoma Atractylodis Macrocephalaes of Rhizoma Dioscoreae Bulbiferae
450 parts of 130 parts of Radixs Astragali of 220 parts of Rhizoma Smilacis Glabraes of Radix Trichosanthis
4. according to the arbitrary described medicine of claim 1-3, it is characterized in that this pharmaceutical dosage form is a drop pill.
5. according to the preparation method of the described medicine of claim 4, it is characterized in that this medicine made by the following step:
(1) Balanophora dioica R Br ex Royle, Rhizoma Dioscoreae Bulbiferae, the Rhizoma Atractylodis Macrocephalae, Radix Trichosanthis, Rhizoma Smilacis Glabrae, astragalus membranaceus powder are broken into coarse powder, decoct with water each 1.5 hours three times, collecting decoction left standstill 12 hours, filtered, filtrate decompression is concentrated into the clear paste that relative density is 1.0-1.3 (55 ℃), is spray dried to dried cream powder, and is standby;
(2) Herba Hedyotidis Diffusae, Radix Sophorae Flavescentis add the 50%-70% alcohol heating reflux and extract, and extracting solution filters, and filtrate decompression concentrates, and is spray dried to dried cream powder, and is standby;
(3) Aspongopus adds the extraction of 50%-70% alcohol heating reflux, and extracting solution filters, and concentrating under reduced pressure is standby.
(4) get above-mentioned two kinds of dried cream powders, add above-mentioned Aspongopus clear paste again, promptly get total mixture, join Macrogol 2000: the Macrogol 4000 weight ratio is in 2: 1 the fused solution, (Macrogol 4000: ratio polyethylene glycol 6000=2: 1) is to stir at 1: 1, and melting mixing liquid is moved on to dropping-pill machine system for medicine and substrate; The temperature of water dropper remains on 60-90 ℃, and condensing agent is selected liquid paraffin or dimethicone, or the mixture of the two, condensation temperature 3-5 ℃, drips and makes drop pill.
6. according to the described medicine of claim 1-4, it is characterized in that being used for the treatment of primary hepatocarcinoma.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107126527A (en) * | 2017-05-22 | 2017-09-05 | 何东良 | A kind of Chinese medicine composition and its preparation for treating liver cancer |
| CN108686158A (en) * | 2017-04-07 | 2018-10-23 | 北京蕴汇医药科技有限公司 | A kind of Chinese medicine composition and preparation method thereof for preventing hepatic precancerosis and liver cancer |
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| CN1759881A (en) * | 2005-10-09 | 2006-04-19 | 云南黄家医圈制药有限公司 | Medicine of Fufang Luxiancao for treating liver cancer |
| CN1857575A (en) * | 2006-04-13 | 2006-11-08 | 贵州信邦制药股份有限公司 | Compound Chinese medicine preparation for treating primary liver carcinoma caused by stagnation of liver-Qi and poisonous obstruction and its preparing process |
| CN1857566A (en) * | 2006-03-31 | 2006-11-08 | 江西中兴汉方药业有限公司 | Compound dioecious balanophora herb capsule |
| CN102688317A (en) * | 2012-06-25 | 2012-09-26 | 鲁邦卫 | Traditional Chinese medicine for treating liver cancer |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1759881A (en) * | 2005-10-09 | 2006-04-19 | 云南黄家医圈制药有限公司 | Medicine of Fufang Luxiancao for treating liver cancer |
| CN1857566A (en) * | 2006-03-31 | 2006-11-08 | 江西中兴汉方药业有限公司 | Compound dioecious balanophora herb capsule |
| CN1857575A (en) * | 2006-04-13 | 2006-11-08 | 贵州信邦制药股份有限公司 | Compound Chinese medicine preparation for treating primary liver carcinoma caused by stagnation of liver-Qi and poisonous obstruction and its preparing process |
| CN102688317A (en) * | 2012-06-25 | 2012-09-26 | 鲁邦卫 | Traditional Chinese medicine for treating liver cancer |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108686158A (en) * | 2017-04-07 | 2018-10-23 | 北京蕴汇医药科技有限公司 | A kind of Chinese medicine composition and preparation method thereof for preventing hepatic precancerosis and liver cancer |
| CN108686158B (en) * | 2017-04-07 | 2021-03-16 | 北京蕴汇医药科技有限公司 | A Chinese medicinal composition for preventing and treating precancerous lesion of liver cancer and liver cancer, and its preparation method |
| CN107126527A (en) * | 2017-05-22 | 2017-09-05 | 何东良 | A kind of Chinese medicine composition and its preparation for treating liver cancer |
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Application publication date: 20130724 |