CN103126252B - Multi-function portable box - Google Patents
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- CN103126252B CN103126252B CN201310035958.XA CN201310035958A CN103126252B CN 103126252 B CN103126252 B CN 103126252B CN 201310035958 A CN201310035958 A CN 201310035958A CN 103126252 B CN103126252 B CN 103126252B
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Abstract
The invention relates to a multi-function portable box. The multi-function portable box is characterized by comprising a cuboid-shaped hollow box body, a sliding door is connected on the upper top edge of the box body in a shaft mode, a clamping button is arranged on the position, corresponding to the side edge of the box body, of the side edge of the sliding door, a pulley is arranged on the bottom surface of one end of the box body, a telescopic pull rod is connected in the center of the other end of the box body, a Chinese medicine bag is arranged in the hollow box body, components in the Chinese medicine bag cooperated with each other and can display the function of synergistic treatment, a multi-function portable box is prepared for the Chinese medicine bag, and thus the multi-function portable box is convenient to store and transport, and has the function of a wooden bench, has a good therapeutic effect to dilated cardiomyopathy after clinical validation, is low in cost, reduces burden of patients, and has broad application prospect.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, concrete, relate to
a kind of Multi-function portable box.
Background technology
Dilated cardiomyopathy (dilated cardiomyopathy, DCM) is a kind of going down with myocardium shrinkage function and the ventricular dilatation cardiomyopathies that is feature, and its incidence of disease is higher, occupies myocardiac first place, and it is in the majority to fall ill with a middle-aged person.Principal character is one-sided or the bilateral chambers of the heart expands, and myocardium shrinkage function goes down, and accompanies or does not accompany heart failure (heart failure) (chronicheart failure, CHF).Its clinical manifestation is with Progressive symmetric erythrokeratodermia heart failure, arrhythmia cordis, thromboembolism or die suddenly as essential characteristic, finally show as malignant arrhythmia and sudden cardiac death, the disease such as out of breath, palpitaition, pain weak, dizzy, uncomfortable in chest that clinical common weight does not wait, cough, abdominal distension, oedema.Dilated cardiomyopathy is more common, its illness rate is 1: 2500, the 3rd reason of heart failure, first reason of heart transplant, in recent years, dilated cardiomyopathy is that Progressive symmetric erythrokeratodermia increases the weight of, and death can betide disease any stage, male sex's incidence of disease, higher than women (2.5: 1), is not 35,/10 ten thousand ~ 84,/10 ten thousand not etc. at the incidence of disease of this disease of China.The generation of this disease is thought at present may be relevant with the factor such as virus infections, autoimmune response, heredity, metabolic disorder, and its basic pathological changes is myocardial hypertrophy, the chambers of the heart expands and myocardial fibrosis.
It is vasodilator agent, angiotensin converting enzyme inhibitor, beta-blocker, diuretics, cardiotonic drug etc. is base therapy scheme that current western medicine mainly adopts, although make moderate progress to the long term survival rate of dilated cardiomyopathy, but because dilated cardiomyopathy pathologic, physiologic is complicated, clinical manifestation differs, above-mentioned methods for the treatment of is larger to hepatorenal damage, toxic and side effect is obvious, and curative effect is not remarkable.
Motherland's medical science is thought, the sick position of dilated cardiomyopathy is at the heart, and the internal organs such as lung, spleen, kidney can be involved, with positive unsaturated vapor for this, heat poison, hemostasis, water is wet, phlegm and retained fluid is mark, be in a bad way, develop into heart-yang collapse, negative and positive, from dying suddenly absolutely, belong to the category of the traditional Chinese medical science " palpitaition ", " palpitation ", " obstruction of qi in the chest ", " dyspnea ", and the factors such as improper and repeated infection warm poison heresy of taking good care of oneself itself and native endowment, idiosyncrasy, the day after tomorrow are relevant.Warm poison is evil invades from mouth and nose, enters ying blood by defending gas, volt in poison is evil, and ying blood is become estranged, and poison stays passages through which vital energy circulates, removes for a long time and not, inside gives up in the heart, causes heart network numbness and hinders obstructed forming.The malicious evil whole pathologic process occurring through dilated cardiomyopathy, develop and change, finally because poison causes the stasis of blood, because poison is just being hindered.Poison, the stasis of blood, void are the Etiological interpretation of the cause, onset and process of an illness, and three mutually promotes, and form vicious circle, and the evil dark volt of poison, patient's condition is touching, and seriously ill difficulty more.In response to cardiac muscle is vertical to be controlled to repair in treatment, treat the merit of " wound of flesh ", multiple flesh.Short " gas of the heart ", and " blood of the heart ", cardiac muscle hinder control.
That is familiar with dilated cardiomyopathy along with motherland's medical science gos deep into, embody the incomparable advantage of doctor trained in Western medicine improving in the symptom of dilated cardiomyopathy, sign, raising patient survival, compared with doctor trained in Western medicine, Chinese medicine has that bad reaction is few, toxic and side effect is little and not easily produces the features such as drug resistance, is good biological respinse mediator agent.
Summary of the invention
The object of this invention is to provide
a kind of Multi-function portable box, comprise the hollow box body medicine box of cuboid, connect sliding door at the upper topside axle of casing, and the side of sliding door and the side corresponding position of casing are provided with buckle; Be provided with pulley in the bottom surface, one end of casing, arrange expansion link in casing other end center, described hollow box body is placed with middle cartridge bag, can use under described medicine box storing state as stool.
Another object of the present invention be to provide a kind ofly to treat both principal and secondary aspect of disease, have no side effect, safe ready, cheap pure traditional Chinese compound medicine.
The secret recipe that present inventor is spread in conjunction with forefathers, in conjunction with oneself practice of practising medicine for many years, by the research to traditional Chinese medicine, and in conjunction with dialectical demonstration, in many ways the length of many families is collected, seek therapeutic regimen, from motherland's medical treasure-house, filter out the natural traditional Chinese medicine of invigorate blood circulation foster flesh, supplementing qi and nourishing yin, by theory of traditional Chinese medical science prescription, skim the cream off milk, be meticulously mixed with the Chinese traditional compound medicine for the treatment of dilated cardiomyopathy of the present invention in conjunction with Traditional Chinese Medicine technology, there is larger advantage improving in the symptom of dilated cardiomyopathy, sign, raising patient survival.
For achieving the above object, the technical solution used in the present invention is as follows:
a kind of Multi-function portable box, it is characterized in that, comprise the hollow box body medicine box of cuboid, connect sliding door at the upper topside axle of casing, and the side of sliding door and the side corresponding position of casing are provided with buckle; Pulley is provided with, at the affixed telescopic lever of casing other end center position, and at the affixed handle of the other end of expansion link in the bottom surface, one end of casing.Described hollow box body is placed with middle cartridge bag, and described Chinese medicine is bundled into and is divided into: the red sage root 15 parts, the radix paeoniae rubrathe 15 parts, the Radix Astragali 13 parts, curcuma zedoary 13 parts, rhizoma zingiberis 12 parts,
Cattail pollen 10 parts, 10 parts, Poria cocos, Rhizoma Sparganii 10 parts, plantain seed 8 parts, the root of three-nerved spicebush 8 parts,
Windproof 7 parts, Ligusticum wallichii 7 parts, honeysuckle 7 parts, cassia twig 5 parts, 5 parts, Chinese prickly ash,
5 parts, madder, root tuber of aromatic turmeric 4 parts, cortex albiziae 3 parts, the capsule of weeping forsythia 3 parts, the bark of official magnolia 2 parts, the banksia rose 2 parts (above-mentioned with parts by weight).
The invention also discloses, a kind of Chinese medicine preparation for the treatment of dilated cardiomyopathy, it is prepared by following weight proportioning raw material and obtains,
The red sage root 15 parts, the radix paeoniae rubrathe 15 parts, the Radix Astragali 13 parts, curcuma zedoary 13 parts, rhizoma zingiberis 12 parts,
Cattail pollen 10 parts, 10 parts, Poria cocos, Rhizoma Sparganii 10 parts, plantain seed 8 parts, the root of three-nerved spicebush 8 parts,
Windproof 7 parts, Ligusticum wallichii 7 parts, honeysuckle 7 parts, cassia twig 5 parts, 5 parts, Chinese prickly ash,
5 parts, madder, root tuber of aromatic turmeric 4 parts, cortex albiziae 3 parts, the capsule of weeping forsythia 3 parts, the bark of official magnolia 2 parts, the banksia rose 2 parts.
Its preparation of pharmaceutical composition of the present invention and instructions of taking are: the bulk drug getting above-mentioned parts by weight, mixes, and is decocted in water for oral dose, bag distribution packaging, one bag of 100ml, every day two doses, and a point morning and evening takes for twice.
Concrete operations are:
1) each bulk drug is taken, for subsequent use;
2) by step 1) in bulk drug be soaked in water (water covers powder 2 ~ 3cm and is advisable) after 15 ~ 30 minutes, intense fire boils, 20 ~ 30 minutes at a simmer, cooling, filter after obtain filtrate and the dregs of a decoction;
3) by step 2) in the dregs of a decoction boiling that obtains, amount of water was not to have dregs of a decoction face 1 ~ 2cm, and intense fire boils, 15 ~ 20 minutes at a simmer, cooling, filter after obtain filtrate and filter residue,
4) Chinese medicine preparation of described treatment dilated cardiomyopathy is namely obtained after merging twice filtrate.
Medicine drug composition of the present invention also can be made into capsule, and its method is, the bulk drug getting above-mentioned mass fraction mixes, add clear water, decoct 3 times, 3 decocting liquids are merged, filter, be condensed into the clear cream that relative density is 1-1.2, after 50-60 DEG C of dryings, be ground into 100-120 object medicinal powder, in incapsulating, sterilization obtains capsule product, each oral 3-5 grain, twice on the one.
Its use result of Chinese medicine preparation that the present invention treats dilated cardiomyopathy shows there is following advantage:
1, the present invention selects natural Chinese traditional medicines raw material, and each component meets pharmaceutical control law regulation, utilizes the comprehensive function of each taste Chinese medicine, ingredients is worked in coordination with mutually, and adopting based on eliminating blood stasis and smoothing collaterals, foster flesh of invigorating blood circulation, is auxiliary principle in conjunction with supplementing qi and nourishing yin, treatment dilated cardiomyopathy, for dilated cardiomyopathy caused by motive weakness, distinguish disease treating, curative effect is fast, cost is low, determined curative effect, prevention effect is remarkable, double basis of taking stopgap measures.
2, this product is without chemical addition agent, harmless to human non-toxic, and cost is low, effective, and does not produce drug resistance.Cheap, simple for production.
Description of drawings 1 is portable multifunctional stool of the present invention, wherein 1: rectangle hollow box body 2: sliding door 3: buckle 4: pulley 5: telescopic lever 6: middle cartridge bag
Detailed description of the invention
Embodiment 1
A kind of portable multifunctional medicine box, is characterized in that, comprise the hollow box body 1 of cuboid, connects sliding door 2 at the upper topside axle of casing, and the side of sliding door and the side corresponding position of casing are provided with buckle 3; Pulley 4 is provided with, at the affixed telescopic lever 5 of casing other end center position, and at the affixed handle of the other end of expansion link in the bottom surface, one end of casing.Described hollow box body is placed with middle cartridge bag 6, and described middle cartridge bag is: a kind of Chinese medicine preparation for the treatment of dilated cardiomyopathy, and it is prepared by following weight proportioning raw material and obtains,
The red sage root 15 parts, the radix paeoniae rubrathe 15 parts, the Radix Astragali 13 parts, curcuma zedoary 13 parts, rhizoma zingiberis 12 parts,
Cattail pollen 10 parts, 10 parts, Poria cocos, Rhizoma Sparganii 10 parts, plantain seed 8 parts, the root of three-nerved spicebush 8 parts,
Windproof 7 parts, Ligusticum wallichii 7 parts, honeysuckle 7 parts, cassia twig 5 parts, 5 parts, Chinese prickly ash,
5 parts, madder, root tuber of aromatic turmeric 4 parts, cortex albiziae 3 parts, the capsule of weeping forsythia 3 parts, the bark of official magnolia 2 parts, the banksia rose 2 parts.
Its preparation of pharmaceutical composition of the present invention and instructions of taking are: the bulk drug getting above-mentioned parts by weight, mixes, and is decocted in water for oral dose, bag distribution packaging, one bag of 100ml, every day two doses, and a point morning and evening takes for twice.
Concrete operations are:
1) each bulk drug is taken, for subsequent use;
2) by step 1) in bulk drug be soaked in water (water covers powder 2 ~ 3cm and is advisable) after 15 ~ 30 minutes, intense fire boils, 20 ~ 30 minutes at a simmer, cooling, filter after obtain filtrate and the dregs of a decoction;
3) by step 2) in the dregs of a decoction boiling that obtains, amount of water was not to have dregs of a decoction face 1 ~ 2cm, and intense fire boils, 15 ~ 20 minutes at a simmer, cooling, filter after obtain filtrate and filter residue,
4) Chinese medicine preparation of described treatment dilated cardiomyopathy is namely obtained after merging twice filtrate.
Embodiment 2
Safety testing
Animal used as test and environment: cleaning grade SD rat, Kunming mouse.Experimental session experimental situation temperature 21 DEG C-25 DEG C, humidity 40%-58%.
Acute toxicity test in mice: select body weight to be the healthy Kunming mouse 20 of 18g-22g, male and female half and half.Fasting is after 12 hours, and preparation prepared by Example 1, according to the concentration gavage of 2 grams/ml, is administered twice altogether on the 1st, each 1ml, interval 3 hours per os gavage at twice.Continuous Observation two weeks after gavage, record poisoning manifestations and death condition.
30 days feeding trials: select the SD rat of just ablactation to be divided into two groups at random, i.e. control group and tested group, often organize 20, male and female half and half.Control group gives isopyknic distilled water.Give animal subject gavage respectively, every day gavage once, gavage volume is 0.2ml/100g.bw, continuous 30 days.Each treated animal is all fed with normal diet, feeds, free diet, drinking-water in cage.
Assay:
1. acute oral LD50 result: after two weeks, rat ordinary circumstance is good, and feed is normal, and fur is bright and clean, and occur without dead, therefore LD50 cannot measure, drug use safety of the present invention, belongs to non-poisonous material.
2.30 days feeding trial results: experimental group per os gavage 30 days, duration of test, animal growth is good, each dosage group body weight, weightening finish, food utilization, routine blood indexes, blood biochemistry index, organ coefficient compare with control group, there was no significant difference (P > 0.05).Gross anatomy and tissue pathology checking have no the abnormal change relevant with sample.Prompting submitted sample is fed and is not produced obvious toxic-side effects to the every observation index of rat for 30 days.
Embodiment 3
Clinical data
Case selection
This research include in altogether dilated cardiomyopathy case 131 example, wherein the male sex 68 example, women 65 example, between 31 ~ 75 years old age, the course of disease half a year ~ 7 years.MethodsThe cases enrolled is divided into treatment group and control group at random, treatment group 66 example, control group 65 example.In treatment group, heart function II grade group 25 example, Ⅲcardiac function group 23 example, heart function IV grade group 18 example, in control group, heart function II grade group 21 example, Ⅲcardiac function group 23 example, heart function IV grade group 21 example, two groups of sexes, age, heart function, state of an illness etc. compare, no significant difference (P ﹥ 0.05), has comparativity.
Inclusive criteria:
All meet 1999 " to myocardiac diagnosis normative reference in national myocarditis, cardiomyopathy seminar ".Get rid of the organic heart disease that coronary heart disease, valvular heart disease, congenital heart disease, pericardial disease, vital myocarditis, pulmonary heart disease and other a variety of causes are clear and definite, cardiogenic shock, severe arrhythmia, atrioventricular block, bradycardia (heart rate < 60 times/min), be associated with liver, kidney and the severe primary such as internal system and hemopoietic system Disease.
Methods for the treatment of
Control group: use enalapril 5mg, 2 times on the 1st; Metoprolol 12. 5 ~ 25mg, 2 times on the 1st; Spirolactone 20mg, 1 time on the 1st; FRUSEMIDE 20mg, 1 time on the 1st.
Treatment group: on the basis identical with treatment of control group, simultaneously oral traditional Chinese medicine oral liquid of the present invention, each 100mL, every day 2 times.
Two groups equal 1 month be a course for the treatment of, treat 3 courses for the treatment of.
Observation index
Clinical symptoms and sign, (by USA New York heart disease association NYHA cardiac functional grading, Color Doppler flow imaging imager observes diastasis left ventricular interior diameter (LVDD), end-systole left atrial diameter LAD and Left Ventricular Ejection Fraction (LVFE) to cardiac functional grading.
Criterion of therapeutical effect
Effective: clinical symptoms, sign obviously alleviate, oedema disappears, hepatomegaly retraction more than 2.0cm, and heart function improves more than I level;
Effective: after treatment, clinical symptoms, sign have certain improvement before all comparatively treating, and oedema alleviates, hepatomegaly retraction 1.0cm, heart function recovery I level;
Invalid: treatment front and back clinical symptoms, sign are all unchanged, and cardiac functional grading is without change.
Result
Treatment group and control group comparing difference remarkable.
Result for the treatment of
| Group | Effective | Effectively | Invalid | Total effective rate |
| Treatment group | 37 | 15 | 4 | 93％ |
| Control group | 29 | 21 | 15 | 77％ |
Embodiment 4
Exemplary embodiments
1 Chen, man, 35 years old, after the tired metasternum of main suit more than discomfort, palpitaition, the slight asthma moon, makes palpitaition and asthma increase the weight of, and feels like jelly unable with two lower limb, need to halt a moment and have a rest after stepping on building 3-4 floor on foot.Adopt conventional western medicine treatment dissatisfied before.Audible inspection, hear and a small amount of bubble at the two base of lung, percussion heart circle expands slightly to the left, hears and apex III level systolic murmur and presystolic gallop rhythm.Electrocardiogram shows slight ST-T ripple and changes and second degree A-V block; Doppler ultrasound detects atrium sinistrum, left ventricle obviously expands, and Assessment of Left Ventricular Systolic Function declines, and measures LVEF≤36%.On conventional western medicine treatment basis, medicine prepared by continuous application embodiment 1, after two months, the above-mentioned clinical manifestation of patient starts to fade away, electrocardiographic abnormality significantly improves, doppler ultrasound detects atrium sinistrum, left ventricle is contracted to normal border line, and measure LVEF > 45%, patient's daily life and work return to normality.Follow up a case by regular visits to 1 year, without recurrence.
2 Zhus, female, 51 years old, the main palpitaition, out of breath, uncomfortable in chest stated, sometimes have a sleepless night, night is often watchful, can not put down sleeping, this time medically checks, pareordia is heard and III level systolic murmur, increased heart rate and proiosystole; Electrocardiogram display nodal tachycardia, Premature atrial contraction and ST-T ripple change widely; Doppler ultrasound detects left ventricle dilation and slight mitral orifice reflux, and clinical correction is diagnosed as dilated cardiomyopathy, with congestive heart failure.On conventional western medicine treatment basis, take medicine prepared by embodiment 1, after one month, above-mentioned symptom is eased, uncomfortable in chestly to alleviate, sleep improvement, continue a course for the treatment of of medication, electrocardiographic abnormality be improved significantly, above-mentioned all diseases disappear, and patient's daily life and work recover normal, follow up a case by regular visits to without recurrence.
Above-mentioned each Chinese medicine that the present invention adopts makes compatibility mutually, its collaborative curing the disease effect can be played, there is between each composition of Chinese medicine material used drug effect and be interweaved and mutually promote and coordinate usefulness, and described Chinese medicine is packed for Multifunctional medicine box, convenient storage, transport, and medicine box also possesses the function of stool, wherein cartridge bag is through clinical verification, good result for the treatment of is had to dilated cardiomyopathy, and with low cost, alleviate the burden of patient, have broad application prospects.
Claims (1)
1. a Multi-function portable box, is characterized in that, described portable box is the hollow box body medicine box of cuboid, connects sliding door at the upper topside axle of casing, and the side of sliding door and the side corresponding position of casing are provided with buckle; Pulley is provided with in the bottom surface, one end of casing, in casing other end center, telescopic lever is set, described hollow box body is placed with middle cartridge bag, described Chinese medicine is bundled into and is divided into: the red sage root 15 parts, the radix paeoniae rubrathe 15 parts, the Radix Astragali 13 parts, curcuma zedoary 13 parts, rhizoma zingiberis 12 parts, cattail pollen 10 parts, 10 parts, Poria cocos, Rhizoma Sparganii 10 parts, plantain seed 8 parts, the root of three-nerved spicebush 8 parts, windproof 7 parts, Ligusticum wallichii 7 parts, honeysuckle 7 parts, cassia twig 5 parts, 5 parts, Chinese prickly ash, 5 parts, madder, root tuber of aromatic turmeric 4 parts, cortex albiziae 3 parts, the capsule of weeping forsythia 3 parts, the bark of official magnolia 2 parts, the banksia rose 2 parts.
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| CN103126252B true CN103126252B (en) | 2015-07-15 |
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| CN205795137U (en) * | 2016-05-26 | 2016-12-14 | 深圳市前海安测信息技术有限公司 | Multifunctional health case for diabetics |
| CN105902984A (en) * | 2016-05-29 | 2016-08-31 | 山东仁和堂药业有限公司 | Propafenone hydrochloride tablets and preparation method thereof |
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| CN101322801B (en) * | 2007-06-15 | 2011-07-20 | 河北以岭医药研究院有限公司 | Use of Chinese medicinal composition in preparing medicament for treating dilated cardiomyopathy |
| CN102038844B (en) * | 2010-12-31 | 2011-11-16 | 纪承寅 | Chinese medicine composition for treating dilated cardiomyopathy |
| CN202198751U (en) * | 2011-08-23 | 2012-04-25 | 中国人民解放军第二军医大学 | Comprehensive anesthesia first-aid kit |
| CN102824612B (en) * | 2012-09-20 | 2013-09-11 | 河南中医学院 | Traditional Chinese medicine for treating dilated cardiomyopathy |
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