CN103115852A - Transdermal diffusion apparatus - Google Patents
Transdermal diffusion apparatus Download PDFInfo
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- CN103115852A CN103115852A CN201310013563XA CN201310013563A CN103115852A CN 103115852 A CN103115852 A CN 103115852A CN 201310013563X A CN201310013563X A CN 201310013563XA CN 201310013563 A CN201310013563 A CN 201310013563A CN 103115852 A CN103115852 A CN 103115852A
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Abstract
The invention discloses a transdermal diffusion apparatus which comprises a diffusion pool and a heating block component, wherein the diffusion pool is arranged on the heating block component; the heating block component comprises an overflow pipe, a front heat insulation cover, a rear heat insulation cover, a heating block bottom plate and multiple heating blocks in linear arrangement; a heating block is fixed on the heating block bottom plate; a heating element is arranged on the side surface of the heating block; one end of the overflow pipe is connected with the heating block; and the front heat insulation cover and the rear heat insulation cover are arranged on the front side and rear side of the heating block respectively. The transdermal diffusion apparatus disclosed by the invention is heated as a whole by the heating block component, and the temperature consistency of the diffusion pool is guaranteed so as to guarantee the same diffusion rate.
Description
Technical field
The present invention relates to a kind of diffusion instrument, particularly relate to a kind of transdermal diffusion instrument.
Background technology
Usually the experiment of transdermal disperser consumes manpower very much, and the purpose of experiment is the speed of research medicine transdermal.Traditional experimental technique is folder one deck skin between bottleneck (giving body) and body (acceptor), and it is that in the solvent on basis, upside infiltrates in medicine to be measured that the skin downside infiltrates at physiological saline.There is special glass tube the diffusion cell side, in order to inject solvent.The temperature of diffusion cell is controlled at 32-37 ℃ of left and right by water-bath, and the warm water in external water-bath circulates by pipeline, keeps the temperature of diffusion cell.The stirrer that is magnetic in diffusion cell, externally magnet and motor evenly distribute inner solvent concentration temperature under driving.Contribute the pond upper opening, ventilate with external environment condition.If necessary, can use dropper to add quantitative medicine.Medicine slowly sees through skin, is dissolved in solvent, and the experimenter regularly extracts sample out, analyzes.Usually experiment needs three groups of diffusion cells to carry out simultaneously, gets the mean value of experimental result.
There is following problem in existing transdermal disperser: one, each diffusion cell temperature is inconsistent, causes rate of diffusion different.Two, water-bath is heated, and after long-term the use, at pipe inner wall, fungus growth is arranged.Three, the diffusion cell processed complex made of glass, technological requirement is high, and is with high costs.Four, form bubble under skin, contacting of isolated skin and solvent causes diffusion area to reduce.After user sampling manually inversion even stir diffusion cell, bubble is deviate from.Five, after bubble is deviate from, must replenish the solvent that carries out respective volume, cause each diffusion cell inner volume uneven.Six, this type of experiment is often carried out considerable time, even can reach 7 days, and each collected specimens was separated by 2 hours, and the experimenter must day and night wait for by diffusion cell, must not have a rest.
Summary of the invention
Technical matters to be solved by this invention is to provide a kind of transdermal diffusion instrument, and it adopts the whole heating of heat block assembly, has guaranteed that the diffusion cell temperature is consistent, thereby guarantees that rate of diffusion is identical.
The present invention solves above-mentioned technical matters by following technical proposals: a kind of transdermal diffusion instrument, it is characterized in that, described transdermal diffusion instrument comprises diffusion cell and heat block assembly, diffusion cell is positioned on the heat block assembly, the heat block assembly comprises the heat block of run-down pipe, preincubation cover, rear stay-warm case, heat block base plate, a plurality of line spread, heat block is fixed on the heat block base plate, the side of heat block is provided with heating element, one end of run-down pipe is connected with heat block, and preincubation cover and rear stay-warm case lay respectively at front side and the rear side of heat block.
Preferably, described diffusion cell comprises bottleneck, degasification upper end, gas removing pipe, bottle, diffusion cell bottom, fluid infusion thief hatch, clamping fixture, bottleneck is positioned at the top of degasification upper end, one end of gas removing pipe is connected with the degasification upper end, bottle is positioned at the below of degasification upper end, and diffusion cell bottom is positioned at the bottom of bottle, and an end of fluid infusion thief hatch is connected bottom diffusion cell, clamping fixture is clamped bottleneck, degasification upper end, bottle, and the other end of gas removing pipe is connected with run-down pipe.
Preferably, described transdermal diffusion instrument also comprises experiment table, hinge, handle, bearing base, handle jacket, the rear end of heat block assembly and the top of experiment table are rotationally connected by hinge, handle is connected with an end of handle jacket, the other end of handle jacket and heat block assembly are fixed, bearing base is positioned at the side of heat block assembly, and the top of bearing base and experiment table is fixed.
Preferably, described transdermal diffusion instrument also comprises fixed support, elevating lever, motor, and fixed support is positioned at the inside of experiment table, and motor is connected with fixed support, and an end of elevating lever is connected with the bottom of heat block assembly, and the other end of elevating lever is connected with motor.
Preferably, described transdermal diffusion instrument also comprises artificial sample support and artificial sample syringe, and the artificial sample support is positioned at the top of experiment table, and the artificial sample syringe is enclosed within on the artificial sample support.
Preferably, the front end of described experiment table is provided with temperature control display device.
Positive progressive effect of the present invention is: one, and the present invention adopts the whole heating of heat block assembly, has guaranteed that the diffusion cell temperature is consistent, thereby guarantees that rate of diffusion is identical.Two, the present invention adopts the anhydrous dry heat of heat block energising, has avoided the generation of mould.Three, the diffusion cell in the present invention is simple in structure, and is with low cost.Four, the diffusion cell automatic vent in the present invention designs generation and the exhaust of the bubble that effectively solves, thereby has guaranteed the accurate and accuracy of experimental result.Five, the present invention is because the automatic vent of diffusion cell so be limit fluid infusion limit exhaust, has guaranteed that the volume of solvent in diffusion cell is even.Six, the present invention can connect full-automatic sampling system, realizes automatic sampling, fluid infusion, exhaust etc. by computer program, need not the experimenter and day and night waits for.
Description of drawings
Fig. 1 is the side schematic view of transdermal diffusion instrument of the present invention (the heat block assembly is when horizontality).
Fig. 2 is the side schematic view of transdermal diffusion instrument of the present invention (the heat block assembly is when heeling condition).
Fig. 3 is the perspective view of transdermal diffusion instrument of the present invention.
Fig. 4 is the explosive view of transdermal diffusion instrument of the present invention.
Fig. 5 is the structural representation of diffusion cell in transdermal diffusion instrument of the present invention.
Fig. 6 is the schematic diagram of diffusion cell degassing procedure in transdermal diffusion instrument of the present invention.
Fig. 7 is the structural representation of heat block assembly in transdermal diffusion instrument of the present invention.
Fig. 8 is the structural representation of wing drop mechanism (the heat block assembly is when horizontality) in transdermal diffusion instrument of the present invention.
Fig. 9 is the structural representation of wing drop mechanism (the heat block assembly is when heeling condition) in transdermal diffusion instrument of the present invention.
Embodiment
Provide preferred embodiment of the present invention below in conjunction with accompanying drawing, to describe technical scheme of the present invention in detail.
as Fig. 1, Fig. 2, Fig. 3, Fig. 4, Fig. 5, Fig. 6, Fig. 7, Fig. 8, shown in Figure 9, transdermal diffusion instrument of the present invention comprises diffusion cell 11, artificial sample syringe 14, artificial sample support 15, experiment table 17, heat block assembly 20, hinge 22, handle 25, bearing base 26, handle jacket 27, diffusion cell 11 is positioned on heat block assembly 20, artificial sample support 15 is positioned at the top of experiment table 17, artificial sample syringe 14 is enclosed within on artificial sample support 15, the top of the rear end of heat block assembly 20 and experiment table 17 is rotationally connected by hinge 22, handle 25 is connected with an end of handle jacket 27, the other end of handle jacket 27 and heat block assembly 20 are fixing, bearing base 26 is positioned at the side of heat block assembly 20, bearing base 26 is fixed with the top of experiment table 17.
The front end of experiment table 17 is provided with temperature control display device 16, and temperature control display device 16 can control and show, temperature control display device 16 can be a touch-screen.
Diffusion cell is inserted in heat block and heats, and gas removing pipe communicates with run-down pipe, and preincubation cover, the isolated Air Flow of rear stay-warm case keep the heat block temperature stabilization.The artificial sample support has pipeline to be connected with the fluid infusion thief hatch of diffusion cell, and the artificial sample syringe can extract respectively the sample liquid in each diffusion cell.Diffusion cell of the present invention is automatic degassing type Frantz diffusion cell, directly heats, and does not need water-bath and water pump, has simplified design, avoids the microorganism that hot water causes to grow.Diffusion cell automatic vent in the present invention designs generation and the exhaust of the bubble that effectively solves, thereby has guaranteed the accurate and accuracy of experimental result.The present invention can tilt the heat block assembly, and discharges the bubble in diffusion cell when tilting.The side of heat block is provided with heating element, controls temperature by temperature control display device, by contact, diffusion cell is heated.Can establish additional heat block on heat block, when the diffusion cell volume is larger, when the relative heat block of glass tube was longer, additional heat block can be placed in heat block top, and diffusion cell is all highly heated, and guaranteed minimum thermograde.In the process of injecting solvent, heat block assembly inclined (Fig. 2), this diffusion cell keeps tilting equally, making becomes most significant end, solvent injects from following fluid infusion thief hatch, gas is discharged from the top gas removing pipe, guarantee that solvent contacts on the experiment area fully with skin or other experimental films.Front end at experiment porch is provided with the artificial sample support, and on the artificial sample support, the fluid infusion thief hatch of each joint and back has respectively pipeline to link, and joint and artificial sample syringe match, and syringe can be plugged in advance, at the moment draw samples of regulation.Diffusion cell is when the filling solvent, and air and unnecessary solvent flow into run-down pipe from gas removing pipe, relies on gravity to import waste liquid bottle.After solvent thoroughly was full of diffusion cell, volume was determined by the volume of diffusion cell fully, guarantees that its numerical value is constant.Add preincubation cover and rear stay-warm case before and after heat block and diffusion cell, can isolating inner air and outer air circulate, reduce heat loss in diffusion cell, play better constant temperature effect.Simultaneously, the color of preincubation cover and the color of rear stay-warm case all are made as dark color, prevent that photosensitive composition is subjected to illumination rotten.
Diffusion cell can be selected by the motor-driven inclination of leaning device, also can handle be set in heat block institutional affiliation side, to reduce equipment manufacturing cost.Handle is attached on handle jacket, and handle jacket is fixed on the side of heat block assembly, and the front portion of handle is straight line, can all around slide in sleeve, perhaps along the sleeve axial rotation.When packing up, handle is pushed the rear to, and handle rear end is bent upwards, and is the dotted line state in Fig. 1.When being inclined upwardly diffusion cell, handle is pulled out (solid line state in Fig. 1), so that the user upwards lifts the heat block assembly, then the user is with handle downward anti-turnback vertically, handle rear end will point to the below, fall in the bearing base that is fixed on experiment table, support the heat block assembly and keep heeling condition.The heat block assembly rotates take hinge as axle, on one side hinge is fixed on the experiment table plane, the hinge another side is fixed on the base plate back side of heat block assembly.Pull handle, and rotate handle, make the other end of handle withstand bearing base and heat block assembly, raise up centered by hinge, diffusion cell is tilted.Inject solvent to sampling fluid infusion mouth this moment, and air will be discharged automatically from gas removing pipe, if adopt syringe pump to inject solvent, will realize replenishing the robotization of solvent.Lifting handle, and counter-rotation handle slowly put down handle, and the heat block assembly descends thereupon, reply flat condition (Fig. 1), the experiment below continuing.
The present invention can also comprise wing drop mechanism, wing drop mechanism comprises fixed support 29, elevating lever 23, motor 28, realize the said function of handle 25, bearing base 26, handle jacket 27 (handle 25, bearing base 26, handle jacket 27 consist of manual leaning device), namely can realize the electronic inclination of heat block assembly, be provided with simultaneously wing drop mechanism and manual leaning device on same equipment, the user can experimentally need to select experiment or artificial sample automatically.Fixed support 29 is positioned at the inside of 17 experiment tablees, and motor 28 is connected with fixed support 29, and an end of elevating lever 23 is connected with the bottom of heat block assembly 20, and the other end of elevating lever 23 is connected with motor 28.The heat block assembly rotates take hinge as axle, on one side hinge is fixed on the experiment table plane, another side is fixed on the heat block assembly base plate back side.Be provided with motor in experiment table, motor includes screw-nut body, can drive elevating lever and do straight reciprocating motion.Fixed support is responsible for the straight line performance element is fixed on machine bed plate.When doing automotive elevating under system controls, the motor-driven elevating lever rises, and jack-up heat block assembly raises up centered by hinge axis, makes diffusion cell inclination (Fig. 8).Inject solvent to sampling fluid infusion mouth this moment, and air will be discharged automatically from gas removing pipe, if adopt syringe pump to inject solvent, will realize replenishing the robotization of solvent.Elevating lever descends (Fig. 9), and the heat block assembly descends thereupon, replys flat condition, the experiment below continuing.
One, the present invention adopts the whole heating of heat block assembly, has guaranteed that the diffusion cell temperature is consistent, thereby guarantees that rate of diffusion is identical.Two, the present invention adopts the anhydrous dry heat of heat block energising, has avoided the generation of mould.Three, the diffusion cell in the present invention is simple in structure, and is with low cost.Four, the diffusion cell automatic vent in the present invention designs generation and the exhaust of the bubble that effectively solves, thereby has guaranteed the accurate and accuracy of experimental result.Five, the present invention is because the automatic vent of diffusion cell so be limit fluid infusion limit exhaust, has guaranteed that the volume of solvent in diffusion cell is even.Six, the present invention can connect full-automatic sampling system, realizes automatic sampling, fluid infusion, exhaust etc. by computer program, need not the experimenter and day and night waits for.
Those skilled in the art can carry out various remodeling and change to the present invention.Therefore, the present invention has covered various remodeling and the change in the scope that falls into appending claims and equivalent thereof.
Claims (6)
1. transdermal diffusion instrument, it is characterized in that, described transdermal diffusion instrument comprises diffusion cell and heat block assembly, diffusion cell is positioned on the heat block assembly, the heat block assembly comprises the heat block of run-down pipe, preincubation cover, rear stay-warm case, heat block base plate, a plurality of line spread, and heat block is fixed on the heat block base plate, and the side of heat block is provided with heating element, one end of run-down pipe is connected with heat block, and preincubation cover and rear stay-warm case lay respectively at front side and the rear side of heat block.
2. transdermal diffusion instrument as claimed in claim 1, it is characterized in that, described diffusion cell comprises bottleneck, degasification upper end, gas removing pipe, bottle, diffusion cell bottom, fluid infusion thief hatch, clamping fixture, bottleneck is positioned at the top of degasification upper end, one end of gas removing pipe is connected with the degasification upper end, bottle is positioned at the below of degasification upper end, the diffusion cell bottom is positioned at the bottom of bottle, one end of fluid infusion thief hatch is connected bottom diffusion cell, clamping fixture is clamped bottleneck, degasification upper end, bottle, and the other end of gas removing pipe is connected with run-down pipe.
3. transdermal diffusion instrument as claimed in claim 2, it is characterized in that, described transdermal diffusion instrument also comprises experiment table, hinge, handle, bearing base, handle jacket, the rear end of heat block assembly and the top of experiment table are rotationally connected by hinge, handle is connected with an end of handle jacket, the other end of handle jacket and heat block assembly are fixed, and bearing base is positioned at the side of heat block assembly, and the top of bearing base and experiment table is fixed.
4. transdermal diffusion instrument as claimed in claim 3, it is characterized in that, described transdermal diffusion instrument also comprises fixed support, elevating lever, motor, fixed support is positioned at the inside of experiment table, motor is connected with fixed support, one end of elevating lever is connected with the bottom of heat block assembly, and the other end of elevating lever is connected with motor.
5. transdermal diffusion instrument as claimed in claim 4, is characterized in that, described transdermal diffusion instrument also comprises artificial sample support and artificial sample syringe, and the artificial sample support is positioned at the top of experiment table, and the artificial sample syringe is enclosed within on the artificial sample support.
6. transdermal diffusion instrument as claimed in claim 5, is characterized in that, the front end of described experiment table is provided with temperature control display device.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310013563XA CN103115852A (en) | 2013-01-15 | 2013-01-15 | Transdermal diffusion apparatus |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310013563XA CN103115852A (en) | 2013-01-15 | 2013-01-15 | Transdermal diffusion apparatus |
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| CN103115852A true CN103115852A (en) | 2013-05-22 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103323496A (en) * | 2013-05-24 | 2013-09-25 | 阮仕荣 | High throughput skin corrosion and absorption detecting boards |
| CN104422634A (en) * | 2013-08-22 | 2015-03-18 | 中国科学院大连化学物理研究所 | Method for characterization of polyelectrolyte plate hydrogel or hydrogel film density |
| CN105910962A (en) * | 2016-05-25 | 2016-08-31 | 延边大学 | Full-automatic in-vitro transdermal vertical dispersion testing device |
| CN109612898A (en) * | 2018-11-12 | 2019-04-12 | 禄根仪器(镇江)有限公司 | A kind of suspending agent flowing release test flowing lumen |
Citations (3)
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|---|---|---|---|---|
| CN2479500Y (en) * | 2001-03-02 | 2002-02-27 | 许景峰 | External osmotic deffusion experiment instrument |
| CN101221160A (en) * | 2007-01-09 | 2008-07-16 | 浙江中医药大学 | Pulsation circulation type transdermal experiment instrument |
| US20110120214A1 (en) * | 2009-11-23 | 2011-05-26 | Logan Instruments Corp. | Transdermal diffusion cell testing vessel and methods using same |
-
2013
- 2013-01-15 CN CN201310013563XA patent/CN103115852A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2479500Y (en) * | 2001-03-02 | 2002-02-27 | 许景峰 | External osmotic deffusion experiment instrument |
| CN101221160A (en) * | 2007-01-09 | 2008-07-16 | 浙江中医药大学 | Pulsation circulation type transdermal experiment instrument |
| US20110120214A1 (en) * | 2009-11-23 | 2011-05-26 | Logan Instruments Corp. | Transdermal diffusion cell testing vessel and methods using same |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103323496A (en) * | 2013-05-24 | 2013-09-25 | 阮仕荣 | High throughput skin corrosion and absorption detecting boards |
| CN104422634A (en) * | 2013-08-22 | 2015-03-18 | 中国科学院大连化学物理研究所 | Method for characterization of polyelectrolyte plate hydrogel or hydrogel film density |
| CN105910962A (en) * | 2016-05-25 | 2016-08-31 | 延边大学 | Full-automatic in-vitro transdermal vertical dispersion testing device |
| CN105910962B (en) * | 2016-05-25 | 2018-08-14 | 延边大学 | The vertical diffusion test device of full-automatic transdermal test in vitro |
| CN109612898A (en) * | 2018-11-12 | 2019-04-12 | 禄根仪器(镇江)有限公司 | A kind of suspending agent flowing release test flowing lumen |
| CN109612898B (en) * | 2018-11-12 | 2021-06-04 | 禄根仪器(镇江)有限公司 | Flowable release test circulation cavity for suspending agent |
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Application publication date: 20130522 |