CN103099931A - Pharmaceutical composition - Google Patents
Pharmaceutical composition Download PDFInfo
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- CN103099931A CN103099931A CN2013100592692A CN201310059269A CN103099931A CN 103099931 A CN103099931 A CN 103099931A CN 2013100592692 A CN2013100592692 A CN 2013100592692A CN 201310059269 A CN201310059269 A CN 201310059269A CN 103099931 A CN103099931 A CN 103099931A
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Abstract
The invention relates to a pharmaceutical composition, comprising dandelion, raw rhubarb, herba violae, gardenia, tuckahoe and yam. The composition has excellent effect on acne caused by long-term staying up all night, spicy food and bad mood, and efficiency higher than 80%.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, belong to biomedicine field.
Background technology
Acne is commonly called as comedo, be chronic inflammation pilosebaceous unit disease, be one of modal disease of department of dermatologry, its morbidity is main and sex hormone level, sebaceous gland are secreted in a large number, propionibacterium acnes propagation, the factor analysis such as the dyskeratosis of pilosebaceous duct and inflammation.Be apt to occur in hebetic masculinity and femininity, the male is slightly more than the women, but women's morbidity is early than the male.Have the teenager of 80%-90% to suffer from acne, often can naturally go down or fully recover after adolescence, individual patient also can extend to more than 30 years old.Although acne is the disease that the spontaneous recovery tendency is arranged, the untimely cicatrix that causes of acne itself and acne treatment can have a strong impact on Quality of Life, causes patient's stress and financial burden, need cause concern.Acne is apt to occur in buccal, forehead, buccal and nasolabial fold, is secondly chest, back and shoulder.
According to international improved method, acne is divided into 4 grades:
1. slight (I level): take acne as main, a small amount of papulopustule, total skin lesion is less than 30;
2. moderate (II level): acne are arranged, the pimple of moderate quatity and pustule, total skin lesion is at 30-50;
3. moderate (III level): a large amount of pimples and pustule, accidental large struvite skin lesion, widely distributed, total skin lesion number is between 51-100, and tuberosity is less than 3;
4. severe (IV level): nodositas, cyst and or the property acne, with pain and form cyst, total skin lesion is more than 100, tuberosity or cyst are more than 3.
Acne is an easily disease of recurrence, and the influence factor is a lot, and single therapy often is difficult to receive good effect, need to take Comprehensive Treatment according to the state of an illness.The common oral drugs of Acne treatment mainly contain:
1. antibiotics: oral antibiotic is one of important method of severe acne in treatment, and selecting the antibiotic for the propionibacterium acnes sensitivity is important starting point, first-selected Tetracyclines, and secondly Macrolide, reach therapeutic effect by suppressing its breeding.
2. tretinoin: oral isotretinoin is the standard treatments of the serious acne such as tuberosity cyst type, aggretion type, and its therapeutic effect is remarkable, but also have teratogenesis, blood fat raises and the side effect such as skin mucosa drying, should use under physician guidance.
3. hormones: the effect to androgen antagonist in pathogenesis of acne, reduce sebum secretion and suppress acne and generate, mainly comprise estrogen and the large class of progestogen two, as cyproterone, ethinylestradiol, diethylstilbestrol etc., also have other antagonism androgens medicines such as spironolactone, cimetidine.
4. glucocorticoid: oral glucocorticoid is mainly used in acne fulminans or acne conglobata, plays the effect of immunosuppressant and antiinflammatory.
5. Chinese patent medicine class: coptos bolus for clearing the upper heat, fangfeng tongsheng pill, danzhi xiaoyao pills, Radix Et Rhizoma Rhei Eupolyphaga seu steleophaga ball, ZHIBAI DIHUANG WAN etc.
Local external use's treatment sterilizes as main take degrease, dissolving cutin, antiinflammatory.Commonly used comprises: tretinoin preparation, benzoyl peroxide, erythromycin, chloromycetin, contain sulfur class lotion etc.
Summary of the invention
The purpose of this invention is to provide a kind of pharmaceutical composition, the weak point that exists to solve existing Drug therapy acne.
The technical solution used in the present invention is: a kind of pharmaceutical composition is characterized in that being prepared from by the crude drug of following weight portion:
Herba Taraxaci 9-15 part Radix Et Rhizoma Rhei 5-15 part
Herba Violae 15-30 part Fructus Gardeniae 5-10 part
Poria 9-15 part Rhizoma Dioscoreae 15-30 part
Above-mentioned raw materials also can adopt extract, for example the commercially available extract of above-mentioned raw materials except adopting former powder.
A kind of pharmaceutical composition of the present invention, upper on the basis of mentioned component directly or again adds suitable edible or pharmaceutic adjuvant, can make capsule, tablet, granule, oral liquid, powder, teabag etc.
The above-mentioned edible or pharmaceutic adjuvant that can add comprises: diluent, suspending agent, antioxidant, emulsifying agent, disintegrating agent, adhesive and antiseptic.
Above-mentioned diluent comprises vegetable oil, molecular weight polyethylene glycol 200-6000, the third two liquor-saturated, glycerol, sorbitol, D-xylitol, calcium glycerophosphate, polyvinylpolypyrrolidone, inositol, maltose alcohol, lactobionic acid, cyclodextrin, lactose, calcium oxide, cellulose, glucose, carboxymethyl cellulose, polyvinyl butyral resin etc., and one or more in mineral oil.
Above-mentioned antioxidant comprises one or more in dibenzylatiooluene (BHT), butylated hydroxyarisol (BHA), propyl gallate, tert-butyl hydroquinone (TBHQ), malic acid, glutathion, D-xylose, glycine, a-tocopherol, a-tocopheryl acetate, sodium sulfite, inositol, ascorbic acid, phytic acid, sodium ascorbate, lecithin, hydroquinone, xylitol, succinic acid, tea polyphenols.
Above-mentioned suspending agent comprises one or more in Cera Flava, xanthan gum, arabic gum, casein, methylcellulose, Carboxymethyl cellulose sodium, carbomer, polyvinyl alcohol, hydroxyethyl-cellulose, sodium alginate, chitin, chitose, hydroxypropyl emthylcellulose, ethyl cellulose, agar, hydroxyethylmethyl-cellulose, hyprolose.
Mentioned emulsifier comprises one or more in ethylhydroxyethylcellulose, methylcellulose, glyceryl monostearate, hydroxylated lecithin, the single glycerol vinegar of acetylation, orthoformic acid, casein, ethylene glycol monostearate, diacetyl monoglyceride, acetic acid-fatty acid glycerine vinegar, Emulsifier LM-102, propylene glycol alginate.
Above-mentioned binding agent comprises methylcellulose (MC), polyvinylpyrrolidone (PVP), hydroxypropyl cellulose (HPC), hydroxypropyl emthylcellulose (HPMC), polyvinyl alcohol (PVA), Cellulose Acetate Phthalate (CAP), PVP K30, ethyl cellulose (EC), microcrystalline Cellulose (CC), acrylic resin, Semen Maydis unit, Resina persicae, maltose alcohol, poloxamer; One or more in sodium alginate, liquid glucose, Nulomoline, the acid of sucrose mono laurate.
Above-mentioned disintegrating agent comprises one or more in silica sol, Magnesiumaluminumsilicate, magnesium stearate, pregelatinized starch, cross-linking sodium carboxymethyl cellulose.
Foregoing preservatives comprises one or more in sorbic acid, Sodium Methyl Hydroxybenzoate, benzoic acid, sorbic acid methyl ester, methyl parahydroxybenzoate, P-hydroxybenzoic acid phenyl ester, butyl p-hydroxybenzoate calcium, Oleum Caryophylli, benzyl alcohol, P-hydroxybenzoic acid the third phenol sodium.
Above-mentioned capsule also comprises soft capsule except common gelatin hard-shell capsule.
The specific embodiment
The preparation of embodiment 1. capsules
10 parts of 12 parts of Radix Et Rhizoma Rhei of Herba Taraxaci
7 parts of 22 portions of Fructus Gardeniaes of Herba Violae
23 parts of 12 portions of Rhizoma Dioscoreaes of Poria
Pulverize, cross 100 mesh sieves, encapsulated, granulate, and get final product.
The preparation of embodiment 2. oral liquids
5 parts of 15 parts of Radix Et Rhizoma Rhei of Herba Taraxaci
5 parts of 30 portions of Fructus Gardeniaes of Herba Violae
30 parts of 9 portions of Rhizoma Dioscoreaes of Poria
Add 30 times of amounts of water, be forced into 300Mpa with hyperpressure extraction equipment, pressurize 5 minutes, extracting solution ultrafiltration, concentrated, fill, and get final product.
The preparation of embodiment 3. powders
15 parts of 9 parts of Radix Et Rhizoma Rhei of Herba Taraxaci
10 parts of 15 portions of Fructus Gardeniaes of Herba Violae
15 parts of 15 portions of Rhizoma Dioscoreaes of Poria
Pulverize, cross 100 mesh sieves, packing, and get final product.
Claims (3)
1. pharmaceutical composition is characterized in that being prepared from by the crude drug of following weight portion:
Herba Taraxaci 9-15 part Radix Et Rhizoma Rhei 5-15 part
Herba Violae 15-30 part Fructus Gardeniae 5-10 part
Poria 9-15 part Rhizoma Dioscoreae 15-30 part.
2. a kind of pharmaceutical composition as claimed in claim 1, is characterized in that also containing edible or pharmaceutic adjuvant.
3. as any one described a kind of pharmaceutical composition of claim 1-2, it is characterized in that the former powder of raw material or extract, directly or again add edible or pharmaceutic adjuvant, be prepared into capsule, tablet, granule, oral liquid, powder, teabag etc.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN2013100592692A CN103099931A (en) | 2013-02-26 | 2013-02-26 | Pharmaceutical composition |
Applications Claiming Priority (1)
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CN2013100592692A CN103099931A (en) | 2013-02-26 | 2013-02-26 | Pharmaceutical composition |
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CN103099931A true CN103099931A (en) | 2013-05-15 |
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CN2013100592692A Pending CN103099931A (en) | 2013-02-26 | 2013-02-26 | Pharmaceutical composition |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105943852A (en) * | 2016-05-06 | 2016-09-21 | 姚瑶 | External traditional Chinese medicine for treating acne |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1380098A (en) * | 2002-05-20 | 2002-11-20 | 张勇飞 | Anti-infection compound preparation and its preparation method |
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2013
- 2013-02-26 CN CN2013100592692A patent/CN103099931A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1380098A (en) * | 2002-05-20 | 2002-11-20 | 张勇飞 | Anti-infection compound preparation and its preparation method |
Non-Patent Citations (1)
Title |
---|
孙潋等: "痤疮的中医药治疗研究述评", 《中医学报》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105943852A (en) * | 2016-05-06 | 2016-09-21 | 姚瑶 | External traditional Chinese medicine for treating acne |
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Application publication date: 20130515 |