CN103211620B - Breast carcinoma early-stage detecting instrument based on annular array opto-acoustic sensing technology - Google Patents
Breast carcinoma early-stage detecting instrument based on annular array opto-acoustic sensing technology Download PDFInfo
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Abstract
The invention provides a breast carcinoma early-stage detecting instrument based on annular array opto-acoustic sensing technology. The breast carcinoma early-stage detecting instrument based on the annular array opto-acoustic sensing technology comprises a detecting bed, an optical excitation unit, a signal collecting unit, a signal processing unit, a sensing unit, an outer controlling unit and an image displaying unit. A detecting window is formed in the detecting bed. A light permeating glass outer shell is arranged below the detecting window. The optical excitation unit comprises an annular array impulse laser tube, a lens system and a drive circuit. The signal collecting unit is a multiple-channel parallel collecting system. The sensing unit comprises an annular array supersonic sounding device, a supersonic coupling agent and a sealed container. The breast carcinoma early-stage detecting instrument based on the annular array opto-acoustic sensing technology is simple in structure, convenient to operate, low in cost, high in integration degree, easy to apply and popularize, capable of integrating opto-acoustic excitation, coupling and sensing and capable of achieving a small and practical system structure and meets the requirement of breast carcinoma clinical detection, obtains opto-acoustic cross-sectional images in the depth direction of a breast in real time and achieves breast carcinoma early-stage detection by carrying out CT scanning on the breast tissue.
Description
Technical field
The present invention relates to biomedical imaging and technical field of medical instruments, be specially a kind of breast carcinoma earlier detection instrument based on ring-like array light sound sensor technology.
Background technology
Breast carcinoma is one of modal malignant tumor of women, and the whole world about has 1,200,000 women to suffer from breast cancer every year, and about 500,000 women die from breast carcinoma.From late 1970s, breast carcinoma occupies the first place of female tumor always in the world, and every year with 2% speed increase, global breast carcinoma year in 2010 neopathy number of cases reach 1,400,000.Some city of current China such as breast carcinoma in Shanghai, Wuhan has accounted for first of female tumor morbidity, and the cities such as Beijing, Tianjin, Harbin also account for second.Therefore, the generation and the development that how effectively to control breast carcinoma become the task of top priority.
Be applied to clinical breast cancer diagnosis technology at present and mainly comprise mammary X-ray photography, nuclear magnetic resonance, NMR, ultra sonic imaging, the generation of breast carcinoma is easily brought out in mammary X-ray photography, the cost of nuclear magnetic resonance, NMR is too high, the contrast of ultra sonic imaging is lower, these three kinds of technology above-mentioned cannot be diagnosed the tumor that diameter is less than 3 millimeters, so the early diagnosis of breast carcinoma remains the problem being difficult at present solve.
Photoacoustic imaging is a kind of harmless medical imaging procedure newly of development in recent years, it combines the advantage of the high contrast features of pure optical imagery and the high-penetration depth characteristic of pure ultra sonic imaging, can provide the imaging of tissue of high-resolution and high-contrast.Because in biological tissue, 70% is water, ultrasonic penetration is good, so photoacoustic signal has extraordinary transmission characteristic in biological tissue, not by the impact of optical scattering; In addition, the luminous absorptance normal structure of early carcinomatous change tissue exceeds 2 ~ 5 times, has height image contrast, so photoacoustic imaging technology is applicable to the earlier detection of breast carcinoma very much.But, excitaton source vertical irradiation made by the powerful solid state laser of general employing at present, single detector or linear array detector is utilized to adopt the mode acquired signal of rotation sweep in side direction, adopt water or other liquid as ultrasonic coupling agent, device disperses, price is higher, and this imaging mode does not meet the requirement of Clinical detection, hinders its development and apply.
Summary of the invention
Technical problem solved by the invention is to provide a kind of breast carcinoma earlier detection instrument based on ring-like array light sound sensor technology, to solve the problem proposed in above-mentioned background technology.
Technical problem solved by the invention realizes by the following technical solutions:
A kind of breast carcinoma earlier detection instrument based on ring-like array light sound sensor technology, comprise and detect bed, light stimulus unit, signal gathering unit, signal processing unit, sensing unit, external control unit outside and image-display units, described detection bed is provided with detection window, be provided with transparent glass shell below detection window, described light stimulus unit comprises ring-like array pulse laser pipe, lens combination and drive circuit; Described signal gathering unit is multi-channel parallel acquisition system; Described sensing unit comprises annular array ultrasonic detector, ultrasonic coupling agent and sealed container; Described external control unit outside comprises motor and scan control circuit; Described ring-like array ultrasonic sensors and ring-like array pulse laser pipe are positioned on transparent glass shell, described ring-like array ultrasonic sensors is connected with scan control circuit by one-dimensional platform with ring-like array pulse laser pipe, described ring-like array ultrasonic sensors is connected with multi-channel parallel acquisition system by signal processing unit, described ring-like array pulse laser pipe is connected with laser diode control circuit by wire, and described multi-channel parallel acquisition system is connected with described signal display unit.
Further, described signal display unit is computer display.
Further, described signal processing unit comprises signal amplification circuit, gain control circuit, dynamic filter circuits, A/D change-over circuit and pulse signal source.
Further, described one-dimensional platform is by step motor drive.
Further, described pulse laser pipe adopts the tunable semiconductor laser diode of miniaturization.
Operation principle of the present invention is as follows:
(1) laser diode control circuit controls ring-like array pulse laser pipe and produces pulse laser, and pulse laser incides on breast tissue through transparent glass shell, and excitation produces photoacoustic signal;
(2) ring-like array ultrasonic sensors adopts lateral mode detection photoacoustic signal, obtains breast tissue depth direction photoacoustic signal data;
(3) change one-dimensional platform position at vertical direction up and down by scan control circuit, facilitate ring-like array ultrasonic sensors and ring-like array pulse laser pipe to obtain the photoacoustic signal of the multiple position of breast;
(4) photoacoustic signal of multi-channel parallel acquisition system to signal processing unit collection processes, and obtains the photoacoustic image of breast tissue and shows on signal display unit.
Beneficial effect:
The present invention has the following advantages;
(1) structure is simple, and easy and simple to handle, cost is low, and integration degree is high, is easy to application;
(2) integrate photo-acoustic excitation, coupling and sensing, achieve miniaturization and practical system structure, meet the requirement of breast carcinoma Clinical detection;
(3) the optoacoustic faultage image of breast depth direction is obtained in real time; Realize carrying out breast carcinoma earlier detection to the CT scan of breast tissue.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention;
Fig. 2 is the side view in A portion of the present invention.
In figure: 1, ring-like array pulse laser pipe, 2, ring-like array ultrasonic sensors, 3, multi-channel parallel acquisition system, 4, laser diode control circuit, 5, scan control circuit, 6, signal display unit, 7, transparent glass shell, 8, wire, 9, detection window, 10, bed is detected, 11, one-dimensional platform.
Detailed description of the invention
In order to make actualizing technology means of the present invention, creation characteristic, reach object and effect is easy to understand, below in conjunction with concrete diagram, set forth the present invention further.
As shown in Fig. 1 ~ 2, a kind of breast carcinoma earlier detection instrument based on ring-like array light sound sensor technology, comprise and detect bed 10, light stimulus unit, signal gathering unit, signal processing unit, sensing unit, external control unit outside and image-display units, described detection bed 10 is provided with detection window 9, be provided with transparent glass shell 7 below detection window 9, described light stimulus unit comprises ring-like array pulse laser pipe 1, lens combination and drive circuit; Described signal gathering unit is multi-channel parallel acquisition system 3; Described sensing unit comprises annular array ultrasonic detector 2, ultrasonic coupling agent and sealed container; Described external control unit outside comprises motor and scan control circuit 5; Described ring-like array ultrasonic sensors 2 and ring-like array pulse laser pipe 1 are positioned on transparent glass shell 7, described ring-like array ultrasonic sensors 2 is connected with scan control circuit 5 by one-dimensional platform 11 with ring-like array pulse laser pipe 1, described ring-like array ultrasonic sensors 2 is connected with multi-channel parallel acquisition system 3 by signal processing unit, described ring-like array pulse laser pipe 1 is connected with laser diode control circuit 4 by wire, and described multi-channel parallel acquisition system 3 is connected with described signal display unit 6.
Described signal display unit 6 is computer display.Described signal processing unit comprises signal amplification circuit, gain control circuit, dynamic filter circuits, A/D change-over circuit and pulse signal source.Described one-dimensional platform 11 is by step motor drive.Described pulse laser pipe 1 adopts the tunable semiconductor laser diode of miniaturization.
Embodiment 1,
Described pulse laser pipe 1 adopts pulse semiconductor laser diode, and its operation wavelength is 1550nm, and peak power is 45W, and pulsewidth is 150ns, and single pulse energy is about 6.75uJ, and dutycycle DF is 0.1%; Sealed container is provided with between transparent glass shell 7 and ring-like array ultrasonic sensors 2, wherein ultrasonic coupling agent is housed, the laser light transparent glass shell 7 that pulse semiconductor laser diode produces is radiated on breast tissue, and the photoacoustic signal of generation is detected by ultrasonic detector by ultrasonic coupling agent.Wherein, ring-like array pulse semiconductor laser diode, ring-like array ultrasonic sensors 2, transparent glass shell 7 constitute the integrated element exciting, be coupled and detect; Ring-like array pulse semiconductor laser diode and laser diode control circuit 4 form photo-acoustic excitation source, and 360 ° at transparent glass shell 7 circumferentially produce uniform ring-type light source; Ring-like array ultrasonic sensors 2 forms supersonic sounding and acquisition system with multi-channel parallel acquisition system 3, and the photoacoustic signal collected is sent to signal display unit 6; One-dimensional platform 11 and scan control circuit 5 form scanning control system, moved up and down by step motor drive one-dimensional platform, array pulse semiconductor laser diode, ring-like array ultrasonic sensors 2, glass shell 7 entirety are moved up and down, thus realizes the CT scan to breast tissue.
More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Claimed scope of the present invention is defined by appending claims and equivalent thereof.
Claims (5)
1. the breast carcinoma earlier detection instrument based on ring-like array light sound sensor technology, comprise and detect bed, light stimulus unit, signal gathering unit, signal processing unit, sensing unit, external control unit outside and signal display unit, it is characterized in that: described detection bed is provided with detection window, be provided with transparent glass shell below detection window, described light stimulus unit comprises ring-like array pulse laser pipe, lens combination and drive circuit; Described signal gathering unit is multi-channel parallel acquisition system; Described sensing unit comprises annular array ultrasonic detector, ultrasonic coupling agent and sealed container; Described external control unit outside comprises motor and scan control circuit; Described ring-like array ultrasonic sensors and ring-like array pulse laser pipe are positioned on transparent glass shell, described ring-like array ultrasonic sensors is connected with scan control circuit by one-dimensional platform with ring-like array pulse laser pipe, described ring-like array ultrasonic sensors is connected with multi-channel parallel acquisition system by signal processing unit, described ring-like array pulse laser pipe is connected with laser diode control circuit by wire, and described multi-channel parallel acquisition system is connected with described signal display unit.
2. a kind of breast carcinoma earlier detection instrument based on ring-like array light sound sensor technology according to claim 1, is characterized in that: described signal display unit is computer display.
3. a kind of breast carcinoma earlier detection instrument based on ring-like array light sound sensor technology according to claim 1, is characterized in that: described signal processing unit comprises signal amplification circuit, gain control circuit, dynamic filter circuits, A/D change-over circuit and pulse signal source.
4. a kind of breast carcinoma earlier detection instrument based on ring-like array light sound sensor technology according to claim 1, is characterized in that: described one-dimensional platform is by step motor drive.
5. a kind of breast carcinoma earlier detection instrument based on ring-like array light sound sensor technology according to claim 1, is characterized in that: described pulse laser pipe adopts the tunable semiconductor laser diode of miniaturization.
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| CN106073721A (en) * | 2016-07-26 | 2016-11-09 | 成都世恩医疗科技有限责任公司 | A kind of novel optoacoustic mammary gland imager |
| CN106725613A (en) * | 2016-12-28 | 2017-05-31 | 无锡祥生医学影像有限责任公司 | Breast ultrasound detecting system and the scanned imagery device for breast ultrasound detecting system |
| CN107174284A (en) * | 2017-07-08 | 2017-09-19 | 中北大学 | Breast ultrasound imaging system and its detection method based on CMUT annular arrays |
| CN108392187B (en) * | 2018-04-20 | 2021-08-20 | 四川知周光声医疗科技有限公司 | Water circulation system for photoacoustic breast imager |
| CN108814552A (en) * | 2018-04-20 | 2018-11-16 | 成都世恩医疗科技有限责任公司 | Optoacoustic transmission and motor scanning system and method for optoacoustic mammary gland imager |
| CN111772579B (en) * | 2020-05-25 | 2023-06-20 | 中国科学院深圳先进技术研究院 | Panoramic light follow-up device and photoacoustic imaging system thereof |
| CN113229848A (en) * | 2021-04-30 | 2021-08-10 | 武汉维视医学影像有限公司 | Ultrasonic tomography detection method with solid coupling medium and breast detection device |
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