CN1032116C - Exfoliative agent of diseased nail and its making method - Google Patents
Exfoliative agent of diseased nail and its making method Download PDFInfo
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- CN1032116C CN1032116C CN 89103962 CN89103962A CN1032116C CN 1032116 C CN1032116 C CN 1032116C CN 89103962 CN89103962 CN 89103962 CN 89103962 A CN89103962 A CN 89103962A CN 1032116 C CN1032116 C CN 1032116C
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- nail
- exfoliation
- diseased nail
- sick
- diseased
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Abstract
The present invention provides an externally used diseased nail exfoliation agent which is composed of substrate materials processed by diseased nail exfoliation composition. The preferred substrate materials are terylene nonwoven fabric, polyester and cotton nonwoven fabric, vinylon nonwoven fabric and filter paper; the main component of the diseased nail exfoliation composition is urea which is matches with a given amount of polyethylene glycol and water for being made into a solution. The diseased nail exfoliation composition is sufficiently wet or is sprayed and spread on the substrate materials for forming finished products through drying. The diseased nail exfoliation agent is obviously better than a medicine covering nail exfoliation method, salicylic acid plaster, urea plaster, etc., and the diseased nail exfoliation agent has the advantages of good nail softening effect, short time for diseased nail exfoliation, simple production technique, low cost and resource saving.
Description
The present invention relates to a kind of new hygienic material, particularly the manufacture method of the Exfoliative agent of diseased nail made from carbamide etc.
The sick first of traditional removal, the method for treatment tinea unguium all adopt operation to pull out or oral drugs (as the griseofulvin treatment).But these method side effect are big, operation inconvenience, and reaction such as pain is arranged, also influence patient's work.
Remove for solving the problem that sick first exists, a kind ofly came out already with the medicine armored method of stripping off.As Farber in 1978 in the U.S. with carbamide ointment package stripping first, but operation more complicated, as: need earlier smear first week with the ketone musk of resting in peace, reuse adhesive plaster package normal skin also need be coated with layer of plastic film after smearing carbamide ointment on the fingernail, and then use the adhesive plaster package.Another kind method is the inventor's in 1981 invention achievement a---urea plaster.But owing to wherein contain plaster substrate such as gasoline, rubber, Colophonium, easily cause skin allergy, and need contact with sick first again that it is long to influence drug absorption, softening time of peeling off the disease first, and a large amount of cottons of need using up through " plaster substrate ".Also having a kind of method of peeling off the disease first, is the plaster made from salicylic acid etc., because salicylic acid is big to local irritation, easily causes skin allergy, and complicated operation, and cost is higher.
In sum, no matter be to pull out first or oral drugs, and strip off and remove the disease first that pain or anaphylaxis are all arranged, and the operation that has is more complicated also, and cost is higher with methods such as urea plaster and salicylic acid methods with the medicine armored with traditional operation.
The objective of the invention is to overcome the shortcoming of the sick Party A's method of above-mentioned existing removal, make a kind of simple to operate, no pain and anaphylaxis etc., can directly contact with sick first, make that to divest disease first material absorbing fast, softening to peel off the disease first time short, lower-cost Exfoliative agent of diseased nail.
The present invention is achieved in that the sick first of preparation strips off compositions, is substrate with the paper of non-woven fabrics or good water absorption, and sick first is stripped off full and uniform immersion of compositions or full and uniform being sprayed on non-woven fabrics or the paper, and drying is made finished product.
Particularly, to strip off the main component of compositions be carbamide to the used sick first of the present invention.Carbamide has another name called phosphoamide, and molecular formula is (NH
2) CO.It is not only a kind of good nitrogenous fertilizer and feedstuff, is medically can be used as dehydrant.The outer time spent also has antibacterial action, the protein dissolving, and Denaturation increases proteinic hydration, itching-relieving action etc.Carbamide also can significantly increase cuticular water content, makes horny layer swelling, reduces resistance, strengthens skin penetration power etc.The present invention adopts carbamide to strip off the main component of compositions as sick first, just be based on above characteristics, the carbamide of the used commercially available nitrogen content 46.7% of the present invention, be colourless crystallization or white crystalline powder, odorless, very easily water-soluble, the also easy moisture absorption, it strips off in sick first, and content is 15-50% in the compositions, is preferably 20-45% (weight).
The good water solubility of Polyethylene Glycol, and poor to ph stability, and therefore adding an amount of Polyethylene Glycol helps the set of carbamide on non-woven fabrics or paper.Polyethylene Glycol is in the present invention as adhering to the stability that crystallizing agent can strengthen Exfoliative agent of diseased nail.
The sick first that is used to prepare the present invention is stripped off the molecular weight of the Polyethylene Glycol of compositions can be in 500 to 5,000 scopes, and preferred molecular weight range is 1,000 to 4,000.Sick first of the present invention is stripped off the amount that adds Polyethylene Glycol in the compositions and is generally 2.5-35%.Be preferably 4-25% (weight).
The process for preparation that sick first is stripped off compositions is as follows: a certain amount of Polyethylene Glycol is dissolved in 30-55 ℃ of degree distilled water, makes Polyethylene Glycol colloid solution, in addition certain amount of urea also is dissolved in 30-55 ℃ of degree distilled water.Then this glue is stopped the urea liquid that the slow adding of solution has been dissolved in water, supply the water of surplus, be the disease first after stirring and strip off compositions.
The substrate material that is used to make the present invention's Exfoliative agent of diseased nail can be any natural or synthetic fibers and mix the non-woven fabrics that is spun into by above-mentioned natural and synthetic fibers.As: terylene non-woven fabric, polyester-cotton blend non-woven fabrics, wash numb non-woven fabrics, diacetate fiber non-woven fabrics and vinylon non-woven fabrics etc.Or the good paper of the water absorbing properties made from Caulis et Folium Oryzae, cotton, fiber crops etc. as: filter paper, a kind of white tissue paper, half-cooked rice paper etc. all can.Used commercially available terylene non-woven fabric in a preferred embodiment of the invention, polyester-cotton blend non-woven fabrics and vinylon non-woven fabrics and filter paper are as the substrate of making Exfoliative agent of diseased nail of the present invention.
The production technology of Exfoliative agent of diseased nail can adopt spraying or soak the starching seasoning.Sick first is stripped off on the full and uniform paper that is sprayed at good water absorption of compositions, fully spray or be infiltrated on non-woven fabrics, be finished product after drying, drying can make it natural drying or use the drying baker drying in heated dry air.
Embodiment one:
It is 30-55 ℃ distilled water that 10 gram Polyethylene Glycol are dissolved in the 30Ml temperature, obtains the Polyethylene Glycol colloid solution of homogeneous.The carbamide of 90 grams is dissolved in 30-55 ℃ of distilled water of 130ml temperature, stirs.Then the Polyethylene Glycol colloid solution for preparing is slowly poured in the urea liquid under continuing stirring, supplied 200ml, stir, promptly obtain water white sick first and strip off compositions with water.
The polyester-cotton blend non-woven fabrics is soaked in the sick first for preparing as stated above strips off in the compositions, treat that the polyester-cotton blend non-woven fabrics has been stripped off compositions by sick first and fully soaked into the back and take out and to take off the liquid drying, more than can at room temperature operate.Drying can adopt the also available drying baker drying of natural drying, makes finished product.The Exfoliative agent of diseased nail of finished product is that the even firm attachment of white crystalline powder is on non-woven fabrics.Urea content accounts for 90% in its white crystalline powder.
Embodiment two:
It is to be made into colloid solution in 30-55 ℃ of distilled water that 20 gram Polyethylene Glycol are dissolved in the 50ml temperature, it is in 30-55 ℃ of distilled water that 80 carbamide that restrain are dissolved in the 110ml temperature, stir, under continuing stirring, slowly add the Polyethylene Glycol colloid solution for preparing in the urea liquid, supply 200ml with water, the colourless transparent liquid that obtains after stirring is the disease first and strips off compositions.
The vinylon non-woven fabrics is soaked in the disease first strips off in the compositions, treat fully to soak into the back taking-up and take off the liquid drying, more than can at room temperature carry out.Can adopt the oven dry of natural drying or drying room, precut then and be packaged as finished product.Urea content accounts for 80% in the white crystalline powder on the Exfoliative agent of diseased nail of finished product.
Embodiment three:
It is in 30-55 ℃ of distilled water that 40 gram Polyethylene Glycol are dissolved in the 70ml temperature, makes colloid solution.It is in 30-55 ℃ of distilled water that 60 gram carbamide are dissolved in the 90ml temperature, be mixed with urea liquid, and under continuing stirring, Polyethylene Glycol colloid solution slowly added in the urea liquid, add water to 200ml, stir, resulting colourless transparent liquid is the disease first and strips off compositions.
It is even that the above-mentioned sick first for preparing is stripped off compositions, is sprayed at fully on the filter paper, more than can at room temperature carry out.In xeothermic air, make it natural drying, precut packing and make finished product.Urea content accounts for 60% in the white crystalline powder on the Exfoliative agent of diseased nail of finished product.
Embodiment four:
It is to be made into colloid solution in 30-55 ℃ of distilled water that 30 gram Polyethylene Glycol are dissolved in the 60ml temperature.It is in 30-55 ℃ of distilled water that 70 gram carbamide are dissolved in the 100ml temperature, be mixed with urea liquid, and under continuing stirring, the Polyethylene Glycol colloid solution for preparing slowly added in the urea liquid, supply 200ml with water, stir, the colourless transparent liquid that obtains is the disease first and strips off compositions.
Terylene non-woven fabric fully is soaked in the disease first strips off in the compositions, take out and take off the liquid drying.More than can at room temperature carry out.Drying can be in heated dry air drying or drying baker drying, precut then and be packaged as finished product, urea content accounts for 70% in the white crystalline powder on the Exfoliative agent of diseased nail of finished product.
External Exfoliative agent of diseased nail of the present invention is through sick first of 283 tinea unguium of clinical practice such as Beijing consonance (former capital) hospitals.The wide spring pedopathy of Beijing's twin-well chamber is peeled off softening 68 of the toenails that refer to altogether.Think that when peeling off the disease first Exfoliative agent of diseased nail can directly contact with sick first, absorb comparatively fast that hapalonychia is effective, the treatment required time is shorter, and is non-stimulated to local skin, and side effect such as contactless dermatitis take place.
Exfoliative agent of diseased nail of the present invention obviously is better than urea plaster and salicylic acid plaster etc., and And production technology is simple, and is with low cost, except being used for sick first, also can be used for corn, callosity Deng. And easy to use. But saving resource.
Claims (4)
1. manufacture method of stripping off the Exfoliative agent of diseased nail that compositions constitutes by substrate and sick first is characterized in that sick first is stripped off compositions fully soaks into or evenly be sprayed on the substrate material, through natural drying or oven dry and make; Wherein said substrate can be any natural or composite fibre materials, or mixes non-woven fabrics or the strong paper of water absorbing properties that is spun into by natural and synthetic fibers; It is to be that main matrix is equipped with the solution that Polyethylene Glycol and distilled water are made with carbamide that wherein said sick first is stripped off compositions.
2. according to the manufacture method of the Exfoliative agent of diseased nail of claim 1, it is characterized in that carbamide strips off in sick first that added amount is 15～50% in the compositions.
3. according to the manufacture method of the Exfoliative agent of diseased nail of claim 1, it is characterized in that Polyethylene Glycol strips off in sick first that added amount is 2.5～35% in the compositions.
4. according to the manufacture method of the Exfoliative agent of diseased nail of claim 1, it is characterized in that said substrate is selected from terylene non-woven fabric, polyester-cotton blend non-woven fabrics, vinylon non-woven fabrics and filter paper.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 89103962 CN1032116C (en) | 1989-06-23 | 1989-06-23 | Exfoliative agent of diseased nail and its making method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 89103962 CN1032116C (en) | 1989-06-23 | 1989-06-23 | Exfoliative agent of diseased nail and its making method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1048158A CN1048158A (en) | 1991-01-02 |
| CN1032116C true CN1032116C (en) | 1996-06-26 |
Family
ID=4855364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 89103962 Expired - Fee Related CN1032116C (en) | 1989-06-23 | 1989-06-23 | Exfoliative agent of diseased nail and its making method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1032116C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2844197B1 (en) * | 2002-09-05 | 2006-06-23 | Galderma Res & Dev | SOLUTION FOR UNIGEAL AND PERI-UNGEAL APPLICATION |
-
1989
- 1989-06-23 CN CN 89103962 patent/CN1032116C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1048158A (en) | 1991-01-02 |
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