CN103006849B - Application of hedyotis diffusa ultrafine powder in preparation of medicine for improving immunity of livestock and poultry - Google Patents
Application of hedyotis diffusa ultrafine powder in preparation of medicine for improving immunity of livestock and poultry Download PDFInfo
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- CN103006849B CN103006849B CN201210587134.9A CN201210587134A CN103006849B CN 103006849 B CN103006849 B CN 103006849B CN 201210587134 A CN201210587134 A CN 201210587134A CN 103006849 B CN103006849 B CN 103006849B
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Abstract
The invention discloses an application of hedyotis diffusa ultrafine powder in preparation of a medicine for improving immunity of livestock and poultry, and relates a medicine for improving the immunity of the livestock and poultry based on the hedyotis diffusa ultrafine powder as an active ingredient and an application in preparation of a medicine for improving nonspecific immunity, improving specific immunity, and/or promoting the development of an immune organ, and for promoting the growth and development of the livestock and poultry. The hedyotis diffusa ultrafine powder has the functions and purposes of improving the immunity of the livestock and poultry and raising the animal growth speed, can be used as a novel additive for livestock and poultry feed to be applied to the health care and growth promotion of the livestock and poultry.
Description
Technical field
The invention belongs to veterinary drug and feed additive, especially the animal health medicine of screening and preparation from natural plants.The novel form of the Herba Hedyotidis Diffusae superfine powder that is specifically related to be prepared by Herba Hedyotidis Diffusae and their application in improving immunity of livestock drug products.
Background technology
Herba Hedyotidis Diffusae (formal name used at school: Hedyotis diffusa) be the plant of Rubiaceae cerastium.< < Guangxi Chinese medicinal herbal > > begins to be loaded in, its nature and flavor are bitter, sweet, cold, enter the heart, liver, spleen three warps, there is clearing heat, releasing toxin, removing swelling, promoting blood circulation, removing blood stasis and relieving pain, effect that dampness removing is treating stranguria, one of medical material kind of recording for < < Chinese Pharmacopoeia > > version in 2005 ([1] Chinese Pharmacopoeia Commission. Chinese Pharmacopoeia () [S]. Beijing: chemical industry is published, 2005: appendix 22.).Much more the effect that Herba Hedyotidis Diffusae water decoction and extractive with organic solvent improve mouse immunity has report ([2] Luo Xianqin, Lan Bo, Yang Xue, Deng. Herba Hedyotidis Diffusae antitumor and Study immune regulation progress [J]. Chongqing Chinese herbal medicine is studied carefully, 2011, (1): 35-37.), modern pharmacological research proof Herba Hedyotidis Diffusae has good antitumor, anti-inflammation, immunomodulating, anti-chemomorphosis, the effect such as hepatic cholagogic ([3] Dai Long, Yang Peimin, Wei Yongli. Chinese medicine Progress in Research of Hedyotis Diffusa Willd [J]. R&D of modern TCM and practice, 2009, 23 (4): 75-79.), people's antitumor auxiliary treatment and anti-inflammatory therapy have been applied to.But about Herba Hedyotidis Diffusae, the research of the health care growth promoting function of poultry be have not been reported,
Veterinary clinic is mainly used antibiotic etc. to carry out the prevention work of poultry for a long time, because the problems such as fowl poultry immune inhibition disease, bacterial drug resistance and livestock products veterinary drug residue that antibiotic abuse causes are brought significant damage to aquaculture.In this case, take the natural drug that Chinese medicine is representative demonstrates certain advantage.
Chinese medicine ultra-fine powder is to utilize powder technology processing technique leading in the world to implement to Chinese medicine the powder that cell wall breaking processes.Chinese crude drug effective ingredient after cell wall breaking discharges completely, is conducive to poultry body to the absorbing of medicine, and its therapeutic effect has qualitative leap.Meanwhile, can increase the surface area of powder body after micronization of treditional Chinese medicine, increase the contact area of medicine and medicine-feeding part, prolong drug is at the soak time of absorption site.
Have no at present Herba Hedyotidis Diffusae superfine powder and improve in preparation the report of applying in immunity of livestock medicine.
Summary of the invention
In view of the above deficiency of prior art, the object of the invention is to study the purposes of Herba Hedyotidis Diffusae superfine powder in improving immunity of livestock medicine, make it in preparation, improve in immunity of livestock medicine and be used widely.
Herba Hedyotidis Diffusae superfine powder improves the application in immunity of livestock medicine in preparation, take Herba Hedyotidis Diffusae superfine powder as active component manufacture raising immunity of livestock medicine.
The invention provides the purposes of Herba Hedyotidis Diffusae superfine powder, it has the effect purposes that improves immunity of livestock, can be used as a kind of novel immunity of livestock promoter, improves immunity of livestock, shortens marketing time.
Accompanying drawing explanation
Fig. 1 is embodiment of the present invention Electronic Speculum figure.
The specific embodiment
Below in conjunction with embodiment, the invention will be further described.
Zoopery is below to further description of the present invention, but and does not mean that any limitation of the invention.Obviously, due to selected laboratory animal pharmacology feasible had popularity has expressed that the present invention's application should be traceed back and animal realm.
One, the preparation of Herba Hedyotidis Diffusae superfine powder
Herba Hedyotidis Diffusae first uses microphyte sample pulverizer (PZ102) to pulverize, and crosses 200 mesh sieves, then uses microphyte super micron mill (WK-150) to pulverize, and crosses 400 ~ 600 mesh sieves, makes particle diameter at the superfine powder of 40～75nm, as Electronic Speculum Fig. 1.
Two, effect
Herba Hedyotidis Diffusae superfine powder can significantly improve the immunologic function of broiler comprehensively, reduces material anharmonic ratio, improves daily gain, can be used as a kind of novel additive for farm animal feed, for the growth promotion that keeps healthy.
Using dosage: 6～9g/kg feedstuff, successive administration 5～7 days.
Three, application example:
The comparative test of Herba Hedyotidis Diffusae superfine powder and conventional powder, result demonstration, Herba Hedyotidis Diffusae superfine powder can significantly improve nonspecific immunity, humoral immunization and the cellular immune function of broiler, and biological effect is significantly higher than powder.
7 200 of age in days broiler chicken, Zhengda Company's meat chicken material free choice feeding, inoculation newcastle+bird flu (H9) bivalent inactivated vaccine, be divided at random 5 groups, 50 every group, according to the form below mixes the Herba Hedyotidis Diffusae of various dose and feedstuff, grouping is raised, successive administration 7 days.Different time after administration, measures the impact on immune organ, immunologic function and weightening finish.
Grouping situation
1, Herba Hedyotidis Diffusae superfine powder improves broiler immunologic function
(1) improve non-specific immunity
After 6 ‰ Herba Hedyotidis Diffusae superfine powder administrations one week, compare with not administration matched group, the phagocytic activity that can the utmost point significantly improves broiler peripheral blood neutrophil, the phagocytic percentage of the neutrophilic leukocyte of matched group and administration group be respectively 10.5 ± 0.563 and 12.32 ± 0.428(p < 0.01).
(2) improve humoral immune function
The superfine powder of two dosage all can significantly improve the antibody horizontal of serum of broilers newcastle and avian influenza vaccine.
After administration tire (HI, the log2) of different time newcastle epidemic disease antibody
A:P<0.01, difference is extremely remarkable, b:P<0.05, significant difference
Different time avian influenza antibody tire (HI, log2) after administration
Note: a:P<0.01, difference is extremely remarkable, b:P<0.05, significant difference
(3) superfine powder all can significantly improve broiler cellular immune function
The stimulation index of different time chickling peripheral blood lymphocyte after immunity
Note: a:P<0.01, difference is extremely remarkable, b:P<0.05, significant difference
(4) growth of Promote immunity organ
Two dosage of superfine powder all can promote broiler Development of The Spleen, increase spleen weight.After administration, the organ index of 1,3,5 week spleen sees the following form.
The organ index of spleen (‰)
Note: a:P<0.01, difference is extremely remarkable, b:P<0.05, significant difference
2, promote growth of meat chicken to grow, increase broiler weight
Two dosage of superfine powder all can significantly promote broiler growth to grow, and reduce material anharmonic ratio, improve broiler weight.
After administration, different time is respectively organized body weight (g)
Note: a:P<0.01, difference is extremely remarkable, b:P<0.05, significant difference
The material anharmonic ratio of 21 days after administration
Claims (1)
1. Herba Hedyotidis Diffusae superfine powder promotes the application in the medicine of growth of meat chicken growth effect in preparation, it is characterized in that, the Herba Hedyotidis Diffusae superfine powder of take improves the medicine that promotes growth of meat chicken growth effect as active component manufacture; Described Herba Hedyotidis Diffusae superfine powder adopts following method to obtain:
Herba Hedyotidis Diffusae was pulverized after 200 mesh sieves, then pulverized with microphyte super micron mill, crossed 400～600 mesh sieves, made particle diameter and obtained object at the superfine powder of 40～75nm.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210587134.9A CN103006849B (en) | 2012-12-30 | 2012-12-30 | Application of hedyotis diffusa ultrafine powder in preparation of medicine for improving immunity of livestock and poultry |
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| CN201210587134.9A CN103006849B (en) | 2012-12-30 | 2012-12-30 | Application of hedyotis diffusa ultrafine powder in preparation of medicine for improving immunity of livestock and poultry |
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| CN103006849A CN103006849A (en) | 2013-04-03 |
| CN103006849B true CN103006849B (en) | 2014-07-30 |
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| CN104971111A (en) * | 2014-04-14 | 2015-10-14 | 北京大北农动物保健科技有限责任公司 | Traditional Chinese medicine bio-preparation of improving immunity of livestock and poultry, preparation method thereof and feed therewith |
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| CN1775241A (en) * | 2005-11-18 | 2006-05-24 | 汤生玲 | Immunity strengthening agent of traditional Chinese herbs for birds |
| CN102688316A (en) * | 2012-06-18 | 2012-09-26 | 内蒙古华天制药有限公司 | Livestock compound medicine with anti-virus and immune regulation functions |
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Non-Patent Citations (2)
| Title |
|---|
| 中草药饲料添加剂在家禽养殖中的应用;杨帆;《北方牧业》;20090630;第27页 * |
| 杨帆.中草药饲料添加剂在家禽养殖中的应用.《北方牧业》.2009,中草药饲料添加剂在家禽养殖中的应用. |
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Granted publication date: 20140730 Termination date: 20171230 |