CN103126252A - Multi-function portable box - Google Patents
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- CN103126252A CN103126252A CN201310035958XA CN201310035958A CN103126252A CN 103126252 A CN103126252 A CN 103126252A CN 201310035958X A CN201310035958X A CN 201310035958XA CN 201310035958 A CN201310035958 A CN 201310035958A CN 103126252 A CN103126252 A CN 103126252A
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Abstract
The invention relates to a multi-function portable box. The multi-function portable box is characterized by comprising a cuboid-shaped hollow box body, a sliding door is connected on the upper top edge of the box body in a shaft mode, a clamping button is arranged on the position, corresponding to the side edge of the box body, of the side edge of the sliding door, a pulley is arranged on the bottom surface of one end of the box body, a telescopic pull rod is connected in the center of the other end of the box body, a Chinese medicine bag is arranged in the hollow box body, components in the Chinese medicine bag cooperated with each other and can display the function of synergistic treatment, a multi-function portable box is prepared for the Chinese medicine bag, and thus the multi-function portable box is convenient to store and transport, and has the function of a wooden bench, has a good therapeutic effect to dilated cardiomyopathy after clinical validation, is low in cost, reduces burden of patients, and has broad application prospect.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, concrete, relate to
A kind of multifunctional portable box
Background technology
Dilated cardiomyopathy (dilated cardiomyopathy, DCM) be a kind of take myocardium shrinkage function go down and ventricular dilatation as the cardiomyopathies of feature, its incidence of disease is higher, occupies myocardiac first place, and it is in the majority to fall ill with a middle-aged person.Principal character is one-sided or the bilateral chambers of the heart enlarges, and myocardium shrinkage function goes down, and accompanies or do not accompany heart failure (heart failure) (chronicheart failure, CHF).Its clinical manifestation is take carrying out property heart failure, arrhythmia cordis, thromboembolism or sudden death as essential characteristic, finally show as malignant arrhythmia and sudden cardiac death, the disease such as that clinical common weight does not wait is out of breath, palpitaition, pain weak, dizzy, uncomfortable in chest, cough, abdominal distension, oedema.Dilated cardiomyopathy is more common, its illness rate is 1: 2500, the 3rd reason of heart failure, first reason of heart transplant, in recent years, dilated cardiomyopathy is carrying out property to be increased the weight of, and death can betide any stage of disease, male sex's incidence of disease is higher than women (2.5: 1), and the incidence of disease that should disease in China is 35,/10 ten thousand~84,/10 ten thousand not wait.The generation of this disease is thought at present may be relevant with factors such as virus infections, autoimmune response, heredity, metabolic disorders, and its basic pathological changes is that myocardial hypertrophy, the chambers of the heart enlarge and myocardial fibrosis.
It is that vasodilator agent, angiotensin converting enzyme inhibitor, beta-blocker, diuretics, cardiotonic drug etc. are the base therapy scheme that current western medicine mainly adopts, although the long term survival rate to dilated cardiomyopathy makes moderate progress, but because the dilated cardiomyopathy pathologic, physiologic is complicated, clinical manifestation differs, above-mentioned methods for the treatment of is larger to hepatorenal damage, toxic and side effect is obvious, and curative effect is not remarkable.
Motherland's medical science is thought, the sick position of dilated cardiomyopathy is at the heart, and can involve the internal organs such as lung, spleen, kidney, take positive unsaturated vapor as this, heat poison, hemostasis, water is wet, phlegm and retained fluid is mark, be in a bad way and develop into heart-yang collapse, negative and positive belong to the category of the traditional Chinese medical science " palpitaition ", " palpitation ", " obstruction of qi in the chest ", " dyspnea " from dying suddenly absolutely, its take good care of oneself improper with native endowment, idiosyncrasy, the day after tomorrow and the factor such as the warm poison heresy of repeated infection relevant.Warm poison is evil enters ying blood from the mouth and nose invasion by defending gas, volt in poison is evil, and ying blood is become estranged, and poison stays passages through which vital energy circulates, removes for a long time and not, and interior the house in the heart causes obstructed the forming of heart network numbness resistance.The malicious evil whole pathologic process that occurs, develops and change through dilated cardiomyopathy is finally because poison causes the stasis of blood, because poison is just being hindered.Poison, the stasis of blood, void are the Etiological interpretation of the cause, onset and process of an illness, and the three mutually promotes, and form vicious circle, the evil dark volt of poison, and patient's condition is touching, and seriously ill difficulty is more.In response to cardiac muscle is vertical to be controlled to repair, treat the merit of " wound of flesh ", multiple flesh in treatment.Short " gas of the heart ", and " blood of the heart ", cardiac muscle hinder to such an extent that control.
Along with motherland's medical science going deep into dilated cardiomyopathy understanding, embody the incomparable advantage of doctor trained in Western medicine aspect the symptom of dilated cardiomyopathy, sign, raising patient survival rate improving, compare with doctor trained in Western medicine, Chinese medicine has that bad reaction is few, toxic and side effect is little and the characteristics such as difficult generation drug resistance, is good biological respinse mediator agent.
Summary of the invention
The purpose of this invention is to provide
A kind of multifunctional portable box, comprise the hollow box body medicine box of cuboid, connect sliding door at the upper topside axle of casing, and the side corresponding position of the side of sliding door and casing is provided with buckle; A bottom face at casing is provided with pulley, in casing other end center, expansion link is set, and described hollow box body is placed with middle cartridge bag, can use as stool under described medicine box storing state.
Another object of the present invention is to provide and a kind ofly treats both principal and secondary aspect of disease, has no side effect, safe ready, cheap pure traditional Chinese compound medicine.
The secret recipe that the present application people is spread in conjunction with forefathers, in conjunction with oneself practice of practising medicine for many years, by the research to traditional Chinese medicine, and in conjunction with dialectical demonstration, in many ways collect the length of many families, seek therapeutic regimen, from motherland's medical treasure-house, filter out the natural traditional Chinese medicine of invigorate blood circulation foster flesh, supplementing qi and nourishing yin, by the theory of traditional Chinese medical science prescription, skim the cream off milk, meticulously be mixed with the Chinese traditional compound medicine for the treatment of dilated cardiomyopathy of the present invention in conjunction with the Traditional Chinese Medicine technology, have larger advantage aspect the symptom of dilated cardiomyopathy, sign, raising patient survival rate improving.
For achieving the above object, the technical solution used in the present invention is as follows:
A kind of multifunctional portable box, it is characterized in that, comprise the hollow box body medicine box of cuboid, connect sliding door at the upper topside axle of casing, and the side corresponding position of the side of sliding door and casing is provided with buckle; A bottom face at casing is provided with pulley, at the affixed telescopic lever of casing other end center position, and at the affixed handle of the other end of expansion link.Described hollow box body is placed with middle cartridge bag, and described Chinese medicine is bundled into and is divided into: 15 parts of the reds sage root, 15 parts of the radix paeoniae rubrathe, 13 parts of the Radixs Astragali, 13 parts of curcuma zedoarys, 12 parts of rhizoma zingiberis,
10 parts of cattail pollens, 10 parts, Poria cocos, 10 parts of triangulars, 8 parts of plantain seeds, 8 parts of the roots of three-nerved spicebush,
Windproof 7 parts, 7 parts of Ligusticum wallichiis, 7 parts of honeysuckles, 5 parts of cassia twig, 5 parts, Chinese prickly ash,
5 parts, madder, 4 parts of root tubers of aromatic turmeric, 3 parts of cortex albiziaes, 3 parts of the capsules of weeping forsythia, 2 parts of the barks of official magnolia, 2 parts of the banksia rose (above-mentioned in weight portion).
The invention also discloses, a kind of Chinese medicine preparation for the treatment of dilated cardiomyopathy, it is got by the preparation of following weight proportioning raw material,
15 parts of the reds sage root, 15 parts of the radix paeoniae rubrathe, 13 parts of the Radixs Astragali, 13 parts of curcuma zedoarys, 12 parts of rhizoma zingiberis,
10 parts of cattail pollens, 10 parts, Poria cocos, 10 parts of triangulars, 8 parts of plantain seeds, 8 parts of the roots of three-nerved spicebush,
Windproof 7 parts, 7 parts of Ligusticum wallichiis, 7 parts of honeysuckles, 5 parts of cassia twig, 5 parts, Chinese prickly ash,
5 parts, madder, 4 parts of root tubers of aromatic turmeric, 3 parts of cortex albiziaes, 3 parts of the capsules of weeping forsythia, 2 parts of the barks of official magnolia, 2 parts of the banksia rose.
Its preparation of pharmaceutical composition of the present invention and instructions of taking are: get the bulk drug of above-mentioned parts by weight, mix, be decocted in water for oral dose, and bag distribution packaging, one bag of 100ml, divides sooner or later and takes for twice at two doses of every days.
Concrete operations are:
1) take each bulk drug, standby;
2) with step 1) in bulk drug be soaked in water (water covers powder 2~3cm and is advisable) after 15~30 minutes, intense fire boils, and is 20~30 minutes at a simmer, cooling, obtain filtrate and the dregs of a decoction after filtering;
3) with step 2) in resulting dregs of a decoction boiling, amount of water was not to have dregs of a decoction face 1~2cm, intense fire boils, 15~20 minutes at a simmer, cooling, obtain filtrate and filter residue after filtering,
4) namely get the Chinese medicine preparation of described treatment dilated cardiomyopathy after twice filtrate of merging.
Medicine drug composition of the present invention also can be made into capsule, and its method is that the bulk drug of getting above-mentioned mass fraction mixes, add clear water, fry in shallow oil 3 times, 3 decocting liquids are merged, filter, being condensed into relative density is the clear cream of 1-1.2, after 50-60 ℃ of dryings, is ground into 100-120 purpose medicinal powder, in incapsulating, sterilization makes the capsule product, each oral 3-5 grain, twice on the one.
Its use result of Chinese medicine preparation that the present invention treats dilated cardiomyopathy shows that following advantage is arranged:
1, the present invention selects the natural Chinese traditional medicines raw material, and each component meets the pharmaceutical control law regulation, utilizes the comprehensive function of the Chinese medicine of respectively distinguishing the flavor of, ingredients is collaborative mutually, and adopt take eliminating blood stasis and smoothing collaterals, invigorate blood circulation and support flesh as main, be auxiliary principle in conjunction with supplementing qi and nourishing yin, the treatment dilated cardiomyopathy, for dilated cardiomyopathy due to a little less than the heart qi deficiency, distinguish disease treating, curative effect is fast, cost is low, determined curative effect, prevention effect is remarkable, double taking stopgap measures originally.
2, this product is without chemical addition agent, and nontoxic to human body, cost is low, and is effective, and does not produce drug resistance.Cheap, simple for production.
Description of drawings Fig. 1 is portable multifunctional stool of the present invention, wherein 1: rectangle hollow box body 2: sliding door 3: buckle 4: pulley 5: telescopic lever 6: middle cartridge bag
The specific embodiment
Embodiment 1
A kind of portable multifunctional medicine box is characterized in that, comprises the hollow box body 1 of cuboid, connects sliding door 2 at the upper topside axle of casing, and the side corresponding position of the side of sliding door and casing is provided with buckle 3; A bottom face at casing is provided with pulley 4, at the affixed telescopic lever 5 of casing other end center position, and at the affixed handle of the other end of expansion link.Described hollow box body is placed with middle cartridge bag 6, and described middle cartridge bag is: a kind of Chinese medicine preparation for the treatment of dilated cardiomyopathy, and it is got by the preparation of following weight proportioning raw material,
15 parts of the reds sage root, 15 parts of the radix paeoniae rubrathe, 13 parts of the Radixs Astragali, 13 parts of curcuma zedoarys, 12 parts of rhizoma zingiberis,
10 parts of cattail pollens, 10 parts, Poria cocos, 10 parts of triangulars, 8 parts of plantain seeds, 8 parts of the roots of three-nerved spicebush,
Windproof 7 parts, 7 parts of Ligusticum wallichiis, 7 parts of honeysuckles, 5 parts of cassia twig, 5 parts, Chinese prickly ash,
5 parts, madder, 4 parts of root tubers of aromatic turmeric, 3 parts of cortex albiziaes, 3 parts of the capsules of weeping forsythia, 2 parts of the barks of official magnolia, 2 parts of the banksia rose.
Its preparation of pharmaceutical composition of the present invention and instructions of taking are: get the bulk drug of above-mentioned parts by weight, mix, be decocted in water for oral dose, and bag distribution packaging, one bag of 100ml, divides sooner or later and takes for twice at two doses of every days.
Concrete operations are:
1) take each bulk drug, standby;
2) with step 1) in bulk drug be soaked in water (water covers powder 2~3cm and is advisable) after 15~30 minutes, intense fire boils, and is 20~30 minutes at a simmer, cooling, obtain filtrate and the dregs of a decoction after filtering;
3) with step 2) in resulting dregs of a decoction boiling, amount of water was not to have dregs of a decoction face 1~2cm, intense fire boils, 15~20 minutes at a simmer, cooling, obtain filtrate and filter residue after filtering,
4) namely get the Chinese medicine preparation of described treatment dilated cardiomyopathy after twice filtrate of merging.
Embodiment 2
Safety testing
Animal used as test and environment: cleaning level SD rat, Kunming mouse.21 ℃-25 ℃ of experimental session experimental situation temperature, humidity 40%-58%.
Acute toxicity test in mice: selecting body weight is 20 of the healthy Kunming mouses of 18g-22g, male and female half and half.After fasting 12 hours, get the preparation of embodiment 1 preparation according to the concentration gavage of 2 grams/ml, be administered twice altogether in 1st, each 1ml, interval 3 hours is the per os gavage at twice.After gavage, in two weeks of Continuous Observation, record poisoning manifestations and death condition.
30 days feeding trials: select the SD rat of just ablactation to be divided at random two groups, i.e. control group and tested group, 20 every group, male and female half and half.Control group gives isopyknic distilled water.Give respectively the animal subject gavage, every day gavage once, the gavage volume is 0.2ml/100g.bw, continuous 30 days.Each treated animal is all fed with normal diet, feeds free diet, drinking-water in cage.
Assay:
1. acute oral LD50 result: after two weeks, the rat ordinary circumstance is good, and feed is normal, and fur is bright and clean, occur without dead, so LD50 can't measure, and drug use safety of the present invention belongs to non-poisonous material.
2.30 it feeding trial result: experimental group per os gavage 30 days, duration of test, animal growth is good, and each dosage group body weight, weightening finish, food utilization, routine blood test index, blood biochemistry index, organ coefficient and control group compare, there was no significant difference (P>0.05).Gross anatomy has no the abnormal change relevant with sample with tissue pathology checking.The prompting submitted sample was fed the every observation index of rat is not produced obvious toxic-side effects in 30 days.
Embodiment 3
Clinical data
Case is selected
Dilated cardiomyopathy case 131 examples are included in this research altogether in, the male sex's 68 examples wherein, and women's 65 examples, between 31~75 years old age, course of disease half a year~7 year.MethodsThe cases enrolled is divided into treatment group and control group at random, treatment group 66 examples, control group 65 examples.In treatment group, heart function II level group 25 examples, Ⅲcardiac function group 23 examples, heart function IV level group 18 examples are in control group, heart function II level group 21 examples, Ⅲcardiac function group 23 examples, heart function IV level group 21 examples, two groups of sexes, age, heart function, the state of an illness etc. are relatively, difference not statistically significant (P ﹥ 0.05) has comparativity.
Inclusive criteria:
All meet 1999 " in national myocarditis, cardiomyopathy seminar to myocardiac diagnosis normative reference ".Get rid of coronary heart disease, valvular heart disease, congenital heart disease, pericardial disease, vital myocarditis, pulmonary heart disease and the clear and definite organic heart disease of other a variety of causes, cardiogenic shock, severe arrhythmia, atrioventricular block, bradycardia (heart rate<60 time/min), be associated with the serious primary disease patient such as liver, kidney and internal system and hemopoietic system.
Methods for the treatment of
Control group: use enalapril 5mg, 2 times on the 1st; Metoprolol 12. 5~25mg, 2 times on the 1st; Spirolactone 20mg, 1 time on the 1st; FRUSEMIDE 20mg, 1 time on the 1st.
Treatment group: on the basis identical with treatment of control group, oral traditional Chinese medicine oral liquid of the present invention of while, each 100mL, every day 2 times.
Two groups equal 1 month be a course for the treatment of, treat 3 courses for the treatment of.
Observation index
Clinical symptoms and sign, (by the USA New York NYHA of heart disease association cardiac functional grading, the Color Doppler flow imaging imager is observed diastasis left ventricular interior diameter (LVDD), end-systole left atrial diameter LAD and Left Ventricular Ejection Fraction (LVFE) to cardiac functional grading.
Criterion of therapeutical effect
Produce effects: clinical symptoms, sign obviously alleviate, and oedema disappears, more than hepatomegaly retraction 2.0cm, more than heart function improves the I level;
Effectively: after treatment, clinical symptoms, sign all have certain improvement before treatment, and oedema alleviates, hepatomegaly retraction 1.0cm, heart function recovery I level;
Invalid: before and after treatment, clinical symptoms, sign are all unchanged, and cardiac functional grading is without change.
Result
Treatment group and control group comparing difference are remarkable.
Result for the treatment of
Group | Produce effects | Effectively | Invalid | Total effective rate |
Treatment group | 37 | 15 | 4 | 93% |
Control group | 29 | 21 | 15 | 77% |
Embodiment 4
Exemplary embodiments
1 Chen, the man, 35 years old, more than discomfort, palpitaition, the slight asthma moon, after stepping on foot building 3-4 floor, palpitaition and asthma are increased the weight of, and it is unable to feel like jelly with two lower limb after the tired metasternum of main suit, need to halt a moment and have a rest.Adopt conventional western medicine dissatisfied before.Audible inspection is heard and a small amount of bubble at two bases of lung, and percussion heart circle enlarges slightly to the left, hears and apex III level systolic murmur and presystolic gallop rhythm.Electrocardiogram shows that slight ST-T ripple changes and second degree A-V block; Doppler ultrasound detects the atrium sinistrum, left ventricle obviously enlarges, and Assessment of Left Ventricular Systolic Function descends, and measures LVEF≤36%.On conventional western medicine basis, the medicine of continuous application embodiment 1 preparation, after two months, the above-mentioned clinical manifestation of patient begins to fade away, electrocardiographic abnormality significantly improves, doppler ultrasound detects the atrium sinistrum, left ventricle is contracted to normal border line, measures LVEF>45%, and patient's daily life and work return to normality.Followed up a case by regular visits to 1 year, without recurrence.
2 Zhus, the female, 51 years old, main state palpitaition, out of breath, uncomfortable in chest, insomnia sometimes, night is often by watchful, can not put down sleeping, the medical inspection this time, pareordia is heard and III level systolic murmur, increased heart rate and proiosystole; Electrocardiogram shows nodal tachycardia, room proiosystole and ST-T ripple change widely; Doppler ultrasound detects has left ventricle expansion to flow with slightly mitral orifice is counter, and clinical correction is diagnosed as dilated cardiomyopathy, with congestive heart failure.On conventional western medicine basis, take the medicine of embodiment 1 preparation, after one month, above-mentioned symptom is eased, uncomfortable in chest alleviating, sleep improvement continues course for the treatment of of medication, electrocardiographic abnormality be improved significantly, above-mentioned all diseases disappear, and patient's daily life and work recover normal, follow up a case by regular visits to without recurrence.
Above-mentioned each Chinese medicine that the present invention adopts is made compatibility mutually, can bring into play its collaborative curing the disease effect, have drug effect between each composition of Chinese medicine material used and be interweaved and mutually promote and coordinate usefulness, and described Chinese medicine is packed for Multifunctional medicine box, the convenient storage, transportation, and medicine box also possesses the function of stool, and wherein cartridge bag is through clinical verification, dilated cardiomyopathy there is good result for the treatment of, and with low cost, alleviate patient's burden, have broad application prospects.
Claims (4)
1. a multifunctional portable box, is characterized in that, is the hollow box body medicine box of cuboid, connects sliding door at the upper topside axle of casing, and the side corresponding position of the side of sliding door and casing is provided with buckle; A bottom face at casing is provided with pulley, in casing other end center, telescopic lever is set, described hollow box body is placed with middle cartridge bag, described Chinese medicine is bundled into and is divided into: 15 parts of the reds sage root, 15 parts of the radix paeoniae rubrathe, 13 parts of the Radixs Astragali, 13 parts of curcuma zedoarys, 12 parts of rhizoma zingiberis, 10 parts of cattail pollens, 10 parts, Poria cocos, 10 parts of triangulars, 8 parts of plantain seeds, 8 parts of the roots of three-nerved spicebush, windproof 7 parts, 7 parts of Ligusticum wallichiis, 7 parts of honeysuckles, 5 parts of cassia twig, 5 parts, Chinese prickly ash, 5 parts, madder, 4 parts of root tubers of aromatic turmeric, 3 parts of cortex albiziaes, 3 parts of the capsules of weeping forsythia, 2 parts of the barks of official magnolia, 2 parts of the banksia rose (above-mentioned in weight portion).
2. Chinese traditional compound medicine for the treatment of dilated cardiomyopathy, it is by the preparation of following weight proportioning raw material and get,
15 parts of the reds sage root, 15 parts of the radix paeoniae rubrathe, 13 parts of the Radixs Astragali, 13 parts of curcuma zedoarys, 12 parts of rhizoma zingiberis,
10 parts of cattail pollens, 10 parts, Poria cocos, 10 parts of triangulars, 8 parts of plantain seeds, 8 parts of the roots of three-nerved spicebush,
Windproof 7 parts, 7 parts of Ligusticum wallichiis, 7 parts of honeysuckles, 5 parts of cassia twig, 5 parts, Chinese prickly ash,
5 parts, madder, 4 parts of root tubers of aromatic turmeric, 3 parts of cortex albiziaes, 3 parts of the capsules of weeping forsythia, 2 parts of the barks of official magnolia, 2 parts of the banksia rose.
3.
The preparation method of the described Chinese traditional compound medicine of claim 2 is characterized in that:
1) take each bulk drug, standby;
2) with step 1) in bulk drug be soaked in water (water covers powder 2~3cm and is advisable) after 15~30 minutes, intense fire boils, and is 20~30 minutes at a simmer, cooling, obtain filtrate and the dregs of a decoction after filtering;
3) with step 2) in resulting dregs of a decoction boiling, amount of water was not to have dregs of a decoction face 1~2cm, intense fire boils, 15~20 minutes at a simmer, cooling, obtain filtrate and filter residue after filtering,
4) namely get the Chinese traditional compound medicine of described treatment dilated cardiomyopathy after twice filtrate of merging.
4. the described Chinese traditional compound medicine of claim 2-3 is in the purposes for the treatment of in dilated cardiomyopathy.
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CN105902984A (en) * | 2016-05-29 | 2016-08-31 | 山东仁和堂药业有限公司 | Propafenone hydrochloride tablets and preparation method thereof |
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