CN103142998A - Oral medical ice for preventing and treating dental ulcer and infection after chemotherapy - Google Patents
Oral medical ice for preventing and treating dental ulcer and infection after chemotherapy Download PDFInfo
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- CN103142998A CN103142998A CN2013101123165A CN201310112316A CN103142998A CN 103142998 A CN103142998 A CN 103142998A CN 2013101123165 A CN2013101123165 A CN 2013101123165A CN 201310112316 A CN201310112316 A CN 201310112316A CN 103142998 A CN103142998 A CN 103142998A
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Abstract
The invention discloses oral medical ice for preventing and treating dental ulcer and infection after chemotherapy. The oral medical ice includes normal saline; each 100ml of normal saline includes 50-100 micrograms of grain-macrophage colony stimulating factor, 30-100mg of calcium folinate and 250-500mg of lidocaine hydrochloride; and the oral medical ice can be acquired after the normal saline including the above components is frozen to ice. The oral medical ice is used for preventing and treating dental ulcer and infection after high-dose methotrexate chemotherapy or 5-fluorouracil chemotherapy; and the oral medical ice without the calcium folinate can also be used for preventing and treating dental ulcer and infection after other chemotherapies. The oral medical ice disclosed by the invention can be used for alleviating pain, contracting the blood vessels of the oral mucosa, reducing exudation and increasing salivary secretion and can be beneficial to the cleaning of the mouth. The oral medical ice can be slowly molten in the mouth; and the lasting time of the oral medical ice is longer than the time for rinsing the mouth by using collutory. The oral medical ice can be used for improving the chemotherapy tolerance of a patient, promoting the restoration of the oral mucosa ulcer surface, shortening the curing time and reducing the pain of the patient and has no side effects, thereby having good application prospect.
Description
Technical field
The present invention relates to a kind of mouthful of ice, be specifically related to the mouth ice of oral ulcer and infection after a kind of prevention and treatment chemotherapy, belong to adjuvant therapy medicaments technical field after chemotherapy.
Background technology
After chemotherapy, patient's drinking-water, feed reduce, and the oral cavity self-cleaning action weakens, and the normal flora amount reproduction of oral cavity parasitism produces indole, sulfydryl and amine etc. and causes halitosis, destroys internal environment of oral cavity, causes oral mucosa impaired; The chemotherapy of larger dose suppresses the epithelial hypertrophy of oral mucosa, and salivary gland secretion reduces, so that the reparation of oral mucosa and barrier effect decrease; The application of broad ectrum antibiotic easily causes dysbacteriosis in the oral cavity, and neutrophilic granulocyte is lower than 0.5 * 10
9/ L is the key factor that oral cavity infection occurs; The chemotherapeutics such as methotrexate, azathioprine can suppress DNA in Oral Mucosal Cells and (or) RNA and protein synthetic, even directly destroy DNA structure and function, thereby cause cell death, cause ulcer; Chemotherapeutics directly destroys Oral Mucosal Cells or by suppressing hemopoietic function of bone marrow, causes immunity of organisms to descend, thereby make oral cavity bacterium, virus or fungus generation hyper-proliferative, causes oral cavity infection.Above variant factors effect makes that patient's oral ulcer and infection rate increases after chemotherapy.Up to the present, the medicine of prevention commonly used and treatment oral ulcer and infection take the infection collutory medicine of various heterogeneities as main, still rarely has for the medicine that promotes that oral mucosa is repaired clinically.And after chemotherapy almost always with the generation of oral ulcer, therefore, provide a kind of effectively, just extremely important for the medicine of the collutory of using after chemotherapy, have the mucosa repair function or other dosage forms.
Summary of the invention
The mouth ice of oral ulcer and infection after the purpose of this invention is to provide a kind of prevention and treating chemotherapy is to make up the above-mentioned deficiency of prior art.
To achieve these goals, technical scheme of the present invention is as follows:
The mouth ice of oral ulcer and infection after a kind of prevention and treatment chemotherapy, comprise normal saline, it is characterized in that every 100ml normal saline contains following component: granulocyte-macrophage colony-stimulating factor (GM-CSF) 50ug～100ug, calcium folinate (CF) 30～100mg, lidocaine hydrochloride 250mg～500mg; The normal saline that will contain mentioned component is put into sterile chamber, is frozen into ice and gets final product.
Above-mentioned mouthful ice is applied to oral ulcer after High-dose methotrexate chemotherapy or 5-fluorouracil chemotherapy and prevention and the treatment of infection.Heavy dose refers to surpass 3g/m
2, i.e. the application method determined by body surface area of dosage.
The preparation method of the mouth ice of oral ulcer and infection after a kind of prevention and treatment chemotherapy, comprise and to add successively following component in every 100ml normal saline: granulocyte-macrophage colony-stimulating factor (GM-CSF) 50ug～100ug, calcium folinate (CF) 30～100mg, lidocaine hydrochloride 250mg～500mg; The normal saline that will contain above-mentioned three kinds of compositions is contained in a plurality of sterile chambers less than 30ml, is frozen into ice and gets final product.
Above-mentioned mouthful ice using method rises to getting above-mentioned volume between sleep period in every 2 hours less than one, the mouth ice of 30ml morning every day, is put in the oral cavity or containing of ulcer spot.
Also can be different according to the kind of chemotherapeutics used, do not add calcium folinate, be that of the present invention mouthful of ice comprises normal saline, it is characterized in that every 100ml normal saline contains following component: granulocyte-macrophage colony-stimulating factor (GM-CSF) 50ug～100ug, lidocaine hydrochloride 250mg～500mg; The normal saline that will contain mentioned component is put into sterile chamber, is frozen into ice and gets final product.
Its preparation method comprises and will add successively following component in every 100ml normal saline: granulocyte-macrophage colony-stimulating factor (GM-CSF) 50ug～100ug, lidocaine hydrochloride 250mg～500mg; The normal saline that will contain above-mentioned three kinds of compositions is contained in a plurality of sterile chambers less than 30ml, is frozen into ice and gets final product.
Above-mentioned mouthful ice is applied to oral ulcer except High-dose methotrexate and 5-fluorouracil and prevention and the treatment of infection.
Above-mentioned mouthful ice using method rises to getting above-mentioned volume between sleep period in every 2 hours less than one, the mouth ice of 30ml morning every day, is put in the oral cavity or containing of ulcer spot.
The present invention compared with prior art has the following advantages and positive effect:
Clinical experiment of the present invention shows that GM-CSF is to the mechanism of action of oral mucositis: 1. GM-CSF by the GM on oral mucosa-CSF receptor, strengthens transcribing and translating of il-1, promotes the mucosa hypertrophy.Il-1 is considered to have the effect that the protection oral mucosa epithelial cell is avoided the chemotherapeutics damage at present.2. the generation of peripheral white blood cells level and oral mucositis is closely related, and GM-CSF can shorten the low-level time of leukocyte.3. GM-CSF directly stimulates oral mucosa cell growth and propagation, thereby the protection oral mucous epithelia is avoided the attack of chemotherapeutics toxicity.4. G-CSF is a kind of cell growth factor of polypeptide chain, can promote that grain is propagation and the differentiation of CFU-GM, the generation of hasting of maturity neutrophilic granulocyte, and strengthen engulfing, kill and wound and Chemotaxis Function of peripheral blood neutrophil, accelerate local necrosis tissue come off and to the defence capability of invasion antibacterial, promote body from the dissolubility debridement, raising local immunity power is with infection, accelerate wound healing, improve healing quality; On the other hand, GM-CSF can promote the macrophage synthesis secretion to be conducive to cytokine and the somatomedin of wound healing, accelerates wound healing.
Calcium folinate is the formyl derivant of tetrahydrofolic acid, is folic acid activated form in vivo.Calcium folinate is anti-anemic drug, is also the antineoplastic adjuvant drug.Be commonly used for the antidote of methotrexate, change tetrahydrofolic acid into by tetrahydrofolate reductase, can effectively resist the toxic reaction that methotrexate causes.Calcium folinate can limit methotrexate to the Normocellular extent of damage, by mutual Competition, reverses methotrexate to bone marrow and alimentary canal mucous membrane reaction, also can promote differentiation, the maturation of myeloid element and discharge.
Lidocaine hydrochloride is a kind of local anesthetics of amide derivatives, when blood drug level is low, can improve the threshold of pain, plays analgesic activity.
Normal saline is gargled itself can cleaning oral cavity, the growing, breed of prevention oral microorganism.
Of the present invention mouthful of ice, the physical characteristic of utilization itself, namely Cryo Fundamentals, can ease the pain, and makes the oral mucosa vasoconstriction, oozes out minimizing, and salivation increases, and is beneficial to the cleaning in oral cavity.Simultaneously, mouthful ice slowly dissolves in the oral cavity, and the persistent period is with the collutory prolongation of gargling.
Ice of the present invention mouthful, for after chemotherapy without the patient of oral ulcer, generation that can preventing canker sore; For the patient who oral ulcer and infection occur, with other infection collutory use in conjunction, can improve the patient to the tolerance of chemotherapy, promote the reparation of stomatocace face, shorten healing time, shorten the course of disease, reduce patient's misery, and have no side effect, compliance is good, has a good application prospect.
The specific embodiment
The mouth ice of oral ulcer and infection after a kind of prevention and treatment chemotherapy, comprise normal saline, it is characterized in that every 100ml normal saline contains following component: granulocyte-macrophage colony-stimulating factor (GM-CSF) 50ug～100ug, calcium folinate (CF) 30～100mg, lidocaine hydrochloride 250mg～500mg; The normal saline that will contain mentioned component is put into sterile chamber, is frozen into ice and gets final product.
Above-mentioned mouthful ice is applied to oral ulcer after High-dose methotrexate chemotherapy or 5-fluorouracil chemotherapy and prevention and the treatment of infection.Heavy dose refers to surpass 3g/m
2, i.e. the application method determined by body surface area of dosage.
The preparation method of the mouth ice of oral ulcer and infection after above-mentioned prevention and treatment chemotherapy, comprise and to add successively following component in every 100ml normal saline: granulocyte-macrophage colony-stimulating factor (GM-CSF) 50ug～100ug, calcium folinate (CF) 30～100mg, lidocaine hydrochloride 250mg～500mg; The normal saline that will contain above-mentioned three kinds of compositions is contained in a plurality of sterile chambers less than 30ml, is frozen into ice and gets final product.
Above-mentioned mouthful ice using method rises to getting above-mentioned volume between sleep period in every 2 hours less than one, the mouth ice of 30ml morning every day, is put in the oral cavity or containing of ulcer spot.
Also can be different according to the kind of chemotherapeutics used, do not add calcium folinate, be that of the present invention mouthful of ice comprises normal saline, it is characterized in that every 100ml normal saline contains following component: granulocyte-macrophage colony-stimulating factor (GM-CSF) 50ug～100ug, lidocaine hydrochloride 250mg～500mg; The normal saline that will contain mentioned component is put into sterile chamber, is frozen into ice and gets final product.
Its preparation method comprises and will add successively following component in every 100ml normal saline: granulocyte-macrophage colony-stimulating factor (GM-CSF) 50ug～100ug, lidocaine hydrochloride 250mg～500mg; The normal saline that will contain above-mentioned three kinds of compositions is contained in a plurality of sterile chambers less than 30ml, is frozen into ice and gets final product.
Above-mentioned mouthful ice is applied to oral ulcer except High-dose methotrexate and 5-fluorouracil and prevention and the treatment of infection.
Above-mentioned mouthful ice using method rises to getting above-mentioned volume between sleep period in every 2 hours less than one, the mouth ice of 30ml morning every day, is put in the oral cavity or containing of ulcer spot.
Claims (5)
1. the mouth ice of oral ulcer and infection after a prevention and treatment chemotherapy, comprise normal saline, it is characterized in that every 100ml normal saline contains following component: granulocyte-macrophage colony stimulates because of 50ug～100ug, calcium folinate 30～100mg, lidocaine hydrochloride 250mg～500mg; The normal saline that will contain mentioned component is put into sterile chamber, is frozen into ice and gets final product.
2. the application of ice claimed in claim 1 mouthful is characterized in that above-mentioned mouthful of ice is applied to oral ulcer after High-dose methotrexate chemotherapy or 5-fluorouracil chemotherapy and prevention and the treatment of infection.
3. the mouth ice of oral ulcer and infection after a prevention and treatment chemotherapy, comprise normal saline, and it is characterized in that every 100ml normal saline contains following component: granulocyte-macrophage colony stimulates because of 50ug～100ug, lidocaine hydrochloride 250mg～500mg.The normal saline that will contain mentioned component is put into sterile chamber, is frozen into ice and gets final product.
4. the application of ice claimed in claim 3 mouthful is characterized in that above-mentioned mouthful of ice is applied to oral ulcer except High-dose methotrexate and 5-fluorouracil and prevention and the treatment of infection.
5. the using method of claim 1 or 3 mouth ice is characterized in that rising to getting above-mentioned volume between sleep period in every 2 hours less than one, the mouth ice of 30ml morning every day, is put in the oral cavity or containing of ulcer spot gets final product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2013101123165A CN103142998A (en) | 2013-04-02 | 2013-04-02 | Oral medical ice for preventing and treating dental ulcer and infection after chemotherapy |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2013101123165A CN103142998A (en) | 2013-04-02 | 2013-04-02 | Oral medical ice for preventing and treating dental ulcer and infection after chemotherapy |
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| CN103142998A true CN103142998A (en) | 2013-06-12 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105833250A (en) * | 2016-06-01 | 2016-08-10 | 杨力 | Oral medical ice for preventing and treating oral ulcer and infection |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1173355A (en) * | 1997-04-17 | 1998-02-18 | 陈大欣 | Recovering liquid for oral cavity ulcer |
| CN102764372A (en) * | 2012-08-13 | 2012-11-07 | 青岛大学医学院附属医院 | Traditional Chinese medicine buccal ice |
-
2013
- 2013-04-02 CN CN2013101123165A patent/CN103142998A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1173355A (en) * | 1997-04-17 | 1998-02-18 | 陈大欣 | Recovering liquid for oral cavity ulcer |
| CN102764372A (en) * | 2012-08-13 | 2012-11-07 | 青岛大学医学院附属医院 | Traditional Chinese medicine buccal ice |
Non-Patent Citations (2)
| Title |
|---|
| 朱玉娟和周明俐: "亚叶酸钙含漱对预防甲氨蝶呤化疗病人口腔溃疡的效果观察", 《家庭护士》, vol. 6, no. 4, 30 April 2008 (2008-04-30), pages 965 - 966 * |
| 陈钰等: "局部应用rhGM-CSF治疗化疗后口腔粘膜炎疗效观察", 《上海第二医科大学学报》, vol. 22, no. 1, 31 December 2002 (2002-12-31), pages 58 - 60 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105833250A (en) * | 2016-06-01 | 2016-08-10 | 杨力 | Oral medical ice for preventing and treating oral ulcer and infection |
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Application publication date: 20130612 |