CN103156943A - Medicament for treating infertility of obstructive uterine tube - Google Patents

Abstract

The invention relates to a medicament for treating infertility of obstructive uterine tube. The infertility of obstructive uterine tube leads to the clinical symptoms of medical histories such as infertility, pelvic pain, artificial abortion or not and medical abortion. Through an gynecological examination, the adnexa areas at both sides show thickening and have tenderness, and the uterine tube is tested to be completely obstructed or partially obstructed. After a long-term research and clinical verifications, an oral medicament of traditional Chinese medicine for treating infertility of obstructive uterine tube with better curative effect is finally found by the inventor. The dosage of the medicament compositions provided by the invention is also gained through a great deal of development by the inventor and the optimum proportion is as follow: 30 parts of salvia miltiorrhiza, 12 parts of peach seed, 12 parts of cortex moutan, 9 parts of Chinese angelica, 15 parts of szechuan lovage rhizome, 15 parts of radix paeoniae rubra, 9 parts of red flower, 15 parts of bitter orange, 15 parts of dandelion, 15 parts of barbed skullcap herb, 12 parts of stir-baked squama manitis, 15 parts of spina gleditsiae, 3 parts of centipede, 3 parts of pseudo-ginseng and 15 parts of coke hawthorn. Each medicament functions to generate the synergistic effect by combining all which has the effects of activating blood, dissolving stasis and dredging collaterals, and thus effectively treating the infertility of obstructive uterine tube.

Description

A kind of infertile medicine of obstruction of fallopian tube for the treatment of

Technical field

The present invention relates to a kind of Chinese herbal medicine, especially a kind of infertile Chinese herbal medicine of obstruction of fallopian tube for the treatment of.

Background technology

Obstruction of fallopian tube is infertile is one of modal infertility disease reason, account for 1/2, and the obstruction of fallopian tube main cause is pelvic inflammatory disease sequela or endometriosis.Its clinical manifestation is infertile, and pelvic pain is with or without the medical histories such as artificial abortion, drug induced abortion.Gynecologial examination bilateral attachment area thickens tenderness, and tubal patency test is obstructed or logical and not smooth.Treat take antibiotic medicine as main at present, easy drug resistance, perform the operation feasible salpingoplasty or drug-injected into uterine cavity bring very large misery to the patient.

Summary of the invention

The inventor is through studying for a long period of time, and the checking repeatedly by clinical trial, finally found better curative effect arranged be used for the treatment of the infertile extract oral medicine of obstruction of fallopian tube, this medicine has the effects such as blood circulation promoting and blood stasis dispelling collateral dredging.

Technical assignment of the present invention is to provide the infertile Chinese medicine composition of a kind of more efficiently treatment obstruction of fallopian tube.Medicament selection Radix Salviae Miltiorrhizae of the present invention, Semen Persicae, Cortex Moutan, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Flos Carthami, Fructus Aurantii, Herba Taraxaci, Herba Scutellariae Barbatae, stir-baked SQUAMA MANITIS, Spina Gleditsiae, Scolopendra, Radix Notoginseng, Fructus Crataegi (parched to brown) make up, make each efficacy of drugs produce synergism these drug regimens, thereby it is infertile effectively to treat obstruction of fallopian tube.Wherein: Radix Salviae Miltiorrhizae: be the root of Labiatae herbaceos perennial Radix Salviae Miltiorrhizae.The property hot, bitter, be slightly cold.GUIXIN, Liver Channel.Blood circulation promoting and blood stasis dispelling, the removing heat from blood eliminating carbuncle, relieving restlessness is calmed the nerves.

Semen Persicae: be the mature seed of Rosaceae dungarunga peach or Prunus davidiana.The property hot, bitter, flat.GUIXIN, liver, lung, large intestine channel.Blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.

Cortex Moutan: be the root bark of Ranunculaceae undershrub plant Paeonia suffruticosa.The property bitter, hot, be slightly cold.Return kidney, liver, heart channel.Has clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, the effect of reducing the asthenic fever.

Radix Angelicae Sinensis: be the root of Umbelliferae herbaceos perennial Radix Angelicae Sinensis.Property is sweet, hot, temperature.Return liver, suffering, spleen, large intestine channel.Enrich blood, invigorate blood circulation, pain relieving, regulating menstruation, loosening bowel to relieve constipation.

Rhizoma Chuanxiong: be the rhizome of Umbelliferae herbaceos perennial Rhizoma Chuanxiong.The property hot, temperature.GUIXIN, Liver Channel.Has blood-activating and qi-promoting, the wind-expelling pain-stopping effect.

Radix Paeoniae Rubra: be the root of Ranunculaceae herbaceous plant Radix Paeoniae or river Radix Paeoniae Rubra.The property bitter, hot, be slightly cold.Return liver, heart channel.Has clearing away heat and cooling blood, the effect of blood circulation promoting and blood stasis dispelling.

Flos Carthami: be the flower of Compositae annual herb Plant Carthamus Tinctorius L.The property hot, tepor.GUIXIN, Liver Channel.Blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia.

Fructus Aurantii: for Rutaceae dungarunga plant Citrus aurantium Linn. and variety thereof near mellow fruit (removing flesh).The property bitter, hot, be slightly cold.Return spleen, stomach, large intestine channel.Dispelling the stagnated QI is except painful abdominal mass, transforming phlegm and dispersing accumulations.

Herba Taraxaci: be the herb of catananche's Herba Taraxaci.The property bitter, sweet, cold.Return liver, stomach, lung meridian.Has heat-clearing and toxic substances removing, liver heat removing stomach lung-heat, the effect of eliminating damp-heat.

Herba Scutellariae Barbatae: be the herb of the perennial trailing plant Herba Lobeliae Chinensis of campanulaceae.The property sweet, light, cold.Return small intestinal, the heart, lung meridian.Heat-clearing and toxic substances removing, inducing diuresis to remove edema.

Stir-baked SQUAMA MANITIS: be the scale of vertebrates Manidae Squama Manis, stir-baking in sand is to heaving, cleaning, drying.Property is salty, is slightly cold.Return liver, stomach warp.The Xiao Disorder that invigorates blood circulation stimulates the menstrual flow, stimulating milk secretion, detumescence and apocenosis.

Spina Gleditsiae: the evacuation of pus of drawing out pus by applying a plaster to the affected part, promoting blood circulation and detumescence.Main component: Saponin, flavone, pectin, tannin, phenolic substance, alkaloid, organic acid, saccharide and oils and fats etc.Flavone is induced natural killer cell, interferon, tumor necrosis factor etc. and is generated and propose highly active effect.

Scolopendra: be the dry body of Scolopendridae animal Scolopendpa Subspinipes Mutilans L. KOCH.The property hot, temperature.Poisonous.Return Liver Channel.Relieving spasm by subduing liver-wind, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.

Radix Notoginseng: be the root of Araliaceae herbaceos perennial Radix Notoginseng.Property is hot, sweet, little puckery, temperature.Return liver, heart channel.Hemostasia and dissipation blood stasis, reducing swelling and alleviating pain.Main chemical compositions: arasaponin class, dencichine, flavone, saccharide etc.Arasaponin class, flavone have the effect of blood circulation promoting and blood stasis dispelling, improve blood and stick, gather, coagulate state, to endometrial hyperplasia person successful.

Fructus Crataegi (parched to brown): be the mature fruit of Rosaceae machaka or dungarunga plant Fructus Pyri Pashiae, Fructus Crataegi or Crataegi cuneatae.Property acid, sweet, tepor.Return spleen, stomach, Liver Channel.Promoting digestion and removing stagnation, the circulation of qi promoting dissipating blood stasis.

The consumption of drug component of the present invention is also groped to draw through the inventor in a large number, and each amounts of components is for to have curative effect preferably in the following weight proportioning: Radix Salviae Miltiorrhizae 5-30 part, Semen Persicae 5-15 part, Cortex Moutan 6-12 part, Radix Angelicae Sinensis 5-15 part, Rhizoma Chuanxiong 3-15 part, Radix Paeoniae Rubra 10-15 part, Flos Carthami 3-9 part, Fructus Aurantii 3-30 part, Herba Taraxaci 10-30 part, Herba Scutellariae Barbatae 10-60 part, stir-baked SQUAMA MANITIS 3-12 part, Spina Gleditsiae 3-15 part, Scolopendra 3-5 part, Radix Notoginseng 3-12 part, Fructus Crataegi (parched to brown) 10-30 part.

Its best proportioning is: 30 parts of Radix Salviae Miltiorrhizaes, 12 parts, Semen Persicae, 12 parts of Cortex Moutans, 9 parts of Radix Angelicae Sinensis, 15 parts of Rhizoma Chuanxiongs, 15 parts of Radix Paeoniae Rubra, 9 parts, Flos Carthami, 15 parts of Fructus Aurantiis, 15 parts of Herba Taraxacis, 15 parts of Herba Scutellariae Barbataes, 12 parts of stir-baked SQUAMA MANITISs, 15 parts of Spina Gleditsiae, 3 parts of Scolopendras, 3 parts of Radix Notoginseng, 15 parts of Fructus Crataegi (parched to brown)s.

Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, as pill, powder, tablet, oral liquid etc.For example these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Can use decocting, get after filtration filtrate, make oral liquid; Also can directly take decoction in case of necessity.

Medicine of the present invention has the effects such as blood circulation promoting and blood stasis dispelling collateral dredging, and short treating period is evident in efficacy, without any side effects, according to clinical 200 routine patients being observed statistics, uses 80%, two of one of the medicine of the present invention obvious effective rate course for the treatment of obvious effective rate course for the treatment of 86%.

The specific embodiment

Take following each medicine:

30 parts of Radix Salviae Miltiorrhizaes, 12 parts, Semen Persicae, 12 parts of Cortex Moutans, 9 parts of Radix Angelicae Sinensis, 15 parts of Rhizoma Chuanxiongs, 15 parts of Radix Paeoniae Rubra, 9 parts, Flos Carthami, 15 parts of Fructus Aurantiis, 15 parts of Herba Taraxacis, 15 parts of Herba Scutellariae Barbataes, 12 parts of stir-baked SQUAMA MANITISs, 15 parts of Spina Gleditsiae, 3 parts of Scolopendras, 3 parts of Radix Notoginseng, 15 parts of Fructus Crataegi (parched to brown)s.

Said medicine is put in mortar successively grind well, cross 100 mesh sieves, then fry in shallow oil soup packing one pouch; During application, once a day, once a bag, hang oneself began in rear 3-5 days, and clothes to next menstrual onset stops continuously, approximately takes per month 20 doses, is a course for the treatment of.

The below is the clinical data that the patient uses medicine of the present invention:

One, physical data

Accept patient's totally 200 examples for medical treatment, all make a definite diagnosis through gynecologial examination, its age 22-51 year, average 32 years old.

Two, diagnostic criteria

1, medical history: infertile, pelvic pain is with or without the medical histories such as artificial abortion, drug induced abortion.2, gynecologial examination: the bilateral attachment area thickens tenderness.3, tubal patency test: obstructed or logical and not smooth.

Three, Therapeutic Method

The patient uses medicine of the present invention, once a day, and once a bag.

Four, efficacy assessment standard

Produce effects: after finishing the course for the treatment of, clinical symptoms disappears fully.

Take a turn for the better: symptom is alleviated substantially.

Invalid: remission is not obvious.

Five, therapeutic outcome

Treatment time	Produce effects (example)	Obvious effective rate %	Take a turn for the better (example)	Improvement rate %	Invalid (example)	Inefficiency %
							One course for the treatment of	160	80	32	16	8	4
Two courses for the treatment of	172	86	10	20	8	4

Model case:

One, Mrs Yang, 28 years old, From Shandong Rizhao people, patient miscarried 2 times, and infertile more than 1 year afterwards, dizzy weak, dim complexion had stomachache when patient tells sexual intercourse.Gynecologial examination bilateral attachment area thickens tenderness.Tubal patency test is logical and not smooth.Be diagnosed as obstruction of fallopian tube infertile.

Oral medicine of the present invention is after course for the treatment of, and the patient feels symptom obviously to be alleviated, and continues to use medicine of the present invention after course for the treatment of, and the gynecologial examination attachment area thickens tenderness and alleviates, and continues a course for the treatment of, and is conceived after four months.

Two, Mrs Wang, 24 years old, people from Linyi, Shandong told post-abortion infertile, hypogastralgia.Gynecologial examination bilateral attachment area thickens tenderness.Tubal patency test is logical and not smooth.Be diagnosed as obstruction of fallopian tube infertile.

Use medicine of the present invention after course for the treatment of, hypogastralgia disappears, and the gynecologial examination sign is clearly better, and continues to consolidate curative effect two courses for the treatment of pregnancy after 5 courses for the treatment of.

Claims (2)

1. treat the infertile medicine of obstruction of fallopian tube for one kind, it is characterized in that it is made by the crude drug of following weight proportion: Radix Salviae Miltiorrhizae 5-30 part, Semen Persicae 5-15 part, Cortex Moutan 6-12 part, Radix Angelicae Sinensis 5-15 part, Rhizoma Chuanxiong 3-15 part, Radix Paeoniae Rubra 10-15 part, Flos Carthami 3-9 part, Fructus Aurantii 3-30 part, Herba Taraxaci 10-30 part, Herba Scutellariae Barbatae 10-60 part, stir-baked SQUAMA MANITIS 3-12 part, Spina Gleditsiae 3-15 part, Scolopendra 3-5 part, Radix Notoginseng 3-12 part, Fructus Crataegi (parched to brown) 10-30 part.

2. medicine according to claim 1 is characterized in that it is made by the crude drug of following weight proportion:

30 parts of Radix Salviae Miltiorrhizaes, 12 parts, Semen Persicae, 12 parts of Cortex Moutans, 9 parts of Radix Angelicae Sinensis, 15 parts of Rhizoma Chuanxiongs, 15 parts of Radix Paeoniae Rubra, 9 parts, Flos Carthami, 15 parts of Fructus Aurantiis, 15 parts of Herba Taraxacis, 15 parts of Herba Scutellariae Barbataes, 12 parts of stir-baked SQUAMA MANITISs, 15 parts of Spina Gleditsiae, 3 parts of Scolopendras, 3 parts of Radix Notoginseng, 15 parts of Fructus Crataegi (parched to brown)s.