CN103083662A - Preparation and application of wild buckwheat rhizome superfine powder - Google Patents
Preparation and application of wild buckwheat rhizome superfine powder Download PDFInfo
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- CN103083662A CN103083662A CN2013100382266A CN201310038226A CN103083662A CN 103083662 A CN103083662 A CN 103083662A CN 2013100382266 A CN2013100382266 A CN 2013100382266A CN 201310038226 A CN201310038226 A CN 201310038226A CN 103083662 A CN103083662 A CN 103083662A
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- fagopyri dibotryis
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Abstract
The invention discloses application of wild buckwheat rhizome superfine powder in preparing a vaccine adjuvant for improving the poultry vaccine protection effect and prolonging the protection time and in preparing a feed additive for promoting the poultry growth and development and shortening the yielding time. The wild buckwheat rhizome superfine powder disclosed by the invention has the functions of improving the poultry vaccine protection effect, prolonging the protection time and promoting the poultry growth and development, and can be used as a novel vaccine adjuvant and a feed additive.
Description
Technical field
The invention belongs to fowl vaccine adjuvant, feed additive.Be specifically related to the novel form of the Rhizoma Fagopyri Dibotryis superfine powder that prepared by Rhizoma Fagopyri Dibotryis and their the protection effect that improves poultry vaccine, extend guard time and promote the poultry growth promoter, shorten marketing time, application in improving the price of deed.
Background technology
Fagopyrum cymosum Meisn. is that the Dicotyledoneae Polygonaceae is supported the wheat platymiscium, is China's a kind of Chinese medicine commonly used among the people, medicinal its rhizome, and the traditional Chinese medical science is thought its flavor little suffering, puckery, and is cool in nature, has heat-clearing and toxic substances removing, evacuation of pus is eliminated the phlegm, the effect of the removing dampness of dispeling the wind.modern pharmacological research is found, Rhizoma Fagopyri Dibotryis has the functions such as stronger antibacterial activity and reinforcement body oneself epidemic prevention ability, can be used for clinically treating cancer, antibacterial infects and diabetes in opposing, hyperlipemia, the various diseases such as rheumatism ([1] Chinese Pharmacopoeia Commission. Pharmacopoeia of People's Republic of China (an one) [M]. Beijing: Chemical Industry Press, 2005:69, 89, 109, 52 appendix 31, appendix 32.[2] Zhou Yuyan, Qiao Hongjie. Rhizoma Fagopyri Dibotryis extract antibacterial activity in vitro research [J]. Chinese veterinarian's medical magazine, 2009, 5:44-46.[3] Chen Xiaofeng, Gu Zhenlun, Yang Haihua. Rhizoma Fagopyri Dibotryis Fr4 is to Mouse With Lewis Lung Cancer cell MMP-9, the impact [J] of TIMP one 1 protein expressions. University Of Suzhou's journal 2005, 25 (3): 383).
Rhizoma Fagopyri Dibotryis is mainly used in resisting various antibacterials, viral disease in the people doctor at present, uses as anti-infectives.Usage and purposes are more single, as: the Rhizoma Fagopyri Dibotryis sheet, this medicine is evident in efficacy to the patient of the inflammation of respiratory tract infection and intestinal infection, and pulmonary abscess is had specially good effect; The Rhizoma Fagopyri Dibotryis capsule, a kind of novel anti-infection medicine is described as " Chinese medicine class antibiotic ", and the clinical heat-clearing and toxic substances removing, evacuation of pus blood stasis dispelling, expelling phlegm for arresting cough of often being applied to relievingd asthma.
In veterinary applications, the research of Rhizoma Fagopyri Dibotryis is treated various antibacterials infection and Rhizoma Fagopyri Dibotryis greenfeed raising hog slaughtering performance and quality as main take Rhizoma Fagopyri Dibotryis extract.Studies show that, the Rhizoma Fagopyri Dibotryis ethanol extract has stronger fungistatic effect to actinobacillus pleuropneumoniae, Streptococcus suis, staphylococcus aureus and Salmonella, to haemophilus parasuis, pasteurella multocida, colibacillary fungistatic effect relatively a little less than.The Rhizoma Fagopyri Dibotryis ethanol extract also can be obvious timeliness and dose-effect relationship ([2] Zhou Yuyan to chicken spleen Proliferation of lymphocytes activity simultaneously, Qiao Hongjie etc. Rhizoma Fagopyri Dibotryis extract antibacterial activity in vitro research [J]. Chinese veterinarian's medical magazine, 2009,5:44-46.[4] Ai Qun, Wang Bin, kingdom is clear. the antibacterial research [J] of Cymose buckwheat rhizome preparation. and Heilungkiang medical science, 2002,9(26): 666.[5] Zhang Yongxian, royal power. the antibiotic anti-infectious function ［ J ］ of efficient element of golden buckwheat. Yunnan animal and veterinary, 1996 (2): 5; 22,2010,31 (3): 44-48. [6] Ai Qun, Wang Bin, kingdom is clear. the antibacterial research [J] of Cymose buckwheat rhizome preparation. and Heilungkiang medical science, 2002,9(26): 666.[7] Qiao Hongjie, Wang Guiping, Li Chunling. the serum pharmacological research [J] of Rhizoma Fagopyri Dibotryis root extract on the impact of chicken spleen lymphocyte activity. animal medicine progress, 2010,31 (3): 44-48.).The Deng Rong researcher of Guizhou Farming Animal Science and Veterinary Research Institute carries out swine rearing test ([8] Deng Rong with the concentrate of wild Rhizoma Fagopyri Dibotryis greenfeed replacement 12%～14%, Liang Yinglin, Zhang Dinghong etc. the impact [J] of feeding Rhizoma Fagopyri Dibotryis on pig Slaughter and meat. HEILONGJIANG ANIMAL SCIENCE AND VETERINARY MEDICINE, 2012,6:69.), and carry out Slaughter and measure, result shows with the Rhizoma Fagopyri Dibotryis greenfeed replacement part concentrate pig of feeding can improve dressing percentage of hog, lean meat percentage, cold cuts rate, reduce fat thickness between 6～7 thoracic vertebras, increase crude protein, ash, phosphorus content, thereby improve Meat Flavor and quality.
In sum: Rhizoma Fagopyri Dibotryis extract can effectively be treated various antibacterials and be infected, and the Rhizoma Fagopyri Dibotryis greenfeed improves hog slaughtering performance and quality.But numerous and diverse due to the extraction process of various extracts, extraction cost is high, when Rhizoma Fagopyri Dibotryis is as feed additive in addition, addition up to 12%～14%, has further improved again production cost, therefore be difficult to realize in production practices.
Chinese medicine ultra-fine powder is to utilize powder technology processing technique leading in the world to implement to Chinese medicine the powder that cell wall breaking processes.Increase because fine particles causes surface volume and voidage, make superfine powder have unique physical and chemical performance, as good dispersibility, adsorptivity, dissolubility, chemism, biological activity etc.Chinese crude drug discharges fully through effective ingredient after cell wall breaking, be conducive to animal body absorbing medicine, simultaneously, can increase the surface area of powder body after micronization of treditional Chinese medicine, increase the contact area of medicine and medicine-feeding part, prolong drug is at the soak time of absorption site, thereby therapeutic effect has qualitative leap.
Chinese medicine ultra-fine powder is compared with Chinese medicine huge advantage, but has no at present the preparation technology of Rhizoma Fagopyri Dibotryis superfine powder and protection effect that the Rhizoma Fagopyri Dibotryis superfine powder can improve poultry vaccine, extends guard time and promote the poultry growth promoter, shortens marketing time, improves the report of the price of deed.
Summary of the invention
In view of the huge advantage of Chinese medicine crushing technology and the above deficiency of prior art; the objective of the invention is to study the Rhizoma Fagopyri Dibotryis superfine powder and improve the protection effect of poultry vaccine as vaccine adjuvant; extend guard time and as the growth promoter of feed additive promotion poultry, the purposes of shortening marketing time, it is used widely in the feed additive for preparing the protection effect that improves poultry vaccine, the vaccine adjuvant that extends guard time and promotion poultry growth promoter, shortening marketing time, the raising price of deed.
The invention provides the purposes of Rhizoma Fagopyri Dibotryis superfine powder, can be used as a kind of novel poultry vaccine adjuvant, improve vaccine to the protection effect of poultry and extend guard time.As feed additive, the growth promoter that promotes poultry, the effect that shortens marketing time, the raising price of deed are arranged.
The invention provides a kind of preparation method of Rhizoma Fagopyri Dibotryis superfine powder, the Rhizoma Fagopyri Dibotryis superfine powder mean diameter that the method makes is below 40～75nm of superfine powder standard.
Description of drawings
Fig. 1: Rhizoma Fagopyri Dibotryis superfine powder
Fig. 2: Rhizoma Fagopyri Dibotryis superfine powder stereoscan photograph
The specific embodiment
One, Rhizoma Fagopyri Dibotryis superfine preparation method:
The objective of the invention is to be achieved through the following technical solutions, the preparation method of Rhizoma Fagopyri Dibotryis superfine powder comprises the following steps:
1, adopt quality standard to meet the Rhizoma Fagopyri Dibotryis decoction pieces of the Pharmacopoeia of the People's Republic of China as raw material;
2, with plant sample pulverizer, the Rhizoma Fagopyri Dibotryis decoction pieces is pulverized, crossed 6 mesh sieves, make the coarse granule of 3mm left and right.
3, coarse granule is pulverized with super micron mill, crosses 400 mesh sieves, repeatedly pulverizes twice, makes the superfine powder of particle diameter 40～75nm.
Detect resulting superfine powder particle diameter all below 75nm through scanning electron microscope.
Two, application example
Below zoopery be to further description of the present invention, but and do not mean that any limitation of the invention.Obviously, due to the selected laboratory animal pharmacology feasible popularity that has expressed the present invention use should trace back and the animal realm.
160 healthy white plumage broiler of 1 age in days, be divided at random 4 groups, every group 40,7 ages in days are with newcastle live vaccine collunariums, 1 part/only, while cervical region subcutaneous injection newcastle-bird flu bivalent inactivated vaccine, 0.3ml/ only, after the 12h of interval, each group is fed respectively and is contained the feedstuff of different pharmaceutical, free choice feeding, the I group is blank, does not add any medicine in feedstuff; Add the 400ppm astragalus polysaccharides in II group feedstuff, be the medicine matched group; Add 7.5 ‰ Rhizoma Fagopyri Dibotryis superfine powder in III group feedstuff, be high dose group; Add 4.5 ‰ Rhizoma Fagopyri Dibotryis superfine powder in IV group feedstuff, be low dose group.
1. the Rhizoma Fagopyri Dibotryis superfine powder improves vaccine dialogue plumage broiler protection effect, extends guard time
After immunity, different time organizes respectively that chicken Newcastle disease and influenza antibodies level see Table 1, table 2.
Respectively organize newcastle epidemic disease antibody tire (log2) after table 1 immunity
Annotate: a:P＜0.01, difference are extremely remarkable, b:P＜0.05, significant difference
Statistical result showed:
The 7th day high and low dose group and blank group difference remarkable (P〉0.05) after immunity, medicine matched group and blank group significant difference (P＜0.05); The 21st day high dose group, medicine matched group and blank group difference extremely remarkable (P＜0.01) after immunity, low dose group and blank group significant difference (P＜0.05); The 35th day high and low dose group, medicine matched group and blank group significant difference (P＜0.05) after immunity.
Respectively organize influenza antibodies tire (log2) after table 2 immunity
Annotate: a:P＜0.01, difference are extremely remarkable, b:P＜0.05, significant difference
Statistical result showed:
The 7th day high and low dose group and blank group difference remarkable (P〉0.05) after immunity, medicine matched group and blank group significant difference (P＜0.05); The 21st day high dose group and blank group difference extremely significantly (P＜0.01) after immunity, low dose group and blank group difference remarkable (P〉0.05), medicine matched group and blank group significant difference (P＜0.05); The 35th day high and low dose group, medicine matched group and blank group significant difference (P＜0.05) after immunity.
Conclusion: the Rhizoma Fagopyri Dibotryis superfine powder can improve the protection effect of vaccine dialogue plumage broiler and extend guard time.
2. the Rhizoma Fagopyri Dibotryis superfine powder improves white plumage broiler cellular immune function
(1) the Rhizoma Fagopyri Dibotryis superfine powder can improve the thin conversion ratio of white plumage broiler periphery lymph, the results are shown in Table 3.
The stimulation index of table 3 broiler peripheral blood lymphocyte
Annotate: a:P＜0.01, difference are extremely remarkable, b:P＜0.05, significant difference
Statistical result showed:
The 7th day high dose group and matched group difference remarkable (P〉0.05) after immunity, low dose group, medicine matched group and blank group significant difference (P＜0.05); The 21st day high dose group and blank group difference not significantly (P〉0.05) after immunity, low dose group and blank group significant difference (P＜0.05), medicine matched group and blank group difference is remarkable (P＜0.01) extremely; The 35th day high dose group, medicine matched group and blank group difference extremely remarkable (P＜0.01) after immunity, low dose group and blank group significant difference (P＜0.05).
(2) the Rhizoma Fagopyri Dibotryis superfine powder improves white plumage broiler peripheral blood neutrophil phagocytic activity, the results are shown in Table 4.
After table 4 immunity, different time is respectively organized peripheral blood neutrophil phagocytic activity percentage phagocytosis and phagocytic index
Annotate: a:P＜0.01, difference are extremely remarkable, b:P＜0.05, significant difference
Statistical result showed:
Percentage phagocytosis: the 7th day high dose group, low dose group, medicine matched group and blank group difference remarkable (P〉0.05) after immunity; The 21st day high dose group, low dose group, medicine matched group and blank group difference remarkable (P〉0.05) after immunity, the 35th day high dose group, medicine matched group and blank group difference remarkable (P〉0.05) after immunity, low dose group and blank group significant difference (P＜0.05).
Phagocytic index: the 7th day high dose group, low dose group and blank group significant difference (P＜0.05) after immunity, medicine matched group and blank group difference is (P〉0.05) not significantly, the 21st day high dose group and blank group difference extremely remarkable (P＜0.01) after immunity, low dose group, medicine matched group and blank group difference is (P〉0.05) not significantly, the 35th day high, medicine matched group group and matched group difference remarkable (P〉0.05) after immunity, low dose group and matched group significant difference (P＜0.05).
Conclusion: the be significantly improved effect of white plumage broiler cellular immune function of Rhizoma Fagopyri Dibotryis superfine powder
3. the Rhizoma Fagopyri Dibotryis superfine powder improves the growth promoter of white each epidemic disease organ of plumage broiler
(1) the Rhizoma Fagopyri Dibotryis superfine powder improves the growth promoter of white plumage broiler spleen, fabricius bursa immune organ, the results are shown in Table 5,6.
The organ index (mg/g) of different time spleen after each group immunity of table 5
Annotate: a:P＜0.01, difference are extremely remarkable, b:P＜0.05, significant difference
Statistical result showed:
The 7th day high and low dose group, medicine matched group and blank group difference remarkable (P〉0.05) after immunity; The 21st day high dose group, low dose group and blank group significant difference (P＜0.05) after immunity, medicine matched group and blank group difference remarkable (P〉0.05); The 35th day high dose group, low dose group and blank group significant difference (P＜0.05) after immunity, medicine matched group and blank group difference remarkable (P〉0.05);
After table 6 immunity, different time is respectively organized fabricius bursa index (mg/g)
Annotate: a:P＜0.01, difference are extremely remarkable, b:P＜0.05, significant difference
Statistical result showed:
The 7th day high and low dose group, medicine matched group and blank group difference remarkable (P〉0.05) after immunity; The 21st day high dose group and blank group significant difference (P＜0.05) after immunity, low dose group, medicine matched group and blank group difference remarkable (P〉0.05); The 35th day high and low dose group, medicine matched group and blank group difference remarkable (P〉0.05) after immunity;
Conclusion: the Rhizoma Fagopyri Dibotryis superfine powder has growth, the growth of the white plumage broiler of obvious promotion immune organ, and then has improved the non-specific immunity of white plumage broiler.
4. the Rhizoma Fagopyri Dibotryis superfine powder promotes white plumage growth of meat chicken, growth, accelerates marketing time, improves the price of deed
(1) Rhizoma Fagopyri Dibotryis superfine powder dialogue plumage broiler has obvious gaining effect, the results are shown in Table 7.
After table 7 administration, different time sections is respectively organized chickling body weight (g)
Annotate: a:P＜0.01, difference are extremely remarkable, b:P＜0.05, significant difference
Statistical result showed:
The 7th day high and low dose group, medicine matched group and blank group significant difference (P＜0.05) after immunity; The 21st day high and low dose group, medicine matched group and blank group significant difference (P＜0.05) after immunity.
(2) the Rhizoma Fagopyri Dibotryis superfine powder reduces white plumage broiler material anharmonic ratio, improves the price of deed
After administration, different time is respectively organized white plumage broiler material anharmonic ratio and be the results are shown in Table 8.
After table 8 administration, different time is respectively organized the material anharmonic ratio of chickling
Conclusion: the Rhizoma Fagopyri Dibotryis superfine powder can promote the growth promoter of white plumage broiler, improves the price of deed.
In sum: the Rhizoma Fagopyri Dibotryis superfine powder can well improve vaccine to the protection effect of poultry and extend guard time, can be used as a kind of novel poultry vaccine adjuvant and uses.The growth promoter that promotes poultry is arranged as feed additive, shorten marketing time, can improve the effect of poultry autoimmune function.The Rhizoma Fagopyri Dibotryis superfine powder adds in all feeds with natural plants simultaneously, has the advantages such as consumption is few, with low cost, convenient, safety, drug residue free.
Claims (3)
1. the Rhizoma Fagopyri Dibotryis superfine powder has the application in the vaccine adjuvant that improves poultry vaccine protection effect, extends guard time in preparation, improves the vaccine adjuvant of poultry vaccine protection effect take the Rhizoma Fagopyri Dibotryis superfine powder as the active component manufacturing.
2. the Rhizoma Fagopyri Dibotryis superfine powder has the application in the feed additive that promotes the poultry growth promoter, shortens marketing time in preparation, promotes the feed additive of poultry growth promoter take the Rhizoma Fagopyri Dibotryis superfine powder as the active component manufacturing.
3. according to claim 1,2 described application is characterized in that, described Rhizoma Fagopyri Dibotryis superfine powder adopts following method to obtain:
The Rhizoma Fagopyri Dibotryis decoction pieces was pulverized 6 mesh sieves, made the coarse granule of 3mm left and right, and coarse granule is pulverized with super micron mill, crossed 400 mesh sieves, pulverized twice, made particle diameter and namely got object at the superfine powder of 40～75nm.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105432963A (en) * | 2015-12-22 | 2016-03-30 | 浙江农林大学 | Animal feed capable of encouraging growth and resisting infection, and preparation method and application thereof |
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Application publication date: 20130508 |