CN103071047B - Decoction for treating silicosis and preparation method thereof - Google Patents
Decoction for treating silicosis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a decoction for treating silicosis and a preparation method thereof. The decoction is prepared from raw materials of low-cost traditional Chinese medicinal herbs, which mainly include red-rooted salvia root, red paeony root, Szechuan lovage rhizome, pinellia tuber, plantain herb, platycodon root, hairy asiabell root, manyflower solomonseal rhizome, root of straight ladybell, liquorice and the like, and the decoction is simple in preparation method and is obtained through decocting based on reasonable compatibility according to the basic principle of strengthening the body resistance to eliminate pathogenic factors. According to the invention, because the traditional Chinese medicinal herbs are adopted, the decoction has low cost and can be popularized and used in a large range; due to adoption of the pure natural Chinese medicinal herbs, not only is the curative effect enhanced based on the synergism of all medicinal herbs, but also the side effects of the medicinal herbs are reduced, and the decoction is easy to accept by patients; and the decoction can be used to alleviate onset pains of the patients, is suitable for being taken by patients of all age groups suffering from the silicosis of various stages, and has a short treat course and rapid response.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of decoction for the treatment of pneumosilicosis and preparation method thereof.
Background technology
The numeral of announcing according to Ministry of Public Health, in recent years, the annual new anthraco-silicosis of China is up to 10,000 examples, and expert estimates that 10 years from now on to 15 years China's anthraco-silicosis morbidity sums also will be continuation ascendant trend.
Pneumosilicosis refers to that coal miner sucks the general name of the caused pulmonary lesion of dust in production environment for a long time, and coal pneumoconiosis is the fibrosis that sucks for a long time the lung tissue that coal dust (containing 5% following free silicon dioxide) causes.Be more common in coal-getter, coal separation work, coal handling work.Miner's operation transfer is frequent, and the miner who really contacts pure coal dust is also few, and what major part contacted is coal silicon mixing dirt.What a large amount of coal silicious dusts of long-term suction caused is called anthracosilicosis take pulmonary fibrosis as main disease.
Anthraco-silicosis is to turn to main systemic disease with pulmonary Diffuse fiber, and its cardinal symptom is uncomfortable in chest, chest pain, breathe hard, cough, general weakness.The clinical manifestation of Silicosis Patients is mainly take Respiratory symptoms as main cough, expectoration, chest pain, the large symptom of dyspnea four, still has in addition and pants, spits blood and some General Symptoms.
The basic lesion of pneumosilicosis is to form silicon tuberosity and the extensive fibrosis of interstitial lung, and the silicon tuberosity that lung fibrosis forms is irreversible, must go up this disease, and development, finally causes death because lungs lose respiratory function gradually.
The traditional Chinese medical science think pneumosilicosis be because of dust poisonous substance evil poison invade human body, foul smell is jammed in the heart, inhibited pulmonary QI, lung network block, and is retarded by silt and agglutinates into tuberosity.Long-term poisonous substance sucks and causes body imbalance between YIN and YANG, function disorder, disharmony between QI and blood.Impairment of dispersing and descending function of the lung, the liver failing to maintain the normal flow of QI, failure of the kidney in receiving QI, dysfunction of the spleen in transportation accumulatively wet raise phlegm, flaccidity of the heart-yang, functional activity of QI being not smooth and all cards produce.Free silicon dioxide belongs to the dry strong product of metal and stone, and the strongly fragrant liquid that can burn in lung is expectorant, again can heat-transformation impairment of YIN.
The lung being the dominator of QI, the kidney being the root of QI, with the passing of time the delay of breathing with cough must undermine in kidney, and deficiency of kidney-essence is difficult to dissolve vigour, and the not solid gas of aerial root is difficult to return root, and more very, dyspnea pneumosilicosis can be divided deficiency and excess to cough with asthma, and the true person of pneumosilicosis is inhibited pulmonary QI, stagnation of QI due to depression of the liver blood stasis; Pneumosilicosis belongs to empty person, how due to the heart, lung, spleen, kidney qi insufficiency of blood.Clinically excess syndrome with the passing of time QI and blood consumption wound can cause deficiency syndrome, in deficiency syndrome, can be mingled with excess syndrome, deficiency in origin and excess in superficiality.
The relative incidence rate of pneumosilicosis constantly increases in recent years, and the medicine for the treatment of at present pneumosilicosis has multiple, and these medicines all have certain curative effect, but also show larger limitation.In the past the treatment of pneumosilicosis was adopted to single variety more, for example (,) the medicine such as zinc gluconate, piperaquine phosphate, Teroo hydrochloride, xanthorrhiza, when these medicines are used separately, drug effect is not good, and overall therapeutic effect can not be satisfactory; Also have some treatment pneumosilicosis pure Chinese medicinal formulae, some belongs to cures the symptoms, not the disease, some uses expensive composition, some in application process due to uncertain therapeutic efficacy cut interrupt use, also have some using method comparatively loaded down with trivial details being not suitable for use on a large scale.In a word, lack a kind of medicine of effective, evident in efficacy, the treatment pneumosilicosis that has no side effect always.
Summary of the invention
For solving various difficult problems for above-mentioned treatment pneumosilicosis, the invention provides Chinese medicine decoction of a kind of new treatment pneumosilicosis and preparation method thereof, adopt Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Chuanxiong, the Rhizoma Pinelliae, Herba Plantaginis, Radix Platycodonis, Radix Codonopsis, Rhizoma Polygonati, Radix Adenophorae (Radix Glehniae), Radix Glycyrrhizae to make, can effectively treat the pneumosilicosis that a variety of causes causes, evident in efficacy, cheap and few side effects.
Basic treatment theory of the present invention be make patient's sputum and silicious dust expectoration come, cough clean, allow patient no longer chest pain, uncomfortable in chest, breathe hard, improved patient's sleep simultaneously, improve patient's immunity, strengthen patient's body constitution.
According to above basic treatment theory, the present invention realizes by following concrete technical scheme:
A kind of decoction for the treatment of pneumosilicosis, by weight, proportioning is its effective ingredient: 5～15 parts of Radix Salviae Miltiorrhizaes, 4～10 parts of Radix Paeoniae Rubra, 2～8 parts of Rhizoma Chuanxiongs, 5～15 parts of the Rhizoma Pinelliaes, 5～15 parts of Herba Plantaginiss, 5～15 parts of Radix Platycodoniss, 15～45 parts of Radix Codonopsis, 10～20 parts of Rhizoma Polygonatis, 5～15 parts of Radix Adenophorae (Radix Glehniae), 1～6 part, Radix Glycyrrhizae;
By weight, its proportioning is the effective ingredient of the decoction of described treatment pneumosilicosis: 7～12 parts of Radix Salviae Miltiorrhizaes, 6～8 parts of Radix Paeoniae Rubra, 4～6 parts of Rhizoma Chuanxiongs, 7～12 parts of the Rhizoma Pinelliaes, 7～12 parts of Herba Plantaginiss, 7～12 parts of Radix Platycodoniss, 25～35 parts of Radix Codonopsis, 13～17 parts of Rhizoma Polygonatis, 7～12 parts of Radix Adenophorae (Radix Glehniae), 2～4 parts, Radix Glycyrrhizae.
Studying for a long period of time and manufacturing experimently through inventor, when the proportioning of the above-mentioned Chinese medicine of final discovery is following value, the effect for the treatment of is best, and the weight portion of this proportioning is: 10 parts of Radix Salviae Miltiorrhizaes, 7 parts of Radix Paeoniae Rubra, 5 parts of Rhizoma Chuanxiongs, 10 parts of the Rhizoma Pinelliaes, 10 parts of Herba Plantaginiss, 10 parts of Radix Platycodoniss, 30 parts of Radix Codonopsis, 15 parts of Rhizoma Polygonatis, 10 parts of Radix Adenophorae (Radix Glehniae), 3 parts, Radix Glycyrrhizae.
Pneumosilicosis is a kind of Combination pneumosilicosis, has the pathological characters of pneumosilicosis and coal pneumoconiosis concurrently, is the most common one type of China's coal-mine pneumosilicosis.Primary disease belongs to the category of the diseases such as the cough, phlegm retention, chest pain, pulmonary distension, lung expectorant, lung waterlogging of motherland's medical science.Motherland's medical science is thought lung governing qi, and department breathes; Lung governing diffusion and respectful falling.So between < < element, a five internal organs generation piece of writing > > says: " all gas persons, all belong to lung ".Be that exopathogen (silica dust) is invaded lung for a long time, cause the tired resistance of lung network, functional activity of QI being not smooth, insufficiency of lung-QI, a surname sends out unable, respectfully falls element unrest, with the passing of time lung network impaired due to.The symptom of anthraco-silicosis is more, can stimulate due to the silica dust sucking, and causes respiratory inflammation and cough have reflex cough.The degree of cough and concurrent bronchitis or pulmonary's secondary infection have substantial connection, but also inconsistent with the weight of pneumosilicosis.Chest pain, patients more than half have acupuncture sample chest pain, the middle and upper part of shirtfront, one or both sides, often occur in rainy weather when changeable pain in the lung obvious, but with breathing, position and work are irrelevant.Degree uncomfortable in chest, out of breath is relevant with extent of disease and character, and has the property of carrying out aggravation.Except Respiratory symptoms, with symptoms such as dizzy, weak, insomnia, cardiopalmus, anorexia and dyspepsias.According to etiology and pathogenesis and clinical manifestation, generally can divide turbid phlegm obstructing in the lung, the scorching types such as lung, lung qi expectorant are stagnant, YIN-deficiency of the lung and kidney, deficiency of spleen-YANG and kidneyYANG, deficiency of heart-YANG and kidney-YANG that accumulate.
Modern medicine study: Radix Salviae Miltiorrhizae, Radix Codonopsis, Radix Adenophorae (Radix Glehniae) have the effect that strengthens and regulate immune function; Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra have blood vessel dilating, increase blood flow, the function of improving cardiac muscle, lungs fibrosis and repairing cardiopulmonary.The present invention is with Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Chuanxiong, the Rhizoma Pinelliae, Herba Plantaginis, Radix Platycodonis, Radix Codonopsis, Rhizoma Polygonati, Radix Adenophorae (Radix Glehniae), the Radix Glycyrrhizae benefit motive, the moon that nourishes heart, mind calming god; Blood circulation promoting and blood stasis dispelling, nourishes heart; YIN and YANG balance regulating, turns round and look at and protects the five internal organs; Radix Glycyrrhizae is longer than reinforce functional activities of the heart, Yiqi and vein recovery, and the compositions such as the alkaloid that it contains have the effect of antiviral, antiinflammatory.All medicines share, and have benefiting QI and nourishing blood, the multiple feeling pulse merit of activating yang.
The present invention has the pneumosilicosis pathological changes of inhibition, protection macrophage, anti-silicon dioxide cytotoxicity, the effects such as antibacterial and anti-hemolysis.The present invention focuses on clinical, and not according to plain body situation, new evil old complaint, institute's tool symptom difference is carried out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.
The main effect of its effective ingredient is:
The blood circulation promoting and blood stasis dispelling effect of Radix Salviae Miltiorrhizae is excellent, and can nourish blood, and has saying of " simply, merit being with four things for Radix Salviae Miltiorrhizae ".Radix Salviae Miltiorrhizae not only has blood circulation promoting and blood stasis dispelling, promote blood circulation and improve microcirculatory effect, and animal experiment shows, Radix Salviae Miltiorrhizae has the effect that promotes synthetic fibers to absorb and promote fibrin degradation, can alleviate the fibrosis of silicotic pulmonary.Rhizoma Chuanxiong energy blood circulation promoting and blood stasis dispelling, has circulation of qi promoting effect concurrently, is " the gas medicine in blood ", again can stasis-dispelling and pain-killing.Share of these two kinds of medicines, can accelerate the blood flow rate of silicotic pulmonary, removes pulmonary's blood capillary spasm, improves the blood supply of pulmonary, thereby can alleviate symptom uncomfortable in chest, chest pain.
Radix Salviae Miltiorrhizae, Radix Codonopsis, Radix Adenophorae (Radix Glehniae), through a large amount of zooperies and clinical observation on the therapeutic effect, can obviously improve subjective symptoms and the pulmonary ventilation function of Silicosis Patients, improve immunity of organisms and oxidation resistance, suppress or delay PD.In addition, the respiratory system diseases such as tracheitis, bronchitis and flu are all had to certain preventive and therapeutic effect.Sleep improvement after taking medicine, appetite increases, and times of common cold obviously reduces before taking medicine, and cough, expectoration, uncomfortable in chest, breathing hard alleviates, and symptom improvement rate reaches 100%.
For silicotic occur cough, expectoration, pant and by expectorants, antitussives and anti-asthmatics medicine (Rhizoma Pinelliae, Radix Platycodonis etc.) and damp-clearing drug (Herba Plantaginis), achieve the goal.The cough that Rhizoma Pinelliae decoct causes the right pleura of iodine solution injection cat has obvious antitussive effect, and drug effect can maintain more than five hours.Radix Platycodonis decoct, the contained Saponin of Radix Platycodonis have significant phlegm-dispelling functions.Anesthetized dog gavage Radix Platycodonis decoct 1g/kg, after anesthetized cat gavage Radix Platycodonis decoct, its respiratory tract mucus secretory volume obviously increases, and action time is sustainable more than 7 hours, and its intensity is similar to ammonium chloride.Radix Platycodonis lung qi dispersing gas, the stimulation to pharyngolaryngeal mucosa when phlegm-dispelling functions is oral mainly due to its contained Saponin, makes to reflexive bronchial mucosa secretion increase, and sputum dilution makes the sputum of retention in trachea and bronchus be easy to discharge.It is wet that Herba Plantaginis can be oozed diuretic as damp-clearing drug, and tonneau urine can discharge phlegm retention from urine, has greatly strengthened the effect of expelling phlegm for arresting cough.
Radix Codonopsis focuses on " benefit ", is the Qi-tonifying drug of Chinese medicine, raw with benefit defending consolidating superficial resistance, inducing diuresis to remove edema, promoting pus discharge and tissue regeneration strengthening.Immunologic function not only being had to potentiation, also have dual regulation, is a kind of immunomodulator.The huge function of biting to mouse lung macrophage has potentiation.Normal person takes after Radix Codonopsis IgM, IgE and CAMP in blood to be increased significantly, to chronic tracheitis, can make its serum I sE, IgA, IsM raise.Can make the hyperplasia of animal spleen entoplasm, enhancing antibody is synthetic, and humoral immune function is had to facilitation.Effect and the enhancing of Radix Codonopsis " QI invigorating ", " righting " and regulate body's immunity, improve body resistance against diseases, the balance that maintains organismic internal environment is closely related.Radix Salviae Miltiorrhizae and Radix Codonopsis share, more can enhancing human body immunity function.So silicotic takes this decoction, can improve body immunity, improve the ability of body opposing and dispeling disease and evil, and can regulate and promote metabolism and the energy metabolism of the materials such as nucleic acid, sugar, protein, lipid, the impact of Endocrine system and improve the adaptive capacity of the internal environment of body, enhancing body function of detoxification and improve hemopoietic system function, improves body ability to work.
Radix Paeoniae Rubra, Rhizoma Chuanxiong, the Rhizoma Pinelliae, Herba Plantaginis, Radix Platycodonis have the features such as fast effect low toxicity, and silicotic is all had to the curative effects such as body constitution enhancing in various degree, times of common cold minimizing, biochemical index improvement.
Radix Adenophorae (Radix Glehniae), Radix Glycyrrhizae clinical observation on the therapeutic effect result show the symptom effects of taking an evident turn for the better such as cough, expectoration, chest pain and the dyspnea to improving patient, patient's flu and Bronchopulmonary infection frequency obviously reduce, Patients with Lung ventilatory function (FVC and FEV1) is significantly increased, be improved silicotic's clinical symptoms, improve immunity of organisms, strengthen pulmonary ventilation function, and delay the curative effect effect of pneumosilicosis lesion growth.Great advantage is that the clinical adverse causing is not obvious, clinical practice safety.
Rhizoma Polygonati has the lesion growth of delaying, and improves patient symptom, Signs, adjusting immunologic function, stablizes the state of an illness, extends the effect in patient's life-span.Rhizoma Polygonati has therapeutical effect to pneumosilicosis, can anti-quartz, the hemolytic toxicity of asbestos, show as interstitial pulmonary fibrosis lighter, and tuberosity rareness, profile is little, and in specific stain finding tuberosity, collagen fiber are little.Rhizoma Polygonati can be protected the macrophage of liver at liver, promote the foreign body of liver to get rid of, thereby effectively suppresses the formation of liver fiber.Rhizoma Polygonati has slight inhibition peptide chain and is cross-linked the effect into collagen, makes collagen structure loose.
Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for the treatment of the weakness of the spleen and stomach of pneumosilicosis, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, cushion toxicity, strong.Strong, the coordinating the actions of various ingredients in a prescription of mediation other drug.
Prepare the method for the decoction for the treatment of pneumosilicosis of the present invention, its concrete steps are:
(1) take the Radix Salviae Miltiorrhizae of recipe quantity, soak 30 minutes, after decocting with high heat and boiling, change at a simmer boiling 30 minutes, filter and make filtering liquid medicine one time; In filtering residue, add water, intense fire changes slow fire and boils 15-25 minute after decocting and boiling, and filters to obtain secondary filter medicinal liquid, and twice filtering liquid medicine obtaining mixed stand-by;
(2) by prescription, get Radix Paeoniae Rubra, Rhizoma Chuanxiong, the Rhizoma Pinelliae, Radix Codonopsis, Rhizoma Polygonati, Radix Adenophorae (Radix Glehniae), soak 30 minutes, after decoction is boiled with high heat, change at a simmer boiling after 25 minutes, add Herba Plantaginis, Radix Platycodonis, the Radix Glycyrrhizae of recipe quantity, stir, slow fire boils 5 minutes, filters and makes filtering liquid medicine one time; In filtering residue, add water, intense fire changes slow fire and boils 5-15 minute after decocting and boiling, and filters to obtain secondary filter medicinal liquid, and twice filtering liquid medicine obtaining mixed;
(3) by step (1) and step (2) gained medicinal liquid mix homogeneously, obtain target decoction.
The factors such as inventor boils medicine while preparing according to decoction more than the evaporation of time length, moisture less, the size of spice water absorbing properties and the amount of medicinal liquid, prove described in step (1) and step (2) that amount of water adds 10 milliliters, water with 1 gram of Chinese medicine to be advisable.
Pharmacological research shows that in Radix Salviae Miltiorrhizae, liposoluble ingredient has anticoagulant, antioxidative activity, wherein salvianolic acid B is the active component that content is the highest, the less stable of document prompting salvianolic acid B, in Salvia miltiorrhiza Bge water solution, salvianolic acid B temperature influence degradation reaction meets first order reaction, salvianolic acid B is more stable under mild acid conditions, all unstable under strong acid, neutrality and alkali condition.According to reaction power mathematic(al) parameter and the behavior of salvianolic acid B mass spectrum, change, in Radix Salviae Miltiorrhizae preparation process, reduce temperature as far as possible, the minimizing time, keep weak acid, reduce the loss of salvianolic acid B.In the present invention, heating Radix Salviae Miltiorrhizae is in order to protect salvianolic acid B to avoid loss as far as possible separately.
In step (2) because Herba Plantaginis, Radix Platycodonis, Radix Glycyrrhizae will be soft fluffy after boiling heating, easily heavy the bottom of a pan adhesion, not boiling resistance is easy to expand, therefore when heating for the first time, should not put into Radix Paeoniae Rubra, Rhizoma Chuanxiong, the Rhizoma Pinelliae, Radix Codonopsis, Rhizoma Polygonati, one of Radix Adenophorae (Radix Glehniae), while heating first, only in the later stage, add and boil 5 minutes, with the anti-stick the bottom of a pan.
Innovative point of the present invention is: 1, adopt Chinese medicine formula, reduced toxic and side effects, make patient acceptant, be applicable to the each phase silicotic of various age brackets and take.2, plurality of Chinese is rationally combined, and can bring into play synergism, makes the drug effect stack of medicine, prolong drug action time, improves curative effect; By different pharmacology mechanism, intervene the multiple mechanism of pneumosilicosis, the untoward reaction that effectively prevents single therapy to cause.3, decoction of the present invention need be implemented by rational interval time, reduced anaphylaxis, effectively avoided the associating of main toxicity, the overlapping medicine of mechanism of action.Gram effective prolong drug of the dirt Drug combination action time of different blood peak concentration of drug effect times.4, each Chinese medicine ingredients compatibility is reasonable, not only can bring into play effective antidusting but also can reduce toxicity, and adverse reaction rate and degree are obviously reduced.5, the present invention adopts Chinese herbal medicine, cheap, can promote the use of on a large scale, has improved benefit-cost ratio, has reduced expense.
Through clinical verification for many years, medicine provided by the present invention has quick permeation, absorbs fast, rapid-action feature, while taking, and patients with mild, once-a-day, substantially recover 2～3 courses for the treatment of; Moderate patient, a twice-daily, substantially alleviate for 3～5 courses for the treatment of; Severe patient, three times on the one, can take effect general 5～8 courses for the treatment of.It is 200-250 milliliter that clinicist requires dose once, and children's is cut down according to the circumstance.Therapeutic process is roughly divided into following three phases:
First stage: remission phase
Cough with asthma alleviates, and sputum is weakened by thickness, by black, is shoaled, and amount of expectoration increases on the contrary, and the alleviation of panting is breathed comparatively smooth and easyly, and patient changes into and can have a rest by semireclining position by not lying low.Sleep improvement, anoxia cyanosis phenomenon is obviously alleviated.
Second stage: repairing and treating phase
The impaired place of respiratory mucosa is repaired, and cough stops, time have a small amount of clearing away phlegm, asthma is calmed down, but respiratory drive is still not enough (as severe patient still has not obvious anoxia performance, slightly cyanosis of mouth, lip, finger tip.Respiratory frequency is faster than ordinary person), appetite, sleep recover normal, and muscle power strengthens, and can carry out orthobiosis.Meet various risk factors, cough with asthma no longer recurs.
Phase III: rehabilitation consolidation
Respiratory mucosa renews comprehensively, obtains a lung taking on an entirely new look.Respiratory drive is abundant, and anoxia phenomenon is removed completely, breathes sedate, strong, light.Under x-ray, visible two lungs are full, and elastic force is pure, and vital capacity improves 20%.
Medicine medication provided by the present invention is accurate, effect is remarkable, it is the medicine of researching and developing for silicotic specially, accomplished that special disease specially controls, adopt Drug therapy pneumosilicosis provided by the present invention, its rehabilitation course is an appreciable process, and sputum increases when starting to take, the expectorant of expectoration is sticky expectorant, black expectorant, purulent sputum, to sputum, reduce, cough, breathe heavily progressively to stop, disappearing and all can physical experience arrive.After rehabilitation, then take one to three course for the treatment of, just can eliminate hidden danger, consolidate curative effect, remission.
Through clinical experiment, Most patients was taken after 1-3 the course for the treatment of, patient's cough, cough up phlegm, the symptom such as chest pain and dyspnea obviously improves, patient's flu and Bronchopulmonary infection obviously reduce; X-ray rabat pathological changes is in taking a turn for the better or steady statue; Pulmonary ventilation function after treatment is significantly increased before treating.
From the improvement of clinical symptoms, the improvement of rabat, vim and vigour improve these multi-target effects, can prove the treatment of this Chinese medicine decoction, can impel silicotic's body to rebuild the interior environment of an optimum harmony: to strengthen the tolerance of dust cell to dust, suppress the gathering of collagen protein, improve the microcirculation of the important organs such as lung kidney, enhance metabolism, softening, decompose pulmonary fibrosis tuberosity, suppress autoimmune reaction, improve cellular immunization, separate gas removing pipe, bronchospasm, improve pulmonary ventilation and pulmonary gas exchange, alleviate the kidney injury that autoantigen antibody complex causes, improve renal function, thereby improve the cough with asthma of anthraco-silicosis, breast is suppressed, cough up phlegm, easy catching a cold, many symptoms such as invisible nephropathy easily occur together.
In sum, the decoction for the treatment of pneumosilicosis provided by the present invention, manufacture method is simple, according to the fundamentum of strengthening vital QI to eliminate pathogenic factors, according to reasonable compatibility, decocts and obtains.The present invention is owing to adopting Chinese medicine, cheap, can promote the use of on a large scale; Owing to adopting the Chinese crude drug of pure natural, various drug synergisms, had both strengthened curative effect, had reduced again side effects of pharmaceutical drugs, and patient is acceptant; Misery in the time of can alleviating patient and fall ill, is applicable to the each phase silicotic of various age brackets and takes; Treatment time is short, instant effect.
The specific embodiment
Embodiment 1
Treat a decoction for pneumosilicosis, its effective ingredient is counted by weight: 10 parts of Radix Salviae Miltiorrhizaes, 7 parts of Radix Paeoniae Rubra, 5 parts of Rhizoma Chuanxiongs, 10 parts of the Rhizoma Pinelliaes, 10 parts of Herba Plantaginiss, 10 parts of Radix Platycodoniss, 30 parts of Radix Codonopsis, 15 parts of Rhizoma Polygonatis, 10 parts of Radix Adenophorae (Radix Glehniae), 3 parts, Radix Glycyrrhizae, wherein 1 part refers to 1 gram.
The concrete preparation process of this decoction is:
(1) take the Radix Salviae Miltiorrhizae of recipe quantity, add 100 ml waters and soak 30 minutes, after decocting with high heat and boiling, change at a simmer boiling 30 minutes, filter and make filtering liquid medicine one time; In filtering residue, add 100 ml waters, intense fire changes slow fire and boils 15 minutes after decocting and boiling, and filters to obtain secondary filter medicinal liquid, and twice filtering liquid medicine obtaining mixed stand-by;
(2) by prescription, get Radix Paeoniae Rubra, Rhizoma Chuanxiong, the Rhizoma Pinelliae, Radix Codonopsis, Rhizoma Polygonati, Radix Adenophorae (Radix Glehniae), adding 770 ml waters soaks 30 minutes, after decoction is boiled with high heat, change at a simmer boiling after 25 minutes, add Herba Plantaginis, Radix Platycodonis, the Radix Glycyrrhizae of recipe quantity, stir, slow fire boils 5 minutes, filters and makes filtering liquid medicine one time; In filtering residue, add 1000 ml waters, intense fire changes slow fire and boils 5 minutes after decocting and boiling, and filters to obtain secondary filter medicinal liquid, and twice filtering liquid medicine obtaining mixed;
(3) by step (1) and step (2) gained medicinal liquid mix homogeneously, obtain target decoction.
Embodiment 2
Treat a decoction for pneumosilicosis, its effective ingredient is counted by weight: 5 parts of Radix Salviae Miltiorrhizaes, 4 parts of Radix Paeoniae Rubra, 2 parts of Rhizoma Chuanxiongs, 5 parts of the Rhizoma Pinelliaes, 5 parts of Herba Plantaginiss, 5 parts of Radix Platycodoniss, 15 parts of Radix Codonopsis, 10 parts of Rhizoma Polygonatis, 5 parts of Radix Adenophorae (Radix Glehniae), 1 part, Radix Glycyrrhizae, wherein 1 part refers to 5 grams.
The concrete preparation process of this decoction is:
(1) take the Radix Salviae Miltiorrhizae of recipe quantity, add 250 ml waters and soak 30 minutes, after decocting with high heat and boiling, change at a simmer boiling 30 minutes, filter and make filtering liquid medicine one time; In filtering residue, add 250 ml waters, intense fire changes slow fire and boils 25 minutes after decocting and boiling, and filters to obtain secondary filter medicinal liquid, and twice filtering liquid medicine obtaining mixed stand-by;
(2) by prescription, get Radix Paeoniae Rubra, Rhizoma Chuanxiong, the Rhizoma Pinelliae, Radix Codonopsis, Rhizoma Polygonati, Radix Adenophorae (Radix Glehniae), adding 410 ml waters soaks 30 minutes, after decoction is boiled with high heat, change at a simmer boiling after 25 minutes, add Herba Plantaginis, Radix Platycodonis, the Radix Glycyrrhizae of recipe quantity, stir, slow fire boils 5 minutes, filters and makes filtering liquid medicine one time; In filtering residue, add 520 ml waters, intense fire changes slow fire and boils 15 minutes after decocting and boiling, and filters to obtain secondary filter medicinal liquid, and twice filtering liquid medicine obtaining mixed;
(3) by step (1) and step (2) gained medicinal liquid mix homogeneously, obtain target decoction.
Embodiment 3
Treat a decoction for pneumosilicosis, its effective ingredient is counted by weight: 15 parts of Radix Salviae Miltiorrhizaes, 10 parts of Radix Paeoniae Rubra, 6 parts of Rhizoma Chuanxiongs, 15 parts of the Rhizoma Pinelliaes, 15 parts of Herba Plantaginiss, 15 parts of Radix Platycodoniss, 45 parts of Radix Codonopsis, 20 parts of Rhizoma Polygonatis, 15 parts of Radix Adenophorae (Radix Glehniae), 4 parts, Radix Glycyrrhizae, wherein 1 part refers to 1 gram.
The concrete preparation process of this decoction is:
(1) take the Radix Salviae Miltiorrhizae of recipe quantity, add 150 ml waters and soak 30 minutes, after decocting with high heat and boiling, change at a simmer boiling 30 minutes, filter and make filtering liquid medicine one time; In filtering residue, add 150 ml waters, intense fire changes slow fire and boils 18 minutes after decocting and boiling, and filters to obtain secondary filter medicinal liquid, and twice filtering liquid medicine obtaining mixed stand-by;
(2) by prescription, get Radix Paeoniae Rubra, Rhizoma Chuanxiong, the Rhizoma Pinelliae, Radix Codonopsis, Rhizoma Polygonati, Radix Adenophorae (Radix Glehniae), adding 1110 ml waters soaks 30 minutes, after decoction is boiled with high heat, change at a simmer boiling after 25 minutes, add Herba Plantaginis, Radix Platycodonis, the Radix Glycyrrhizae of recipe quantity, stir, slow fire boils 5 minutes, filters and makes filtering liquid medicine one time; In filtering residue, add 1450 ml waters, intense fire changes slow fire and boils 10 minutes after decocting and boiling, and filters to obtain secondary filter medicinal liquid, and twice filtering liquid medicine obtaining mixed;
(3) by step (1) and step (2) gained medicinal liquid mix homogeneously, obtain target decoction.
Embodiment 4
Treat a decoction for pneumosilicosis, its effective ingredient is counted by weight: 7 parts of Radix Salviae Miltiorrhizaes, 6 parts of Radix Paeoniae Rubra, 8 parts of Rhizoma Chuanxiongs, 7 parts of the Rhizoma Pinelliaes, 7 parts of Herba Plantaginiss, 12 parts of Radix Platycodoniss, 25 parts of Radix Codonopsis, 17 parts of Rhizoma Polygonatis, 7 parts of Radix Adenophorae (Radix Glehniae), 2 parts, Radix Glycyrrhizae, wherein 1 part refers to 2 grams.
The concrete preparation process of this decoction is:
(1) take the Radix Salviae Miltiorrhizae of recipe quantity, add 140 ml waters and soak 30 minutes, after decocting with high heat and boiling, change at a simmer boiling 30 minutes, filter and make filtering liquid medicine one time; In filtering residue, add 140 ml waters, intense fire changes slow fire and boils 20 minutes after decocting and boiling, and filters to obtain secondary filter medicinal liquid, and twice filtering liquid medicine obtaining mixed stand-by;
(2) by prescription, get Radix Paeoniae Rubra, Rhizoma Chuanxiong, the Rhizoma Pinelliae, Radix Codonopsis, Rhizoma Polygonati, Radix Adenophorae (Radix Glehniae), adding 1400 ml waters soaks 30 minutes, after decoction is boiled with high heat, change at a simmer boiling after 25 minutes, add Herba Plantaginis, Radix Platycodonis, the Radix Glycyrrhizae of recipe quantity, stir, slow fire boils 5 minutes, filters and makes filtering liquid medicine one time; In filtering residue, add 1820 ml waters, intense fire changes slow fire and boils 7 minutes after decocting and boiling, and filters to obtain secondary filter medicinal liquid, and twice filtering liquid medicine obtaining mixed;
(3) by step (1) and step (2) gained medicinal liquid mix homogeneously, obtain target decoction.
Embodiment 5
Treat a decoction for pneumosilicosis, its effective ingredient is counted by weight: 12 parts of Radix Salviae Miltiorrhizaes, 8 parts of Radix Paeoniae Rubra, 4 parts of Rhizoma Chuanxiongs, 12 parts of the Rhizoma Pinelliaes, 12 parts of Herba Plantaginiss, 7 parts of Radix Platycodoniss, 35 parts of Radix Codonopsis, 13 parts of Rhizoma Polygonatis, 12 parts of Radix Adenophorae (Radix Glehniae), 6 parts, Radix Glycyrrhizae, wherein 1 part refers to 1 gram.
The concrete preparation process of this decoction is:
(1) take the Radix Salviae Miltiorrhizae of recipe quantity, add 120 ml waters and soak 30 minutes, after decocting with high heat and boiling, change at a simmer boiling 30 minutes, filter and make filtering liquid medicine one time; In filtering residue, add 120 ml waters, intense fire changes slow fire and boils 21 minutes after decocting and boiling, and filters to obtain secondary filter medicinal liquid, and twice filtering liquid medicine obtaining mixed stand-by;
(2) by prescription, get Radix Paeoniae Rubra, Rhizoma Chuanxiong, the Rhizoma Pinelliae, Radix Codonopsis, Rhizoma Polygonati, Radix Adenophorae (Radix Glehniae), adding 840 ml waters soaks 30 minutes, after decoction is boiled with high heat, change at a simmer boiling after 25 minutes, add Herba Plantaginis, Radix Platycodonis, the Radix Glycyrrhizae of recipe quantity, stir, slow fire boils 5 minutes, filters and makes filtering liquid medicine one time; In filtering residue, add 1090 ml waters, intense fire changes slow fire and boils 8 minutes after decocting and boiling, and filters to obtain secondary filter medicinal liquid, and twice filtering liquid medicine obtaining mixed;
(3) by step (1) and step (2) gained medicinal liquid mix homogeneously, obtain target decoction.
Embodiment 6
Treat a decoction for pneumosilicosis, its effective ingredient is counted by weight: 9 parts of Radix Salviae Miltiorrhizaes, 7 parts of Radix Paeoniae Rubra, 5 parts of Rhizoma Chuanxiongs, 11 parts of the Rhizoma Pinelliaes, 8 parts of Herba Plantaginiss, 9 parts of Radix Platycodoniss, 30 parts of Radix Codonopsis, 16 parts of Rhizoma Polygonatis, 11 parts of Radix Adenophorae (Radix Glehniae), 3 parts, Radix Glycyrrhizae, wherein 1 part refers to 1 gram.
The concrete preparation process of this decoction is:
(1) take the Radix Salviae Miltiorrhizae of recipe quantity, add 90 ml waters and soak 30 minutes, after decocting with high heat and boiling, change at a simmer boiling 30 minutes, filter and make filtering liquid medicine one time; In filtering residue, add 90 ml waters, intense fire changes slow fire and boils 21 minutes after decocting and boiling, and filters to obtain secondary filter medicinal liquid, and twice filtering liquid medicine obtaining mixed stand-by;
(2) by prescription, get Radix Paeoniae Rubra, Rhizoma Chuanxiong, the Rhizoma Pinelliae, Radix Codonopsis, Rhizoma Polygonati, Radix Adenophorae (Radix Glehniae), adding 800 ml waters soaks 30 minutes, after decoction is boiled with high heat, change at a simmer boiling after 25 minutes, add Herba Plantaginis, Radix Platycodonis, the Radix Glycyrrhizae of recipe quantity, stir, slow fire boils 5 minutes, filters and makes filtering liquid medicine one time; In filtering residue, add 1000 ml waters, intense fire changes slow fire and boils 8 minutes after decocting and boiling, and filters to obtain secondary filter medicinal liquid, and twice filtering liquid medicine obtaining mixed;
(3) by step (1) and step (2) gained medicinal liquid mix homogeneously, obtain target decoction.
Experimental example 1
Guo patient, man, 68 years old, III phase pneumosilicosis, the pulmonary function second phase, through inventor, provide, take the medicine of the treatment pneumosilicosis making according to proportioning described in the embodiment of the present invention 2 and method, three times on the one, one time 200 milliliters, a course for the treatment of on the 30th.30 days, interval, then second course for the treatment of.Continuous three courses for the treatment of.Patient reacts well, has no side effect, and symptom is significantly alleviated.
Experimental example 2
Patient's Qi, man, 71 years old, II phase pneumosilicosis, the pulmonary function second phase, through inventor, provide, take the medicine of the treatment pneumosilicosis making according to proportioning described in the embodiment of the present invention 1 and method, a twice-daily, one time 200 milliliters, a course for the treatment of on the 30th.30 days, interval, then second course for the treatment of.Continuous two courses for the treatment of.Patient's symptom alleviates, and has no side effect.
Experimental example 3
Patient cattle, man, 59 years old, I phase pneumosilicosis, the pulmonary function second phase, through inventor, provide, take the medicine of the treatment pneumosilicosis making according to proportioning described in the embodiment of the present invention 3 and method, once a day, one time 250 milliliters, a course for the treatment of on the 30th.30 days, interval, then second course for the treatment of.Continuous three courses for the treatment of.Patient's transference cure, has no side effect.
With decoction duration of test provided by the present invention, to diagnosing the patient who makes a definite diagnosis to be divided at random two groups by national silicosis'X-ray diagnostic criteria (GBZ70-2002) collective, treat: treatment group 28 examples, are male, 59 ± 13.2 years old age.Matched group 23 examples, male 22 examples, female's 1 example, 57 ± 11.8 years old age.
It is infection that matched group adopts conventional therapy scheme, relieving asthma, oxygen uptake, adds by cepharanthine (Guizhou pharmaceutical factory of Golden Bridge product, authentication code (93), defend No. X-67, the accurate word of medicine) 80mg, every day 3 times is oral, gives Radix Salviae Miltiorrhizae Injection 20ml simultaneously, adds 5%～10% glucose 250ml intravenous drip, every day 1 time, two medicine couplings 30 days were 1 course for the treatment of; Treatment group, on conventional therapy basis, is taken the prepared decoction of the embodiment of the present invention, every day 3 times, one time 250 milliliters, within 30 days, be 1 course for the treatment of.
Result shows, treatment group patient's cough, cough up phlegm, the symptom such as chest pain and dyspnea obviously improves, effective percentage is 89.3%; Patient's flu and Bronchopulmonary infection obviously reduce; X-ray rabat pathological changes is in improvement or steady statue, difference significance (P < 0.05) compared with matched group (effective percentage is 66.7%); Pulmonary ventilation function (FVC and FEV1) after treatment is significantly increased (P < 0.01) before treating.The above results shows that decoction provided by the present invention has significant curative effect.
Claims (4)
1. treat the decoction of pneumosilicosis for one kind, it is characterized in that: by weight, its proportioning is its raw material: 5～15 parts of Radix Salviae Miltiorrhizaes, 4～10 parts of Radix Paeoniae Rubra, 2～8 parts of Rhizoma Chuanxiongs, 5～15 parts of the Rhizoma Pinelliaes, 5～15 parts of Herba Plantaginiss, 5～15 parts of Radix Platycodoniss, 15～45 parts of Radix Codonopsis, 10～20 parts of Rhizoma Polygonatis, 5～15 parts of Radix Adenophorae (Radix Glehniae), 1～6 part, Radix Glycyrrhizae;
Its preparation method is: (1) takes the Radix Salviae Miltiorrhizae of recipe quantity, soaks 30 minutes, after decoction is boiled with high heat, changes at a simmer boiling 30 minutes, filters and makes filtering liquid medicine one time; In filtering residue, add water, intense fire changes slow fire and boils 15-25 minute after decocting and boiling, and filters to obtain secondary filter medicinal liquid, and twice filtering liquid medicine obtaining mixed stand-by;
(2) by prescription, get Radix Paeoniae Rubra, Rhizoma Chuanxiong, the Rhizoma Pinelliae, Radix Codonopsis, Rhizoma Polygonati, Radix Adenophorae (Radix Glehniae), soak 30 minutes, after decoction is boiled with high heat, change at a simmer boiling after 25 minutes, add Herba Plantaginis, Radix Platycodonis, the Radix Glycyrrhizae of recipe quantity, stir, slow fire boils 5 minutes, filters and makes filtering liquid medicine one time; In filtering residue, add water, intense fire changes slow fire and boils 5-15 minute after decocting and boiling, and filters to obtain secondary filter medicinal liquid, and twice filtering liquid medicine obtaining mixed;
(3) by step (1) and step (2) gained medicinal liquid mix homogeneously, obtain target decoction.
2. a kind of decoction for the treatment of pneumosilicosis according to claim 1, it is characterized in that: by weight, its proportioning is its raw material: 7～12 parts of Radix Salviae Miltiorrhizaes, 6～8 parts of Radix Paeoniae Rubra, 4～6 parts of Rhizoma Chuanxiongs, 7～12 parts of the Rhizoma Pinelliaes, 7～12 parts of Herba Plantaginiss, 7～12 parts of Radix Platycodoniss, 25～35 parts of Radix Codonopsis, 13～17 parts of Rhizoma Polygonatis, 7～12 parts of Radix Adenophorae (Radix Glehniae), 2～4 parts, Radix Glycyrrhizae.
3. a kind of decoction for the treatment of pneumosilicosis according to claim 1, it is characterized in that: by weight, proportioning is its raw material: 10 parts of Radix Salviae Miltiorrhizaes, 7 parts of Radix Paeoniae Rubra, 5 parts of Rhizoma Chuanxiongs, 10 parts of the Rhizoma Pinelliaes, 10 parts of Herba Plantaginiss, 10 parts of Radix Platycodoniss, 30 parts of Radix Codonopsis, 15 parts of Rhizoma Polygonatis, 10 parts of Radix Adenophorae (Radix Glehniae), 3 parts, Radix Glycyrrhizae.
4. the method for the decoction of pneumosilicosis is treated in preparation as described in claim 1 or 2 or 3, it is characterized in that: its step is as follows:
(1) take the Radix Salviae Miltiorrhizae of recipe quantity, soak 30 minutes, after decocting with high heat and boiling, change at a simmer boiling 30 minutes, filter and make filtering liquid medicine one time; In filtering residue, add water, intense fire changes slow fire and boils 15-25 minute after decocting and boiling, and filters to obtain secondary filter medicinal liquid, and twice filtering liquid medicine obtaining mixed stand-by;
(2) by prescription, get Radix Paeoniae Rubra, Rhizoma Chuanxiong, the Rhizoma Pinelliae, Radix Codonopsis, Rhizoma Polygonati, Radix Adenophorae (Radix Glehniae), soak 30 minutes, after decoction is boiled with high heat, change at a simmer boiling after 25 minutes, add Herba Plantaginis, Radix Platycodonis, the Radix Glycyrrhizae of recipe quantity, stir, slow fire boils 5 minutes, filters and makes filtering liquid medicine one time; In filtering residue, add water, intense fire changes slow fire and boils 5-15 minute after decocting and boiling, and filters to obtain secondary filter medicinal liquid, and twice filtering liquid medicine obtaining mixed;
(3) by step (1) and step (2) gained medicinal liquid mix homogeneously, obtain target decoction.
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| CN105311258A (en) * | 2015-12-11 | 2016-02-10 | 齐鲁工业大学 | Traditional Chinese medicine composition for clearing away heat and toxic materials and preparation method thereof |
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| CN1048638C (en) * | 1994-08-19 | 2000-01-26 | 江西弋阳制药厂 | Xifukang Chinese herb medicine compound preparation for silicosis and its preparing method |
| CN1201758C (en) * | 2002-04-29 | 2005-05-18 | 史艳梅 | Chines medicine for treating silicosis |
| CN101249105B (en) * | 2008-02-26 | 2010-09-08 | 朱天柱 | Tuberculosis resistance Chinese medicine and method of preparing the same |
| CN101757409B (en) * | 2008-10-24 | 2013-02-27 | 河北以岭医药研究院有限公司 | Application of traditional Chinese medicine composition in preparation of medicines for treating silicosis |
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