CN103083506A

CN103083506A - Oral medicine used for treating hepatitis B

Info

Publication number: CN103083506A
Application number: CN2011103405025A
Authority: CN
Inventors: 李传运
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-11-02
Filing date: 2011-11-02
Publication date: 2013-05-08

Abstract

The invention discloses an oral medicine used for treating hepatitis B. An original medicine is composed of, by weight, 40 parts of Mongolian milkvetch root, 20 parts of polyporus umbellatus, 20g of largehead atractylodes rhizome, 20g of lightyellow sophora root, 20g of giant knotweed rhizome, 20 parts of capillary wormwood herb, 20g of Chinese thorowax root, 10g of golden thread, 15g of figwortflower picrorhiza rhizome, 15g of weeping forsythia fruit, 20g of honeysuckle flower, 40g of epimedium, 20g of nutgrass galingale rhizome, 20g of common leafflower herb, 4 parts of ass-hide gelatin, 20 parts of turtle shell, 5g of core-removed crataegus pinnatifida, 5 parts of polyrhachisvicina roger, and 13 parts of fresh chinese magnoliavine fruit. Tolerance ranges of the components are controlled at -2% to 2%. The added components are mixed, dried, and grinded into powder, such that a composite medicine is formed.

Description

The oral medicine for the treatment of hepatitis B

Technical field the present invention relates to treat the medicine of hepatitis B.

Background technology is present, and oral drugs are mainly taked in the treatment of hepatitis B, and minority adopts injection, the method such as adopt that plaster sticks extremely individually.Therapeutic effect lastingly and not repeatedly oral medicine also is difficult to see.Being no lack of clinically promising hepatitis B patients provides the example of antiviral oral medicine, but can not be to the fundamentally generation effect for the treatment of hepatitis B.

Summary of the invention purpose of the present invention is exactly that a kind of oral medicine for the treatment of hepatitis B will be provided, and it can solve the problem that the oral medicine of existing treatment hepatitis B is difficult to fundamentally treat hepatitis B effectively.

The object of the present invention is achieved like this, the oral medicine for the treatment of hepatitis B, crude drug in whole is comprised of the black ant 5 of the component Radix Astragali 40, Polyporus 20, the Rhizoma Atractylodis Macrocephalae 20, Radix Sophorae Flavescentis 20, Rhizoma Polygoni Cuspidati 20, Herba Artemisiae Scopariae 20, Radix Bupleuri 20, Rhizoma Coptidis 10, Rhizoma Picrorhizae 15, Fructus Forsythiae 15, Flos Lonicerae 20, Herba Epimedii 40, Rhizoma Cyperi 20, Cacumen Securinegae Suffruticosae 20, Colla Corii Asini 4, Carapax Trionycis 20, enucleation Fructus Crataegi 5, ancient cooking vessel bur, fresh schisandra chinensis 13 by weight ratio, and the margin of tolerance of each component is controlled at ± and 2%; Described Radix Astragali component is take Radix Astragali extract powder needle-like astragalus polysaccharides as adding ingredient; Described Polyporus component is take the polyporus extract polyporusum bellatus as adding ingredient; Described Rhizoma Atractylodis Macrocephalae component is take the Rhizoma Atractylodis Macrocephalae extract atractylone as adding ingredient; Described Radix Sophorae Flavescentis component is with the Radix Sophorae Flavescentis extract matrine, and oxymatrine is adding ingredient; Described Rhizoma Polygoni Cuspidati component is take the Rhizoma Polygoni Cuspidati decocting in water, remove slag, the dry extract of extracting juice after concentrated be as adding ingredient; Described Herba Artemisiae Scopariae component is take two blocks of ketone of the colourless hexagonal plate crystal of Herba Artemisiae Scopariae extract Herba Artemisiae Scopariae as adding ingredient; Described Radix Bupleuri component is take Radix Bupleuri extract volatile oil as adding ingredient; Described Rhizoma Coptidis component is take the Rhizoma Coptidis extract berberine as adding ingredient; Described Rhizoma Picrorhizae component is take kutkinol extract mixed crystal Rhizoma Picrorhizae general glycoside as adding ingredient; Described Fructus Forsythiae component is that ursolic acid is adding ingredient with Fructus Forsythiae ethanol extraction white, needle-shaped crystals oleanolic acid; Described Flos Lonicerae component is with the Flos Lonicerae extract chlorogenic acid, and isochlorogenic acid is adding ingredient; Described Herba Epimedii component is take Herba Epimedii alcohol extract flavone compound as adding ingredient; Described Rhizoma Cyperi component is take the Rhizoma Cyperi decocting in water, remove slag, the dry extract of extracting juice after concentrated be as adding ingredient; Described Cacumen Securinegae Suffruticosae component is take the Cacumen Securinegae Suffruticosae ethanol extraction as adding ingredient; Described Colla Corii Asini component be powder take Colla Corii Asini development as adding ingredient, described Carapax Trionycis component is the Carapax Trionycis coarse powder decocting in water that is developed into take Carapax Trionycis, remove slag, the dry extract of extracting juice after concentrated be as adding ingredient; Described enucleation Fructus Crataegi is to cross 80 mesh sieve coarse powder as adding ingredient after enucleation Fructus Crataegi drying and crushing; The black ant of described ancient cooking vessel bur is to pulverize 80 mesh sieve coarse powder as adding ingredient take the black ant of dried ancient cooking vessel bur; It is take fresh schisandra chinensis sarcocarp, Nucleolar Segregation that described fresh schisandra chinensis forms, get the coarse powder of sarcocarp drying and crushing as adding ingredient; Get the kernel drying with ethanol extraction rectangle crystallization schisantherin A, colourless flaky crystal γ-schisandrin B is adding ingredient; Described each adding ingredient through mix, dry, grind the formation composition of medicine into powder.

Further scheme of the present invention is: the residue medicinal residues that also comprise the Radix Astragali, Polyporus, Fructus Schisandrae Chinensis kernel, the Rhizoma Atractylodis Macrocephalae, Radix Sophorae Flavescentis, Rhizoma Polygoni Cuspidati, Artemisia anethoicles Mattf, Radix Bupleuri, Rhizoma Coptidis, Rhizoma Picrorhizae, Fructus Forsythiae, Flos Lonicerae, Herba Epimedii, Rhizoma Cyperi, all adding ingredients of Cacumen Securinegae Suffruticosae in described adding ingredient are the decocting in water concentrated dry extract of extracting juice that removes slag altogether.

The present invention is owing to being the primary Chinese medicinal components that filters out for the hepatitis B pathogenesis etiology, and primary Chinese medicinal components is take effective component extracting as adding ingredient, thereby the property of the present invention is directed to is stronger, therefore, therapeutic effect is also comparatively obvious, by the follow-up investigation that 167 routine hepatitis "great three positive"s, 51 routine hepatitis B small three positive patients were taken medicine rear 2 years, there are 146 examples to cure; There are 36 examples HBSAb+, HBCAb+ to occur; 21 routine HBSAg+; 8 routine HBSAb+, HBeAb+, HBCAb+, 7 routine HBSAg+, HBeAb+, HBCAb+.

Specific embodiment the present invention treats the oral medicine of hepatitis B, crude drug in whole is comprised of the component Radix Astragali 40, Polyporus 20, the Rhizoma Atractylodis Macrocephalae 20, Radix Sophorae Flavescentis 20, Rhizoma Polygoni Cuspidati 20, Herba Artemisiae Scopariae 20, Radix Bupleuri 20, Rhizoma Coptidis 10, Rhizoma Picrorhizae 15, Fructus Forsythiae 15, Flos Lonicerae 20, Herba Epimedii 40, Rhizoma Cyperi 20, Cacumen Securinegae Suffruticosae 20, Colla Corii Asini 4, Carapax Trionycis 20, enucleation Fructus Crataegi 5, the black ant 5 of ancient cooking vessel bur, fresh schisandra chinensis 13 by weight ratio, the margin of tolerance of each component is controlled at ± and 2%, preferred ± 1%.Described Radix Astragali component is take Radix Astragali extract powder needle-like astragalus polysaccharides as adding ingredient; Described Polyporus component is take the polyporus extract polyporusum bellatus as adding ingredient; Described Rhizoma Atractylodis Macrocephalae component is take the Rhizoma Atractylodis Macrocephalae extract atractylone as adding ingredient; Described Radix Sophorae Flavescentis component is with the Radix Sophorae Flavescentis extract matrine, and oxymatrine is adding ingredient; Described brave institute cane component is take the Rhizoma Polygoni Cuspidati decocting in water, remove slag, the dry extract of extracting juice after concentrated be as adding ingredient; Described Herba Artemisiae Scopariae component is take the colourless hexagonal plate crystal of Herba Artemisiae Scopariae extract capillin as adding ingredient; Described Radix Bupleuri component is take Radix Bupleuri extract volatile oil as adding ingredient; Described Rhizoma Coptidis component is take the Rhizoma Coptidis extract berberine as adding ingredient; Described Rhizoma Picrorhizae component is take kutkinol extract mixed crystal Rhizoma Picrorhizae general glycoside as adding ingredient; Described Fructus Forsythiae component is take Fructus Forsythiae ethanol extraction white, needle-shaped crystals oleanolic acid, ursolic acid as adding ingredient; Described Flos Lonicerae component is with the Flos Lonicerae extract chlorogenic acid, and isochlorogenic acid is adding ingredient; Described Herba Epimedii component is take Herba Epimedii alcohol extract flavone compound as adding ingredient; Described Rhizoma Cyperi component is take the Rhizoma Cyperi decocting in water, remove slag, the dry extract of extracting juice after concentrated be as adding ingredient; Described Cacumen Securinegae Suffruticosae component is take the Cacumen Securinegae Suffruticosae ethanol extraction as adding ingredient; Described Colla Corii Asini component is that powder take Colla Corii Asini development is as adding ingredient; Described Carapax Trionycis component is the Carapax Trionycis coarse powder decocting in water that is developed into take Carapax Trionycis, remove slag, the dry extract of extracting juice after concentrated be as adding ingredient; Described enucleation Fructus Crataegi component is to cross 80 mesh sieve coarse powder as adding ingredient after enucleation Fructus Crataegi drying and crushing; The black ant component of institute's ancient cooking vessel bur is to pulverize 80 mesh sieve coarse powder as adding ingredient take the black ant of dried ancient cooking vessel bur; Described fresh schisandra chinensis component is with fresh schisandra chinensis sarcocarp, Nucleolar Segregation, and the coarse powder of getting the sarcocarp drying and crushing is adding ingredient; Get the kernel drying with ethanol extraction rectangle crystallization schisantherin A, colourless flaky crystal γ-schisandrin B is divided into for adding; Described each adding ingredient is ground the formation composition of medicine into powder through mixing, drying.

In the oral medicine for the treatment of hepatitis B of the present invention, the crude drug in whole component Radix Astragali, Polyporus, the Rhizoma Atractylodis Macrocephalae, Radix Sophorae Flavescentis, Rhizoma Polygoni Cuspidati, Herba Artemisiae Scopariae, Radix Bupleuri, Rhizoma Coptidis, Rhizoma Picrorhizae, Fructus Forsythiae, Flos Lonicerae, Herba Epimedii, Rhizoma Cyperi, Cacumen Securinegae Suffruticosae, Fructus Schisandrae Chinensis kernel are produced the technical process of adding ingredient separately, can meet the demands traditionally.

The residue medicinal residues that can also comprise the Radix Astragali, Polyporus, the Rhizoma Atractylodis Macrocephalae, Radix Sophorae Flavescentis, Rhizoma Polygoni Cuspidati, Herba Artemisiae Scopariae, Radix Bupleuri, Rhizoma Coptidis, Rhizoma Picrorhizae, Fructus Forsythiae, Flos Lonicerae, Herba Epimedii, Rhizoma Cyperi, Cacumen Securinegae Suffruticosae, all adding ingredients of Fructus Schisandrae Chinensis kernel in described each adding ingredient of the oral medicine for the treatment of hepatitis B of the present invention altogether decocting in water, remove slag, the dry extract of extracting juice after concentrated.

The oral medicine for the treatment of hepatitis B of the present invention can be made into electuary, also can be made into capsule.The patient is each serving using the dosage that is equivalent to crude drug in whole total amount 38 grams, and every day three times, warm water delivery service gets final product.

Claims

1. oral medicine for the treatment of hepatitis B is characterized in that:

A. crude drug in whole is comprised of the black ant 5 of the component Radix Astragali 40, Polyporus 20, the Rhizoma Atractylodis Macrocephalae 20, Radix Sophorae Flavescentis 20, Rhizoma Polygoni Cuspidati 20, Herba Artemisiae Scopariae 20, Radix Bupleuri 20, Rhizoma Coptidis 10, Rhizoma Picrorhizae 15, Fructus Forsythiae 15, Flos Lonicerae 20, Herba Epimedii 40, Rhizoma Cyperi 20, Cacumen Securinegae Suffruticosae 20, Colla Corii Asini 4, Carapax Trionycis 20, enucleation Fructus Crataegi 5, ancient cooking vessel bur, fresh schisandra chinensis 13 by weight ratio, and the margin of tolerance of each component is controlled at ± and 2%;

B. described Radix Astragali component is take Radix Astragali extract powder needle-like astragalus polysaccharides as adding ingredient;

C. described Polyporus component is take the polyporus extract polyporusum bellatus as adding ingredient;

D. described Rhizoma Atractylodis Macrocephalae component is take the Rhizoma Atractylodis Macrocephalae extract atractylone as adding ingredient;

E. described Radix Sophorae Flavescentis component is with the Radix Sophorae Flavescentis extract matrine, and oxymatrine is adding ingredient;

F. described Rhizoma Polygoni Cuspidati component is with the Rhizoma Polygoni Cuspidati decocting in water, removes slag, and the dry extract after extracting juice is concentrated is adding ingredient;

G. described Herba Artemisiae Scopariae component is take the colourless hexagonal plate crystal of Herba Artemisiae Scopariae extract capillin as adding ingredient;

H. described Radix Bupleuri component is take Radix Bupleuri extract volatile oil as adding ingredient;

I. described Rhizoma Coptidis component is take the Rhizoma Coptidis extract berberine as adding ingredient;

J. described Rhizoma Picrorhizae component is take kutkinol extract mixed crystal Rhizoma Picrorhizae general glycoside as adding ingredient;

K. described Fructus Forsythiae component is take Fructus Forsythiae ethanol extraction white, needle-shaped crystals oleanolic acid, ursolic acid as adding ingredient;

L. described Flos Lonicerae component is with the Flos Lonicerae extract chlorogenic acid, and isochlorogenic acid is adding ingredient;

M. described Herba Epimedii component is take the Herba Epimedii extract flavone compound as adding ingredient;

N. described Rhizoma Cyperi component is with the Rhizoma Cyperi decocting in water, removes slag, and the concentrated dry extract of extracting juice is adding ingredient;

O. described Cacumen Securinegae Suffruticosae component is take the Cacumen Securinegae Suffruticosae ethanol extraction as adding ingredient;

P. described Colla Corii Asini component is that powder take Colla Corii Asini development is as adding ingredient;

Q. described Carapax Trionycis component is the Carapax Trionycis coarse powder decocting in water that is developed into Carapax Trionycis, removes slag, and dried the soaking after extracting juice is concentrated is adding ingredient;

R. described enucleation Fructus Crataegi component is to cross 80 mesh sieve coarse powder as adding ingredient after enucleation Fructus Crataegi drying and crushing;

S. the black ant component of described ancient cooking vessel bur is to pulverize 80 mesh sieve coarse powder as adding ingredient take the black ant of dried ancient cooking vessel bur;

T. described fresh schisandra chinensis component is with fresh schisandra chinensis sarcocarp, Nucleolar Segregation, and the coarse powder of getting the sarcocarp drying and crushing is adding ingredient; Get the kernel drying with ethanol extraction rectangle crystallization schisantherin A, colourless flaky crystal γ--schisandrin B is adding ingredient.

2. treat according to claim 1 the oral medicine of hepatitis B, it is characterized in that: the residue medicinal residues that also further contain the Radix Astragali, Polyporus, Fructus Schisandrae Chinensis kernel, the Rhizoma Atractylodis Macrocephalae, Radix Sophorae Flavescentis, Rhizoma Polygoni Cuspidati, Herba Artemisiae Scopariae, Radix Bupleuri, Rhizoma Coptidis, Rhizoma Picrorhizae, Fructus Forsythiae, Flos Lonicerae, Herba Epimedii, Rhizoma Cyperi, all adding ingredients of Cacumen Securinegae Suffruticosae in described adding ingredient are the decocting in water concentrated dry extract of extracting juice that removes slag altogether.