CN103054996A - Traditional Chinese medicine for treating damp-heat type osteoarthritis and preparation method thereof - Google Patents
Traditional Chinese medicine for treating damp-heat type osteoarthritis and preparation method thereof Download PDFInfo
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- CN103054996A CN103054996A CN2012105732914A CN201210573291A CN103054996A CN 103054996 A CN103054996 A CN 103054996A CN 2012105732914 A CN2012105732914 A CN 2012105732914A CN 201210573291 A CN201210573291 A CN 201210573291A CN 103054996 A CN103054996 A CN 103054996A
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Abstract
The invention aims to provide a traditional Chinese medicine for treating damp-heat type osteoarthritis and a preparation method thereof. The traditional Chinese medicine comprises peach seed, safflower, phellodendron, rhubarb root and rhizome, sweet wormwood, achyranthes root and borneol. According to the invention, the peach seed and safflower invigorate blood circulation and dispel blood stasis so as to relieve pains, borneol, phellodendron, rhubarb root and rhizome and sweet wormwood clear heat, cool blood and activate meridians to stop pains, and the achyranthes root ensures proper downward flowing of the blood. The traditional Chinese medicine provided by the invention has the advantages of reasonable composition of raw materials, effects of clearing heat, invigorating blood circulation and activating meridians to stop pains, a good therapeutic effect on damp-heat type osteoarthritis, no toxic and side effects, safety and reliability.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of Chinese medicine for the treatment of the damp-heat type osteoarthritis and preparation method thereof.
Background technology
Osteoarthritis (osteoarthritis) is because the birth defect in old age or other reasons such as wound, joint, joint deformity etc. cause that the non-inflammation degeneration of articular cartilage and edge, joint hyperosteogeny form, the clinical symptoms such as arthralgia, limitation of activity and joint deformity that produce.The title of osteoarthritis is extremely many, such as HOA, degenerative osteoarthritis, degeneration arthritis, hyperplastic osteoarthritis or osteoarthritis etc., and the domestic unified osteoarthritis of using.Osteoarthritis is with far-end and the proximal interphalangeal joint of hands, and knee joint, elbow and shoulder joint and joint of vertebral column are easily got involved, and wrist, ankle joint be less morbidity then.
The cause of disease more complicated of osteoarthritis comprises chronic injury, obesity, aging, over loading motion, diet, sex, race, environment, cytokine, and immune factor etc.Be divided into stagnation of cold-damp type, damp-heat accumulation type, asthenia of qi and blood decline type, deficiency of both the liver and kidney type Four types.It is early stage that damp-heat accumulation type is more common in rheumatoid arthritis, main card shape is joint or muscle Red Indian race heat shoulder, the heating of touching, joint stuffiness, rise stiff morning, can relate to one or more little joints, or the arthralgia migration is indefinite, heating, dry mouth with bitter taste. red tongue, white or yellow thin fur, or few tongue, amidine is contributed number.Result of laboratory test is that erythrocyte sedimentation rate speeds, and rheumatoid factor is positive.
The patient of damp-heat type knee osteoarthritis, the clinical expectant treatment of mostly taking, mainly be that to have a rest be main, primary disease is more common in middle-aged and elderly people, complication is also apparent: because blood viscosity behind the lying on bed for a long time increases, blood flow slows down, easily cause the two lower limb vein thrombus of patient, very person's body produces stress, bring out disordered brain function, the symptoms such as fever of the body, delirium occur.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine for the treatment of the damp-heat type osteoarthritis and preparation method thereof, the Chinese medicine for the treatment of damp-heat type osteoarthritis provided by the present invention can be treated the damp-heat type osteoarthritis preferably, has no side effect, and is safe and reliable.
The Chinese medicine for the treatment of damp-heat type osteoarthritis of the present invention is to be prepared from by the raw material that comprises following weight portion:
Semen Persicae 10～50 Flos Carthamis 10～50 Cortex Phellodendris 10～50 Radix Et Rhizoma Rhei 10～50
QINGSONG 10～50 Radix Achyranthis Bidentataes 10～50 Borneolum Syntheticums 1～10.
The Chinese medicine for the treatment of damp-heat type osteoarthritis of the present invention, its preferred version are to be prepared from by the raw material that comprises following weight portion:
Semen Persicae 20～40 Flos Carthamis 20～40 Cortex Phellodendris 20～40 Radix Et Rhizoma Rhei 20～40
QINGSONG 20～40 Radix Achyranthis Bidentataes 20～40 Borneolum Syntheticums 3～8.
The Chinese medicine for the treatment of damp-heat type osteoarthritis of the present invention, its further preferred version is to be prepared from by the raw material that comprises following weight portion:
Semen Persicae 30 Flos Carthamis 30 Cortex Phellodendris 30 Radix Et Rhizoma Rhei 30
QINGSONG 30 Radix Achyranthis Bidentataes 30 Borneolum Syntheticums 5.
The Chinese medicine for the treatment of damp-heat type osteoarthritis of the present invention, its active component is prepared from by the following method:
Get 6 flavor medical materials except Borneolum Syntheticum, added the volume by volume concentration be equivalent to 1～2 times of this 6 flavor medical material gross weight and be 40%～60% alcohol dipping 12～48 hours, then be that 40%～60% ethanol carries out percolation with the speed that per minute accounts for raw material gross weight 0.2%～0.6% with volume by volume concentration, collection is equivalent to the percolate that this 7 flavor medical material gross weight 5-10 doubly measures, Recycled ethanol, be evaporated to 1～2 times that is equivalent to 6 flavor medical material gross weights, filter, obtain medicinal liquid A;
Medicinal liquid A and Borneolum Syntheticum are active component.
The Chinese medicine for the treatment of damp-heat type osteoarthritis of the present invention, its active component are to be prepared from by following method for optimizing:
Get 6 flavor medical materials except Borneolum Syntheticum, added the volume by volume concentration be equivalent to 1～2 times of this 6 flavor medical material gross weight and be 50%～56% alcohol dipping 24～36 hours, then be that 50%～56% ethanol carries out percolation with the speed that per minute accounts for raw material gross weight 0.3%～0.5% with volume by volume concentration, collection is equivalent to the percolate that this 6 flavor medical material gross weight 5-10 doubly measures, Recycled ethanol, be evaporated to 1～2 times that is equivalent to 7 flavor medical material gross weights, filter, obtain medicinal liquid A;
Medicinal liquid A and Borneolum Syntheticum are active component.
The Chinese medicine for the treatment of damp-heat type osteoarthritis of the present invention can cooperate with pharmaceutically acceptable carrier, makes various common dosage forms.
The Chinese medicine details is as follows among the present invention:
Semen Persicae
This product is rosaceous plant peach Prunus persica(L.) Batsch or Prunus davidiana Prunus davidiana(Cars.) dry mature seed of Franch..Gather behind the fruit maturation, remove sarcocarp and nucleocapsid, take out seed, dry.Bitter in the mouth, sweet, property is flat.GUIXIN, liver, large intestine channel.The function blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma.Be used for the amenorrhea dysmenorrhea, abdominal mass abdominal mass mass in the abdomen, lung abscess acute appendicitis, injury from falling down, dryness of the intestine constipation, cough and asthma.
Flos Carthami
This product is the dried floral of feverfew Flos Carthami Carthamus tinctorius L..Pluck when summer flower is red by xanthochromia, dry in the shade or dry.Acrid in the mouth, warm in nature.GUIXIN, Liver Channel.The function promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.Be used for amenorrhea, dysmenorrhea, lochia, addiction abdominal mass mass in the abdomen, obstruction of qi in the chest and cardialgia, the stasis of blood stagnates and suffers from abdominal pain, the twinge of the breast side of body, injury from falling down, skin infection swells and ache.
Borneolum Syntheticum
This product is borneolum syntheticum.Meet " the requirements under Chinese pharmacopoeia 2010 version 136 pages of Borneolum Syntheticums of a text (borneolum syntheticum).
Cortex Phellodendri
This product is the dry bark of rutaceae wampee Phellodendron chinenseSchneid.Practise and claim " Cortex Phellodendri ".After stripping bark, remove rough bark, dry.Bitter in the mouth, cold in nature.Return ' kidney, urinary bladder channel.The function heat clearing and damp drying, pathogenic fire purging is except steaming, and skin ulcer is treated in detoxifcation.Be used for damp-heat dysentery, the jaundice dark coloured urine, leukorrhagia pudendal pruritus, the puckery pain of pyretic stranguria, the beriberi flaccidity is preesed, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema eczema.The stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.Be used for hyperactivity of fire caused by deficiency of YIN, the night sweat hectic fever due to YIN-deficiency.
Radix Et Rhizoma Rhei
This product is dry root and the rhizome of polygonum rheum palmatum Rheum palmatum L., Rheum tanguticum Rheum tangicum Maxim.ex Balf. or Rheum officinale Rheumofficinale Baill..Autumn Mo in the withered or inferior spring of stem and leaf excavates before germinateing, and removes radicula, scrapes off crust, valve cutting or section, and rope is worn bunchiness drying or convection drying.Bitter in the mouth, cold in nature.Return spleen, stomach, large intestine, liver, pericardium channel.The function heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, dampness removing jaundice eliminating.Be used for the stagnant constipation of excess-heat, heat in blood is told nosebleed, conjunctival congestion pharyngeal swelling, carbuncle furuncle, abdominalgia with intestinal abscess, blood stasis amenorrhea, postpartum stagnation, traumatic injury, hygropyretic dysentery, jaundice dark coloured urine, stranguria, edema; Externally treating burns and scalds.Radix et Rhizoma Rhei (stir-fried with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.Be used for the conjunctival congestion pharyngeal swelling, gingivitis.Radix Et Rhizoma Rhei rushes down exerts oneself to delay eliminating fire and detoxication.Be used for pathogenic fire,toxin and furuncles.The hemostasis of charred Radix Et Rhizoma Rhei cooling blood and removing stasis.Be used for heat in blood stasis of blood hemorrhage is arranged.
QINGSONG
This product is the dry aerial parts of feverfew Herba Artemisiae annuae Artemisia annua L..Spend autumn when blooming and tap, remove old stem, dry in the shade.Bitter in the mouth, suffering, cold in nature.Return liver, gallbladder meridian.The function clearing away summer-heat is except steaming preventing the attack (or recurrence) of malaria.Be used for the pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, jaundice due to damp-heat.
Radix Achyranthis Bidentatae
This product is the dry root of amaranthaceous plant Radix Achyranthis Bidentatae Achyranthes bidentata BL..Excavate when stem and leaf is withered winter, removes fibrous root and silt, ties into wisp, shines as for after the wrinkle, and the top is trimmed, and dries.Bitter in the mouth, sweet, sour, property is flat.Return liver, kidney channel.The function eliminating blood stasis and inducing menstruation, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, conducting blood to flow downwards.Be used for amenorrhea, dysmenorrhea, soreness of waist and knee joint, muscles and bones is unable, stranguria, edema, headache, dizzy, toothache, day skin ulcer is spitted blood epistaxis.
Semen Persicae of the present invention, Flos Carthami blood circulation promoting and blood stasis dispelling be with pain relieving, Borneolum Syntheticum, Cortex Phellodendri, Radix Et Rhizoma Rhei, QINGSONG clearing away heat and cooling blood, removing obstruction in the collateral to relieve pain; The Radix Achyranthis Bidentatae conducting blood to flow downwards.Ingredients of the present invention is reasonable, has the merit of heat clearing and blood circulation promoting, removing obstruction in the collateral to relieve pain, the kind damp-heat type knee osteoarthritis of controlling.
Clinical test results such as embodiment 7 and embodiment 8 shows, Chinese medicine of the present invention has preferably effect by external application for curing damp-heat type osteoarthritis, and effective percentage reaches 93.3%, is better than celecoxib medicine matched group; And execute in the process of controlling clinical, have no toxic and side effects, safe and reliable.
Chinese medicine provided by the invention has overcome the defective of prior art, has outstanding substantive distinguishing features and progressive significantly with respect to prior art.
The specific embodiment
Embodiment 1
Semen Persicae 100g Flos Carthami 100g Cortex Phellodendri 100g Radix Et Rhizoma Rhei 100g
QINGSONG 100g Radix Achyranthis Bidentatae 100g Borneolum Syntheticum 10g
Get 6 flavor medical materials except Borneolum Syntheticum, the volume by volume concentration that adds 600g is 40% alcohol dipping 12 hours, then be that 40% ethanol carries out percolation with the speed that per minute accounts for raw material gross weight 0.2% with volume by volume concentration, collect the percolate of 3000g, Recycled ethanol, be evaporated to 600g, filter, obtain medicinal liquid A;
Medicinal liquid A and Borneolum Syntheticum are active component.
Embodiment 2
Semen Persicae 300g Flos Carthami 400g Cortex Phellodendri 500g Radix Et Rhizoma Rhei 200g
QINGSONG 100g Radix Achyranthis Bidentatae 400g ices 100g
Get 6 flavor medical materials except Borneolum Syntheticum, the volume by volume concentration that adds 3800g is 60% alcohol dipping 48 hours, then be that 60% ethanol carries out percolation with the speed that per minute accounts for raw material gross weight 0.6% with volume by volume concentration, collect the percolate of 19000g, filter, add Borneolum Syntheticum, stir, filter, namely get tincture of the present invention.
Embodiment 3
Semen Persicae 300g Flos Carthami 300g Cortex Phellodendri 300g Radix Et Rhizoma Rhei 300g
QINGSONG 300g Radix Achyranthis Bidentatae 300g Borneolum Syntheticum 50g
Get 6 flavor medical materials except Borneolum Syntheticum, the volume by volume concentration that adds 2700g is 50% alcohol dipping 24 hours, then be that 52% ethanol carries out percolation with the speed that per minute accounts for raw material gross weight 0.3% with volume by volume concentration, collect the percolate of 14400g, Recycled ethanol, be evaporated to 2340g, filter, obtain medicinal liquid A;
With a small amount of dissolve with ethanol of Borneolum Syntheticum, with medicinal liquid A, an amount of antioxidant, propellant mix homogeneously, namely get aerosol of the present invention.
Embodiment 4
Semen Persicae 200g Flos Carthami 200g Cortex Phellodendri 300g Radix Et Rhizoma Rhei 200g
QINGSONG 400g Radix Achyranthis Bidentatae 200g Borneolum Syntheticum 30g
Get 6 flavor medical materials except Borneolum Syntheticum, the volume by volume concentration that adds 1950g is 56% alcohol dipping 36 hours, then be that 54% ethanol carries out percolation with the speed that per minute accounts for raw material gross weight 0.5% with volume by volume concentration, collect the percolate of 9000g, Recycled ethanol, be evaporated to 2550g, filter, obtain medicinal liquid A;
With a small amount of dissolve with ethanol of Borneolum Syntheticum, get solution B;
Medicinal liquid A is concentrated in right amount, mixes with solution B, cooperate with an amount of water-soluble base, stir, namely get ointment of the present invention.
Embodiment 5
Semen Persicae 400g Flos Carthami 200g Cortex Phellodendri 400g Radix Et Rhizoma Rhei 300g
QINGSONG 350g Radix Achyranthis Bidentatae 350g Borneolum Syntheticum 60g
Get 6 flavor medical materials except Borneolum Syntheticum, the volume by volume concentration that adds 3800g is 40%～60% alcohol dipping 28 hours, then be that 48% ethanol carries out percolation with the speed that per minute accounts for raw material gross weight 0.4% with volume by volume concentration, collect the percolate of 14000g, Recycled ethanol, be evaporated to 2800g, filter, obtain medicinal liquid A;
With a small amount of dissolve with ethanol of Borneolum Syntheticum, get solution B;
Medicinal liquid A is concentrated in right amount, mixes with solution B, add the adjuvants such as an amount of adhesive, wetting agent, filler, stir, coat on the back lining materials, namely get gel rubber plaster unguentum of the present invention.
Embodiment 6
Semen Persicae 150g Flos Carthami 250g Cortex Phellodendri 350g Radix Et Rhizoma Rhei 150g
QINGSONG 150g Radix Achyranthis Bidentatae 500g Borneolum Syntheticum 90g
Get 6 flavor medical materials except Borneolum Syntheticum, the volume by volume concentration that adds 2950g is 51% alcohol dipping 40 hours, then be that 47% ethanol carries out percolation with the speed that per minute accounts for raw material gross weight 0.3% with volume by volume concentration, collect the percolate of 14760g, Recycled ethanol, be evaporated to 2780g, filter, obtain medicinal liquid A;
Medicinal liquid A is concentrated in right amount, mixes with solution B, cooperate with an amount of water-soluble base, stir, namely get ointment of the present invention.
Embodiment 7
1, case is selected
Treatment group: treat at random 30 examples, between the patient age scope 63.02 ± 6.9 years old, the course of disease time was in 6.25 ± 3.9 years.
Matched group: treat at random 30 examples, between the patient age scope 61.26 ± 7.2, the course of disease time was in 6.01 ± 4.1 years.
2, diagnostic criteria
Adopt the diagnostic criteria of knee osteoarthritis in " osteoarthritis diagnosis and treatment guide " (version in 2007), " the new Chinese medicine guideline of clinical investigations ".
1. the gonalgia repeatedly in nearly 1 month; 2. X-ray film (standing or Weight carrying position) show that the joint space narrows down, Subchondral bone sclerosis and (or) cystis degeneration, joint margins hyperosteogeny form; 3. limpid, the thickness of joint fluid (at least 2 times), WBC＜2000/ml; 4. middle-older patient (" is 40 years old); 5. morning stiff " 30min; Bone friction sense is arranged when 6. movable.
Comprehensively clinical, laboratory and X sheet check, meet 1+2 bar or 1+3+5+6 bar or 1+4+5+6 bar, and diagnosable is knee osteoarthritis.
3, curative effect determinate standard:
The middle symptom of " the new Chinese medicine guideline of clinical investigations " that adopts Ministry of Public Health to develop and publish, sign scale scoring score are judged curative effect than (therapeutic index).Integration * 100%(nimodipine method before therapeutic index=(integration after integration before the treatment-treatment)/treatment)
Produce effects: transference cure, joint motion are not limited, therapeutic index " 70%;
Effectively: symptom disappears substantially, and joint motion is slightly limited, therapeutic index " 30%, " 70%;
Invalid: symptom and range of motion be without obvious improvement, therapeutic index " 20%.
4, drug use method
Treatment group is coated on the gauze with the medicine of the embodiment of the invention 4, sticks in the affected part with immobilization with adhesive tape, and every day 1 time, each medicine that is equivalent to crude drug amount 80g that uses, continuous 2 weeks were 1 course for the treatment of.But 2 courses for the treatment of of repetitive therapy.
Matched group: give oral celecoxib, once a day, each 200mg serve on 1-2 course of therapy.
5, clinical treatment result
Table 1 liang group treatment Clinical efficacy comparison
| Group | The example number | Produce effects | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 30 | 17（56.7） | 11(36.70) | 2(6.7) | 93.33 |
| Matched group | 30 | 14（46.7） | 11(36.7) | 5(16.7) | 83.33 |
Embodiment 8
The king * *, man, 66 years old, Guangxi Luzhai people from county, medical history 4 years, symptom: right knee joint pain, difficulty in walking.Look into: right knee joint is slightly red, ring tenderness, mobility 5-90 degree.Tongue is dark, yellow fur, wiry and frequent pulse.X-ray shows: right knee joint regression.Through Herbal medicines for external use bilateral Xiyan of the present invention, treat rehabilitation after 10 days, evident in efficacy, therapeutic index 80%.
Case 2,
*, woman, 72 years old, Liuzhou city, Guangxi province people, medical history 2 years, symptom: two knee joint pain, difficulty in walking.Look into: two knee joint skin temperature are slightly high, and the ring tenderness is obvious with the inboard, mobility 0-110 degree.Tongue is dim, yellow fur, wiry and frequent pulse.X-ray shows: two knee joint regressions.Through Herbal medicines for external use bilateral Xiyan of the present invention, tsu san li, treat that symptom is clearly better therapeutic index 80% after 12 days.
Case 3,
The king * *, woman, 76 years old, Liuzhou city, Guangxi province people, medical history 1 year, symptom: two knee joint pain, difficulty in walking.Look into: two knee joints are slightly red, ring tenderness, adductor atrophy, mobility 0-90 degree.Tongue is dim, yellow fur, stringy pulse.X-ray shows: two knee joint regressions.Through Herbal medicines for external use bilateral Xiyan of the present invention, tsu san li, treat rehabilitation after 14 days, therapeutic index 78%.
Claims (6)
1. Chinese medicine for the treatment of the damp-heat type osteoarthritis is characterized in that it is to be prepared from by the raw material that comprises following weight portion:
Semen Persicae 10～50 Flos Carthamis 10～50 Cortex Phellodendris 10～50 Radix Et Rhizoma Rhei 10～50
QINGSONG 10～50 Radix Achyranthis Bidentataes 10～50 Borneolum Syntheticums 1～10.
2. the Chinese medicine for the treatment of damp-heat type osteoarthritis as claimed in claim 1 is characterized in that it is to be prepared from by the raw material that comprises following weight portion:
Semen Persicae 20～40 Flos Carthamis 20～40 Cortex Phellodendris 20～40 Radix Et Rhizoma Rhei 20～40
QINGSONG 20～40 Radix Achyranthis Bidentataes 20～40 Borneolum Syntheticums 3～8.
3. the Chinese medicine for the treatment of damp-heat type osteoarthritis as claimed in claim 2 is characterized in that it is to be prepared from by the raw material that comprises following weight portion:
Semen Persicae 30 Flos Carthamis 30 Cortex Phellodendris 30 Radix Et Rhizoma Rhei 30
QINGSONG 30 Radix Achyranthis Bidentataes 30 Borneolum Syntheticums 5.
4. the Chinese medicine for the treatment of damp-heat type osteoarthritis as claimed in claim 1 is characterized in that its active component is prepared from by the following method:
Get 6 flavor medical materials except Borneolum Syntheticum, added the volume by volume concentration be equivalent to 1～2 times of this 6 flavor medical material gross weight and be 40%～60% alcohol dipping 12～48 hours, then be that 40%～60% ethanol carries out percolation with the speed that per minute accounts for raw material gross weight 0.2%～0.6% with volume by volume concentration, collection is equivalent to the percolate that this 7 flavor medical material gross weight 5-10 doubly measures, Recycled ethanol, be evaporated to 1～2 times that is equivalent to 6 flavor medical material gross weights, filter, obtain medicinal liquid A;
Medicinal liquid A and Borneolum Syntheticum are active component.
5. the Chinese medicine of damp-heat type osteoarthritis is treated in treatment as claimed in claim 1, it is characterized in that its active component is prepared from by the following method:
Get 6 flavor medical materials except Borneolum Syntheticum, added the volume by volume concentration be equivalent to 1～2 times of this 6 flavor medical material gross weight and be 50%～56% alcohol dipping 24～36 hours, then be that 50%～56% ethanol carries out percolation with the speed that per minute accounts for raw material gross weight 0.3%～0.5% with volume by volume concentration, collection is equivalent to the percolate that this 6 flavor medical material gross weight 5-10 doubly measures, Recycled ethanol, be evaporated to 1～2 times that is equivalent to 7 flavor medical material gross weights, filter, obtain medicinal liquid A;
Medicinal liquid A and Borneolum Syntheticum are active component.
6. a Chinese medicine preparation for the treatment of the damp-heat type osteoarthritis comprises the Chinese medicine of each treatment damp-heat type osteoarthritis in the claim 1～5 and pharmaceutically acceptable carrier.
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| CN105963650A (en) * | 2015-03-10 | 2016-09-28 | 彭光宗 | Medicinal liquor for treating arthritis and wound |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102091289A (en) * | 2010-09-21 | 2011-06-15 | 孙玉宝 | Traditional Chinese medicine preparation with functions of clearing heat and cooling blood, promoting blood circulation to remove blood stasis and eliminating swelling and alleviating pain |
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| CN102091289A (en) * | 2010-09-21 | 2011-06-15 | 孙玉宝 | Traditional Chinese medicine preparation with functions of clearing heat and cooling blood, promoting blood circulation to remove blood stasis and eliminating swelling and alleviating pain |
Non-Patent Citations (1)
| Title |
|---|
| 南京中医药大学: "《中药大辞典》", 31 March 2006, article "牛膝，青蒿" * |
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| CN105963650A (en) * | 2015-03-10 | 2016-09-28 | 彭光宗 | Medicinal liquor for treating arthritis and wound |
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Granted publication date: 20140507 Termination date: 20181226 |