CN103083395A - Preparation method of lamiophlomis rotate dry extract - Google Patents
Preparation method of lamiophlomis rotate dry extract Download PDFInfo
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- CN103083395A CN103083395A CN201210590528XA CN201210590528A CN103083395A CN 103083395 A CN103083395 A CN 103083395A CN 201210590528X A CN201210590528X A CN 201210590528XA CN 201210590528 A CN201210590528 A CN 201210590528A CN 103083395 A CN103083395 A CN 103083395A
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- lamiophlomidis rotatae
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Abstract
The invention discloses a preparation method of lamiophlomis rotate dry extract. The transfer rate of an effective ingredient is improved by soaking by crude drugs and totally-enclosed refluxing; the lamiophlomis rotate drug belongs to the herbal traditional Chinese medicine; and complete extraction of a solvent on the effective ingredient is facilitated after soaking by cold water. Energy conservation is facilitated by totally-enclosed refluxing and extracting, and loss of the effective ingredient can be prevented; extraction effect of the effective ingredient is improved; the content of the effective ingredient is improved by double-effect vacuum concentration; a double-effect concentrator evaporates by double effects at the same time; secondary steam is fully utilized; investment on a boiler is saved; energy consumption is also saved; the energy consumption is reduced by 50% in comparison with that of a single-effect concentrator; the cooling water can be saved by 47%; the damage of long-time high-temperature concentration on the effective ingredient of the extract is large; vacuum low-temperature concentration is adopted; the concentration temperature is reduced; and loss of the effective ingredients, namely general flavones and digitoflavone is reduced.
Description
Technical field
The present invention relates generally to a kind of preparation method of dry extract, relates in particular to a kind of preparation method of Radix Lamiophlomidis Rotatae dry extract.
Background technology
Radix Lamiophlomidis Rotatae is perennial short and small draft.Root and rhizome is upright, and is thicker, and transverse diameter can reach 2 centimetres of left and right, and the surface has rib to corrugate.Acaulescence.Single phyllopodium gives birth to, and 4 pieces, the spoke shape is relative in twos, and is open and flat; Pedicellus et Pericarpium Trapae shape circle or kidney shape, matter is thick, 6～12 centimetres, footpath, edge tool knuckle-tooth, lower veil arteries and veins caves in more, and is close by the floss hair; Petiole is wide.Wheel umbrella inflorescence forms head or short spike, long 3.5～7 centimetres; Bract is thread, tip aciculiform; Calyx is purple green, and funnel-form is about 8 millimeters, dredges by thick and stiff hair, the short carnassial tooth of tool, increment thorn-like; Corolla is little, light red purple, and lip, the upper lip helmet is by undercoat; Stamen 4; Style and is born in the ovary substrate, and top 2 is split.The pyrene oval.Radix Lamiophlomidis Rotatae has promoting blood circulation and hemostasis, wind-expelling pain-stopping, and the effect of yellow fluid reducing is used for the treatment of traumatic injury, traumatic hemorrhage, rheumatic arthralgia, grasserie etc.Clinical have report to can be used for treating the painful diseases such as pain due to gynecological and neurosurgery related disease, treatment trigeminal neuralgia obvious analgesic effect is arranged, and have simultaneously hemostasis, antibacterial, improve specificity and nonspecific immunity, obviously improve the effect such as Pain Threshold, especially can be used as the adjuvant drug that the first ladder is used when treatment tumprigenicity pain, without the addiction of obvious toxic-side effects and medicine.
Summary of the invention
The object of the invention just is to provide a kind of.
The present invention is achieved by the following technical solutions:
A kind of preparation method of Radix Lamiophlomidis Rotatae dry extract comprises the following steps:
(1) get the Radix Lamiophlomidis Rotatae medical material, sieving cleans, and removes the impurity such as silt dust;
(2) above-mentioned Radix Lamiophlomidis Rotatae was soaked in frozen water 3-5 hour, then be placed in totally enclosed reflux, extract, tank, add for the first time 12-15 water doubly, decocted under 90-100 ℃ 1-2 hour, filter; For the second time, for the third time, add respectively for the 4th time filtering residue weight portion 10-12 doubly, 8-10 doubly, 6-8 times water decocts under 90-100 ℃, decocting time was respectively 1-1.5 hour, 0.8-1 hour, 0.6-0.8 hour, filter cleaner, merging filtrate;
(3) above-mentioned filtrate being concentrated into relative density with the economic benefits and social benefits vacuum concentrator is 1.10-1.12, gets concentrated solution;
(4) above-mentioned concentrated solution is carried out spray drying in spray dryer, inlet temperature is 170-180 ℃, and outlet temperature is 95-105 ℃, receives powder, namely gets described Radix Lamiophlomidis Rotatae dry extract.
The Radix Lamiophlomidis Rotatae dry extract that uses the present invention to produce can be produced tablet or finished granule.
Advantage of the present invention is:
1, medical material soaks, total enclosing refluxes the raising effective ingredient rate of transform: the Radix Lamiophlomidis Rotatae medical material belongs to traditional Chinese medicine of whole straw, after cold water soak, is conducive to solvent complete to the extraction of effective ingredient.The total enclosing reflux, extract, both had been conducive to energy-conservation, can prevent again scattering and disappearing of effective ingredient, improved the extraction effect of effective ingredient.
2, the economic benefits and social benefits vacuum concentration improves the extractum active constituent content: dual-effect concentrator adopts the evaporation simultaneously of two effects, and indirect steam is fully used and has both been saved the investment of boiler, energy efficient again, and energy consumption is compared with haplo-effect concentrator and is reduced by 50%, saves cooling water 47%.High temperature is concentrated larger to extractum effective ingredient destruction for a long time, adopts vacuum and low temperature concentrated, reduces the loss that thickening temperature reduces effective ingredient total flavones, luteolin.
3, spray drying improves the extractum active constituent content: spray drying has been avoided traditional evaporation operation and drying under reduced pressure technique length consuming time, the poor shortcoming of dry mass, has greatly improved the quality of production efficiency and extract dry.Extractum is Powdered, and is little, homogeneous than extractum good fluidity, the water content of traditional drying, solubility property is good.The instantaneous drying of simultaneous spray drying, in time powder delivery has avoided long-time drying to the destruction of extractum effective ingredient.Effect composition total flavones and the content of luteolin produced all are significantly improved.
The specific embodiment
Embodiment 1
A kind of preparation method of Radix Lamiophlomidis Rotatae dry extract comprises the following steps:
(1) get the Radix Lamiophlomidis Rotatae medical material, sieving cleans, and removes the impurity such as silt dust;
(2) above-mentioned Radix Lamiophlomidis Rotatae was soaked in frozen water 3-5 hour, then be placed in totally enclosed reflux, extract, tank, add for the first time 12-15 water doubly, decocted under 90-100 ℃ 1-2 hour, filter; For the second time, for the third time, add respectively for the 4th time filtering residue weight portion 10-12 doubly, 8-10 doubly, 6-8 times water decocts under 90-100 ℃, decocting time was respectively 1-1.5 hour, 0.8-1 hour, 0.6-0.8 hour, filter cleaner, merging filtrate;
(3) above-mentioned filtrate being concentrated into relative density with the economic benefits and social benefits vacuum concentrator is 1.10-1.12, gets concentrated solution;
(4) above-mentioned concentrated solution is carried out spray drying in spray dryer, inlet temperature is 170-180 ℃, and outlet temperature is 95-105 ℃, receives powder, namely gets described Radix Lamiophlomidis Rotatae dry extract.
The Radix Lamiophlomidis Rotatae dry extract that uses the present invention to produce can be produced tablet or finished granule.
Performance test:
Following table is three batches of dry extract samples of the present invention that-2010 on the 20th August, JIUYUE was produced during 20 days in 2010, and the receipts cream rate of three times is respectively: 31.0%, 30.6%, 30.8%, and assay such as following table:
Claims (2)
1. the preparation method of a Radix Lamiophlomidis Rotatae dry extract is characterized in that comprising the following steps:
(1) get the Radix Lamiophlomidis Rotatae medical material, sieving cleans, and removes the impurity such as silt dust;
(2) above-mentioned Radix Lamiophlomidis Rotatae was soaked in frozen water 3-5 hour, then be placed in totally enclosed reflux, extract, tank, add for the first time 12-15 water doubly, decocted under 90-100 ℃ 1-2 hour, filter; For the second time, for the third time, add respectively for the 4th time filtering residue weight portion 10-12 doubly, 8-10 doubly, 6-8 times water decocts under 90-100 ℃, decocting time was respectively 1-1.5 hour, 0.8-1 hour, 0.6-0.8 hour, filter cleaner, merging filtrate;
(3) above-mentioned filtrate being concentrated into relative density with the economic benefits and social benefits vacuum concentrator is 1.10-1.12, gets concentrated solution;
(4) above-mentioned concentrated solution is carried out spray drying in spray dryer, inlet temperature is 170-180 ℃, and outlet temperature is 95-105 ℃, receives powder, namely gets described Radix Lamiophlomidis Rotatae dry extract.
2. the preparation method of a kind of Radix Lamiophlomidis Rotatae dry extract according to claim 1, is characterized in that, the Radix Lamiophlomidis Rotatae dry extract that uses the present invention to produce can be produced tablet or finished granule.
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| CN201210590528.XA CN103083395B (en) | 2012-12-31 | 2012-12-31 | Preparation method of lamiophlomis rotate dry extract |
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| CN201210590528.XA CN103083395B (en) | 2012-12-31 | 2012-12-31 | Preparation method of lamiophlomis rotate dry extract |
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| CN103083395B CN103083395B (en) | 2015-03-25 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111358830A (en) * | 2020-04-15 | 2020-07-03 | 重庆心康制药有限公司 | Lamiophlomis rotata pill and preparation method thereof |
Citations (6)
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| CN1562209A (en) * | 2004-04-12 | 2005-01-12 | 成都圣诺科技发展有限公司 | 'Unique taste' disintegration tablet of oral cavity use and preparation method |
| CN1628833A (en) * | 2004-09-13 | 2005-06-22 | 叶耀良 | Formulation of 'Duyiwei' with improved bioavailability and drug effect and preparation process thereof |
| CN1255100C (en) * | 2004-04-20 | 2006-05-10 | 成都优他制药有限责任公司 | Soft capsule preparation of Tibet medicine 'unique taste' |
| CN101612192A (en) * | 2009-07-28 | 2009-12-30 | 甘肃独一味生物制药股份有限公司 | Radix Lamiophlomidis Rotatae extract, the pharmaceutical composition that contains this extract and method of quality control |
| CN101618067A (en) * | 2008-07-03 | 2010-01-06 | 北京大学 | Lamiophlomis rotata cataplasm and preparation method thereof |
| CN101744875A (en) * | 2010-02-01 | 2010-06-23 | 唐良平 | Lamiophlomis rotata traditional chinese medicine and preparation method thereof |
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2012
- 2012-12-31 CN CN201210590528.XA patent/CN103083395B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1562209A (en) * | 2004-04-12 | 2005-01-12 | 成都圣诺科技发展有限公司 | 'Unique taste' disintegration tablet of oral cavity use and preparation method |
| CN1255100C (en) * | 2004-04-20 | 2006-05-10 | 成都优他制药有限责任公司 | Soft capsule preparation of Tibet medicine 'unique taste' |
| CN1628833A (en) * | 2004-09-13 | 2005-06-22 | 叶耀良 | Formulation of 'Duyiwei' with improved bioavailability and drug effect and preparation process thereof |
| CN101618067A (en) * | 2008-07-03 | 2010-01-06 | 北京大学 | Lamiophlomis rotata cataplasm and preparation method thereof |
| CN101612192A (en) * | 2009-07-28 | 2009-12-30 | 甘肃独一味生物制药股份有限公司 | Radix Lamiophlomidis Rotatae extract, the pharmaceutical composition that contains this extract and method of quality control |
| CN101744875A (en) * | 2010-02-01 | 2010-06-23 | 唐良平 | Lamiophlomis rotata traditional chinese medicine and preparation method thereof |
Non-Patent Citations (2)
| Title |
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| 丁新爱: "独一味提取工艺研究", 《河南中医学院学报》, vol. 21, no. 2, 31 March 2006 (2006-03-31) * |
| 赖先荣等: "藏药独一味提取工艺优化研究", 《中国实用医药》, vol. 3, no. 33, 30 November 2008 (2008-11-30) * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111358830A (en) * | 2020-04-15 | 2020-07-03 | 重庆心康制药有限公司 | Lamiophlomis rotata pill and preparation method thereof |
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| CN103083395B (en) | 2015-03-25 |
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