CN104815116A - Pharmaceutical composition for treating dysmenorrhea - Google Patents
Pharmaceutical composition for treating dysmenorrhea Download PDFInfo
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- CN104815116A CN104815116A CN201510209586.7A CN201510209586A CN104815116A CN 104815116 A CN104815116 A CN 104815116A CN 201510209586 A CN201510209586 A CN 201510209586A CN 104815116 A CN104815116 A CN 104815116A
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Abstract
The invention discloses pharmaceutical composition for treating dysmenorrhea. The pharmaceutical composition for treating the dysmenorrhea is prepared from raw materials comprising 8 to 12 parts of ginseng, 8 to 12 parts of Chinese angelica, 5 to 7 parts of Sichuan lovage rhizome, 9 to 12 parts of prepared rhizome of rehmannia, 5 to 8 parts of pulp of dogwood fruit, 5 to 8 parts of medcinal evodia fruit, 8 to 12 parts of the root of bidentate achyranthes, 5 to 9 parts of the seed of Chinese dodder, 3 to 8 parts of corydalis tuber, 3 to 8 parts of nutgrass galingale rhizome, 4 to 9 parts of motherwort, 5 to 9 parts of the root of red-rooted salvia, 5 to 7 parts of angelica root, 5 to 7 parts of trogopterus dung, 9 to 12 parts of bighead atractylodes rhizome and 6 to 10 parts of liquorice by weight. The pharmaceutical composition for treating the dysmenorrhea rationally combines the traditional Chinese medicines, plays roles of warming meridians, invigorating pulse, dissipating blood stasis, relieving pain and clearing heat for detumescence and has an obvious effect for treating the dysmenorrhea. The pharmaceutical composition for treating the dysmenorrhea has advantages of obvious curative effect, fast effect, no toxic and side effects and simple preparation method; the clinical verification proves that the effective rate for treating the dysmenorrhea is 94%.
Description
Technical field
The invention belongs to technical field of Chinese medicines, specifically a kind of pharmaceutical composition for the treatment of dysmenorrhea.
Background technology
What dysmenorrhea referred to that women sends out with every menstrual phase take pain as the disease of cardinal symptom.The primary disease cause of disease is many, and pathogenesis is complicated, and repeatability is large, treats thorny.Clinically often be divided into constitutional and Secondary cases two kinds at present, primary dysmenorrhea many fingers genitals without obvious pathological changes person, therefore also known as primary dysmenorrhea, is more common in adolescent girls, the unmarried and married person of not educating.This kind of dysmenorrhea pain after normal labor to be alleviated or disappears.Secondary dysmenorrhea is then many to be had caused by organic disease because of genitals.
Application number is the Chinese invention patent application of 201310274866.7, disclose a kind of pharmaceutical composition for the treatment of menalgia, adopt raw material and composition by weight respectively: Semen Celosiae 23 parts, Radix Scrophulariae 25 parts, Herba pterocephali 33 parts, Herba Polygoni cymosi 35 parts, Flos Bombacis Malabarici 34 parts, Herba Lophatheri 32 parts, Herba Thlaspis 26 parts, Fructus Arctii 18 parts, 24 parts, Radix Glycyrrhizae, Rhizoma Smilacis Chinensis 25 parts, Flos Lonicerae 36 parts, Herba Gendarussae 23 parts, Radix Panacis Quinquefolii 21 parts, Rhizoma Dioscoreae Septemlobae 24 parts, 28 parts, the Radix Rehmanniae, Caulis Mahoniae 33 parts, Retinervus Luffae Fructus 23 parts, Herba Asari 36 parts, Folium Sauropi 36 parts, Radix Scutellariae 30 parts, Medulla Stachyuri (Medulla Helwingiae) 37 parts, Radix Paeoniae Rubra 28 parts, Herba Siegesbeckiae 26 parts, Semen Lablab Album 37 parts, Radix Angelicae Sinensis 29 parts, Folium Sennae 33 parts, Semen Litchi 27 parts, Concha Arcae 25 parts, Herba Agrimoniae 34 parts, RADIX PEUCEDANI 23 parts, 27 parts, Poria, Fructus Broussonetiae 25 parts, Ramulus Cinnamomi 21 parts, Periostracum Cicadae 20 parts, 28 parts, Semen Persicae, the Rhizoma Pinelliae 23 parts, Olibanum 25 parts, Thallus Laminariae (Thallus Eckloniae) 27 parts, Herba Cichorii 37 parts, Cortex Syingae Amurensis 35 parts, Nodus Nelumbinis Rhizomatis 33 parts and Fructus Litseae 35 parts.This invention is used for prevention and therapy dysmenorrhea successful, and applicable women takes, but its formula kind medication quantity is too many, too complex, in decoction process, the various reaction that liquidates can be there is unavoidably between each side, drug effect is given a discount, simultaneously also to make up a prescription and decoction work brings very large trouble.
In addition, about the Chinese medicine composition for the treatment of dysmenorrhea, also there are many reports and research, but all more or less there is the weak point of DeGrain.Therefore study a kind of good effect, instant effect, have no side effect, the Chinese medicine composition that preparation method simply treats dysmenorrhea is very necessary.
Summary of the invention
The object of this invention is to provide a kind of pharmaceutical composition for the treatment of dysmenorrhea, this pharmaceutical composition develops with natural Chinese medicines, selects Chinese medicine Radix Ginseng, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Fructus Corni, Fructus Evodiae, Radix Achyranthis Bidentatae, Semen Cuscutae, Rhizoma Corydalis, Rhizoma Cyperi, Herba Leonuri, Radix Salviae Miltiorrhizae, the Radix Angelicae Dahuricae, Oletum Trogopterori, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae combines, make each efficacy of drugs produce synergism, be used for the treatment of dysmenorrhea, determined curative effect and having no side effect.
The present invention adopts following technical scheme:
Treat a pharmaceutical composition for dysmenorrhea, be made up of the crude drug of following weight: Radix Ginseng 8-12 part, Radix Angelicae Sinensis 8-12 part, Rhizoma Chuanxiong 5-7 part, Radix Rehmanniae Preparata 9-12 part, Fructus Corni 5-8 part, Fructus Evodiae 5-8 part, Radix Achyranthis Bidentatae 8-12 part, Semen Cuscutae 5-9 part, Rhizoma Corydalis 3-8 part, Rhizoma Cyperi 3-8 part, Herba Leonuri 4-9 part, Radix Salviae Miltiorrhizae 5-9 part, Radix Angelicae Dahuricae 5-7 part, Oletum Trogopterori 5-7 part, Rhizoma Atractylodis Macrocephalae 9-12 part, Radix Glycyrrhizae 6-10 part.
Preferably, the pharmaceutical composition of described treatment dysmenorrhea, is made up of the crude drug of following weight: Radix Ginseng 9 parts, Radix Angelicae Sinensis 9 parts, Rhizoma Chuanxiong 5 parts, 9 parts, Radix Rehmanniae Preparata, Fructus Corni 6 parts, Fructus Evodiae 6 parts, Radix Achyranthis Bidentatae 9 parts, Semen Cuscutae 6 parts, Rhizoma Corydalis 5 parts, Rhizoma Cyperi 6 parts, Herba Leonuri 7 parts, Radix Salviae Miltiorrhizae 8 parts, the Radix Angelicae Dahuricae 6 parts, Oletum Trogopterori 6 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, 6 parts, Radix Glycyrrhizae.
The preparation method of the pharmaceutical composition of described treatment dysmenorrhea is: take each crude drug by above-mentioned weight, crude drug is put into the container of decocting Chinese medicine, clean, add cold clear water and do not have powder to be about 4-6 centimetre, soak after 30-40 minute, carry out twice decoction.First time decocts to decoct with high heat uses slow fire boiling 20 ~ 30 minutes after boiling; Second time decocts, slow fire boiling 15 ~ 20 minutes after water boils.Twice decoction is removed slag extracting juice, merges.
The instructions of taking of Chinese medicine of the present invention is: every day 1 pair, and divide and take for 2 times, early, respectively take 1 time evening, 1 menstrual period is 1 course for the treatment of.
In the middle of drug regimen composition formula of the present invention, the pharmacology analysis of each crude drug is as follows:
Radix Ginseng: sweet in the mouth, micro-hardship, slightly warm in nature, returns spleen, lung, the heart, kidney channel, gas Xiong Tirun, rises more than falling; There is invigorating QI to relieve exhaustion, spleen invigorating lung benefiting, mind calming Fructus Alpiniae Oxyphyllae, effect of nourishing blood to promote the production of body fluid.
Radix Angelicae Sinensis: having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation.The phagocytosis of peritoneal macrophage can be improved, improve the immunologic function of body, have dual regulation to uterus.
Rhizoma Chuanxiong: activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Radix Rehmanniae Preparata: sweet in the mouth, tepor, matter is moistened, and YIN nourishing of both having enriched blood, again can vital essence replenishing and marrow benifiting.
Fructus Corni: sour, puckery, tepor.Liver and kidney tonifying, arresting seminal emission hidroschesis.The soreness of waist for deficiency of the liver and kindey is passed out semen, have a dizzy spell, menorrhagia and the disease such as frequent micturition, spontaneous perspiration.
Fructus Evodiae: pungent, bitter, hot, is attributed to liver, spleen, stomach, kidney channel.Can dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.Be usually used in headache due to JUE YIN disorder, colic of cold type is suffered from abdominal pain, the treatment of the disturbance of lower legs due to pathogenic cold and dampness, and to abdominal pain during menstruation, abdominal distention, vomiting acid regurgitation, Diarrhoea, hypertension also have significant curative effect.Meanwhile, it can also external treatment aphtha, ulcer, toothache, eczema etc.
Radix Achyranthis Bidentatae: there is invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to restore menstrual flow, ignite that (blood) is descending, effect of inducing diuresis for treating stranguria syndrome.
Semen Cuscutae: be put down simply to mend the good medicine of kidney,liver,spleen, is clinically mainly used in that lumbago due to renal deficiency, the seminal emission of positive paralysis, frequent micturition, cold womb are infertile, the order secretly just kidney yin YANG asthenia disease such as the pool.
Rhizoma Corydalis: pungent, bitter, temperature.Return liver, spleen channel.Invigorate blood circulation, promoting the circulation of QI, pain relieving.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.
Rhizoma Cyperi: pungent micro-hardship is sweet, flat.Enter lung, liver, spleen, stomach four warp.There is the effect of resolving depression of regulating the flow of vital energy, be used for the treatment of stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia.Have effect of menstruction regulating and pain relieving, be used for the treatment of menoxenia, amenorrhea dysmenorrhea, colic of cold type is suffered from abdominal pain, distending pain of the breast.
Herba Leonuri: bitter, pungent, is slightly cold.Return liver, pericardium channel.Promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.
Radix Salviae Miltiorrhizae: bitter, is slightly cold.GUIXIN, Liver Channel.Promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, clear away heart-fire relieving restlessness, nourishing blood to tranquillize the mind.Cure mainly menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, the diseases such as pyretic arthralgia pain.
The Radix Angelicae Dahuricae: there is expelling wind and cold, evacuation of pus of invigorating blood circulation, granulation promoting pain relieving, dampness leukorrhagia stopping, the effect such as blood pressure lowering.
Oletum Trogopterori: sweet, temperature.Enter Liver Channel.Promoting blood circulation, eliminating stasis to stop pain, hemostasis by removing blood stasis.
The Rhizoma Atractylodis Macrocephalae: return spleen, stomach warp, bitter in the mouth, sweet and warm in nature.Function is invigorating the spleen and benefiting QI, dampness diuretic, and hidroschesis is antiabortive.
Radix Glycyrrhizae: sweet in the mouth, property is put down, nontoxic.Treating disorders in five ZANG-organs six internal organs cold and heat pathogen, hard muscles and bones, longue meat, times strength, removing toxic substances, clothes are made light of one's life by commiting suicide and are prolonged life for a long time.Raw by pathogenic fire purging heat, ripe use is fallen apart exterior cold, goes pharyngalgia, except pathogenic heat, and slow healthy energy, yin nourishing blood, tonifying the spleen and stomach, lung moistening.
In side, all medicines share, and play effect of warming the meridian and promoting blood circulation, eliminating stasis to stop pain, clearing heat for detumescence altogether, jointly reach the object for the treatment of dysmenorrhea.
Beneficial effect of the present invention is: above-mentioned various raw material of Chinese medicine carries out reasonably combined by the present invention, and all medicines of formula share the effect with warming the meridian and promoting blood circulation, eliminating stasis to stop pain, clearing heat for detumescence, and combine Be very effective in treatment dysmenorrhea.The present invention has evident in efficacy, instant effect, has no side effect, the simple advantage of preparation method, and through clinical verification, it is 94% that the present invention treats dysmenorrhea effective percentage.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in detail, but do not form limiting the scope of the invention.
Embodiment 1: take Radix Ginseng 9 parts by weight, Radix Angelicae Sinensis 9 parts, Rhizoma Chuanxiong 5 parts, 9 parts, Radix Rehmanniae Preparata, Fructus Corni 6 parts, Fructus Evodiae 6 parts, Radix Achyranthis Bidentatae 9 parts, Semen Cuscutae 6 parts, Rhizoma Corydalis 5 parts, Rhizoma Cyperi 6 parts, Herba Leonuri 7 parts, Radix Salviae Miltiorrhizae 8 parts, the Radix Angelicae Dahuricae 6 parts, Oletum Trogopterori 6 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, 6 parts, Radix Glycyrrhizae.Crude drug is put into the container of decocting Chinese medicine, clean, add cold clear water and do not have powder to be about 4-6 centimetre, soak after 30-40 minute, carry out twice decoction.First time decocts to decoct with high heat uses slow fire boiling 20 ~ 30 minutes after boiling; Second time decocts, slow fire boiling 15 ~ 20 minutes after water boils.Twice decoction is removed slag extracting juice, merges.
Embodiment 2: take Radix Ginseng 8 parts by weight, Radix Angelicae Sinensis 8 parts, Rhizoma Chuanxiong 5 parts, 9 parts, Radix Rehmanniae Preparata, Fructus Corni 5 parts, Fructus Evodiae 5 parts, Radix Achyranthis Bidentatae 8 parts, Semen Cuscutae 5 parts, Rhizoma Corydalis 3 parts, Rhizoma Cyperi 3 parts, Herba Leonuri 4 parts, Radix Salviae Miltiorrhizae 5 parts, the Radix Angelicae Dahuricae 5 parts, Oletum Trogopterori 5 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, 6 parts, Radix Glycyrrhizae.Crude drug is put into the container of decocting Chinese medicine, clean, add cold clear water and do not have powder to be about 4-6 centimetre, soak after 30-40 minute, carry out twice decoction.First time decocts to decoct with high heat uses slow fire boiling 20 ~ 30 minutes after boiling; Second time decocts, slow fire boiling 15 ~ 20 minutes after water boils.Twice decoction is removed slag extracting juice, merges.
Embodiment 3: take Radix Ginseng 12 parts by weight, Radix Angelicae Sinensis 12 parts, Rhizoma Chuanxiong 7 parts, 12 parts, Radix Rehmanniae Preparata, Fructus Corni 8 parts, Fructus Evodiae 8 parts, Radix Achyranthis Bidentatae 12 parts, Semen Cuscutae 9 parts, Rhizoma Corydalis 8 parts, Rhizoma Cyperi 8 parts, Herba Leonuri 9 parts, Radix Salviae Miltiorrhizae 9 parts, the Radix Angelicae Dahuricae 7 parts, Oletum Trogopterori 7 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, 10 parts, Radix Glycyrrhizae.Crude drug is put into the container of decocting Chinese medicine, clean, add cold clear water and do not have powder to be about 4-6 centimetre, soak after 30-40 minute, carry out twice decoction.First time decocts to decoct with high heat uses slow fire boiling 20 ~ 30 minutes after boiling; Second time decocts, slow fire boiling 15 ~ 20 minutes after water boils.Twice decoction is removed slag extracting juice, merges.
curative effect is investigated:
1. diagnosis basis
Diagnosis meets following standard:
, there is lower abdomen or flank pain in menstrual period and front and back thereof, even pain and waist sacrum.Severe patient can accompany nausea and vomiting, dripping cold sweat, deadly cold hand and foot, even faints.
2. ordinary circumstance
Choose 150 routine dysmenorrhea patients, the oldest person 38 years old, age reckling 14 years old, 28 years old mean age.
3. curative effect determinate standard
(1) clinical cure: pain disappears, and recurrence is seen at continuous 3 menstrual cycle ends;
(2) effective: pain relief or pain disappear, but can not maintain more than 3 months;
(3) invalid: menstrual period, pain had no improvement.
4. result
By Drug therapy dysmenorrhea patient 150 example of the present invention, through the Ureteral Calculus of 2-3 the course for the treatment of, clinical cure 113 example, effective 28 examples, no effect 9, total effective rate is 94%.
5. side effect
Do not find any toxic and side effects.
Model case:
Bai, female, 32 years old, dysmenorrhea heals for a long time and not, stomachache pain lower abdomen under umbilicus, and first day of rising stomachache is very acute, and to finding that film sample is shown in again a burst of severe pain before coming off, clot falls then alleviation of pain then, red tongue, stringy pulse, be diagnosed as hot pain, Yu Jinghang starts to take pharmaceutical composition of the present invention for first 5 days, after taking 3 courses for the treatment of, dysmenorrhea transference cure, continuous 3 menstrual cycle do not recur.
Huang, female, 16 years old, just had dysmenorrhea from 14 years old menarche, and at every turn in the period have hypogastralgia, falling inflation sense, and menstrual period are afraid of cold; Yu Jinghang starts to take pharmaceutical composition of the present invention for first 5 days, and after taking 2 courses for the treatment of, dysmenorrhea transference cure, continuous 3 menstrual cycle do not recur.
Revive certain, 26 years old, with dysmenorrhea symptom 8 years, the symptom such as insomnia, headache and dizzy, pale complexion, extremity are ice-cold that often has abdominal part distending pain, cold type of pain, distending pain of the breast, the heart to shy under menstrual period, Yu Jinghang starts to take this component invention thing for first 5 days, after taking 3 courses for the treatment of, dysmenorrhea transference cure, continuous 3 menstrual cycle do not recur.
The above-mentioned description to specific embodiment is to make further description and illustration to the present invention better, but the invention is not restricted to given example, on basis of the present invention, can make some amendments to it and improve, this will be apparent to those skilled in the art.Therefore, modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (2)
1. treat a pharmaceutical composition for dysmenorrhea, it is characterized in that being made up of the crude drug of following weight: be made up of the crude drug of following weight: Radix Ginseng 8-12 part, Radix Angelicae Sinensis 8-12 part, Rhizoma Chuanxiong 5-7 part, Radix Rehmanniae Preparata 9-12 part, Fructus Corni 5-8 part, Fructus Evodiae 5-8 part, Radix Achyranthis Bidentatae 8-12 part, Semen Cuscutae 5-9 part, Rhizoma Corydalis 3-8 part, Rhizoma Cyperi 3-8 part, Herba Leonuri 4-9 part, Radix Salviae Miltiorrhizae 5-9 part, Radix Angelicae Dahuricae 5-7 part, Oletum Trogopterori 5-7 part, Rhizoma Atractylodis Macrocephalae 9-12 part, Radix Glycyrrhizae 6-10 part.
2. pharmaceutical composition according to claim 1, is characterized in that being made up of the crude drug of following weight: Radix Ginseng 9 parts, Radix Angelicae Sinensis 9 parts, Rhizoma Chuanxiong 5 parts, 9 parts, Radix Rehmanniae Preparata, Fructus Corni 6 parts, Fructus Evodiae 6 parts, Radix Achyranthis Bidentatae 9 parts, Semen Cuscutae 6 parts, Rhizoma Corydalis 5 parts, Rhizoma Cyperi 6 parts, Herba Leonuri 7 parts, Radix Salviae Miltiorrhizae 8 parts, the Radix Angelicae Dahuricae 6 parts, Oletum Trogopterori 6 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, 6 parts, Radix Glycyrrhizae.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105749240A (en) * | 2016-04-27 | 2016-07-13 | 李博 | Traditional Chinese medicine for treating cold-damp coagulation type dysmenorrhea |
| CN113117037A (en) * | 2021-04-25 | 2021-07-16 | 曾纪 | Composition for treating irregular menstruation, preparation method and application |
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| CN102836395A (en) * | 2011-06-23 | 2012-12-26 | 于海华 | Traditional Chinese medicine composition used for treating dysmenorrhea |
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| CN100998724A (en) * | 2006-12-26 | 2007-07-18 | 任家福 | Traditional Chinese medicine for treating gynaopathy |
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| CN113117037A (en) * | 2021-04-25 | 2021-07-16 | 曾纪 | Composition for treating irregular menstruation, preparation method and application |
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Application publication date: 20150805 |