CN103189371B - 丙型肝炎病毒抑制剂 - Google Patents

丙型肝炎病毒抑制剂 Download PDF

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Publication number
CN103189371B
CN103189371B CN201180053127.4A CN201180053127A CN103189371B CN 103189371 B CN103189371 B CN 103189371B CN 201180053127 A CN201180053127 A CN 201180053127A CN 103189371 B CN103189371 B CN 103189371B
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CN
China
Prior art keywords
alkyl
methyl
mmol
carbonyl
reaction mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201180053127.4A
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English (en)
Chinese (zh)
Other versions
CN103189371A (zh
Inventor
罗伯特·默里·麦金内尔
丹尼尔·D·朗
洛里·琼·范奥登
姜岚
曼迪·洛
大介·罗兰·齐藤
希拉·齐普费尔
埃里克·L·施坦格兰
卡萨德拉·莱帕科
加文·奥加瓦
黄晓军
张伟江
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Theravance Biopharma R&D IP LLC
Original Assignee
Theravance Biopharma R&D IP LLC
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Filing date
Publication date
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Publication of CN103189371A publication Critical patent/CN103189371A/zh
Application granted granted Critical
Publication of CN103189371B publication Critical patent/CN103189371B/zh
Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201180053127.4A 2010-11-04 2011-11-03 丙型肝炎病毒抑制剂 Expired - Fee Related CN103189371B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US41026710P 2010-11-04 2010-11-04
US61/410,267 2010-11-04
US201161444046P 2011-02-17 2011-02-17
US61/444,046 2011-02-17
US201161492267P 2011-06-01 2011-06-01
US61/492,267 2011-06-01
PCT/US2011/059061 WO2012061552A1 (en) 2010-11-04 2011-11-03 Novel inhibitors of hepatitis c virus

Publications (2)

Publication Number Publication Date
CN103189371A CN103189371A (zh) 2013-07-03
CN103189371B true CN103189371B (zh) 2015-04-01

Family

ID=44993923

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180053127.4A Expired - Fee Related CN103189371B (zh) 2010-11-04 2011-11-03 丙型肝炎病毒抑制剂

Country Status (9)

Country Link
US (2) US8921372B2 (enExample)
EP (1) EP2635571B1 (enExample)
JP (1) JP5891235B2 (enExample)
CN (1) CN103189371B (enExample)
AR (1) AR083757A1 (enExample)
CA (1) CA2814534A1 (enExample)
ES (1) ES2548286T3 (enExample)
TW (1) TW201249827A (enExample)
WO (1) WO2012061552A1 (enExample)

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NZ581823A (en) * 2007-06-12 2012-09-28 Technolines Llc High speed and high power laser scribing system with a laser, mirror and controller
US8937150B2 (en) 2009-06-11 2015-01-20 Abbvie Inc. Anti-viral compounds
RS52854B (sr) 2009-06-11 2013-12-31 Abbvie Bahamas Limited Inhibitori hepatitis c virusa
NZ605440A (en) 2010-06-10 2014-05-30 Abbvie Bahamas Ltd Solid compositions comprising an hcv inhibitor
WO2012061552A1 (en) * 2010-11-04 2012-05-10 Theravance, Inc. Novel inhibitors of hepatitis c virus
US8552047B2 (en) 2011-02-07 2013-10-08 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9546160B2 (en) 2011-05-12 2017-01-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
SI2723732T1 (sl) 2011-06-22 2017-05-31 Purdue Pharma Lp One Stamford Forum Antagonisti trpv1, vključno z dihidroksi substituentom, in njihova uporaba
SG11201401891RA (en) * 2011-11-03 2014-05-29 Theravance Inc Rod -like hepatitis c virus inhibitors containing the fragement {2- [4- (bi phenyl - 4 - yl) - 1h - imidazo - 2 - yl] pyrrolidine - 1 - carbonlymethyl} amine
US9034832B2 (en) 2011-12-29 2015-05-19 Abbvie Inc. Solid compositions
US9326973B2 (en) 2012-01-13 2016-05-03 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
PT2850075T (pt) 2012-04-25 2017-05-02 Theravance Biopharma R&D Ip Llc Compostos de piperazina-piperidina como inibidores do vírus da hepatite c
CA2869908C (en) * 2012-04-25 2018-02-20 Theravance Biopharma R&D Ip, Llc Hepatitis c virus inhibitors
WO2013165796A1 (en) * 2012-05-03 2013-11-07 Theravance, Inc. Crystalline form of a pyridyl-piperazinyl hepatitis c virus inhibitor
US11484534B2 (en) 2013-03-14 2022-11-01 Abbvie Inc. Methods for treating HCV
US9717712B2 (en) 2013-07-02 2017-08-01 Bristol-Myers Squibb Company Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus
US20150023913A1 (en) 2013-07-02 2015-01-22 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
JP2016527232A (ja) 2013-07-17 2016-09-08 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｈｃｖの治療に使用するためのビフェニル誘導体を含む組み合わせ
EP3089757A1 (en) 2014-01-03 2016-11-09 AbbVie Inc. Solid antiviral dosage forms
US10617675B2 (en) 2015-08-06 2020-04-14 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
CN105175401A (zh) * 2015-10-16 2015-12-23 北京康立生医药技术开发有限公司 一种依匹哌唑的制备方法
CN112409336B (zh) * 2017-11-27 2021-09-14 常州寅盛药业有限公司 适于工业化生产的达卡他韦起始原料的合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101558059A (zh) * 2006-08-11 2009-10-14 百时美施贵宝公司 丙型肝炎病毒抑制剂

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0421908D0 (en) * 2004-10-01 2004-11-03 Angeletti P Ist Richerche Bio New uses
PT1940786E (pt) * 2005-09-16 2010-10-04 Arrow Therapeutics Ltd Derivados de bifenilo e sua utilização no tratamento de hepatite c
US7659270B2 (en) 2006-08-11 2010-02-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8303944B2 (en) 2006-08-11 2012-11-06 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7745636B2 (en) 2006-08-11 2010-06-29 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8329159B2 (en) * 2006-08-11 2012-12-11 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7910722B2 (en) * 2007-07-05 2011-03-22 Florida State University Research Foundation RNAi therapeutic for treatment of hepatitis C infection
SI2250163T1 (sl) 2008-02-12 2012-08-31 Bristol Myers Squibb Co Hepatitis c virus inhibitorji
JP2012510525A (ja) 2008-12-03 2012-05-10 プレシディオ ファーマシューティカルズ インコーポレイテッド Ｈｃｖｎｓ５ａの阻害剤
WO2010094977A1 (en) 2009-02-23 2010-08-26 Arrow Therapeutics Limited Novel biphenyl compounds useful for the treatment of hepatitis c
EP2398474A4 (en) 2009-02-23 2012-12-05 Presidio Pharmaceuticals Inc HCV NS5A SHEMMER
US8822700B2 (en) 2009-09-11 2014-09-02 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
WO2011031934A1 (en) 2009-09-11 2011-03-17 Enanta Pharmaceuticals, Inc. Hepatitis c virus inhibitors
US8653070B2 (en) 2009-12-14 2014-02-18 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US8377980B2 (en) 2009-12-16 2013-02-19 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2011153396A1 (en) 2010-06-04 2011-12-08 Enanta Pharmaceuticals, Inc Hepatitis c virus inhibitors
WO2012061552A1 (en) * 2010-11-04 2012-05-10 Theravance, Inc. Novel inhibitors of hepatitis c virus
SG11201401891RA (en) 2011-11-03 2014-05-29 Theravance Inc Rod -like hepatitis c virus inhibitors containing the fragement {2- [4- (bi phenyl - 4 - yl) - 1h - imidazo - 2 - yl] pyrrolidine - 1 - carbonlymethyl} amine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101558059A (zh) * 2006-08-11 2009-10-14 百时美施贵宝公司 丙型肝炎病毒抑制剂

Also Published As

Publication number Publication date
US20150071878A1 (en) 2015-03-12
AR083757A1 (es) 2013-03-20
US8921372B2 (en) 2014-12-30
EP2635571A1 (en) 2013-09-11
CN103189371A (zh) 2013-07-03
JP5891235B2 (ja) 2016-03-22
WO2012061552A1 (en) 2012-05-10
CA2814534A1 (en) 2012-05-10
US20120114600A1 (en) 2012-05-10
US9260414B2 (en) 2016-02-16
ES2548286T3 (es) 2015-10-15
JP2013544812A (ja) 2013-12-19
TW201249827A (en) 2012-12-16
EP2635571B1 (en) 2015-08-12

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: SCHWAN BIOPHARMA RESEARCH + DEVELOPMENT IP CO., LT

Free format text: FORMER OWNER: SCHWAN PHARMACY

Effective date: 20140828

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20140828

Address after: American California

Applicant after: THERAVANCE BIOPHARMA R.D IP, LLC

Address before: American California

Applicant before: Shiwan Pharmaceuticals Inc.

C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20150401

Termination date: 20181103