CN103191838B - Curved surface body container for plasma continuous separation - Google Patents
Curved surface body container for plasma continuous separation Download PDFInfo
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- CN103191838B CN103191838B CN201210003575.XA CN201210003575A CN103191838B CN 103191838 B CN103191838 B CN 103191838B CN 201210003575 A CN201210003575 A CN 201210003575A CN 103191838 B CN103191838 B CN 103191838B
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Abstract
The invention relates to a curved surface body container used for plasma continuous separation. A separation lacuna is arranged inside the curved surface body container, blood is injected into the separation lacuna, the separation lacuna rotates at a high speed around the rotating shaft of the curved surface body container, blood components are separated by using centrifugal force according to density size, segmentation and regionalization are formed inside the separation lacuna, whole blood input is performed and visible components such as plasma, blood corpuscle and the like are respectively extracted out to achieve dynamical equilibrium, and continuous collection of a single component of plasma is achieved. In the invention, by optimally designing internal forms of the curved surface body container, closely linked to plasma flow rate, separation lacuna height, plasma separating factors, curve factors and the like, the thickness of the separation lacuna, particularly the thickness of a part close to a separation interface, is controlled, the curved surface body container is enabled to be more reasonable and has the advantage of improving single plasma collecting efficiency and quality.
Description
Technical field
The present invention relates to blood constituent and separate, particularly relate to blood plasma continuous centrifugal and separate the thinking and the method for designing that gather mean camber body container optimal design, make curved body container more reasonable.
Background technology
No matter be scientific research or clinical medicine practice or industrial production, and more occasion, all need blood to separate, as gone out single component from separation of whole blood, conventionally use centrifugal process from blood, to isolate various single components, for occasions such as clinical treatment, scientific research or raw materials.Modal is that whole blood is isolated to red blood cell, granulocyte, monocyte, blood platelet and blood plasma by centrifugal separation system, maybe the FRC washing after thawing is isolated to red blood cell and cleaning solution.
The operation principle of continuous centrifugal separation system is: the primary structure of said system includes centrifuge, infusion pump and control device; By the infusion pipeline that is connected with infusion pump, blood is introduced on centrifuge in the soft bag in knock-out drum, High Rotation Speed knock-out drum, and drive this soft bag synchronous high-speed to rotate, the not same-action that blood in it is subject to centrifugal force field causes the visible component such as blood plasma and blood cell to do centrifugal sedimentation campaign, and by the big or small layering of density or proportion or sedimentation coefficient separately; In the time reaching sedimentation equilibrium, arrange by the high to Low enrichment of density the each single component layer that forms concentric circles to axle center from periphery radially, then utilize infusion pump again the single component layer of separation to be extracted.
It is rotary power to be provided and to be played the effect of continuous input and extraction by airtight flexible pipe that blood single component is realized continuous acquisition in this system, one end of flexible pipe is communicated with the soft bag that separates in knock-out drum, with knock-out drum high-speed rotation, the other end of flexible pipe is fixed on support, therefore, rotation one end, flexible pipe one end is fixed, having in the middle of it coil arrangement to realize the flexible pipe solution of untwisting twines, make whole blood to be inputed in the knock-out drum of rotation under rotation status, and extract the single component such as blood plasma and blood cell out in the knock-out drum of rotation.Knock-out drum, i.e. separator disk, combines and has realized blood continuous centrifugal and separate with coil arrangement.
What in prior art, relate to the separator disk that is applied on blood continuous centrifugal separation equipment and coil arrangement mainly contains U.S. Pat 5360542.In this patent, separator disk be one columnar structured, be called knock-out drum, in it, have a columnar lacuna, soft bag is placed on the centrifugation that realizes blood in circular lacuna; Coil arrangement includes underframe, rotatable top-support, suspends knock-out drum in midair on top-support, a flexible pipe extend into knock-out drum bottom after fixing two bearings through top-support side in cabinet place, the end of its flexible pipe is a square spigot, extend in the square groove of knock-out drum central axis.Flexible pipe is hollow structure, has several transfer pipelines in it, and realize power provides and liquid conveying function simultaneously.Based on above-mentioned structure, power makes top-support rotation, drives flexible pipe untwist and produce torque forces, and this power transmission to knock-out drum is made it to produce rotating in same direction, and then realize the separation process of blood continuous centrifugal.
In Chinese patent application 200710046991.7, disclose the separator disk of another version.In this patent, point out: the separator disk in many cells composition mixing material piece-rate system, comprise durable hard chassis and disposable soft bag, the circular discs being formed by inner core and base on hard chassis, between inner core and base, form one section around continuous lacuna this hard chassis circle core shaft one week and that stem and afterbody do not seal, soft bag is for being provided with the single cavity structure of liquid inlet and outlet pipe, and this soft bag can be inserted in described lacuna.Because centrifugal force everywhere in described continuous lacuna is inconsistent, therefore, under centrifugal force continuous action, the each composition of mixing material is segmentation distribution in soft bag, can in above-mentioned segmentation, extract corresponding single component.Above-mentioned inner core is equivalent to described interior cylinder, base and is equivalent to described outer cylinder.Above-mentioned hard chassis that is to say separator disk.
No matter be foreign patent or domestic patent, all adopted separator disk to add the mode of soft bag, soft bag is disposable consumptive material parts.The mentality of designing difference that the separator disk of these two kinds of forms separates due to blood in actual use, the former is concentric design, and the latter is non-concentric design, and the latter's separative efficiency improves a lot compared with the former.Though the latter is comparatively ingenious with the design that separates soft bag on hard chassis, and has in practice certain effect, but still there is the leeway of the design of improving.
Summary of the invention
The object of the invention is to prior art to improve design the efficiency separating in the hope of improving efficiently blood plasma continuous centrifugal.The present invention relates to a kind of for blood plasma continuous separate from curved body container, curved body container of the present invention blood plasma continuous separate from can improve Plasma Pheresis/Apheresis Plasma efficiency and quality.
In order to reach foregoing invention object, the invention provides following technical scheme:
A kind of for blood plasma continuous separate from curved body container, it is characterized in that, in described curved body container, be provided with separation lacuna, described separation lacuna is the curved body that includes lateral wall and madial wall, and the curve of lateral wall curved surface projection in the plane perpendicular to rotating shaft of this separation lacuna is as follows with polar coordinate representation:
Wherein, polar limit O is the intersection point of rotating shaft and described plane, and polar pole axis L is the directions of rays that limit arrives curve most proximal end, the positive direction of polar angle is counterclockwise, r is the utmost point footpath of any point on curve, and R is the utmost point footpath of curve distal-most end, θ
1for the polar angle of curve initiating terminal, 0 degree that its value is this polar coordinate system, θ
2for curve and plasma separation factor critical radius F
rthe polar angle of intersection point, plasma separation factor critical radius F
rthe required minimum centrifugal radius of plasma separation in unit interval while determining for rotating speed, θ
3be a polar angle, its value is θ
21.5～3.5 times, θ
4for the polar angle of curve distal-most end; In described separation lacuna, [θ
1, θ
2) be blood plasma district, [θ
2, θ
3) be chaotic region, [θ
3, θ
4] be blood cell district, b
1for the curve coefficients in blood plasma district, b
2for the curve coefficients of chaotic region, b
3for the curve coefficients in blood cell district; The madial wall curved-surface shape of this separation lacuna can be identical with lateral wall, can be not identical yet, and θ
2＇ is for separating lacuna madial wall curve and plasma separation factor critical radius F
rthe polar angle of intersection point; Blood plasma district, chaotic region, blood cell district have different separation and collection effect while adopting inconsistent lacuna thickness, but the average thickness in region is that parameter is controlled in a design before and after separation lacuna closes on plasma separation interface; Described separation lacuna is at [θ
2, θ
2＇] interval be to close on to form the separated space region at plasma separation interface, this interval in, the curved surface of separation lacuna lateral wall and madial wall at spacing or the average headway D of rotating shaft vertical plane Projective Curve is:
Wherein K is constant, and v is that blood plasma is at [θ
2, θ
2＇] flow velocity in interval, h is for separating lacuna at the axial height of rotation, F (n
2, r) for separating lacuna at [θ
2, θ
2＇] centrifugal force in interval.The curved surface form of described separation lacuna lateral wall and madial wall is at [θ
2, θ
2＇] when identical in interval, it separates lacuna thickness and equates, therefore the curved surface of this separation lacuna lateral wall and madial wall is D in the spacing of rotating shaft vertical plane Projective Curve; The curved surface form of described separation lacuna lateral wall and madial wall is at [θ
2, θ
2＇] when different in interval, it is unequal that it separates lacuna thickness, and the curved surface of this separation lacuna lateral wall and madial wall is D at the average headway of rotating shaft vertical plane Projective Curve.
Space D is at interval [θ
2, θ
2＇] in be directly proportional to plasma flow rate, in the time that required separative efficiency is constant and plasma flow rate increases, blood plasma axial flow increases the drag force effect of the visible components such as the blood cell in closing on separating interface, therefore can increase this interval cavity volume by increasing spacing in this interval, reduce the flow velocity of blood plasma in this interval, reduce the drag force effect of blood plasma axial flow to visible components such as the blood cells in closing on separating interface to reach.
Space D is at interval [θ
2, θ
2＇] in separate lacuna height and be inversely proportional to, while separating the increase of lacuna height, the separation cavity volume in this interval is increased, increase the time that blood plasma stops in this interval, reduce separative efficiency, therefore control this interval separation cavity volume by adjusting spacing, to maintain the flow velocity of blood plasma in this interval.
Space D is at interval [θ
2, θ
2＇] in be inversely proportional to curved body arc length, when curved body arc length increases, the separation cavity volume in this interval increases, increase the time that blood plasma stops in this interval, reduce separative efficiency, thus this interval cavity volume controlled by adjusting spacing, to maintain the flow velocity of blood plasma in this interval.
Space D with separate lacuna at interval [θ
2, θ
2＇] in centrifugal force size be inversely proportional to.In the case of the height of plasma flow rate, curved body and arc length are all constant, centrifugal force increases, and the time that blood plasma stops in this interval domestic demand can reduce, therefore reduce this interval and separate cavity volume by reducing spacing; Square being directly proportional of the size of centrifugal force and rotating speed, is directly proportional to separation semidiameter, when therefore rotating speed or separation semidiameter increase, can reduce this interval cavity volume by reducing spacing.
In the situation that the conditions such as rotating speed, separation semidiameter, whole blood input flow velocity, curved body arc length are all constant, only change and separate lacuna, in the time that spacing is widened, make at this interval plasma separation interface to widen the unstable eddy current that input produces with whole blood and increase due to blood plasma axial flow face, cause separating interface diffusion, directly affect separating effect and efficiency; In the time that spacing narrows, because the axial flow face of blood plasma diminishes, flow velocity is accelerated, and blood plasma axial flow increases the drag force effect of the visible components such as blood cell, and the visible components such as blood cell are strengthened to the near-end disperse of blood plasma district, also can affect separating effect.
Based on foregoing invention content, the present invention carries out in the method for continuous centrifugal separation, having following technique effect compared with method of the prior art to blood:
1. the present invention separates in order to realize blood continuous centrifugal more efficiently, the factor that affects curved body Vessel Design from analyze continuous centrifugal separation process is set about, confirm that separating lacuna thickness is a key factor in design link, the Optimization Design of the curved body container of a continuous centrifugal separation has been proposed based on this thought, this curved body internal tank shows as one and separates lacuna, in this separation lacuna, can hold one and separate soft bag, when blood engorgement, separate soft bag and separate the lacuna inside and outside wall formation separated space that fits, in the separated space that blood forms at curved surface, carry out segmentation and regionalization according to density difference, the thickness that separates lacuna directly affects plasma separation efficiency by separated space, therefore to separating lacuna optimal design in curved body container, especially it closes on the thickness of separating interface part to control separation lacuna, in the hope of improving plasma separation efficiency.
2. the present invention is by optimizing and revising and control the design parameter of curved body container, and then affects plasma separation interface, realizes and do not increase separation costs, and can improve output and the quality of separated product.
Accompanying drawing explanation
Fig. 1 is centrifugal separation system structural representation.
Fig. 2 is curved body structural representation.
Fig. 3 is the curve synoptic diagram that separates outer wall curved surface projection in the plane perpendicular to rotating shaft of lacuna.
Fig. 4 separates the curved surface form of lacuna lateral wall and madial wall at [θ
2, θ
2＇] when identical in interval, at rotating shaft vertical plane Projective Curve spacing schematic diagram.
Fig. 5 separates the curved surface form of lacuna lateral wall and madial wall at [θ
2, θ
2＇] when different in interval, at the average headway schematic diagram of rotating shaft vertical plane Projective Curve.
Fig. 6 separates lacuna along the axial generalized section of rotation.
The specific embodiment
Below in conjunction with the drawings and specific embodiments, the present invention is described in further detail for the method that improves blood plasma continuous centrifugal separative efficiency; in the hope of understanding more lucidly version of the present invention and specific works flow process, but can not limit the scope of the invention with this.
The invention belongs to a kind of for blood plasma continuous separate from the method for designing of curved body container.As shown in Figure 1, the party's ratio juris is blood to be placed in to one have the curved body container that separates lacuna, by this separation container of High Rotation Speed, thereby blood plasma in blood and other visible components is separated.In blood, density differs and is red blood cell and blood plasma to the maximum, wherein erythrocytic density maximum, and the density minimum of blood plasma, and also the blood plasma of single component and red blood cell are the blood constituents of expense maximum in medical science.Therefore, the blood plasma in blood being carried out to continuous centrifugal separation is the most basic, the simplest component separation.
For blood plasma single component continuous separate from gather in, improve Plasma Pheresis/Apheresis Plasma efficiency and quality, therefore by optimal design and plasma flow rate, separate lacuna height, plasma separation factor, the closely related curved body internal tank form of curve coefficients, especially it closes on the thickness of separating interface part to control separation lacuna, make curved body container more reasonable, as shown in Figure 2, described separation lacuna 3 includes outer wall 2 and inwall 1, and the curve of outer wall curved surface projection in the plane perpendicular to rotating shaft of this separation lacuna is as follows with polar coordinate representation:
Wherein, as shown in Figure 3, polar limit O is the intersection point of rotating shaft and described plane, polar pole axis L is the ray that limit arrives curve initiating terminal direction, and the positive direction of polar angle is that r is the utmost point footpath of any point on curve clockwise, R is the utmost point footpath of curve distal-most end, θ
1for the polar angle of curve initiating terminal, 0 degree that its value is this polar coordinate system, θ
2for curve and plasma separation factor critical radius F
rthe polar angle of intersection point, plasma separation factor critical radius F
rthe required minimum centrifugal radius of plasma separation in unit interval while determining for rotating speed, θ
3be a polar angle, its value is θ
21.5～3.5 times, θ
4for the polar angle of curve distal-most end; In described separation lacuna, [θ
1, θ
2) be blood plasma district, [θ
2, θ
3) be chaotic region, [θ
3, θ
4] be blood cell district, b
1for the curve coefficients in blood plasma district, b
2for the curve coefficients of chaotic region, b
3for the curve coefficients in blood cell district; The madial wall curved-surface shape of this separation lacuna can be identical with lateral wall, also can be different, and θ
2＇ is for separating lacuna madial wall curve and plasma separation factor critical radius F
rthe polar angle of intersection point; Blood plasma district, chaotic region, blood cell district have different separation and collection effect while adopting inconsistent lacuna thickness, but the average thickness in region is that parameter is controlled in a design before and after separation lacuna closes on plasma separation interface; Described separation lacuna is at [θ
2, θ
2＇] interval be to close on to form the separated space region at plasma separation interface, this interval in, the curved surface of separation lacuna lateral wall and madial wall at spacing or the average headway D of rotating shaft vertical plane Projective Curve is:
Wherein K is constant, and v is that blood plasma is at [θ
2, θ
2＇] flow velocity in interval, h is for separating lacuna at the axial height of rotation, F (n
2, r) for separating lacuna at [θ
2, θ
2＇] centrifugal force in interval.The curved surface form of described separation lacuna lateral wall and madial wall is at [θ
2, θ
2＇] when identical in interval, it separates lacuna thickness and equates, as shown in Figure 4, therefore the curved surface of this separation lacuna lateral wall and madial wall is D in the spacing 4 of rotating shaft vertical plane Projective Curve; The curved surface form of described separation lacuna lateral wall and madial wall is at [θ
2, θ
2＇] when different in interval, it is unequal that it separates lacuna thickness, as shown in Figure 5, the curved surface of this separation lacuna lateral wall and madial wall is D at the average headway 5 of rotating shaft vertical plane Projective Curve, and in Fig. 5, D1, D2, D3 are the spacing that separates three diverse locations of lacuna.
Space D is at interval [θ
2, θ
2＇] in be directly proportional to plasma flow rate v, in the time that required separative efficiency is constant and plasma flow rate increases, blood plasma axial flow increases the drag force effect of the visible components such as the blood cell in closing on separating interface, increase this interval cavity volume therefore can increase spacing by design in this interval, reduce the flow velocity of blood plasma in this interval, reduce the drag force effect of blood plasma axial flow to visible components such as the blood cells in closing on separating interface to reach.
Space D is at interval [θ
2, θ
2＇] in separate lacuna height h and be inversely proportional to, while separating the increase of lacuna height, the separation cavity volume in this interval is increased, increase the time that blood plasma stops in this interval, reduce separative efficiency, therefore control this interval separation cavity volume by adjusting spacing, to maintain the flow velocity of blood plasma in this interval.
Space D is at interval [θ
2, θ
2＇] in be inversely proportional to curved body arc length, when curved body arc length increases, the separation cavity volume in this interval increases, increase the time that blood plasma stops in this interval, reduce separative efficiency, thus this interval cavity volume controlled by adjusting spacing, to maintain the flow velocity of blood plasma in this interval.
Space D with separate lacuna at interval [θ
2, θ
2＇] interior centrifugal force size F (n
2, r) be inversely proportional to.In the case of the height of plasma flow rate, curved body and arc length are all constant, centrifugal force increases, and the time that blood plasma stops in this interval domestic demand can reduce, therefore reduce this interval and separate cavity volume by reducing spacing; Square being directly proportional of the size of centrifugal force and rotating speed, is directly proportional to separation semidiameter, when therefore rotating speed or separation semidiameter increase, can reduce this interval cavity volume by reducing spacing.
In the situation that rotating speed, separation semidiameter, whole blood input flow velocity, curved body arc length are all constant, only change and separate lacuna, in the time that spacing is widened, make at this interval plasma separation interface to widen the unstable eddy current that input produces with whole blood and increase due to blood plasma axial flow face, cause separating interface diffusion, directly affect separating effect and efficiency; In the time that spacing narrows, because the axial flow face of blood plasma diminishes, flow velocity is accelerated, and blood plasma axial flow increases the drag force effect of the visible components such as blood cell, and the visible components such as blood cell are strengthened to the near-end disperse of blood plasma district, also can affect separating effect.
As shown in Figure 6, in this separation lacuna, can hold one and separate soft bag, when blood engorgement, separate soft bag and separate the lacuna inside and outside wall formation separated space that fits, in the separated space that blood forms at curved surface, carry out segmentation and regionalization according to density difference, therefore to separating lacuna optimal design in curved body container, realize and do not increase separation costs, and can improve output and the quality of separated product.
Embodiment 1
The separation lacuna of the present embodiment mean camber body container is made up of outer separator disk madial wall and interior separator disk lateral wall, and the curved surface form of the lateral wall of this separation lacuna and madial wall is identical, and its spacing D is:
Wherein, constant K equals 1.725*10
6, plasma flow rate is 80ml/min, separates lacuna height 50mm, curved body arc length is 120mm, b
2=0.2, θ
2=90
o, θ
2＇=145
o, separate lacuna [90
o, 145
o] centrifugal force in interval is 2300g, show that the spacing or the average headway that separate lacuna are 10mm.
When whole blood is full of after whole separation lacuna, whole blood continues input from blood inlet, and blood plasma continues from visible components such as blood plasma mouth and blood cells from blood cell mouth to extract out, and input quantity equates with discharge, the total liquid volume that makes to separate in lacuna keeps balance, thereby can realize the object of blood plasma continuous acquisition.
Certainly, structure composition and curve form that the method that the present invention separates blood continuous centrifugal is enumerated in above-described embodiment, can also be formed and curve form by other similar structures.Generally speaking, protection scope of the present invention also comprises the conversion that other it will be apparent to those skilled in the art that and substitutes.
Claims (3)
- One kind for blood plasma continuous separate from curved body container, it is characterized in that, in described curved body container, be provided with separation lacuna, described separation lacuna is the curved body that includes lateral wall and madial wall, and the curve of lateral wall curved surface projection in the plane perpendicular to rotating shaft of this separation lacuna is as follows with polar coordinate representation:
Wherein, polar limit O is the intersection point of rotating shaft and described plane, and polar pole axis L is the ray that limit arrives curve initiating terminal direction, the positive direction of polar angle is clockwise, r is the utmost point footpath of any point on curve, and R is the utmost point footpath of curve distal-most end, θ 1for the polar angle of curve initiating terminal, 0 degree that its value is this polar coordinate system, θ 2for curve and plasma separation factor critical radius F rthe polar angle of intersection point, plasma separation factor critical radius F rthe required minimum centrifugal radius of plasma separation in unit interval while determining for rotating speed, θ 3be a polar angle, its value is θ 21.5～3.5 times, θ 4for the polar angle of curve distal-most end; In described separation lacuna, [θ 1, θ 2) be blood plasma district, [θ 2, θ 3) be chaotic region, [θ 3, θ 4] be blood cell district, b 1for the curve coefficients in blood plasma district, b 2for the curve coefficients of chaotic region, b 3for the curve coefficients in blood cell district; θ 2＇ is drop shadow curve and the plasma separation factor critical radius F that separates lacuna madial wall curved surface rthe polar angle of intersection point; Described separation lacuna is at [θ 2, θ 2＇] interval in the curved surface of this separation lacuna lateral wall and madial wall in the space D of rotating shaft vertical plane Projective Curve be:
Wherein K is constant, and v is that blood plasma is at [θ 2, θ 2＇] flow velocity in interval, h is for separating lacuna at the axial height of rotation, F (n 2, r) for separating lacuna at [θ 2, θ 2＇] centrifugal force in interval. - According to claim 1 a kind of for blood plasma continuous separate from curved body container, it is characterized in that, described separation lacuna lateral wall and the curved surface form of madial wall are at [θ 2, θ 2＇] when identical in interval, it separates lacuna thickness and equates, and the curved surface of this separation lacuna lateral wall and madial wall is D in the spacing of rotating shaft vertical plane Projective Curve.
- According to claim 1 a kind of for blood plasma continuous separate from curved body container, it is characterized in that, described separation lacuna lateral wall and the curved surface form of madial wall are at [θ 2, θ 2＇] when different in interval, it is unequal that it separates lacuna thickness, and the curved surface of this separation lacuna lateral wall and madial wall is D at the average headway of rotating shaft vertical plane Projective Curve.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210003575.XA CN103191838B (en) | 2012-01-09 | 2012-01-09 | Curved surface body container for plasma continuous separation |
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| CN103191838B true CN103191838B (en) | 2014-05-28 |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4342420A (en) * | 1979-09-28 | 1982-08-03 | Gambro Dialysatoren Kg | Device for separating liquids, especially whole blood |
| US5360542A (en) * | 1991-12-23 | 1994-11-01 | Baxter International Inc. | Centrifuge with separable bowl and spool elements providing access to the separation chamber |
| US6277060B1 (en) * | 1998-09-12 | 2001-08-21 | Fresenius Ag | Centrifuge chamber for a cell separator having a spiral separation chamber |
| CN101172207A (en) * | 2007-10-12 | 2008-05-07 | 经建中 | Separator disk on multi-cell component mix liquid separating system and application method of the same |
| CN202526652U (en) * | 2012-01-09 | 2012-11-14 | 金卫医疗科技(上海)有限公司 | Curved surface container for controlling separation interface |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7473216B2 (en) * | 2005-04-21 | 2009-01-06 | Fresenius Hemocare Deutschland Gmbh | Apparatus for separation of a fluid with a separation channel having a mixer component |
-
2012
- 2012-01-09 CN CN201210003575.XA patent/CN103191838B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4342420A (en) * | 1979-09-28 | 1982-08-03 | Gambro Dialysatoren Kg | Device for separating liquids, especially whole blood |
| US5360542A (en) * | 1991-12-23 | 1994-11-01 | Baxter International Inc. | Centrifuge with separable bowl and spool elements providing access to the separation chamber |
| US6277060B1 (en) * | 1998-09-12 | 2001-08-21 | Fresenius Ag | Centrifuge chamber for a cell separator having a spiral separation chamber |
| CN101172207A (en) * | 2007-10-12 | 2008-05-07 | 经建中 | Separator disk on multi-cell component mix liquid separating system and application method of the same |
| CN202526652U (en) * | 2012-01-09 | 2012-11-14 | 金卫医疗科技(上海)有限公司 | Curved surface container for controlling separation interface |
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