CN103060185B - Spatial carrier of biological samples - Google Patents
Spatial carrier of biological samples Download PDFInfo
- Publication number
- CN103060185B CN103060185B CN201210379760.9A CN201210379760A CN103060185B CN 103060185 B CN103060185 B CN 103060185B CN 201210379760 A CN201210379760 A CN 201210379760A CN 103060185 B CN103060185 B CN 103060185B
- Authority
- CN
- China
- Prior art keywords
- spatial carrier
- biological samples
- tube
- silica gel
- sealing cover
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000012472 biological sample Substances 0.000 title claims abstract description 16
- 239000000523 sample Substances 0.000 claims abstract description 19
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000000741 silica gel Substances 0.000 claims abstract description 5
- 229910002027 silica gel Inorganic materials 0.000 claims abstract description 5
- 239000004417 polycarbonate Substances 0.000 claims abstract description 4
- 238000007789 sealing Methods 0.000 claims description 15
- 244000005700 microbiome Species 0.000 claims description 8
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 claims description 3
- 230000005540 biological transmission Effects 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 229920005668 polycarbonate resin Polymers 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 238000007493 shaping process Methods 0.000 claims description 3
- 238000012360 testing method Methods 0.000 abstract description 11
- 230000006837 decompression Effects 0.000 abstract description 4
- 230000035939 shock Effects 0.000 abstract description 3
- 238000013461 design Methods 0.000 abstract description 2
- 208000033999 Device damage Diseases 0.000 abstract 1
- 229920000515 polycarbonate Polymers 0.000 abstract 1
- 239000002245 particle Substances 0.000 description 4
- 238000012797 qualification Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 229920002379 silicone rubber Polymers 0.000 description 3
- 239000004945 silicone rubber Substances 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 241000209094 Oryza Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000005486 microgravity Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
Landscapes
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention relates to a spatial carrier of biological samples. The spatial carrier comprises a star-shaped pipe and two seal covers with silica gel. The device is made of polycarbonate, is designed into a structure with a star shape, is equally divided into eight independent space and can load eight kinds of biological samples. After the seal covers with silica gel are well screwed, the airtightness is very good and not only can sample leakage be avoided but also pollution among the samples can be avoided. The spatial carrier has the prominent characteristic that under the condition of loading the biological samples, the spatial carrier can endure such extreme environment tests needed by spaceship carrying as vibration, shock and rapid decompression and can avoid sample leakage caused by device damage. The spatial carrier has a simple structure, is novel in design, is small, flexible, convenient and practical and can meet the requirements of carrying various biological samples with the spaceship and strictly controlling the total carrying weight.
Description
Technical field
The present invention relates to a kind of biological sample Spatial carrier, belong to space biomedical research field.
Background technology
Biological spaceship-carried be the important component part of space treatment, it mainly brings test organism sample into space by the space craft such as retrievable satellite, airship, be placed in one with the diverse radiation environment of tellurian figure at the biology of spaceflight, mainly comprise from the electronics of magnetic field traps, proton and Low-energy heavy particles; From the Millikan's rays in the Via lastis as proton, particle and heavier high energy heavy particle; From the proton of magnetic storm and heavy particle etc., this causes the DNA double splitting of chain in cell, and microgravity, high vacuum environment further suppress again the reparation of damage dna simultaneously, thus cause its biological nature to change.
Pass through space carrying, space environment experiment porch can be utilized, research space environment on the impact of the biological sample such as microorganism, cell or tissue, for improve spacefarer space environment adaptability and working efficiency, ensure the experimental basis that the health of spacefarer provides important; Contribute to clear and definite space environment to the impact of vital movement and mechanism, and find effective counter measure, likely solve the more insoluble medical science bottleneck problems of ground research, the mankind are to the understanding of disease incidence mechanism in in-depth simultaneously; Contribute to developing and improve biotechnological formulation output and active new way, have most important theories to explore and practical significance to space bio-pharmaceuticals, serve human health.
Current existing biological sample Spatial carrier has sample sack, sample hose etc., and volume ratio is comparatively large, when strict control gross weight to load kind limited.
Summary of the invention
Technology of the present invention is dealt with problems and is: meet the Proteins of multiple biological sample and will strictly control to carry the needs of gross weight.
Technical solution of the present invention: a kind of microorganism and cell Spaceship Carrying device, it is made up of meter Zi Guan and two sealing cover, sealing cover is at the two ends of M-tube, be connected with meter Zi Guan by silica gel and screw thread, described meter Zi Guan is structurally designed to M shape, be divided into 8 ~ 12 separate space, for loading semisolid, liquid or dry powder microorganism or cell sample.
The separate space of described meter Zi Guan can be uniform, also can be heterogeneous.
The material of preparing of described meter Zi Guan and sealing cover is polycarbonate or ABS resin, has the feature of unique high transmission rate, high refractive index, impact, dimensional stability and easily machine-shaping.
The present invention's advantage compared with prior art: the present invention can fill 8 ~ 12 kinds of microorganisms and cell sample altogether in meter Zi Guan, after twisting band silica gel sealing lid, can bear the extreme environment tests such as the vibration needed for Spaceship Carrying, impact, fast decompression and not generating unit damage and cause sample leakage.Structure of the present invention is simple, novel in design, small and exquisite flexible, convenient and practical, can meet the multiple biological sample of Spaceship Carrying and strictly will control to carry the needs of gross weight.
Accompanying drawing explanation
Fig. 1 is rice tubular construction schematic diagram;
Fig. 2 is loading device structure iron;
Embodiment
As shown in Figure 1, for rice tubular construction schematic diagram, as can be seen from the figure, described meter Zi Guan is a cylindrical tube, and body is cylindric, end face structure is designed to M shape, long 30mm, diameter is 15mm, is divided into 8 ~ 12 separate space, the present embodiment adopts 8 separate space, for loading semisolid, liquid or the biological sample such as dry powder microorganism or cell sample.
The separate space of described meter Zi Guan can be uniform, also can be heterogeneous, the even separate space structure that the present embodiment adopts.
As shown in Figure 2, be loading device schematic diagram of the present invention, it is made up of meter Zi Guan and two sealing cover, in figure, most two ends is sealing cover, and that middle is meter Zi Guan, and part is between the two silicone rubber pad, meter Zi Guan is processed into screw thread in two ends when practical application, for being connected with sealing cover; Sealing cover at the two ends of M-tube, for being with female cylindrical cap.Described sealing cover external diameter 20.89mm, long 4.5mm, the thick silicone rubber pad of 0.5mm is inlayed in bottom, sealing cover is connected with meter Zi Guan by silicone rubber pad and screw thread and is fixed, sealing cover is screwed to meter Zi Guan two ends energy sealed inside sample completely, both there will not be sample leakage, and sample room also can not occur and pollute.
The material of preparing of described meter Zi Guan and sealing cover is polycarbonate or ABS resin, has the feature of unique high transmission rate, high refractive index, impact, dimensional stability and easily machine-shaping.
It is simple, flexibly small and exquisite that the present invention has structure, very convenient and practical feature.
Qualification level vibration test, qualification level shock test and fast decompression test have been carried out to microorganism of the present invention and cell loading device.Test front and back, carry bag to sample respectively and sample tube is tested, and sample carries bag and sample tube all stands intact, No leakage.Inst. of Space Medical Engineering, according to " the manned transport vessel of astronaut system, target aircraft bunker Product environment experimental technique condition ", has provided qualification level vibration test, qualification level shock test and fast decompression test products envrionment test certificate.
This device is successfully applied to " No. eight, divine boat ", and biological sample carries, and has carried 32 strain microorganisms and cell biological sample altogether, has returned after ground is fetched and do not occur sample leakage, sample room does not occur yet and pollutes, and successfully achieves biological sample and carries.
Claims (1)
1. a biological sample Spatial carrier; it is characterized in that: it is made up of a M-tube and two sealing covers; sealing cover is at the two ends of M-tube; be connected with M-tube by silica gel and screw thread; described M-tube is structurally designed to M shape; be divided into 8 ~ 12 separate space, for loading semisolid, liquid or dry powder microorganism or cell sample; The separate space of described M-tube can be uniform, also can be heterogeneous; The material of preparing of described meter Zi Guan and sealing cover is polycarbonate or ABS resin, has the feature of unique high transmission rate, high refractive index, impact, dimensional stability and easily machine-shaping.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210379760.9A CN103060185B (en) | 2012-09-26 | 2012-09-26 | Spatial carrier of biological samples |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210379760.9A CN103060185B (en) | 2012-09-26 | 2012-09-26 | Spatial carrier of biological samples |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103060185A CN103060185A (en) | 2013-04-24 |
| CN103060185B true CN103060185B (en) | 2015-02-04 |
Family
ID=48103088
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210379760.9A Expired - Fee Related CN103060185B (en) | 2012-09-26 | 2012-09-26 | Spatial carrier of biological samples |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103060185B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5527705A (en) * | 1994-09-12 | 1996-06-18 | Becton, Dickinson And Company | Roller bottle for trans-membrane co-culture of cells and method for its use |
| CN1334338A (en) * | 2001-08-20 | 2002-02-06 | 武汉中敏基因工程有限公司 | Multi-division centrifugal tube |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1316007C (en) * | 2004-03-18 | 2007-05-16 | 中日友好医院 | Outer space carrying device for gene engineering cell |
-
2012
- 2012-09-26 CN CN201210379760.9A patent/CN103060185B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5527705A (en) * | 1994-09-12 | 1996-06-18 | Becton, Dickinson And Company | Roller bottle for trans-membrane co-culture of cells and method for its use |
| CN1334338A (en) * | 2001-08-20 | 2002-02-06 | 武汉中敏基因工程有限公司 | Multi-division centrifugal tube |
Non-Patent Citations (1)
| Title |
|---|
| 北京航空材料研究所.航空材料.《航空材料学》.上海科学技术出版社,1985, * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103060185A (en) | 2013-04-24 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150204 |