CN103142907B - Immunopotentiator for preventing and treating newcastle diseases - Google Patents
Immunopotentiator for preventing and treating newcastle diseases Download PDFInfo
- Publication number
- CN103142907B CN103142907B CN201310073212.8A CN201310073212A CN103142907B CN 103142907 B CN103142907 B CN 103142907B CN 201310073212 A CN201310073212 A CN 201310073212A CN 103142907 B CN103142907 B CN 103142907B
- Authority
- CN
- China
- Prior art keywords
- weight portions
- weight portion
- weight
- portions
- herba
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides an immunopotentiator containing traditional Chinese medicines for preventing and treating newcastle diseases. The immunopotentiator comprises the following raw materials: gynostemma pentaphylla, spina gleditsiae, chrysanthemum, codonopsis pilosula, white hyacinth beans, male fern rhizome, herba epimedii, aloe, dragonwort, dandelion, common andrographis herbs, eclipta, barbary wolfberry fruits, mulberry, liquorice, caulis polygoni multiflori, indigo naturalis, radix stemonae, brucea javanica, radix ophiopogonis and flatstem milkvetch seeds. The immunopotentiator is used for regulating the immunity of an organism by acting an organism immunity system, thereby obtaining the effects of strengthening body resistance to eliminate evils and supporting the healthy energy. As a result, the newcastle diseases are treated and prevented.
Description
Technical field
The present invention relates to herbal medicine technical field, relate in particular to a kind of for preventing and treat the immunostimulant of Newcastle disease.
Background technology
Newcastle disease (Newcastle disease, ND) claim again philippine fowl disease, by newcastle disease virus (Newcastle disease virus, NDV) a kind of height contact of the chicken causing, acute, deadly infectious disease, often present septicemia process, and this disease morbidity is anxious, mortality rate is up to more than 90%, serious harm the development of various countries' poultry husbandries, be that the harm of China aviculture is maximum, one of fowl diseases that economic loss is the most serious.The control of this disease is mainly adopted to chemicals vaccine immunopotentiator, because immune effect is undesirable, in vaccinated flock, usually broke out in recent years Newcastle Disease, show as inferior clinical symptom or atypical newcastle disease, and when running into strong virus attack, still can fall ill, and adopt chemicals existing toxic and side effects, pollute residual, body and absorb the drawbacks such as slow in various degree, cause meat, egg drug residue, affect health, therefore, find suitable enhancing ND Vaccine immune effect reinforcing agent, on poultry is produced, there is practical significance.
Along with the development of modern intensive aviculture, the stressors in environment is more and more, causes animal immune function to decline, and body disease-resistant power reduces, and even affects immune effect of vaccine.
Viral disease belongs to epidemic disease category in Chinese medicine, and relevant Chinese medicine is applied to clinical prevention disease of viral infection and has been reported.Chinese herbal medicine resource, in treatment newcastle disease process, can be accelerated the growth of immune cell as a kind of immunostimulant, the humoral immunization of enhancing body and cellular immunization, thus improve the premunition of body, maintain the balance of organismic internal environment; Can be used as again a kind of medicine and in the situation that body catches, treat epidemic disease.The bioactive substances such as alkaloid, polysaccharide, glycoside volatile oil tannin, organic acid, flavonoid and bioflavonoids that contain bateriostatics composition in Chinese medicine, can improve the histiocytic activity of immune system, increase the growth of immune cell and synthesizing of antibody, regulate immunologic function and the non-specific antibacterial action of body, thereby improve the premunition of body, maintain organismic internal environment balance, there is obvious immunological enhancement.
Chinese herbal medicine mostly is root, stem and the leaf of natural plants, have no side effect and drug residue, compare with synthetic drug, there is the features such as untoward reaction is few, toxic and side effects is little, pleiotropy, no dependence, and body is had to significant immunoregulation effect, the advantage aspect safety in utilization in addition, and become the focus of vaccine adjuvant research, therefore, adopt Chinese herbal medicine to be used for preventing newcastle disease to there is the advantage that chemicals does not have as immunostimulant.
Summary of the invention
Technical problem to be solved by this invention is to be to provide a kind of novel for preventing the Chinese traditional immunopoteniators of Newcastle disease, utilize traditional Chinese medical science organic conception and the dialectical theory treating, by effect body immune system, regulate immunity of organisms, reach strengthening body resistance and dispelling evil, the effect of strengthening the body resistance, realizes the prevention of Newcastle disease and treatment.
In order to solve above-mentioned technology, ask, the invention provides a kind ofly for preventing and treat the Chinese traditional immunopoteniators of Newcastle disease, it comprises following crude drug: Herb Gynostemmae Pentaphylli, Spina Gleditsiae, Flos Chrysanthemi, Radix Codonopsis, Semen Lablab Album, Rhizoma Dryopteris Crassirhizomatis, Herba Epimedii, Aloe, Rhizoma Bistortae, Herba Taraxaci, Herba Andrographis, Herba Ecliptae, Fructus Lycii, Fructus Mori, Radix Glycyrrhizae, Caulis Polygoni Multiflori, Indigo Naturalis, the Radix Stemonae, Fructus Bruceae, Radix Ophiopogonis, Semen Astragali Complanati.
Wherein, in described Chinese traditional immunopoteniators, the weight portion of each crude drug is respectively: Herb Gynostemmae Pentaphylli 30 weight portion～40 weight portions, Spina Gleditsiae 15 weight portion～25 weight portions, Flos Chrysanthemi 20 weight portion～30 weight portions, Radix Codonopsis 60 weight portion～70 weight portions, Semen Lablab Album 40 weight portion～50 weight portions, Rhizoma Dryopteris Crassirhizomatis 20 weight portion～30 weight portions, Herba Epimedii 30 weight portion～40 weight portions, Aloe 10 weight portion～20 weight portions, Rhizoma Bistortae 15 weight portion～25 weight portions, Herba Taraxaci 20 weight portion～30 weight portions, Herba Andrographis 20 weight portion～30 weight portions, Herba Ecliptae 40 weight portion～50 weight portions, Fructus Lycii 35 weight portion～45 weight portions, Fructus Mori 30 weight portion～40 weight portions, Radix Glycyrrhizae 35 weight portion～45 weight portions, Caulis Polygoni Multiflori 20 weight portion～30 weight portions, Indigo Naturalis 40 weight portion～50 weight portions, the Radix Stemonae 10 weight portion～20 weight portions, Fructus Bruceae 20 weight portion～30 weight portions, Radix Ophiopogonis 30 weight portion～40 weight portion, Semen Astragali Complanati 40 weight portion～50 weight portions.
Wherein, in described Chinese traditional immunopoteniators, the weight portion of each crude drug is respectively: Herb Gynostemmae Pentaphylli 35 weight portions, Spina Gleditsiae 20 weight portions, Flos Chrysanthemi 25 weight portions, Radix Codonopsis 65 weight portions, Semen Lablab Album 45 weight portions, Rhizoma Dryopteris Crassirhizomatis 25 weight portions, Herba Epimedii 35 weight portions, Aloe 15 weight portions, Rhizoma Bistortae 20 weight portions, Herba Taraxaci 25 weight portions, Herba Andrographis 25 weight portions, Herba Ecliptae 45 weight portions, Fructus Lycii 40 weight portions, Fructus Mori 35 weight portions, Radix Glycyrrhizae 40 weight portions, Caulis Polygoni Multiflori 25 weight portions, Indigo Naturalis 45 weight portions, the Radix Stemonae 15 weight portions, Fructus Bruceae 25 weight portions, Radix Ophiopogonis 35 weight portion, Semen Astragali Complanati 45 weight portions.
Wherein, Chinese traditional immunopoteniators provided by the invention can be prepared into decoction, powder and injection.
For solving the problems of the technologies described above, the present invention also provides a kind of fodder compound, it comprises: as above-mentioned Chinese traditional immunopoteniators powder and the normal feedstuff of additive, with respect to the normal feedstuff of 100 weight portions, the addition of Chinese traditional immunopoteniators powder is 8 weight portion～12 weight portions.
For solving the problems of the technologies described above, the present invention also provides a kind of Chinese traditional immunopoteniators decoction, and the crude drug that described decoction comprises is Herb Gynostemmae Pentaphylli, Spina Gleditsiae, Flos Chrysanthemi, Radix Codonopsis, Semen Lablab Album, Rhizoma Dryopteris Crassirhizomatis, Herba Epimedii, Aloe, Rhizoma Bistortae, Herba Taraxaci, Herba Andrographis, Herba Ecliptae, Fructus Lycii, Fructus Mori, Radix Glycyrrhizae, Caulis Polygoni Multiflori, Indigo Naturalis, the Radix Stemonae, Fructus Bruceae, Radix Ophiopogonis, Semen Astragali Complanati;
The preparation method of described decoction is specially,
Each crude drug component is ground into coarse powder, add water to and flood powder 3～5cm, soak 1h～2h, heating decocts, boil the rear slow fire of using, after boiling for the first time, decoct 30min～60min, leach medicinal liquid, in filtering residue, again add water to and flood powder 3～5cm, heated and boiled, boils the rear slow fire of using, and after boiling for the second time, decocts 15min～30min, filter, the medicinal liquid that merges twice filtration, heating is concentrated into the medicinal liquid that crude drug concentration is 1g/ml～2g/ml, adds after the sodium citrate antiseptic that accounts for quality of liquid medicine 0.4%, in subpackage and 250ml bottle, be placed in 4 ℃ of refrigerators standby.
For solving the problems of the technologies described above, the present invention also provides a kind of Chinese traditional immunopoteniators powder, and the crude drug that described powder comprises is Herb Gynostemmae Pentaphylli, Spina Gleditsiae, Flos Chrysanthemi, Radix Codonopsis, Semen Lablab Album, Rhizoma Dryopteris Crassirhizomatis, Herba Epimedii, Aloe, Rhizoma Bistortae, Herba Taraxaci, Herba Andrographis, Herba Ecliptae, Fructus Lycii, Fructus Mori, Radix Glycyrrhizae, Caulis Polygoni Multiflori, Indigo Naturalis, the Radix Stemonae, Fructus Bruceae, Radix Ophiopogonis, Semen Astragali Complanati;
The preparation method of described powder is specially,
Each crude drug component is ground into coarse powder, adds water to and flood powder 3～5cm, soak 1h～2h, heating decocts, and boils the rear slow fire of using, and after boiling for the first time, decocts 30min～60min, leach medicinal liquid, in filtering residue, again add water to and flood powder 3～5cm, heated and boiled, boil the rear slow fire of using, after boiling for the second time, decoct 15min～30min, filter, the medicinal liquid that merges twice filtration, heating is concentrated except anhydrating, and obtains and gets dry extract, be ground into powder, dry, obtain powder.
For solving the problems of the technologies described above, the present invention also provides a kind of Chinese traditional immunopoteniators injection, and the crude drug that described injection comprises is Herb Gynostemmae Pentaphylli, Spina Gleditsiae, Flos Chrysanthemi, Radix Codonopsis, Semen Lablab Album, Rhizoma Dryopteris Crassirhizomatis, Herba Epimedii, Aloe, Rhizoma Bistortae, Herba Taraxaci, Herba Andrographis, Herba Ecliptae, Fructus Lycii, Fructus Mori, Radix Glycyrrhizae, Caulis Polygoni Multiflori, Indigo Naturalis, the Radix Stemonae, Fructus Bruceae, Radix Ophiopogonis, Semen Astragali Complanati;
The preparation method of described injection is specially,
Each crude drug component is ground into coarse powder, add water to and flood powder 3～5cm, soak 1h～2h, heating decocts, boil rear with slow fire, after boiling for the first time, decoct 30min～60min, leach medicinal liquid, in filtering residue, again add water to and flood powder 3～5cm, heated and boiled, boil rear with slow fire, after boiling for the second time, decoct 15min～30min, filter, the medicinal liquid that merges twice filtration, add 0 to account for quality of liquid medicine .5% active carbon, keep pH value 7.0, heat micro-boiling 15 minutes, cooling, filter, inject water to 1000ml, canned, in 115 ℃ of sterilizings 30 minutes, cold preservation 48 hours, filter, subpackage, obtain injection.
The present invention also provides the preparation method of above-mentioned Chinese traditional immunopoteniators, when the dosage form of described Chinese traditional immunopoteniators is decoction, be specially, each crude drug component is ground into coarse powder, add water to and flood powder 3～5cm, soak 1h～2h, heating decocts, boil rear with slow fire, after boiling for the first time, decoct 30min～60min, leach medicinal liquid, in filtering residue, again add water to and flood powder 3～5cm, heated and boiled, boil rear with slow fire, after boiling for the second time, decoct 15min～30min, filter, the medicinal liquid that merges twice filtration, heating is concentrated into the medicinal liquid that crude drug concentration is 1g/ml～2g/ml, add after the sodium citrate antiseptic that accounts for quality of liquid medicine 0.4%, in subpackage and 250ml bottle, be placed in 4 ℃ of refrigerators standby.
The present invention also provides the preparation method of above-mentioned Chinese traditional immunopoteniators, when the dosage form of described Chinese traditional immunopoteniators is injection, be specially, each crude drug component is ground into coarse powder, add water to and flood powder 3～5cm, soak 1h～2h, heating decocts, boil rear with slow fire, after boiling for the first time, decoct 30min～60min, leach medicinal liquid, in filtering residue, again add water to and flood powder 3～5cm, heated and boiled, boil rear with slow fire, after boiling for the second time, decoct 15min～30min, filter, the medicinal liquid that merges twice filtration, add and account for quality of liquid medicine 0.5% active carbon, keep pH value 7.0, heat micro-boiling 15 minutes, cooling, filter, inject water to 1000ml, canned, in 115 ℃ of sterilizings 30 minutes, cold preservation 48 hours, filter, subpackage, obtain injection.
Beneficial effect of the present invention:
Chinese traditional immunopoteniators provided by the invention regulates immunity of organisms by effect body immune system, reaches strengthening body resistance and dispelling evil, and the effect of strengthening the body resistance realizes the prevention of Newcastle disease and treatment.
The specific embodiment
The invention provides a kind ofly for preventing and treat the Chinese traditional immunopoteniators of Newcastle disease, it comprises following crude drug: Herb Gynostemmae Pentaphylli, Spina Gleditsiae, Flos Chrysanthemi, Radix Codonopsis, Semen Lablab Album, Rhizoma Dryopteris Crassirhizomatis, Herba Epimedii, Aloe, Rhizoma Bistortae, Herba Taraxaci, Herba Andrographis, Herba Ecliptae, Fructus Lycii, Fructus Mori, Radix Glycyrrhizae, Caulis Polygoni Multiflori, Indigo Naturalis, the Radix Stemonae, Fructus Bruceae, Radix Ophiopogonis, Semen Astragali Complanati.
Preferably, described Chinese traditional immunopoteniators is only comprised of above-mentioned raw materials medicine.
In described Chinese traditional immunopoteniators, the weight portion of each crude drug is preferably respectively: Herb Gynostemmae Pentaphylli 30 weight portion～40 weight portions, Spina Gleditsiae 15 weight portion～25 weight portions, Flos Chrysanthemi 20 weight portion～30 weight portions, Radix Codonopsis 60 weight portion～70 weight portions, Semen Lablab Album 40 weight portion～50 weight portions, Rhizoma Dryopteris Crassirhizomatis 20 weight portion～30 weight portions, Herba Epimedii 30 weight portion～40 weight portions, Aloe 10 weight portion～20 weight portions, Rhizoma Bistortae 15 weight portion～25 weight portions, Herba Taraxaci 20 weight portion～30 weight portions, Herba Andrographis 20 weight portion～30 weight portions, Herba Ecliptae 40 weight portion～50 weight portions, Fructus Lycii 35 weight portion～45 weight portions, Fructus Mori 30 weight portion～40 weight portions, Radix Glycyrrhizae 35 weight portion～45 weight portions, Caulis Polygoni Multiflori 20 weight portion～30 weight portions, Indigo Naturalis 40 weight portion～50 weight portions, the Radix Stemonae 10 weight portion～20 weight portions, Fructus Bruceae 20 weight portion～30 weight portions, Radix Ophiopogonis 30 weight portion～40 weight portion, Semen Astragali Complanati 40 weight portion～50 weight portions.
In described Chinese traditional immunopoteniators, the weight portion of each crude drug is respectively: Herb Gynostemmae Pentaphylli 35 weight portions, Spina Gleditsiae 20 weight portions, Flos Chrysanthemi 25 weight portions, Radix Codonopsis 65 weight portions, Semen Lablab Album 45 weight portions, Rhizoma Dryopteris Crassirhizomatis 25 weight portions, Herba Epimedii 35 weight portions, Aloe 15 weight portions, Rhizoma Bistortae 20 weight portions, Herba Taraxaci 25 weight portions, Herba Andrographis 25 weight portions, Herba Ecliptae 45 weight portions, Fructus Lycii 40 weight portions, Fructus Mori 35 weight portions, Radix Glycyrrhizae 40 weight portions, Caulis Polygoni Multiflori 25 weight portions, Indigo Naturalis 45 weight portions, the Radix Stemonae 15 weight portions, Fructus Bruceae 25 weight portions, Radix Ophiopogonis 35 weight portion, Semen Astragali Complanati 45 weight portions.
Chinese traditional immunopoteniators provided by the invention can be prepared into decoction, powder and injection, and decoction can be for gavaging, and powder is stirred in feedstuff and takes, and injection is directly injected.
The present invention also provides the preparation method of above-mentioned Chinese traditional immunopoteniators, when described Chinese traditional immunopoteniators is decoction, is specially:
Each crude drug component is ground into coarse powder, add water to and flood powder 3～5cm, soak 1h～2h, heating decocts, boil the rear slow fire of using, after boiling for the first time, decoct 30min～60min, leach medicinal liquid, in filtering residue, again add water to and flood powder 3～5cm, heated and boiled, boils the rear slow fire of using, and after boiling for the second time, decocts 15min～30min, filter, the medicinal liquid that merges twice filtration, heating is concentrated into the medicinal liquid that crude drug concentration is 1g/ml～2g/ml, adds after the sodium citrate antiseptic that accounts for quality of liquid medicine 0.4%, in subpackage and 250ml bottle, be placed in 4 ℃ of refrigerators standby.
The present invention also provides the preparation method of above-mentioned Chinese traditional immunopoteniators, when described Chinese traditional immunopoteniators is powder, is specially:
Each crude drug component is ground into coarse powder, adds water to and flood powder 3～5cm, soak 1h～2h, heating decocts, and boils the rear slow fire of using, and after boiling for the first time, decocts 30min～60min, leach medicinal liquid, in filtering residue, again add water to and flood powder 3～5cm, heated and boiled, boil the rear slow fire of using, after boiling for the second time, decoct 15min～30min, filter, the medicinal liquid that merges twice filtration, heating is concentrated except anhydrating, and obtains and gets dry extract, be ground into powder, dry, obtain powder.
The present invention also provides the preparation method of above-mentioned Chinese traditional immunopoteniators, when described Chinese traditional immunopoteniators is injection, is specially:
Each crude drug component is ground into coarse powder, add water to and flood powder 3～5cm, soak 1h～2h, heating decocts, boil rear with slow fire, after boiling for the first time, decoct 30min～60min, leach medicinal liquid, in filtering residue, again add water to and flood powder 3～5cm, heated and boiled, boil rear with slow fire, after boiling for the second time, decoct 15min～30min, filter, the medicinal liquid that merges twice filtration, add and account for quality of liquid medicine 0.5% active carbon, keep pH value 7.0, heat micro-boiling 15 minutes, cooling, filter, inject water to 1000ml, canned, in 115 ℃ of sterilizings 30 minutes, cold preservation 48 hours, filter, subpackage, obtain injection.
For solving the problems of the technologies described above, the present invention also provides a kind of fodder compound, it comprises: as above-mentioned Chinese traditional immunopoteniators and the normal feedstuff of additive, with respect to the normal feedstuff of 100 weight portions, the addition of Chinese traditional immunopoteniators is 8 weight portion～12 weight portions.
Described normal feedstuff can be for the conventional normal feedstuff of feeding chicken, as Semen Tritici aestivi, Testa Tritici, Semen Maydis etc.
Can in fodder compound, continue to add other conventional feed additives, as amino acid additive, vitamin(e) supplement etc.
Each crude drug pharmacology:
Herb Gynostemmae Pentaphylli: cold in nature, sweet in the mouth, return lung, spleen, kidney channel, there is QI invigorating, calm the nerves, the effect of blood pressure lowering, for deficiency of vital energy and physically weak, weak breath is weak; Vexed insomnia; Hypertension, Light-headedness; Viral hepatitis; Digestive tract tumor; Chronic bronchitis, the polysaccharide that Herb Gynostemmae Pentaphylli is rich in can improve serum hemolysin content, and humoral immunization is had to facilitation, and the total saponins that Herb Gynostemmae Pentaphylli is rich in can promote lymphocyte transformation, improves the activity of DNA polysaccharide, promotes the synthetic of lymphocyte DNA.
Spina Gleditsiae: acrid in the mouth, warm in nature, return lung meridian, cure mainly swollen ulcer drug, scrofula, skin ulcer rash stubborn dermatitis, puerperal hypogalactia, placenta retention, the cards such as leprosy.
Flos Chrysanthemi: acrid in the mouth, sweet, bitter, cold nature, returns lung, Liver Channel, has the effect of dispelling wind liver heat removing, suppressing the hyperactive liver improving eyesight, removing toxic substances and promoting subsidence of swelling, cure mainly affection due to external wind and heat and epidemic febrile disease from the beginning of, have a dizzy spell, blurring of vision, conjunctival congestion and swelling pain, the cards such as pyretic toxicity carbuncle.
Radix Codonopsis: sweet in the mouth, property is flat, enters lung, spleen channel, has QI invigorating strengthening the spleen, the effect of nourishing blood to promote the production of body fluid, be mainly used in deficiency of both the splenic and pulmonary QI or QI and blood deficiency fatigue and weakness, breathe hard, symptom such as cough spontaneous perspiration etc., Radix Codonopsis is longer than spleen reinforcing nourishing the stomach, adjust regulating the function of middle-JIAO, have the effect of nourishing blood concurrently, its property is flat, spleen invigorating fortune and not dry; Flavour is cloudy and not wet, can improve the immune state of body, improves resistance against diseases, and facilitating digestion absorbs, and improves metabolism, promotes the absorption of intestinal to nutrient substance.
Semen Lablab Album: sweet in the mouth, slightly warm in nature, enter spleen, stomach warp, have invigorating the spleen for eliminating dampness and in the effect of relieving summer heat, for indigestion and loss of appetite abdominal distention, loose stool, aqueous-grainy diarrhea, the cards such as vomiting of feeling sick of weakness of the spleen and stomach.
Rhizoma Dryopteris Crassirhizomatis: cold nature, bitter in the mouth, returns liver, stomach warp, has heat-clearing and toxic substances removing, anthelmintic, the effect of hemostasis, cures mainly cards such as preventing influenza, abdominal pain due to worm stagnation, metrorrhagia.
Herba Epimedii: acrid in the mouth, sweet, warm in nature, enter liver, kidney channel, there is kidney-replenishing, bone and muscle strengthening, the effect of wind-damp dispelling,, cold extremities with aversion to cold soft for impotence due to deficiency of the kidney, seminal emission premature ejaculation, waist knee joint flaccidity; The cards such as arthralgia due to cold-dampnes or spasm of the limbs are numb.
Aloe: bitter in the mouth, cold in nature, return liver, large intestine channel, there is the cool liver of heat clearing away, relieving constipation by purgation, the effect of the infantile malnutrition that disappears parasite killing, cures mainly liver-fire headache, conjunctival congestion and swelling pain, dysphoria with smothery sensation infantile convulsion, constipation with heat retention, abdominal pain due to worm stagnation, infantile malnutrition, eczema scabies, the cards such as hemorrhoid complicated by anal fistula.
Rhizoma Bistortae: bitter in the mouth, cool in nature, return lung, liver, large intestine channel, heat clearing away is relieving convulsion, the wet detumescence of reason.Control that calentura is frightened jerks, tetanus, bloody dysentery, carbuncle, scrofula.Clearing away heat-damp and promoting diuresis; Cooling blood for hemostasis; Detoxicating and resolving stagnation of pathogens.Main cough due to lung-heat, calentura infantile convulsion; Bloody dysentery; Diarrhea of heat type; Spit blood; Epistaxis; Bleeding hemorrhoids; Carbuncle sore tumefacting virus.
Herba Taraxaci: sweet in the mouth, hardship, cold in nature, enter liver, stomach warp, there is the effect of heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, liver heat removing and eyesight improving, inducing diuresis for treating stranguria syndrome, be mainly used in the treatment of sore swollen toxin, especially remarkable to acute mastitis effect, also can be used for the cards such as conjunctival congestion and swelling pain of flaming up of liver-fire.
Herba Andrographis: bitter in the mouth, cold in nature, GUIXIN, lung, large intestine, urinary bladder channel, have heat-clearing and toxic substances removing, removing heat from blood, detumescence, the effect of dampness, cures mainly cold, fever, laryngopharynx swelling and pain, aphtha of the mouth and tongue, pertussis chronic cough, dysentery, the puckery pain of pyretic stranguria, carbuncle skin infection, the cards such as venom.
Herba Ecliptae: sweet in the mouth, acid, cold in nature, return liver, kidney channel, play liver and kidney tonifying, the effect of cooling blood for hemostasis, for having a dizzy spell due to the hepatic and renal YIN deficiency, blurring of vision, soreness of the waist and knees; Being suitable for the deficiency of YIN has hot person, is used for the treatment of the haematemesis of accumulated heat in stomach, the cards such as the hemoptysis of injury of blood vessel of the lung by heat.
Fructus Lycii: sweet in the mouth, property are flat, enter liver, kidney channel, have liver and kidney tonifying, nourish blood enrich blood, the effect of replenishing vital essence to improve eyesight, nourishing the lung to arrest cough, be mainly used in soreness of the waist and knees, dizziness and tinnitus, seminal emission tinnitus, the unconsciously sweat and tire of Liver and kidney two void, asthenia of essence and blood; The sexual impotence of insufficiency of kidney-YANG, sterile; The cards such as the dim-sighted and deficiency of YIN chronic cough of the eyes of deficiency of YIN-essence, deficiency of liver-blood, Fructus Lycii can promote liver cell regeneration, the effect of enhancing non-specific immunity function.
Fructus Mori: sweet in the mouth, acid, cold in nature, GUIXIN, liver, kidney channel, have the YIN nourishing of enriching blood, the effect of promoting the production of body fluid and moisturizing.For vertigo and tinnitus, palpitation and insomnia, early whitening of beard and hair, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, blood deficiency and constipation.Tonifying liver, kidney tonifying, relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and grows liquid.Control hepatic and renal YIN deficiency, quench one's thirst, constipation, order is dark, tinnitus, scrofula, the cards such as articular instability.
Radix Glycyrrhizae: sweet in the mouth, property is flat, enters 12 warps, has heat-clearing and toxic substances removing, is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain, is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, weak; Can alleviate contracture pain in abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, by adding Radix Glycyrrhizae can play QI invigorating, neutralizes, and is in harmonious proportion the effect of each component.
Caulis Polygoni Multiflori: sweet in the mouth, micro-hardship, property is flat; GUIXIN, Liver Channel, having can tranquilizing by nourishing the heart, the effect of dispelling wind and removing obstruction in the collateral, cures mainly insomnia and dreamful sleep, blood deficiency general pain, numbness of the skin, rheumatic arthralgia, the cards such as wind skin ulcer scabies.
Indigo Naturalis: salty in the mouth, cold in nature, enter Liver Channel, there is the effect of heat-clearing and toxic substances removing, cooling blood for hemostasis, purging liver-fire, for epidemic febrile disease, send out the cards such as all cards of pyretic toxicity such as speckle, haematemesis, laryngopharynx swelling and pain, herpes eczema, liver-fire invading the lung, cough chest pain, sputum mixed with blood, high hot infantile convulsion, convulsion with spasms.
The Radix Stemonae: sweet in the mouth, hardship, slightly warm in nature, returns lung meridian, has nourishing the lung to keep the adverse QI downward cough-relieving, and the effect of parasite killing cures mainly new chronic cough and coughs, pulmonary tuberculosis cough, pertussis; Outward for head louse, body louse, enterobiasis, the cards such as pudendum Pruritus.
Fructus Bruceae: bitter in the mouth, cold in nature, return large intestine channel, Liver Channel, there is heat-clearing and toxic substances removing, dysentery relieving, preventing the attack (or recurrence) of malaria, the effect of corrosion wart, cures mainly dysentery, malaria; The cards such as external treatment wart, clavus.
Radix Ophiopogonis: sweet in the mouth, micro-hardship, cold nature, enters the heart, lung, stomach warp, have the effect that nourishing YIN and moistening the lung, preventing phlegm from forming and stopping coughing, heat clearing away nourish heart, curing mainly pathogenic dryness impairing the lung or lung-dryness syndrome due to deficiency of YIN has the dry cough expectorant of heat glutinous, chronic cough hemoptysis, dry pharynx dryness in the nasal cavity, lung abscess, the dry mouth and throat due to thermal burn stomach-Yin or deficiency of stomach-Yin, the few tongue of red tongue, vague epigastralgia, interior-heat is quenched one's thirst, constipation due to dry stool, deficiency of heart-yin and epidemic febrile disease pathogenic heat are disturbed and the heart-nutriment and the dysphoria and insomnia that causes, crimson tongue and the dry card that waits.
Semen Astragali Complanati: warm in nature, sweet in the mouth, has temperature compensation Liver and kidney, controlling nocturnal emission with astringent drugs, reducing urination, the effect of improving eyesight, for impotence due to deficiency of the kidney, seminal emission premature ejaculation, frequent micturition, or leukorrhagia, soreness of the waist and knees, lumbago; Deficiency of the liver and kindey, blurred vision order is dark, the cards such as visual deterioration.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
The preparation of embodiment 1 decoction
By Herb Gynostemmae Pentaphylli 35g, Spina Gleditsiae 20g, Flos Chrysanthemi 25g part, Radix Codonopsis 65g, Semen Lablab Album 45g, Rhizoma Dryopteris Crassirhizomatis 25g, Herba Epimedii 35g, Aloe 15g, Rhizoma Bistortae 20g, Herba Taraxaci 25g, Herba Andrographis 25g, Herba Ecliptae 45g, Fructus Lycii 40g, Fructus Mori 35g, Radix Glycyrrhizae 40g, Caulis Polygoni Multiflori 25g, Indigo Naturalis 45g, Radix Stemonae 15g, Fructus Bruceae 25g, Radix Ophiopogonis 35g, Semen Astragali Complanati 45g is ground into coarse powder, add water to and flood powder 5cm, soak 2h, heating decocts, boil rear with slow fire, after boiling for the first time, decoct 60min, leach medicinal liquid, in filtering residue, again add water to and flood powder 5cm, heated and boiled, boil rear with slow fire, after boiling for the second time, decoct 30min, filter, the medicinal liquid that merges twice filtration, heating is concentrated into the medicinal liquid that crude drug concentration is 2g/ml, add after the sodium citrate antiseptic that accounts for quality of liquid medicine 0.4%, in subpackage and 250ml bottle, be placed in 4 ℃ of refrigerators standby.
The preparation of embodiment 2 powders
By Herb Gynostemmae Pentaphylli 35g, Spina Gleditsiae 20g, Flos Chrysanthemi 25g part, Radix Codonopsis 65g, Semen Lablab Album 45g, Rhizoma Dryopteris Crassirhizomatis 25g, Herba Epimedii 35g, Aloe 15g, Rhizoma Bistortae 20g, Herba Taraxaci 25g, Herba Andrographis 25g, Herba Ecliptae 45g, Fructus Lycii 40g, Fructus Mori 35g, Radix Glycyrrhizae 40g, Caulis Polygoni Multiflori 25g, Indigo Naturalis 45g, Radix Stemonae 15g, Fructus Bruceae 25g, Radix Ophiopogonis 35g, Semen Astragali Complanati 45g is ground into coarse powder, add water to and flood powder 5cm, soak 2h, heating decocts, boil rear with slow fire, after boiling for the first time, decoct 60min, leach medicinal liquid, in filtering residue, again add water to and flood powder 5cm, heated and boiled, boil rear with slow fire, after boiling for the second time, decoct 30min, filter, the medicinal liquid that merges twice filtration, heating is concentrated except anhydrating, obtain and get dry extract, be ground into powder, dry, obtain powder.
The preparation of embodiment 3 injection
By Herb Gynostemmae Pentaphylli 35g, Spina Gleditsiae 20g, Flos Chrysanthemi 25g part, Radix Codonopsis 65g, Semen Lablab Album 45g, Rhizoma Dryopteris Crassirhizomatis 25g, Herba Epimedii 35g, Aloe 15g, Rhizoma Bistortae 20g, Herba Taraxaci 25g, Herba Andrographis 25g, Herba Ecliptae 45g, Fructus Lycii 40g, Fructus Mori 35g, Radix Glycyrrhizae 40g, Caulis Polygoni Multiflori 25g, Indigo Naturalis 45g, Radix Stemonae 15g, Fructus Bruceae 25g, Radix Ophiopogonis 35g, Semen Astragali Complanati 45g is ground into coarse powder, add water to and flood powder 5cm, soak 2h, heating decocts, boil rear with slow fire, after boiling for the first time, decoct 60min, leach medicinal liquid, in filtering residue, again add water to and flood powder 5cm, heated and boiled, boil rear with slow fire, after boiling for the second time, decoct 30min, filter, the medicinal liquid that merges twice filtration, add and account for quality of liquid medicine 0.5% active carbon, keep pH value 7.0, heat micro-boiling 15 minutes, cooling, filter, inject water to 1000ml, canned, in 115 ℃ of sterilizings 30 minutes, cold preservation 48 hours, filter, obtain injection.
The safety experiment of embodiment 4 injection and decoction
7 60 of Japanese instar chicklings, are divided into 3 groups at random, and 20 every group, health status and body weight size are basic identical.The injection 4ml/ of the 1st group of chickling intramuscular injection embodiment 3 preparations only, the 2nd group of chickling injecting normal saline 4ml/ only, inject continuously 3d, the 3rd group of chickling drunk 2 weeks with the decoction of embodiment 1 preparation, gavage 30ml every day, observe day by day to 35 ages in days, the identical feedstuff of feeding, free choice feeding and drinking-water, see and have or not abnormal response.
The injection volume of the injection of the 1st group is 4 times of use amounts, observes 14d, and chickling all survives, and searches for food and drinks water normally, does not find untoward reaction.Cut open the visible splenomegaly of inspection, other internal organs are all normal.The decoction 14d that drinks continuously embodiment 1 preparation to chickling, whole strong living, searches for food, drinks water, spirit is all normal, and internal organs pathologic finding non-toxic reaction, shows that Chinese traditional immunopoteniators safety range of the present invention is wide, and life-time service has no side effect.
Embodiment 5 experimental datas
1. the impact of Chinese traditional immunopoteniators on Immune Organs of Chicken growth and newcastle epidemic disease antibody level
Experimental animal: 1 80 of Japanese instar chicklings, are purchased from chicken farm, Jinan.
The decoction of test Chinese medicine: embodiment 1 preparation.
Newcastle II is vaccine: be purchased from Guangdong biological factory.
Newcastle standard antigen: provided by Shandong Agricultural University.
Red cell suspension: provided by Shandong Agricultural University.
Method: 80 chickling are divided into 2 groups of raisings, and while feeding age in water feeding to 3 week, 1 group is Chinese traditional immunopoteniators group on time, and 1 group is blank group.
Immunity: when divided into groups age in 3 week, eye drip inoculation newcastle disease II is vaccine.
Administration: from chicken immunity in age in 3 week, Chinese drug-treated group gavages the decoction of embodiment 1 preparation to chicken, every day 50ml, administration time 28 days, blank group is not added any medicine.
ND-HI antibody test: after little chicken immune, 14,28 days time, choose at random 10 healthy chickens respectively, heart blood sampling 1～1.5ml, separation of serum, adopts β-micro-newcastle disease hemagglutination inhibition test (ND-HI) method to detect ND-HI antibody titer.
The calculating of immune organ body-mass index: by the aforementioned chicken of adopting blood, provoke at random 5 after carotid artery blood-letting is lethal, gather spleen, thymus, three kinds of immune organs of fabricius bursa, take weight in wet base, calculate Immune Organs Index by following formula.
Spleen (thymus or fabricius bursa) index=spleen (thymus or fabricius bursa) weight in wet base (mg)/chicken live body heavy (g).
Result statistics: all experimental datas are carried out statistical disposition with SPSS10.1 english software.
Experimental result: Chinese traditional immunopoteniators, on the impact of newcastle HI antibody titer, the results are shown in Table 1.
Table 1 Chinese traditional immunopoteniators affects ND-HI antibody titer
| Group | Sample | 2 weeks | 4 weeks |
| Chinese drug-treated group | 40 | 7.800±0.329 | 6.600±0.317 |
| Blank group | 40 | 6.000±0.329 | 4.500±0.402 |
Table 1 can be found out, compares with blank group, adopts Chinese traditional immunopoteniators of the present invention can significantly improve body antibody titer, P<0.05.
The impact of Chinese medicine on Immune Organs Index, in Table 2.Table 2 Chinese traditional immunopoteniators is on the impact of Immune Organs of Chicken index (mg/g)
As can be seen from Table 2, the spleen body-mass index of Chinese medicine experimental group chicken is all higher than blank group, P<0.05, illustrate that Chinese traditional immunopoteniators has the effect that delays atrophy of immune organ, the fabricius bursa body-mass index of Chinese medicine experimental group chicken is all higher than blank group, illustrate that this Chinese traditional immunopoteniators can be by affecting the growth of fabricius bursa, promote the growth of bone-marrow-derived lymphocyte, thereby improve body antibody horizontal, the thymus body-mass index of Chinese medicine experimental group chicken is all higher than blank group, illustrate that this Chinese traditional immunopoteniators can promote the function of thymus development, thereby delay the atrophy of thymus, maintain the special and non-specific immunity of body.
2. the prevention effect of Chinese traditional immunopoteniators to artificial challenge's newcastle disease
Experimental agents: the decoction of the embodiment of the present invention 1 preparation.
Virus: the strain of newcastle disease virus Zhuhai, Shandong Agricultural University provides.
Laboratory animal: 1 400 of Japanese instar chicklings, be purchased from chicken farm, Jinan, according to conventional method, raise, feed in advance 3 weeks.
Experimental technique: 400 chickling feeding after 3 weeks are divided into 4 groups at random, are divided into prevention group, treatment group, blank group and counteracting toxic substances matched group, 100 every group, except blank group, itself and each group is randomly drawed 20 blood samplings before counteracting toxic substances, by ELISA method, measures HI antibody, and measurement result is negative.Counteracting toxic substances dosage is with reference to cell median infective dose (TCID
5010
-4.6) and clinical preliminary test result carry out 10
5dilution, carries out intramuscular injection.Prevention group 3d before counteracting toxic substances carries out chemoprophylaxis, gavages the Chinese traditional immunopoteniators decoction 30ml of embodiment 1 preparation every day, presses the administration for the treatment of group method after counteracting toxic substances; Treatment group gavages the Chinese traditional immunopoteniators decoction 50ml of embodiment 1 preparation, medication phase 10d every day at counteracting toxic substances simultaneously.
Evaluating drug effect: morbidity: duration of test, has obvious Newcastle Disease clinical symptoms or necropsy to have Newcastle Disease feature pathological changes person to be all decided to be morbidity; Dead: duration of test is dead, has obvious Newcastle Disease clinical symptoms or necropsy to have Newcastle Disease feature pathological changes person, be judged to be and infect death.
Sickness rate=morbidity number/this group test chicken number * 100%, mortality rate=death toll/this group test chicken number * 100%, cure rate=not dead sick chicken number/this group morbidity chicken sum * 100%.
Experimental result
Chickens Infected Newcastle Disease come personally symptom and pathological change
Counteracting toxic substances matched group, after infecting 60h, engenders clinical symptoms; After 72h, in succession there is clinical symptoms in other each groups, shows as poor appetite or do not eat, and spirit is depressed, close order slow-witted vertical, draw yellow green feces, dyspnea, gets rid of head, send " cluck,coo " sound, some oral cavities have mucus to flow out, and there is nervous symptoms in part chicken, and 4～6d is the peak mortality phase.The sick chicken of part is cutd open the visible typical newcastle pathological changes of inspection: glandular stomach mucosa edema is hemorrhage between nipple top or nipple; Cecal tonsil enlargement, hemorrhage, downright bad; Small intestinal mucosa has Semen Jujubae shape hemorrhage (fibroid necrosis region); Caecum mucosa has petechia.
100 chickens of counteracting toxic substances matched group after counteracting toxic substances in 240h dead 98, wherein 72h is dead 12, dead 20 of 96h, dead 26 of 120h, dead 18 of 144h, dead 15 of 168h, dead 9 of 196h.
Chinese traditional immunopoteniators anti-new castle disease virus clinical experiment result, in Table 3.
Table 3 Chinese traditional immunopoteniators anti-new castle disease virus clinical experiment result
| Group | Sample | Morbidity number | Sickness rate | Death toll | Mortality rate | Cure rate |
| Blank group | 100 | 0 | 0 | 0 | 0 | 100% |
| Counteracting toxic substances group | 100 | 100 | 100% | 98 | 98% | 2% |
| Prevention group | 100 | 100 | 100% | 36 | 36% | 64% |
| Treatment group | 100 | 100 | 100% | 4 | 4% | 96% |
As can be seen from Table 3, with the comparison of counteracting toxic substances matched group, prevention group and treatment group are having obvious effect aspect prevention and treatment newcastle disease, can obviously reduce mortality rate, improve cure rate, P<0.05, erythrocyte hemagglutination test detects and shows, and the chicken of the rehabilitation for the treatment of through Chinese herb on the prevention is all negative.
All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. for preventing and treat a Chinese traditional immunopoteniators for Newcastle disease, it is characterized in that: described Chinese traditional immunopoteniators only consists of crude drug Herb Gynostemmae Pentaphylli, Spina Gleditsiae, Flos Chrysanthemi, Radix Codonopsis, Semen Lablab Album, Rhizoma Dryopteris Crassirhizomatis, Herba Epimedii, Aloe, Rhizoma Bistortae, Herba Taraxaci, Herba Andrographis, Herba Ecliptae, Fructus Lycii, Fructus Mori, Radix Glycyrrhizae, Caulis Polygoni Multiflori, Indigo Naturalis, the Radix Stemonae, Fructus Bruceae, Radix Ophiopogonis, Semen Astragali Complanati, in described Chinese traditional immunopoteniators, the weight portion of each crude drug is respectively Herb Gynostemmae Pentaphylli 30 weight portion ~ 40 weight portions, Spina Gleditsiae 15 weight portion ~ 25 weight portions, Flos Chrysanthemi 20 weight portion ~ 30 weight portions, Radix Codonopsis 60 weight portion ~ 70 weight portions, Semen Lablab Album 40 weight portion ~ 50 weight portions, Rhizoma Dryopteris Crassirhizomatis 20 weight portion ~ 30 weight portions, Herba Epimedii 30 weight portion ~ 40 weight portions, Aloe 10 weight portion ~ 20 weight portions, Rhizoma Bistortae 15 weight portion ~ 25 weight portions, Herba Taraxaci 20 weight portion ~ 30 weight portions, Herba Andrographis 20 weight portion ~ 30 weight portions, Herba Ecliptae 40 weight portion ~ 50 weight portions, Fructus Lycii 35 weight portion ~ 45 weight portions, Fructus Mori 30 weight portion ~ 40 weight portions, Radix Glycyrrhizae 35 weight portion ~ 45 weight portions, Caulis Polygoni Multiflori 20 weight portion ~ 30 weight portions, Indigo Naturalis 40 weight portion ~ 50 weight portions, the Radix Stemonae 10 weight portion ~ 20 weight portions, Fructus Bruceae 20 weight portion ~ 30 weight portions, Radix Ophiopogonis 30 weight portion ~ 40 weight portion, Semen Astragali Complanati 40 weight portion ~ 50 weight portions.
2. Chinese traditional immunopoteniators as claimed in claim 1, it is characterized in that: in described Chinese traditional immunopoteniators, the weight portion of each crude drug is respectively: Herb Gynostemmae Pentaphylli 35 weight portions, Spina Gleditsiae 20 weight portions, Flos Chrysanthemi 25 weight portions, Radix Codonopsis 65 weight portions, Semen Lablab Album 45 weight portions, Rhizoma Dryopteris Crassirhizomatis 25 weight portions, Herba Epimedii 35 weight portions, Aloe 15 weight portions, Rhizoma Bistortae 20 weight portions, Herba Taraxaci 25 weight portions, Herba Andrographis 25 weight portions, Herba Ecliptae 45 weight portions, Fructus Lycii 40 weight portions, Fructus Mori 35 weight portions, Radix Glycyrrhizae 40 weight portions, Caulis Polygoni Multiflori 25 weight portions, Indigo Naturalis 45 weight portions, the Radix Stemonae 15 weight portions, Fructus Bruceae 25 weight portions, Radix Ophiopogonis 35 weight portion, Semen Astragali Complanati 45 weight portions.
3. Chinese traditional immunopoteniators as claimed in claim 1 or 2, is characterized in that: described Chinese traditional immunopoteniators is prepared into decoction, powder and injection.
4. a Chinese traditional immunopoteniators decoction, is characterized in that: described decoction only consists of crude drug Herb Gynostemmae Pentaphylli, Spina Gleditsiae, Flos Chrysanthemi, Radix Codonopsis, Semen Lablab Album, Rhizoma Dryopteris Crassirhizomatis, Herba Epimedii, Aloe, Rhizoma Bistortae, Herba Taraxaci, Herba Andrographis, Herba Ecliptae, Fructus Lycii, Fructus Mori, Radix Glycyrrhizae, Caulis Polygoni Multiflori, Indigo Naturalis, the Radix Stemonae, Fructus Bruceae, Radix Ophiopogonis, Semen Astragali Complanati;
In described decoction, the weight portion of each crude drug is respectively Herb Gynostemmae Pentaphylli 30 weight portion ~ 40 weight portions, Spina Gleditsiae 15 weight portion ~ 25 weight portions, Flos Chrysanthemi 20 weight portion ~ 30 weight portions, Radix Codonopsis 60 weight portion ~ 70 weight portions, Semen Lablab Album 40 weight portion ~ 50 weight portions, Rhizoma Dryopteris Crassirhizomatis 20 weight portion ~ 30 weight portions, Herba Epimedii 30 weight portion ~ 40 weight portions, Aloe 10 weight portion ~ 20 weight portions, Rhizoma Bistortae 15 weight portion ~ 25 weight portions, Herba Taraxaci 20 weight portion ~ 30 weight portions, Herba Andrographis 20 weight portion ~ 30 weight portions, Herba Ecliptae 40 weight portion ~ 50 weight portions, Fructus Lycii 35 weight portion ~ 45 weight portions, Fructus Mori 30 weight portion ~ 40 weight portions, Radix Glycyrrhizae 35 weight portion ~ 45 weight portions, Caulis Polygoni Multiflori 20 weight portion ~ 30 weight portions, Indigo Naturalis 40 weight portion ~ 50 weight portions, the Radix Stemonae 10 weight portion ~ 20 weight portions, Fructus Bruceae 20 weight portion ~ 30 weight portions, Radix Ophiopogonis 30 weight portion ~ 40 weight portion, Semen Astragali Complanati 40 weight portion ~ 50 weight portions,
The preparation method of described decoction is specially,
Each crude drug component is ground into coarse powder, add water to and flood powder 3 ~ 5cm, soak 1h ~ 2h, heating decocts, boil the rear slow fire of using, after boiling for the first time, decoct 30min ~ 60min, leach medicinal liquid, in filtering residue, again add water to and flood powder 3 ~ 5cm, heated and boiled, boils the rear slow fire of using, and after boiling for the second time, decocts 15min ~ 30min, filter, the medicinal liquid that merges twice filtration, heating is concentrated into the medicinal liquid that crude drug concentration is 1g/ml ~ 2g/ml, adds after the sodium citrate antiseptic that accounts for quality of liquid medicine 0.4%, be sub-packed in 250ml bottle, be placed in 4 ℃ of refrigerators standby.
5. a Chinese traditional immunopoteniators powder, is characterized in that: described powder only consists of crude drug Herb Gynostemmae Pentaphylli, Spina Gleditsiae, Flos Chrysanthemi, Radix Codonopsis, Semen Lablab Album, Rhizoma Dryopteris Crassirhizomatis, Herba Epimedii, Aloe, Rhizoma Bistortae, Herba Taraxaci, Herba Andrographis, Herba Ecliptae, Fructus Lycii, Fructus Mori, Radix Glycyrrhizae, Caulis Polygoni Multiflori, Indigo Naturalis, the Radix Stemonae, Fructus Bruceae, Radix Ophiopogonis, Semen Astragali Complanati;
In described powder, the weight portion of each crude drug is respectively Herb Gynostemmae Pentaphylli 30 weight portion ~ 40 weight portions, Spina Gleditsiae 15 weight portion ~ 25 weight portions, Flos Chrysanthemi 20 weight portion ~ 30 weight portions, Radix Codonopsis 60 weight portion ~ 70 weight portions, Semen Lablab Album 40 weight portion ~ 50 weight portions, Rhizoma Dryopteris Crassirhizomatis 20 weight portion ~ 30 weight portions, Herba Epimedii 30 weight portion ~ 40 weight portions, Aloe 10 weight portion ~ 20 weight portions, Rhizoma Bistortae 15 weight portion ~ 25 weight portions, Herba Taraxaci 20 weight portion ~ 30 weight portions, Herba Andrographis 20 weight portion ~ 30 weight portions, Herba Ecliptae 40 weight portion ~ 50 weight portions, Fructus Lycii 35 weight portion ~ 45 weight portions, Fructus Mori 30 weight portion ~ 40 weight portions, Radix Glycyrrhizae 35 weight portion ~ 45 weight portions, Caulis Polygoni Multiflori 20 weight portion ~ 30 weight portions, Indigo Naturalis 40 weight portion ~ 50 weight portions, the Radix Stemonae 10 weight portion ~ 20 weight portions, Fructus Bruceae 20 weight portion ~ 30 weight portions, Radix Ophiopogonis 30 weight portion ~ 40 weight portion, Semen Astragali Complanati 40 weight portion ~ 50 weight portions,
The preparation method of described powder is specially,
Each crude drug component is ground into coarse powder, adds water to and flood powder 3 ~ 5cm, soak 1h ~ 2h, heating decocts, and boils the rear slow fire of using, and after boiling for the first time, decocts 30min ~ 60min, leach medicinal liquid, in filtering residue, again add water to and flood powder 3 ~ 5cm, heated and boiled, boil the rear slow fire of using, after boiling for the second time, decoct 15min ~ 30min, filter, the medicinal liquid that merges twice filtration, heating is concentrated except anhydrating, and obtains and gets dry extract, be ground into powder, dry, obtain powder.
6. a Chinese traditional immunopoteniators injection, is characterized in that: described injection only consists of crude drug Herb Gynostemmae Pentaphylli, Spina Gleditsiae, Flos Chrysanthemi, Radix Codonopsis, Semen Lablab Album, Rhizoma Dryopteris Crassirhizomatis, Herba Epimedii, Aloe, Rhizoma Bistortae, Herba Taraxaci, Herba Andrographis, Herba Ecliptae, Fructus Lycii, Fructus Mori, Radix Glycyrrhizae, Caulis Polygoni Multiflori, Indigo Naturalis, the Radix Stemonae, Fructus Bruceae, Radix Ophiopogonis, Semen Astragali Complanati;
In described injection, the weight portion of each crude drug is respectively Herb Gynostemmae Pentaphylli 30 weight portion ~ 40 weight portions, Spina Gleditsiae 15 weight portion ~ 25 weight portions, Flos Chrysanthemi 20 weight portion ~ 30 weight portions, Radix Codonopsis 60 weight portion ~ 70 weight portions, Semen Lablab Album 40 weight portion ~ 50 weight portions, Rhizoma Dryopteris Crassirhizomatis 20 weight portion ~ 30 weight portions, Herba Epimedii 30 weight portion ~ 40 weight portions, Aloe 10 weight portion ~ 20 weight portions, Rhizoma Bistortae 15 weight portion ~ 25 weight portions, Herba Taraxaci 20 weight portion ~ 30 weight portions, Herba Andrographis 20 weight portion ~ 30 weight portions, Herba Ecliptae 40 weight portion ~ 50 weight portions, Fructus Lycii 35 weight portion ~ 45 weight portions, Fructus Mori 30 weight portion ~ 40 weight portions, Radix Glycyrrhizae 35 weight portion ~ 45 weight portions, Caulis Polygoni Multiflori 20 weight portion ~ 30 weight portions, Indigo Naturalis 40 weight portion ~ 50 weight portions, the Radix Stemonae 10 weight portion ~ 20 weight portions, Fructus Bruceae 20 weight portion ~ 30 weight portions, Radix Ophiopogonis 30 weight portion ~ 40 weight portion, Semen Astragali Complanati 40 weight portion ~ 50 weight portions,
The preparation method of described injection is specially,
Each crude drug component is ground into coarse powder, add water to and flood powder 3 ~ 5cm, soak 1h ~ 2h, heating decocts, boil rear with slow fire, after boiling for the first time, decoct 30min ~ 60min, leach medicinal liquid, in filtering residue, again add water to and flood powder 3 ~ 5cm, heated and boiled, boil rear with slow fire, after boiling for the second time, decoct 15min ~ 30min, filter, the medicinal liquid that merges twice filtration, add and account for quality of liquid medicine 0.5% active carbon, keep pH value 7.0, heat micro-boiling 15 minutes, cooling, filter, inject water to 1000ml, fill, in 115 ℃ of sterilizings 30 minutes, cold preservation 48 hours, filter, subpackage, obtain injection.
7. a fodder compound, it is characterized in that: only by Chinese traditional immunopoteniators powder and normal feedstuff described in the claim 5 as additive, formed, with respect to the normal feedstuff of 100 weight portions, the addition of Chinese traditional immunopoteniators powder is 8 weight portion ~ 12 weight portions.
8. the preparation method of Chinese traditional immunopoteniators described in claims 1 to 3 any one, it is characterized in that: when the dosage form of described Chinese traditional immunopoteniators is decoction, be specially, each crude drug component is ground into coarse powder, add water to and flood powder 3 ~ 5cm, soak 1h ~ 2h, heating decocts, boil rear with slow fire, after boiling for the first time, decoct 30min ~ 60min, leach medicinal liquid, in filtering residue, again add water to and flood powder 3 ~ 5cm, heated and boiled, boil rear with slow fire, after boiling for the second time, decoct 15min ~ 30min, filter, the medicinal liquid that merges twice filtration, heating is concentrated into the medicinal liquid that crude drug concentration is 1g/ml ~ 2g/ml, add after the sodium citrate antiseptic that accounts for quality of liquid medicine 0.4%, be sub-packed in 250ml bottle, be placed in 4 ℃ of refrigerators standby.
9. the preparation method of Chinese traditional immunopoteniators described in claims 1 to 3 any one, it is characterized in that: when the dosage form of described Chinese traditional immunopoteniators is injection, be specially, each crude drug component is ground into coarse powder, add water to and flood powder 3 ~ 5cm, soak 1h ~ 2h, heating decocts, boil rear with slow fire, after boiling for the first time, decoct 30min ~ 60min, leach medicinal liquid, in filtering residue, again add water to and flood powder 3 ~ 5cm, heated and boiled, boil rear with slow fire, after boiling for the second time, decoct 15min ~ 30min, filter, the medicinal liquid that merges twice filtration, add and account for quality of liquid medicine 0.5% active carbon, keep pH value 7.0, heat micro-boiling 15 minutes, cooling, filter, inject water to 1000ml, fill, in 115 ℃ of sterilizings 30 minutes, cold preservation 48 hours, filter, subpackage, obtain injection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310073212.8A CN103142907B (en) | 2013-03-07 | 2013-03-07 | Immunopotentiator for preventing and treating newcastle diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310073212.8A CN103142907B (en) | 2013-03-07 | 2013-03-07 | Immunopotentiator for preventing and treating newcastle diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103142907A CN103142907A (en) | 2013-06-12 |
| CN103142907B true CN103142907B (en) | 2014-08-27 |
Family
ID=48541416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310073212.8A Expired - Fee Related CN103142907B (en) | 2013-03-07 | 2013-03-07 | Immunopotentiator for preventing and treating newcastle diseases |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103142907B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104094875B (en) * | 2014-06-13 | 2016-09-14 | 安徽强英鸭业集团有限公司 | High viability Misgurni anguillicaudati medicine induced spawning method |
| CN105935105A (en) * | 2016-04-25 | 2016-09-14 | 大新县生产力促进中心 | Pure traditional Chinese medicine chicken feed additive and preparation method thereof |
| CN105901400A (en) * | 2016-04-25 | 2016-08-31 | 大新县生产力促进中心 | Chicken feed additive and preparation method thereof |
| CN105901398A (en) * | 2016-04-25 | 2016-08-31 | 大新县生产力促进中心 | Pure natural chicken feed additive and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1369296A (en) * | 2002-01-30 | 2002-09-18 | 王福田 | 'Jiwenning' for treating chicken pest and its preparing process |
-
2013
- 2013-03-07 CN CN201310073212.8A patent/CN103142907B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1369296A (en) * | 2002-01-30 | 2002-09-18 | 王福田 | 'Jiwenning' for treating chicken pest and its preparing process |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103142907A (en) | 2013-06-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103202974B (en) | Traditional Chinese medicine composition for treating coccidiosis in chicken | |
| CN104187172B (en) | Functional feed for treating enterogastritis diseases of turtles and preparation method of functional feed | |
| CN104474471A (en) | Traditional Chinese medicine composition for treating thyroid | |
| CN103142907B (en) | Immunopotentiator for preventing and treating newcastle diseases | |
| CN103816361A (en) | Traditional Chinese medicine for preventing and treating avian influenza and preparation method thereof | |
| CN103494927B (en) | Traditional Chinese medicine composition for treating chicken respiratory disease and preparation method thereof | |
| CN103041257B (en) | Chinese materia medica preparation for curing high fever and respiratory tract infection of children | |
| CN104840695A (en) | Medicine combination for treating white scour of piglet and preparation method thereof | |
| CN103041255B (en) | Chinese materia medica preparation for curing swollen sore throat and respiratory tract infection of children | |
| CN104189413A (en) | Medicine composition for treating enterogastritis diseases of turtles and preparation method of medicine composition | |
| CN105998400A (en) | Traditional Chinese medicine composition for preventing and treating duck plague and preparation method thereof | |
| CN102349982B (en) | Traditional Chinese medicine composition for cancer rehabilitation | |
| CN103142943B (en) | Traditional Chinese medicine composite with immune function and used for treating mastitis of cows | |
| CN105267696A (en) | Traditional Chinese medicine pill for treating kidney-yin-deficiency type chronic pyelonephritis and preparation method of traditional Chinese medicine pill for treating kidney-yin-deficiency type chronic pyelonephritis | |
| CN104491538A (en) | Traditional Chinese medicine composition for treating cerebral hemorrhage | |
| CN102940760B (en) | Traditional Chinese medicine composition for preventing and treating swine fever | |
| CN103432508B (en) | Chinese medicinal preparation used for treating stomachache | |
| CN103705857B (en) | For preventing the Chinese medicine composition of oral cavity radiomucitis | |
| CN103690771B (en) | Be used for the treatment of medicine of lamb colibacillosis and preparation method thereof | |
| CN113143991B (en) | Traditional Chinese veterinary medicine composition for treating swine fever and preparation method thereof | |
| CN105106842A (en) | Medicine for treating chronic hepatitis B | |
| CN105535626A (en) | Traditional Chinese medicine for treating tuberculosis by combination with anti-tuberculosis western medicine | |
| CN105055896A (en) | Medicine used for treating varicocele induced sterility | |
| CN104784608B (en) | Improve the preparation method of the medicine of toxicity after chemotherapy of tumors | |
| CN103083579B (en) | Immune preparation for improving immunocompetence of piglets |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140827 Termination date: 20210307 |