CN103191170A - Healthcare product for auxiliary treatment of type 2 diabetes, and preparation method thereof - Google Patents
Healthcare product for auxiliary treatment of type 2 diabetes, and preparation method thereof Download PDFInfo
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- CN103191170A CN103191170A CN2012100038230A CN201210003823A CN103191170A CN 103191170 A CN103191170 A CN 103191170A CN 2012100038230 A CN2012100038230 A CN 2012100038230A CN 201210003823 A CN201210003823 A CN 201210003823A CN 103191170 A CN103191170 A CN 103191170A
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Abstract
The invention discloses a healthcare product for the auxiliary treatment of type 2 diabetes, and a preparation method thereof, and relates to the medical healthcare field. The preparation method of the healthcare product comprises the following steps: taking towel gourd seeds of towel gourds, cleaning, baking in a 20-50DEG C baking box, shelling, grinding the shelled towel gourd seeds to form fine powder, and adding auxiliary materials to prepare a pharmaceutically acceptable formulation. The cooperation of the healthcare product and other blood sugar reducing medicines allows the fasting blood sugar of a type 2 diabetic patient to be stably reduced, and the effect to be more substantial than the single use of the blood sugar reducing medicines and blood sugar reducing healthcare products, and has no side effects.
Description
Technical field
The present invention relates to a kind of health product of auxiliary treatment type 2 diabetes mellitus, specifically is the health product that raw material is sneaked into suitable adjuvant preparation with the Chinese herbal medicine.The invention still further relates to preparation method and the using method of these health product.
Background technology
Diabetes, ancient claim " diabetes " is to be caused by the h and E factor interaction.Hyperglycemia is the clinical outstanding features of diabetes.Diabetes have become after tumor, cardiovascular and cerebrovascular disease the serious disease of harm humans health because its sickness rate height, complication are serious.Absolute or the relative hyposecretion of the insulin that diabetes cause and target tissue cell reduce insulin sensitivity, can cause a series of metabolism disorder syndromes such as protein, fat, power and water Xie Zhi, if can not get effective treatment, finally can cause diabetic complication, comprise: diabetic neuropathy, diabetic renal papillary necrosis and diabetic nephropathy.In case develop complications, will be difficult to cure, need to accept lifelong treatment, bring great misery to the patient.
Therefore, for the prevention type 2 diabetes mellitus become particularly important.At present the blood glucose-lowering health-care product majority is the Chinese medicine compound that several Chinese medicines are formed, and not only toxicity is than higher, and is difficult to grasp standardization and the quantification of effective ingredient.Therefore, use folk prescription to go to develop blood glucose-lowering health-care product and have lot of advantages: almost non-toxic property is easy to standardization and quantification, economic dispatch.
Semen Luffae is traditional simply Chinese medicine, but go out the earliest in end of the Ming Dynasty Yao Cheng Suozhu " food book on Chinese herbal medicine ", " China book on Chinese herbal medicine " also is documented.Its bitter in the mouth; Cold in nature.Function mainly shows as: heat clearing away; Diuretic; Relieving constipation; Anthelmintic.Main edema; Stranguria caused by urinary stone; The cough due to lung-heat; Discharging fresh blood stool; Anal fistula; Constipation; Ascariasis.Therefore, Semen Luffae can have no side effect to human body directly as medicinal, and is safe and reliable.For the research of Semen Luffae, currently mainly concentrate on the strand ribosome inactivating protein that separation obtains in the Semen Luffae, do not see the research report of its blood sugar lowering aspect as yet, more be not made into the report of auxiliary treatment type 2 diabetes mellitus health product.
Summary of the invention
The purpose of this invention is to provide and a kind ofly sneak into proper supplementary material by natural drug and make health product, be used for the auxiliary treatment type 2 diabetes mellitus, preparation method and the using method of health product also is provided simultaneously.
An important feature of the present invention is that these health product are to add that by the natural drug Semen Luffae suitable adjuvant is formulated, has no side effect, take easy, economy, effect is remarkable.Simultaneously, because composition is simple, so quantification and standardization easily.Find by clinical research, the Chinese medicine Semen Luffae is sneaked into the health product that specific adjuvant is prepared into and is cooperated other hypoglycemic drugs to use, reduction type 2 diabetes mellitus patient's that can be stable fasting blood sugar, effect is more remarkable with hypoglycemic drug and health-caring product capable of reducing blood sugar than single, and is free from side effects.
Health product of the present invention by following component by weight percentage composition mix and to form:
Semen Luffae powder 50-90% beta-schardinger dextrin-10-50%
For guaranteeing product quality, all working portion carries out in the environment that meets health product production standard, mainly contains following steps:
1) preparation of Semen Luffae powder: get the Semen Luffae of Fructus Luffae, clean, place 40-50 ℃ of baking oven, after 12-18 hour, shell, Semen Luffae core is placed pulverizer, pulverize 10-20 second, cross 100 mesh sieves and can obtain the Semen Luffae powder.
2) add adjuvant by weight percentage, as the beta-schardinger dextrin-that can directly be bought by market.
3) final, behind the above-mentioned raw materials mix homogeneously, No. 1 capsule of packing in the environment of health product production standard is packed, and obtains health product of the present invention.
Health product of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into the preparation of any routine, for example above-mentioned crude drug are made tablet, pill is oral, perhaps make powder and take after mixing it with water etc.But these can not be used for restriction protection scope of the present invention.
For the effect of the auxiliary hyperglycemic that shows health product of the present invention, select 30 routine type 2 diabetes mellitus volunteers clinically for use, the age is between 46-60 between year.During treating, the patient takes blood sugar lowering class medicine and Semen Luffae capsule originally simultaneously, take night and morning, one time 2,2 times on the one, 7 days courses for the treatment of.The dosage range of every day is generally 0.1-10g, and the dosage range with every day is that the 0.2-1g effect is preferable especially.After the course for the treatment of, measure its fasting blood sugar.Statistical result is seen Fig. 1.Simultaneously, experimental result also shows: Semen Luffae or Semen Luffae capsule can be united use with other antidiabetic drugs, and its effect is than using hypoglycemic drug significantly (P＜0.01) separately.Illustrate that Semen Luffae or Semen Luffae capsule can be used as health product auxiliary treatment type 2 diabetes mellitus.Table 1 has exemplified 3 routine clinical implementation cases.
Table 1 the present invention treats type 2 diabetes mellitus patient's instantiation
Select for use simultaneously the volunteer of 30 routine impaired glucose tolerance for the effectiveness of estimating the Semen Luffae capsule clinically again.The unusual person of so-called glycosuria amount refers to patient's fasting blood sugar between 6.1-7.0mmol/L, clinically thinks that this class people is easy to change into type 2 diabetes mellitus, though this class people does not need Drug therapy, needs to control blood glucose, prevents from changing into type 2 diabetes mellitus.During treating, the patient takes the Semen Luffae capsule, take night and morning, one time 1,2 times on the one, 7 days courses for the treatment of.After the course for the treatment of, measure its fasting blood sugar.Statistical result is seen Fig. 2.The result shows: the Semen Luffae capsule is for the therapeutic effect of carbohydrate tolerance patient and potential diabetics significantly (P＜0.01), because the source of Semen Luffae capsule is natural drug, health has no side effect, and is used for the prevention type 2 diabetes mellitus so can make health product or food.Table 2 has exemplified 3 routine clinical implementation cases.
Table 2 the present invention treats carbohydrate tolerance patient's instantiation
Therefore, according to above result, illustrate that Semen Luffae or Semen Luffae capsule can be used as a kind of health product, be used for auxiliary treatment or prevention type 2 diabetes mellitus.Have no side effect, take easy, economy, effect is remarkable.
The specific embodiment
The preparation of embodiment 1 capsule of the present invention
Semen Luffae powder 67% beta-schardinger dextrin-33%
Concrete preparation process is as follows: get the Semen Luffae of Fructus Luffae, clean, place 40 ℃ of baking ovens, after 15 hours, shell, Semen Luffae core is placed pulverizer, pulverize 10-20 second, cross 100 mesh sieves and can obtain the Semen Luffae powder.Again by above-mentioned state proportioning and carry out batch mixing after, get thin medicated powder and incapsulate, every capsules contains Semen Luffae powder 0.15g.
The preparation of embodiment 2 tablets of the present invention
Semen Luffae powder 95% starch 5%
Adopt the method for embodiment 1 to obtain the Semen Luffae powder, precentagewise is sneaked into adjuvant: starch and sodium benzoate, and evenly mix the back tabletting and make tablet, every contains Semen Luffae powder 0.15g.
The preparation of embodiment 3 tablets of the present invention
Semen Luffae powder 95% vitamin C 5%
Concrete preparation process is as follows: get the Semen Luffae of Fructus Luffae, clean, place 50 ℃ of baking ovens, after 10 hours, shell, Semen Luffae core is placed pulverizer, pulverize 10-20 second, cross 100 mesh sieves and can obtain the Semen Luffae powder.Again by above-mentioned state proportioning and carry out batch mixing after, get thin medicated powder and incapsulate, every capsules contains Semen Luffae powder 0.15g.
Clinical experiment result 1
The treatment number: 20 people, the age: in 30-70 year, clinical diagnosis portion is the type 2 diabetes mellitus patient, portion is at use in various degree commercially available hypoglycemic drug and health product, as: metformin hydrochloride, sulfonylurea drugs, insulin injection etc.Unite and take the present invention, take night and morning, one time 2,2 times on the one, 7 days courses for the treatment of.After the course for the treatment of, measure its fasting blood sugar.Fig. 1 is that the present invention is to fasting glucose statistical result relatively before and after the 20 routine type 2 diabetes mellitus patient treatments, can be drawn by figure, the Semen Luffae capsule is united other commercially available hypoglycemic drugs can obviously reduce type 2 diabetes mellitus patient's fasting blood sugar, hypoglycemic effect highly significant (P＜0.01), and effect is more obvious than using commercially available hypoglycemic drug and health-caring product capable of reducing blood sugar effect separately.
Clinical experiment result 2
The treatment number: 20 people, the age: in 30-70 year, clinical diagnosis is impaired glucose tolerance, and the risk that is converted into type 2 diabetes mellitus is very big.If untimely treatment just is easy to be converted into the type 2 diabetes mellitus patient.Take the present invention, take night and morning, one time 1,2 times on the one, 7 days courses for the treatment of.After the course for the treatment of, measure its fasting blood sugar.Fig. 2 is that the present invention is to fasting glucose statistical result (P＜0.01) relatively before and after the 20 routine impaired glucose tolerance patient treatments; can be drawn by figure; the Semen Luffae capsule can drop to all carbohydrate tolerance patients' fasting blood sugar safety value following (6.1mmol/L is following), and does not have any untoward reaction.
Above embodiments of the present invention are described in detail, but the present invention is not limited to above-mentioned embodiment, in the ken that those of ordinary skills possess, can also under the prerequisite that does not break away from aim of the present invention, makes various variations.
Claims (9)
1. the health product of an auxiliary treatment type 2 diabetes mellitus is characterized in that, mainly add that by cmm of simple prescription Semen Luffae powder a certain amount of adjuvant and additive form, and wherein the percentage ratio of each constituent content is: Semen Luffae powder 50-90%, adjuvant 10-50%.
2. health product according to claim 1, it is characterized in that described adjuvant is to be selected from following one or more adjuvant kind: pregelatinized Starch, starch, dextrin, calcium sulfate, microcrystalline Cellulose, light magnesium oxide, maltodextrin, lactose, mannitol, polyvidone, sodium alginate, xanthan gum, sodium carboxymethyl cellulose, kaolin, aluminium-magnesium silicate, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone, carboxymethyl starch sodium, magnesium stearate, calcium stearate, oil with hydrogenated soybean, silicon dioxide, methylcellulose, ethyl cellulose, hyprolose, hypromellose, cellulose acetate, fiber vinegar method fat, polymethacrylates, zein, Glyceryl Behenate, polyvinyl alcohol, carbomer, pectin, vitamin E or vitamin C etc.
3. health product according to claim 1 is characterized in that, described adjuvant is beta-schardinger dextrin-.
4. health product according to claim 1 is characterized in that, the percentage composition of wherein said Semen Luffae powder is 67%, and the adjuvant percentage composition is 33%.
5. according to the preparation method of each described health product in the claim 1 to 5, it is characterized in that, get the Semen Luffae of Fructus Luffae, clean, place baking oven, 20-50 ℃ of oven dry; After shelling, Semen Luffae core is placed pulverizer, pulverize 10-20 second, cross 100 mesh sieves and can obtain the Semen Luffae powder; Sneak into adjuvant and additive by weight percentage; Then, make the preparation of accepting on the pharmaceutics.
6. the preparation method of health product according to claim 6, it is characterized in that described preparation is tablet, capsule, granule, oral liquid, pill, suspensoid, drop pill, pellet, buccal tablet, soft gelatin capsule, soft capsule, spray, aerosol, cataplasma or patch.
7. preparation method according to claim 6 is characterized in that, in the Semen Luffae oven dry processing procedure, the baking oven established temperature is 40 ℃.
8. according to the using method of each described health product in the claim 1 to 5, it is characterized in that every day, the dosage range of Semen Luffae powder was 0.1-10g.
9. according to the using method of each described health product in the claim 1 to 5, it is characterized in that every day, the dosage range of Semen Luffae powder was 0.2-1g.
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| CN201210003823.0A CN103191170B (en) | 2012-01-08 | 2012-01-08 | Healthcare product for auxiliary treatment of type 2 diabetes, and preparation method thereof |
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| CN201210003823.0A CN103191170B (en) | 2012-01-08 | 2012-01-08 | Healthcare product for auxiliary treatment of type 2 diabetes, and preparation method thereof |
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| CN103191170A true CN103191170A (en) | 2013-07-10 |
| CN103191170B CN103191170B (en) | 2015-05-13 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103190608A (en) * | 2012-01-10 | 2013-07-10 | 江苏众红生物工程创药研究院有限公司 | Health food or prevention of type 2 diabetes and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1348778A (en) * | 2000-10-17 | 2002-05-15 | 赵蕊芬 | Pure Chinese medicinal preparation for treating AIDS, cancer, hepatitis, diabetes and angiopathy |
| CN1923848A (en) * | 2006-09-18 | 2007-03-07 | 张聪 | Melon seed polypeptide |
| CN103191171A (en) * | 2012-01-07 | 2013-07-10 | 江苏众红生物工程创药研究院有限公司 | Natural medicine for treating 2 type diabetes, and preparation method thereof |
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2012
- 2012-01-08 CN CN201210003823.0A patent/CN103191170B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1348778A (en) * | 2000-10-17 | 2002-05-15 | 赵蕊芬 | Pure Chinese medicinal preparation for treating AIDS, cancer, hepatitis, diabetes and angiopathy |
| CN1923848A (en) * | 2006-09-18 | 2007-03-07 | 张聪 | Melon seed polypeptide |
| CN103191171A (en) * | 2012-01-07 | 2013-07-10 | 江苏众红生物工程创药研究院有限公司 | Natural medicine for treating 2 type diabetes, and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 江苏新医学院: "《中药大辞典》", 30 June 1986 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103190608A (en) * | 2012-01-10 | 2013-07-10 | 江苏众红生物工程创药研究院有限公司 | Health food or prevention of type 2 diabetes and preparation method thereof |
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| CN103191170B (en) | 2015-05-13 |
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Address after: 213125 Jiangsu city of Changzhou Province Cloud River New District No. 518 Changzhou Qianhong biochemical pharmaceutical biological all red Patentee after: ZonHon Biopharma Institute Inc. Address before: 213022 Room 405, Hua Guan Pioneer Center, 132 middle the Yellow River Road, Xinbei District, Jiangsu, Changzhou Patentee before: ZonHon Biopharma Institute Inc. |
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Address after: 213125, Yunhe Road, Xinbei District, Jiangsu, Changzhou, 518 Patentee after: ZonHon Biopharma Institute Inc. Address before: 213125 Jiangsu city of Changzhou Province Cloud River New District No. 518 Changzhou Qianhong biochemical pharmaceutical biological all red Patentee before: ZonHon Biopharma Institute Inc. |
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Effective date of registration: 20190327 Address after: 213125 No. 518 Yunhe Road, Xinbei District, Changzhou City, Jiangsu Province Patentee after: Jiangsu Jingsen Biomedical New Materials Technology Co., Ltd. Address before: 213125 No. 518 Yunhe Road, Xinbei District, Changzhou City, Jiangsu Province Patentee before: ZonHon Biopharma Institute Inc. |