CN103083550A - Oral liquid for preventing and treating gastric cancer and preparation method thereof - Google Patents
Oral liquid for preventing and treating gastric cancer and preparation method thereof Download PDFInfo
- Publication number
- CN103083550A CN103083550A CN2013100213696A CN201310021369A CN103083550A CN 103083550 A CN103083550 A CN 103083550A CN 2013100213696 A CN2013100213696 A CN 2013100213696A CN 201310021369 A CN201310021369 A CN 201310021369A CN 103083550 A CN103083550 A CN 103083550A
- Authority
- CN
- China
- Prior art keywords
- parts
- oral liquid
- sterilization
- gastric cancer
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000005718 Stomach Neoplasms Diseases 0.000 title claims abstract description 33
- 206010017758 gastric cancer Diseases 0.000 title claims abstract description 31
- 201000011549 stomach cancer Diseases 0.000 title claims abstract description 31
- 239000007788 liquid Substances 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000003814 drug Substances 0.000 claims abstract description 60
- 238000000855 fermentation Methods 0.000 claims abstract description 27
- 230000004151 fermentation Effects 0.000 claims abstract description 27
- 230000001954 sterilising effect Effects 0.000 claims abstract description 21
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 21
- 238000004321 preservation Methods 0.000 claims abstract description 17
- 238000000034 method Methods 0.000 claims abstract description 14
- 238000011081 inoculation Methods 0.000 claims abstract description 11
- 241000222336 Ganoderma Species 0.000 claims abstract description 8
- 238000003756 stirring Methods 0.000 claims abstract description 7
- 229940079593 drug Drugs 0.000 claims description 20
- 239000000243 solution Substances 0.000 claims description 20
- 241000186605 Lactobacillus paracasei Species 0.000 claims description 17
- 239000000843 powder Substances 0.000 claims description 15
- 230000002265 prevention Effects 0.000 claims description 13
- 210000000582 semen Anatomy 0.000 claims description 11
- 239000003651 drinking water Substances 0.000 claims description 10
- 235000020188 drinking water Nutrition 0.000 claims description 10
- 210000004243 sweat Anatomy 0.000 claims description 6
- 241000533849 Gleditsia Species 0.000 claims description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 5
- 239000002196 Pyroceram Substances 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 5
- 238000010790 dilution Methods 0.000 claims description 5
- 239000012895 dilution Substances 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 239000008103 glucose Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 239000000047 product Substances 0.000 claims description 5
- 238000007789 sealing Methods 0.000 claims description 5
- 238000012423 maintenance Methods 0.000 claims description 4
- 239000012467 final product Substances 0.000 claims description 2
- 241000202755 Areca Species 0.000 claims 2
- 241000894006 Bacteria Species 0.000 abstract description 11
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract description 10
- 241000186660 Lactobacillus Species 0.000 abstract description 6
- 150000004676 glycans Chemical class 0.000 abstract description 6
- 229940039696 lactobacillus Drugs 0.000 abstract description 6
- 229920001282 polysaccharide Polymers 0.000 abstract description 6
- 239000005017 polysaccharide Substances 0.000 abstract description 6
- 239000000284 extract Substances 0.000 abstract description 5
- 235000014655 lactic acid Nutrition 0.000 abstract description 5
- 239000004310 lactic acid Substances 0.000 abstract description 5
- 230000004060 metabolic process Effects 0.000 abstract description 4
- 244000080767 Areca catechu Species 0.000 abstract description 3
- 235000006226 Areca catechu Nutrition 0.000 abstract 1
- 241000766380 Iphigenia Species 0.000 abstract 1
- 244000199866 Lactobacillus casei Species 0.000 abstract 1
- 235000013958 Lactobacillus casei Nutrition 0.000 abstract 1
- 244000126002 Ziziphus vulgaris Species 0.000 abstract 1
- 235000008529 Ziziphus vulgaris Nutrition 0.000 abstract 1
- 239000000306 component Substances 0.000 abstract 1
- 230000029087 digestion Effects 0.000 abstract 1
- 238000011049 filling Methods 0.000 abstract 1
- 229940017800 lactobacillus casei Drugs 0.000 abstract 1
- 239000005426 pharmaceutical component Substances 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 5
- 241001250596 Pleione Species 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 238000002512 chemotherapy Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 238000001959 radiotherapy Methods 0.000 description 4
- 241000233866 Fungi Species 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 239000009636 Huang Qi Substances 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 206010000059 abdominal discomfort Diseases 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 206010025482 malaise Diseases 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 201000000498 stomach carcinoma Diseases 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- 241001116389 Aloe Species 0.000 description 1
- 241000208340 Araliaceae Species 0.000 description 1
- 108010059892 Cellulase Proteins 0.000 description 1
- 241000756943 Codonopsis Species 0.000 description 1
- 241000660877 Coridius Species 0.000 description 1
- 241000218176 Corydalis Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000237903 Hirudo Species 0.000 description 1
- 208000007433 Lymphatic Metastasis Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 241000237636 Pheretima Species 0.000 description 1
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 241001530126 Scrophularia Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229940106157 cellulase Drugs 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229940016667 resveratrol Drugs 0.000 description 1
- 210000001779 taste bud Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- HSTZMXCBWJGKHG-CUYWLFDKSA-N trans-piceid Polymers O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=CC(\C=C\C=2C=CC(O)=CC=2)=C1 HSTZMXCBWJGKHG-CUYWLFDKSA-N 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to an oral liquid for preventing and treating a gastric cancer and a preparation method thereof. According to the preparation method, the oral liquid is prepared from spina gleditsiae, Indian iphigenia bulb, radix helicteris, dried Chinese jujubes, lucid ganoderma, rhizoma cyperi, rhizoma polygoni cuspidati, radix actinidiae chinensis and areca catechu through digestion, sterilization, fermentation, filling, and sterilization. In the fermentation, with the adoption of a lactobacillus casei strain, the inoculation proportion is 0.5-0.8g/100kg; and fermentation conditions are as follows: carrying out heat preservation and fermenting for 12 hours at 30-40 DEG C, stirring for 5-8 minutes every two hours in a fermenting process, and controlling the stirring speed to be 60-70rpm. According to the invention, a plurality of traditional Chinese medicine extracts for supporting the healthy energy are fermented by lactic acid bacteria to obtain the oral liquid for preventing and treating the gastric cancer. A fermented culture generates lactobacillus viscous polysaccharides in a metabolic process, so that the unstable phenomenon caused by placing and precipitating effective pharmaceutical components for a long time can be avoided; in addition, compared with the existing similar medicaments, the oral liquid disclosed by the invention has the characteristics of high effective component content, good taste and remarkable efficacy.
Description
Technical field
The present invention relates to a kind of oral preparation of Chinese traditional medicinal, particularly relate to a kind of for preventing and treat extract oral liquid formulation of gastric cancer and preparation method thereof.
Background technology
Gastric cancer is higher, the common malignant tumor of sickness rate in the world, occupies first of all kinds of tumors at its sickness rate of China.At present, treatment gastric cancer is equipped with radiotherapy and chemotherapy in early days substantially take operation as main.Operation no doubt can removal of lesions was, but the probability that causes recurrence of gastric cancer to shift due to the existence of residual cancerous cell or regional lymph node metastasis is quite high; Radiotherapy chemotherapy has certain killing action to cancerous cell, but larger to patient's body injury, even causes many afunctions, for the late gastric cancer patient, Radiotherapy chemotherapy method effect is unsatisfactory, if patient age is bigger than normal in addition weak, continues Radiotherapy chemotherapy and can only accelerate death.
Gastric cancer majority in advance shows as the symptoms such as epigastrium pain, inappetence, gastric abscess, regurgitation, how on the books the traditional medicine of China is also to this type of disease, the Chinese medicine that employing natural drug or its extract component form has shown many-sided particular advantages and obvious curative effect to the misery of preventing and treating gastric cancer, alleviation patients with gastric cancer, and is studied, develops by continuous in conjunction with modern biotechnology.
Application number is 20111041054.6 Chinese patent, discloses the pharmaceutical composition of a kind of prevention or treatment gastric cancer, contains Herba Hedyotidis Diffusae 8-12 part, Semen Impatientis 5-8 part, Spina Gleditsiae 10-15 part, Pseudobulbus Cremastrae Seu Pleiones 8-12 part, Semen Arecae 8-12 part.Application number is 20081010582.3 Chinese patent, disclose a kind of Chinese medicine composition for the treatment of gastric cancer, contained Pheretima 5-15 part, Radix Codonopsis 5-10 part, Radix Rehmanniae Preparata 10-15 part, Spina Gleditsiae 15-20 part, Radix Astragali 15-25 part, Fructus Lycii 10-15 part, Poria 10-20 part, Herba Solani Lyrati 15-20 part, Rhizoma Atractylodis Macrocephalae 20-30 part, Radix Glycyrrhizae 10-25 part, Radix Aucklandiae 20-25 part, Pericarpium Citri Reticulatae 15-25 part, Cortex Magnoliae Officinalis 5-10 part, Radix Ginseng 5-10 part, Herba Hedyotidis Diffusae 10-20 part.Application number is the patent application of CN97107567.0, discloses a kind of oral Chinese medicine composition for the treatment of gastric cancer, contains 1 part of Hirudo, 2 parts of Semen Impatientis, 2 parts of Fructus Cnidiis, 2 parts of Spina Gleditsiaes, 1 part, Pericarpium Zanthoxyli, 2 parts of Radix Scrophulariaes.Application number is the patent application of CN20101026115.7, a kind of Chinese medicine composition for the treatment of gastric cancer is disclosed, the crude drug of making effective ingredient by following weight is: Aspongopus 6-12 gram, Herba Patriniae 20-30 gram, Radix Astragali 10-20 gram, Aloe 5-15 gram, Rhizoma seu Herba Elatostematis stewardii 2-5 gram, Rhizoma Corydalis 10-20 gram and branch of Semen Juglandis 20-30 gram.The existing drug matching basic source in this area is in hospital, use under physician guidance, for convenience of the patient, most hospitals are provided with the decocting for Chinese herbal medicine business, but the most bitter in the mouth of this type of Chinese medicine preparation are tasty, 150-200 milliliters of doses, to get a cancer of the stomach, the patient of stomach discomfort causes the very large difficulty of taking, even take rear generation vomiting phenomenon, and lose, drug effect should be arranged.
Summary of the invention
The technical problem to be solved in the present invention is to provide the Chinese medicine oral liquid of the prevention high, evident in efficacy of a kind of bioavailability and treatment gastric cancer.
For reaching above-mentioned purpose, the preparation method of the oral liquid of a kind of prevention of the present invention and treatment gastric cancer comprises the following steps:
1), drug matching: in weight portion, accurately take following traditional Chinese medicine raw: 100-120 parts of Spina Gleditsiaes, 50-65 parts of Pseudobulbus Cremastrae Seu Pleioness, 50-65 parts of Radix Helicteriss, 80-90 parts of dry-making red dates, 120-150 parts of Ganodermas, 90-125 parts of Rhizoma Cyperis, 120-130 parts of Rhizoma Polygoni Cuspidati, 80-90 parts of Radix Actinidiae Chinensis, 25-30 parts of Semen Arecaes;
2), lixiviate: 5 times that press compatibility Chinese medicine weight are added drinking water in cooker, 90-100 ℃ of maintenances of normal pressure 40-50 minute, then adopt the 60-80 eye mesh screen to filter, replenish drinking water in filtrate to 6 times of compatibility Chinese medicine weight, then the 1%-3% by the Chinese medicine lixiviating solution weight after dilution adds glucose powder, fully dissolving, make the standard lixiviating solution;
3), sterilization: the standard lixiviating solution is imported fermentation tank, heats while stirring, be heated to 115-120 ℃, kept 20-30 minute, then be cooled to 30-40 ℃, standby;
4), fermentation: (1) strain is selected: lactobacillus paracasei (Lactobacillus paracasei), the strain form is freeze-dried powder; (2) inoculation: by the inoculation of the standard lixiviating solution weight after the sterilization of step 3) acquisition lactobacillus paracasei freeze-dried powder, inoculative proportion is 0.5-0.8 gram/double centner; (3) heat-preservation fermentation: 30-40 ℃ heat-preservation fermentation 12 hours stirred 5-8 minute mixing speed 60-70 rev/min in every 2 hours in sweat;
5) fill;
6) sterilization, and get final product.
Method of the present invention, wherein in the described sweat of step 4), fermented bacterium is selected the strain of Chinese industrial microorganism fungus kind preservation administrative center preservation, and name is called: lactobacillus paracasei (Lactobacillus paracasei), deposit number: CICC20245.Purpose is that this bacterium metabolism produces the lactobacillus viscous polysaccharide, and the lactobacillus viscous polysaccharide has obvious inhibitory action to stomach cancer cell, can also improve immunity of organisms.
Further preferably, method of the present invention, described step 1) drug matching: in weight portion, accurately take following traditional Chinese medicine raw: 110 parts of Spina Gleditsiaes, 60 parts of Pseudobulbus Cremastrae Seu Pleioness, 60 parts of Radix Helicteriss, 85 parts of dry-making red dates, 135 parts of Ganodermas, 120 parts of Rhizoma Cyperis, 125 parts of Rhizoma Polygoni Cuspidati, 85 parts of Radix Actinidiae Chinensis, 25 parts of Semen Arecaes.
The preparation method of the oral liquid of the present invention's prevention and treatment gastric cancer, wherein pyroceram bottle liquid drug, then sealing are adopted in preferred described step 5) fill.
The preparation method of the oral liquid of the present invention prevention and treatment gastric cancer, wherein 90-95 ℃ of hot bath sterilization 20 minutes adopted in preferred described step 6) sterilization, is finished product after cooling.
The invention still further relates to the prevention that is obtained by said method and the oral liquid for the treatment of gastric cancer.
The invention difference from existing technology is, the present invention adopts the multiple Fuzheng herbs extract that consolidates of lactic acid bacteria fermentation, prepares a kind of oral liquid that is specifically designed to prevention and treatment gastric cancer.The existing drug matching basic source in this area is in hospital, use under physician guidance, for convenience of the patient, most hospitals are provided with the decocting for Chinese herbal medicine business, but the most bitter in the mouth of this type of Chinese medicine preparation are tasty, 150-200 milliliters of doses, to get a cancer of the stomach, the patient of stomach discomfort causes the very large difficulty of taking, even take rear generation vomiting phenomenon, and lose, drug effect should be arranged.the present invention adopts modern lactic acid bacteria fermentation technology to combine with the Chinese medicine extractive technique, fermented bacterium produces the lactobacillus viscous polysaccharide in metabolic process, has overcome that active drug composition in the oral liquid is long placed in precipitation and the wild effect that occurs, the lactobacillus viscous polysaccharide has obvious inhibitory action to stomach cancer cell, can also improve immunity of organisms, and is all effective in cure to prevention and the treatment of gastric cancer, the Chinese medicine extraction liquid bitter in the mouth is tasty is most of Chinese medicine characteristics, and through after lactic acid bacteria fermentation, the viscosity lactobacillus polysaccharide of generation has been sheltered bitter substance and contacted with the direct of tongue taste bud the automatic embedding of bitter substance, eliminates and takes painful phenomenon, Chinese medicine extracts most heating extraction process by water that adopt, cellulose in some effective ingredient and medical material and Protein formation be network ball-shaped structure closely, as the polyphenols in polygoni cuspidati,radix---resveratrol, this material has obvious anticancer effect, but combine closely with cellulose, exist with the polydatin form, simple heating extraction process by water is difficult to extract to effective ingredient, the application of lactic acid bacteria fermentation technology, make the fermented bacterium metabolism produce the multiple enzymes such as cellulase and protease, after acting on medical material, be convenient to the extraction of effective ingredient, compare with the Chinese medicine extractive technique and have very high novelty.
The specific embodiment
Below in conjunction with embodiment and test data, be described in more detail with other technical characterictic and advantage the present invention is above-mentioned.
Embodiment 1:
The oral liquid of the present invention's prevention and treatment gastric cancer adopts following technique to complete:
1, drug matching: Spina Gleditsiae 100 grams, Pseudobulbus Cremastrae Seu Pleiones 50 grams, Radix Helicteris 50 grams, dry-making red date 80 grams, Ganoderma 120 grams, Rhizoma Cyperi 90 grams, Rhizoma Polygoni Cuspidati 120 grams, Radix Actinidiae Chinensis 80 grams, Semen Arecae 25 grams.
2, lixiviate: 5 times that press compatibility Chinese medicine weight are added drinking water in cooker, 90-100 ℃ of maintenances of normal pressure 45 minutes, then adopt 60 eye mesh screens to filter, replenish drinking water in filtrate to 6 times of compatibility Chinese medicine weight, then add glucose powder by 1% of the Chinese medicine lixiviating solution weight after dilution, fully dissolving, make the standard lixiviating solution.
3, sterilization: the standard lixiviating solution is imported fermentation tank, heat while stirring, be heated to 115-120 ℃, kept 20 minutes, then be cooled to 34 ℃, standby.
4, fermentation: (1) strain is selected: fermented bacterium is selected the strain of Chinese industrial microorganism fungus kind preservation administrative center preservation, name is called: lactobacillus paracasei (Lactobacillus paracasei), deposit number: CICC20245, the strain form is freeze-dried powder; (2) inoculation: by the inoculation of the standard lixiviating solution weight after the sterilization of step 3 acquisition lactobacillus paracasei freeze-dried powder, inoculative proportion is 0.5 gram/double centner; (3) heat-preservation fermentation: 34 ℃ of heat-preservation fermentations 12 hours, stirred 5 minutes 60 rev/mins of mixing speeds in every 2 hours in sweat;
5, fill: adopt pyroceram bottle liquid drug, then sealing;
6, sterilization: adopts 90-95 ℃ of hot bath to sterilize 20 minutes, be finished product after cooling.
Embodiment 2:
The oral liquid of the present invention's prevention and treatment gastric cancer adopts following technique to complete:
1, drug matching: Spina Gleditsiae 120 grams, Pseudobulbus Cremastrae Seu Pleiones 65 grams, Radix Helicteris 65 grams, dry-making red date 90 grams, Ganoderma 150 grams, Rhizoma Cyperi 125 grams, Rhizoma Polygoni Cuspidati 130 grams, Radix Actinidiae Chinensis 90 grams, Semen Arecae 30 grams.
2, lixiviate: 5 times that press compatibility Chinese medicine weight are added drinking water in cooker, normal pressure 90-100 ℃ kept 45 minutes, then adopt 60 eye mesh screens to filter, replenish drinking water in filtrate to 6 times of compatibility Chinese medicine weight, then add glucose powder by 1% of the Chinese medicine lixiviating solution weight after dilution, fully dissolving, make the standard lixiviating solution.
3, sterilization: the standard lixiviating solution is imported fermentation tank, heat while stirring, be heated to 115-120 ℃, kept 20 minutes, then be cooled to 34 ℃, standby.
4, fermentation: (1) strain is selected: fermented bacterium is selected the strain of Chinese industrial microorganism fungus kind preservation administrative center preservation, name is called: lactobacillus paracasei (Lactobacillus paracasei), deposit number: CICC20245, the strain form is freeze-dried powder; (2) inoculation: the standard lixiviating solution weight inoculation lactobacillus paracasei freeze-dried powder after the sterilization that obtains by step 3, inoculative proportion are 0.5 gram/100 kilogram; (3) heat-preservation fermentation: 34 ℃ of heat-preservation fermentations 12 hours, stirred 5 minutes 60 rev/mins of mixing speeds in every 2 hours in sweat;
5, fill: adopt pyroceram bottle liquid drug, then sealing;
6, sterilization: adopts 90-95 ℃ of hot bath to sterilize 20 minutes, be finished product after cooling.
Embodiment 3
The oral liquid of the present invention's prevention and treatment gastric cancer adopts following technique to complete:
1, drug matching: Spina Gleditsiae 110 grams, Pseudobulbus Cremastrae Seu Pleiones 60 grams, Radix Helicteris 60 grams, dry-making red date 85 grams, Ganoderma 135 grams, Rhizoma Cyperi 120 grams, Rhizoma Polygoni Cuspidati 125 grams, Radix Actinidiae Chinensis 85 grams, Semen Arecae 25 grams.
2), lixiviate: 5 times that press compatibility Chinese medicine weight are added drinking water in cooker, 90 ℃ of maintenances of normal pressure 50 minutes, then adopt 80 eye mesh screens to filter, replenish drinking water in filtrate to 6 times of compatibility Chinese medicine weight, then add glucose powder by 3% of the Chinese medicine lixiviating solution weight after dilution, fully dissolving, make the standard lixiviating solution;
3), sterilization: the standard lixiviating solution is imported fermentation tank, heats while stirring, be heated to 120 ℃, kept 20 minutes, then be cooled to 40 ℃, standby;
4), fermentation: (1) strain is selected: lactobacillus paracasei (Lactobacillus paracasei), the strain form is freeze-dried powder; (2) inoculation: by the inoculation of the standard lixiviating solution weight after the sterilization of step 3) acquisition lactobacillus paracasei freeze-dried powder, inoculative proportion is 0.8 gram/double centner; (3) heat-preservation fermentation: 40 ℃ of heat-preservation fermentations 12 hours, stirred 8 minutes 70 rev/mins of mixing speeds in every 2 hours in sweat;
5) fill: adopt pyroceram bottle liquid drug, then sealing;
6) sterilization adopts 90-95 ℃ of hot bath to sterilize 20 minutes, is finished product after cooling.
Clinical effect trial
patients with gastric cancer 112 examples that selection has typical clinical symptom and makes a definite diagnosis through gastroscope and pathology, be divided at random 3 groups, treatment group 68 examples, without medicine matched group 28 examples, medicine matched group 16 examples, the oral liquid of the oral the above embodiment of the present invention for the treatment of group, each 100 milliliters, three times on the one, substitute oral liquid without the medicine matched group with warm water, the medicine matched group is taken the modern good fortune capsule that the inferior gram Pharmaceutical in Zhejiang is produced on request, three groups stop other medication at period in a medicine, be careful in one's diet, keep happy, be in hospital and accomplish, avoid spiritual aspect to stimulate, two groups all take 1 month as 1 course for the treatment of, therapeutic outcome is as follows:
Two groups of clinical manifestations are as follows:
By the data in upper table as can be known, the oral liquid effective percentage that obtains of the present invention is far away higher than without medicine matched group and medicine matched group.Oral liquid of the present invention compares with existing similar drugs, overcome that active drug composition in the oral liquid is long placed in precipitation and the wild effect that occurs, has that active constituent content is high, mouthfeel is better, evident in efficacy, stay-in-grade characteristics.
Above-described embodiment is described the preferred embodiment of the present invention; be not that scope of the present invention is limited; design under the prerequisite of spirit not breaking away from the present invention; various distortion and improvement that those of ordinary skills make technical scheme of the present invention all should fall in the definite protection domain of claims of the present invention.
Claims (5)
1. the preparation method of preventing and treating the oral liquid of gastric cancer, is characterized in that, comprises the following steps:
1), drug matching: in weight portion, accurately take following traditional Chinese medicine raw: 100-120 parts of Spina Gleditsiaes, 50-65 parts of Pseudobulbus Cremastrae Seu Pleioness, 50-65 parts of Radix Helicteriss, 80-90 parts of dry-making red dates, 120-150 parts of Ganodermas, 90-125 parts of Rhizoma Cyperis, 120-130 parts of Rhizoma Polygoni Cuspidati, 80-90 parts of Radix Actinidiae Chinensis, 25-30 parts of Semen Arecaes;
2), lixiviate: 5 times that press compatibility Chinese medicine weight are added drinking water in cooker, 90-100 ℃ of maintenances of normal pressure 40-50 minute, then adopt the 60-80 eye mesh screen to filter, replenish drinking water in filtrate to 6 times of compatibility Chinese medicine weight, then the 1%-3% by the Chinese medicine lixiviating solution weight after dilution adds glucose powder, fully dissolving, make the standard lixiviating solution;
3), sterilization: the standard lixiviating solution is imported fermentation tank, heats while stirring, be heated to 115-120 ℃, kept 20-30 minute, then be cooled to 30-40 ℃, standby;
4), fermentation: (1) strain is selected: lactobacillus paracasei (Lactobacillus paracasei), the strain form is freeze-dried powder; (2) inoculation: by the inoculation of the standard lixiviating solution weight after the sterilization of step 3) acquisition lactobacillus paracasei freeze-dried powder, inoculative proportion is 0.5-0.8 gram/double centner; (3) heat-preservation fermentation: 30-40 ℃ heat-preservation fermentation 12 hours stirred 5-8 minute mixing speed 60-70 rev/min in every 2 hours in sweat;
5) fill;
6) sterilization, and get final product.
2. method according to claim 1, it is characterized in that: described step 1) drug matching: in weight portion, 110 parts of Spina Gleditsiaes, 60 parts of Pseudobulbus Cremastrae Seu Pleioness, 60 parts of Radix Helicteriss, 85 parts of dry-making red dates, 135 parts of Ganodermas, 120 parts of Rhizoma Cyperis, 125 parts of Rhizoma Polygoni Cuspidati, 85 parts of Radix Actinidiae Chinensis, 25 parts of Semen Arecaes.
3. method according to claim 1, is characterized in that: described step 5) fill employing pyroceram bottle liquid drug, then sealing.
4. method according to claim 1 is characterized in that: 90-95 ℃ of hot bath sterilization 20 minutes adopted in described step 6) sterilization, is finished product after cooling.
5. the oral liquid of the prevention that obtains of the described method of claim 1-4 any one and treatment gastric cancer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310021369.6A CN103083550B (en) | 2013-01-21 | 2013-01-21 | Oral liquid for preventing and treating gastric cancer and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310021369.6A CN103083550B (en) | 2013-01-21 | 2013-01-21 | Oral liquid for preventing and treating gastric cancer and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103083550A true CN103083550A (en) | 2013-05-08 |
| CN103083550B CN103083550B (en) | 2014-02-12 |
Family
ID=48197029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310021369.6A Active CN103083550B (en) | 2013-01-21 | 2013-01-21 | Oral liquid for preventing and treating gastric cancer and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103083550B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103877499A (en) * | 2014-03-12 | 2014-06-25 | 张玉珍 | Chinese herbal preparation for treating tumors and preparation method thereof |
| CN104436039A (en) * | 2014-11-18 | 2015-03-25 | 孙永浩 | Antitumor preparation for treating gastric cancer and preparation method thereof |
| CN104770736A (en) * | 2014-01-11 | 2015-07-15 | 山东大学（威海） | Western red ginseng oral liquid preparation method |
| CN105962321A (en) * | 2016-05-10 | 2016-09-28 | 天津膳方缘科技有限公司 | Preparation method of lucid ganoderma fermentation solution |
| CN111281951A (en) * | 2019-12-04 | 2020-06-16 | 红华御康生物科技(江苏)股份有限公司 | Preparation method of traditional Chinese medicine fermented anti-tumor active polypeptide oral liquid |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101579519A (en) * | 2009-04-08 | 2009-11-18 | 李永胜 | Capsule or oral liquid of traditional Chinese medicine for preventing and treating gastric cancer |
| CN102188507A (en) * | 2010-03-10 | 2011-09-21 | 四川省中医药科学院 | Composition possessing antineoplastic function, its preparation method and application |
| CN102600436A (en) * | 2012-04-16 | 2012-07-25 | 山东省中医药研究院 | Traditional Chinese medicine compound preparation for treating gastric cancer and preparation method thereof |
| CN102846674A (en) * | 2012-08-31 | 2013-01-02 | 郑州后羿制药有限公司 | Traditional Chinese drug microecology composition and preparation method thereof |
-
2013
- 2013-01-21 CN CN201310021369.6A patent/CN103083550B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101579519A (en) * | 2009-04-08 | 2009-11-18 | 李永胜 | Capsule or oral liquid of traditional Chinese medicine for preventing and treating gastric cancer |
| CN102188507A (en) * | 2010-03-10 | 2011-09-21 | 四川省中医药科学院 | Composition possessing antineoplastic function, its preparation method and application |
| CN102600436A (en) * | 2012-04-16 | 2012-07-25 | 山东省中医药研究院 | Traditional Chinese medicine compound preparation for treating gastric cancer and preparation method thereof |
| CN102846674A (en) * | 2012-08-31 | 2013-01-02 | 郑州后羿制药有限公司 | Traditional Chinese drug microecology composition and preparation method thereof |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104770736A (en) * | 2014-01-11 | 2015-07-15 | 山东大学（威海） | Western red ginseng oral liquid preparation method |
| CN103877499A (en) * | 2014-03-12 | 2014-06-25 | 张玉珍 | Chinese herbal preparation for treating tumors and preparation method thereof |
| CN104436039A (en) * | 2014-11-18 | 2015-03-25 | 孙永浩 | Antitumor preparation for treating gastric cancer and preparation method thereof |
| CN105962321A (en) * | 2016-05-10 | 2016-09-28 | 天津膳方缘科技有限公司 | Preparation method of lucid ganoderma fermentation solution |
| CN111281951A (en) * | 2019-12-04 | 2020-06-16 | 红华御康生物科技(江苏)股份有限公司 | Preparation method of traditional Chinese medicine fermented anti-tumor active polypeptide oral liquid |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103083550B (en) | 2014-02-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102258708B (en) | Health-preserving wine and preparation method thereof | |
| CN103083550B (en) | Oral liquid for preventing and treating gastric cancer and preparation method thereof | |
| CN104824766B (en) | Persimmon juice beverage and preparation method thereof | |
| CN102475721A (en) | Probiotics oral liquid for health promotion | |
| CN104839536A (en) | Mulberry-lotus root starch honey capable of clearing liver and improving eyesight and preparation method thereof | |
| CN106343567A (en) | Noni oral liquid and preparing method thereof | |
| CN103719672A (en) | Medical rice gruel capable of nourishing Qi and blood | |
| CN101933950A (en) | Application of Trametes robiniophila Murr aqueous extract | |
| CN107541386A (en) | A kind of melon wine and production method | |
| CN103251827A (en) | Traditional Chinese medicine composition for treating diabetes mellitus and preparation method thereof | |
| CN102391937B (en) | A kind of Shaoshing special yellow wine and preparation technology thereof | |
| CN101658316A (en) | Beverage for reinforcing immunity, regulating blood fat, resisting radiation and clearing and nourishing throat | |
| CN105420021B (en) | A method of the special alcoholic drink mixed with fruit juice of women is brewed with bacterium algae rose composition | |
| CN1389229A (en) | Intestine and stomach conditioning oral liquor | |
| CN104857265A (en) | Preparation method of health-care soup for lightening gastrointestinal reaction of cancer patients after chemotherapy | |
| CN103263580A (en) | Traditional Chinese medicine composition for treating diabetes | |
| CN103263595A (en) | Traditional Chinese medicine composition for treating diabetes | |
| CN117085086B (en) | Qi and blood tonifying ferment and preparation process and application thereof | |
| CN101396454B (en) | Traditional Chinese medicine for treating diabetic skin pruritus | |
| CN102631506B (en) | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue | |
| CN106234673A (en) | Stomach reinforcing health preserving Tea containing traditional Chinese medicine beverage and preparation method | |
| CN109453238A (en) | The preparation method of Chinese medicine composition, pharmaceutical preparation and capsule | |
| CN116570682A (en) | Traditional Chinese medicine composition for pulmonary disease convalescence and preparation method thereof | |
| CN104818177A (en) | Wine with effects of stomach protecting, kidney invigorating, and life prolonging, and preparation method thereof | |
| CN102631493B (en) | Health care composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |