CN103048248A - Diffusion cell device capable of adjusting capacity of receiving cell and effective diffusion area - Google Patents
Diffusion cell device capable of adjusting capacity of receiving cell and effective diffusion area Download PDFInfo
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- CN103048248A CN103048248A CN2012105328808A CN201210532880A CN103048248A CN 103048248 A CN103048248 A CN 103048248A CN 2012105328808 A CN2012105328808 A CN 2012105328808A CN 201210532880 A CN201210532880 A CN 201210532880A CN 103048248 A CN103048248 A CN 103048248A
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- accepting
- pond
- clamping disk
- cell
- sample clamping
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- 238000009792 diffusion process Methods 0.000 title claims abstract description 40
- 230000001105 regulatory effect Effects 0.000 claims description 34
- 230000008676 import Effects 0.000 claims description 4
- 239000011148 porous material Substances 0.000 claims description 3
- 238000002474 experimental method Methods 0.000 abstract description 6
- 238000012360 testing method Methods 0.000 abstract description 4
- 239000002699 waste material Substances 0.000 abstract description 2
- 210000004027 cell Anatomy 0.000 abstract 7
- 210000003370 receptor cell Anatomy 0.000 abstract 5
- 239000007788 liquid Substances 0.000 abstract 1
- 239000002547 new drug Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 229940079593 drug Drugs 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 230000003068 static effect Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 2
- 238000012827 research and development Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000003032 molecular docking Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000012858 resilient material Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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Abstract
The invention relates to a diffusion cell device capable of adjusting the capacity of receiving cell and effective diffusion area, comprising a cylindrical supply cell and a receptor cell. Each of the lower end of the supply cell and the upper end of the receptor ell is provided with an outer flange which corresponds to each other and is abutted mutually through a clamping device; the side of the receptor cell is provided with a receptor liquid port. The diffusion cell device is characterized by further comprising more than one capacity adjusting block arranged in the receptor cell, and the outer diameter of the capacity adjusting block is matched with the inner diameter of the receptor cell. The diffusion cell device has the advantages that the device fits for different sample types and meets different experiment requirements, repeated waste of resources is avoided as the size of a sample and the capacity of the receptor cell during testing, the experimental period is shortened, and the experiment data precision and the working efficiency are improved; and the diffusion cell device provides powerful hard conditions for development of new drugs.
Description
Technical field
The present invention relates to a kind of diffusion cell device of regulating effective diffusion area and accepting pool volume, be applied to the static permeable membrane diffusion research of medicine.
Background technology
Chinese patent database (knowing half tone) discloses six patents of " a kind of transdermal diffusion experiment instrument " " In vitro penetration test instrument " " without bubble diffusion cell " " static diffusion cell that is used for diffusion sampling " " a kind of experimental provision of testing drug transdermal " " pick-up unit that a kind of drug transdermal discharges ", wherein main device is diffusion cell, it is a kind of device that the static research of medicine is used that is usually used in, its formation is by supply pool, accept the pond, water bath device and sample tap consist of, weak point is, sample for different sizes, and the experiment of different accuracy or sensitivity requirement, need the different bores of customization and the different product of accepting pool volume.If need in experimentation the sample size, precision or sensitivity are adjusted, and often need again to customize diffusion cell, cause experimentation to lack continuation, have increased experimental cost, have reduced work efficiency, and it is scientific to affect medicament research and development.
Summary of the invention
The object of the invention provides a kind of diffusion cell device of regulating effective diffusion area and accepting pool volume, overcomes big or small to sample that prior art exists, the shortcoming that precision or sensitivity can not be adjusted.
Technical scheme of the present invention is: a kind of diffusion cell device of regulating effective diffusion area and accepting pool volume, comprise columniform supply pool and accept the pond, be respectively equipped with the outward flange of mutual correspondence in the lower end of this supply pool and the upper end of accepting the pond, and mutually dock by clamping device, be provided with acceptable solution imports and exports in this side of accepting the pond, it is characterized in that also comprise being located at the described volume adjustment piece of accepting in the pond more than one, its external diameter matches with this internal diameter of accepting the pond.
Described volume adjustment piece is the annular volume regulating block, is provided with center pit in its axle center.
Be provided with a contour cylindricality volume adjustment piece in the center pit of this annular volume regulating block, its diameter matches with the internal diameter of this annular volume regulating block center pit.
Sample clamping disk and lower sample clamping disk are installed respectively with the upper end of accepting the pond in lower end at described supply pool, sample clamping disk and the coaxial setting of lower sample clamping disk on this, and the aperture of center pit is identical.
On this, be provided with the flange protruding upward that external diameter cooperates with the aperture, lower end of supply pool above the sample clamping disk; Below this time sample clamping disk, be provided with the flange of the downward protrusion that external diameter cooperates with the aperture, upper end of accepting the pond.
Be provided with upper sample clamping disk and the lower sample clamping disk of many cover different pore sizes.
Below the outward flange of described supply pool and above the upper sample clamping disk, and be respectively equipped with mutual corresponding sealed groove above the following outward flange with accepting the pond of lower sample clamping disk, in relative sealed groove, be provided with O-ring seal.
Advantage of the present invention is: can be applicable to the different specimens type, satisfy the different experiments requirement, can in experimentation, adjust the sample size and accept pool volume, avoid repeatability waste resource, shorten experimental period, improve experimental data precision and work efficiency, for the research and development newtype drug provides strong rigid condition.
Description of drawings
Fig. 1 is that general assembly axis of no-feathering of the present invention is to cut-open view;
Fig. 2 is the axial cut-open view of decomposition texture of the present invention.
Description of symbols among the figure: 1, supply pool, 2, upper sample clamping disk, 3, lower sample clamping disk, 4, accept the pond, 5, annular volume regulating block, 6, cylindricality volume adjustment piece, 7, acceptable solution imports and exports, 8, O-ring seal, 9, sealed groove, 10, sealed groove, 11, the supply pool outward flange, 12, accept the pond outward flange.
Embodiment
Referring to Fig. 1 and Fig. 2, a kind of diffusion cell device of regulating effective diffusion area and accepting pool volume of the present invention, comprise the columniform supply pool 1 that fits together successively up and down, upper sample clamping disk 2, lower sample clamping disk 3, accept pond 4, be provided with outward flange 11 in the lower end of this supply pool 1, be provided with the outward flange 12 corresponding with the outward flange 11 of supply pool 1 in this upper end of accepting pond 4, and by clamping device (routine techniques, not shown) mutually docking, be provided with acceptable solution in this side of accepting pond 4 and import and export 7.Also be provided with (size of volume adjusted is determined its number) more than one and be located at the described volume adjustment piece of accepting in the pond 4, its external diameter matches with this internal diameter of accepting the pond.
Described volume adjustment piece can be annular volume regulating block 5, is provided with center pit in its axle center.
Also can be provided with a contour cylindricality volume adjustment piece 6 in the center pit of this annular volume regulating block 5, its diameter matches with the internal diameter of these annular volume regulating block 5 center pits.
The height of annular volume regulating block 5 and cylindricality volume adjustment piece 6 can have multiple, determines as required to put into the annular volume regulating block 5 of accepting pond 4 and/or the number of cylindricality volume adjustment piece 6.
Can be provided with upper sample clamping disk 2 and the lower sample clamping disks 3 of many cover different pore sizes, with the time reach the purpose of regulating diffusion area by the clamping device of changing different model.
Below the outward flange 11 of described supply pool 1 be provided with mutual corresponding sealed groove 9 above the upper sample clamping disk 2, below lower sample clamping disk 3 be provided with mutual corresponding sealed groove 10 above the outward flange 12 of accepting pond 4, in relative sealed groove, respectively be provided with the O-ring seal 8 of resilient material material.
On experimental specimen is clamped between sample clamping disk 2 and the lower sample clamping disk 3, its center pit is effective diffusingsurface, can reach by the clamping device of changing different model the purpose of regulating diffusion area during use.Put into (differing heights) annular volume regulating block 5 of accepting pond 4 and/or the number of cylindricality volume adjustment piece 6 by change, reach and regulate the purpose of accepting pond 4 capacity.As in regulated quantity hour, adopt annular volume regulating block 5, it be positioned over accept the pond at 4 the end, its outside surface with accept pond 4 inside surfaces and contact, magnetic stir bar (not shown) places in the center pit of annular volume regulating block 5, and annular volume regulating block 5 does not hinder the magnetic stir bar motion; Such as the larger regulated quantity of needs, can adopt annular volume regulating block 5 and cylindricality volume adjustment piece 6 to merge the stack of using or adopt many group annular volume regulating blocks 5 and cylindricality volume adjustment piece 6.Cylindricality volume adjustment piece 6 is positioned in the center pit of annular volume regulating block 5, both the upper end concordant, magnetic stir bar be placed on the volume adjustment piece above.Can adopt many annular volume regulating block 5 inner-outer sleeves to be used in combination according to the regulated quantity size together.After experiment finished, as need to effectively testing drawing materials of area to sample, to hold device thinner because of the folder sample, can utilize the operation sharp knife to carry out drawing materials under clamp position, and the standard of drawing materials is simple, shortens and draws materials the time, is conducive to the sample protection.
Do not affect in use magnetic stir bar for fear of annular volume regulating block 5 and cylindricality volume adjustment piece 6 and rotate, can change as required height dimension, or adopt multilayer or encircle the phase Analysis of Nested Design more and regulate.Move betwixt as principle not affect magnetic stir bar with annular volume regulating block 5.
Claims (7)
1. can regulate effective diffusion area and the diffusion cell device of accepting pool volume for one kind, comprise columniform supply pool and accept the pond, be respectively equipped with the outward flange of mutual correspondence in the lower end of this supply pool and the upper end of accepting the pond, and mutually dock by clamping device, be provided with acceptable solution imports and exports in this side of accepting the pond, it is characterized in that also comprise being located at the described volume adjustment piece of accepting in the pond more than one, its external diameter matches with this internal diameter of accepting the pond.
2. the diffusion cell device of regulating effective diffusion area and accepting pool volume according to claim 1 is characterized in that described volume adjustment piece is the annular volume regulating block, is provided with center pit in its axle center.
3. according to claim 2ly regulate effective diffusion area and accept the diffusion cell device of pool volume, it is characterized in that, be provided with a contour cylindricality volume adjustment piece in the center pit of this annular volume regulating block, its diameter matches with the internal diameter of this annular volume regulating block center pit.
4. according to claim 1ly regulate effective diffusion area and accept the diffusion cell device of pool volume, it is characterized in that, sample clamping disk and lower sample clamping disk are installed respectively with the upper end of accepting the pond in lower end at described supply pool, upward sample clamping disk and the coaxial setting of lower sample clamping disk, the aperture of center pit is identical.
5. the diffusion cell device of regulating effective diffusion area and accepting pool volume according to claim 4 is characterized in that, is provided with the flange protruding upward that external diameter cooperates with the aperture, lower end of supply pool on this above the sample clamping disk; Below this time sample clamping disk, be provided with the flange of the downward protrusion that external diameter cooperates with the aperture, upper end of accepting the pond.
6. the diffusion cell device of regulating effective diffusion area and accepting pool volume according to claim 4 is characterized in that, is provided with upper sample clamping disk and the lower sample clamping disk of many cover different pore sizes.
7. according to claim 4ly regulate effective diffusion area and accept the diffusion cell device of pool volume, it is characterized in that, below the outward flange of described supply pool and above the upper sample clamping disk, and be respectively equipped with mutual corresponding sealed groove above the following outward flange with accepting the pond of lower sample clamping disk, in relative sealed groove, be provided with O-ring seal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210532880.8A CN103048248B (en) | 2012-12-11 | 2012-12-11 | The diffusion cell of adjustable effective diffusion area and acceptance pool volume |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210532880.8A CN103048248B (en) | 2012-12-11 | 2012-12-11 | The diffusion cell of adjustable effective diffusion area and acceptance pool volume |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103048248A true CN103048248A (en) | 2013-04-17 |
| CN103048248B CN103048248B (en) | 2015-08-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210532880.8A Active CN103048248B (en) | 2012-12-11 | 2012-12-11 | The diffusion cell of adjustable effective diffusion area and acceptance pool volume |
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| CN (1) | CN103048248B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103299961A (en) * | 2013-05-31 | 2013-09-18 | 江苏省血吸虫病防治研究所 | Device and method for in-vitro preparation of schistosomulum |
| CN104345013A (en) * | 2013-07-29 | 2015-02-11 | 北京大学 | Experimental device for nuclide migration study under high temperature condition |
| CN104422634A (en) * | 2013-08-22 | 2015-03-18 | 中国科学院大连化学物理研究所 | Method for characterization of polyelectrolyte plate hydrogel or hydrogel film density |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2699286Y (en) * | 2004-05-12 | 2005-05-11 | 严衍禄 | Optical range and sample volume adjustable solid sampling pool |
| CA2410267C (en) * | 2000-05-31 | 2006-01-03 | Zinoviy Dmitrievich Khomynets | Operation mode of an oil well pumping unit for well development and device for performing said operation mode |
| CN1961980A (en) * | 2002-01-04 | 2007-05-16 | 德卡产品有限公司 | Loading mechanism for infusion pump |
| FR2874079B1 (en) * | 2004-08-06 | 2008-07-18 | Francis Pelissier | THERMOCHEMICAL CEMENT TREATMENT MACHINE |
| CN201514365U (en) * | 2009-10-29 | 2010-06-23 | 艾丹 | Bubble-free diffusion cell |
| CN102606816A (en) * | 2012-03-06 | 2012-07-25 | 白黎明 | Movable joint type flow limiting device |
-
2012
- 2012-12-11 CN CN201210532880.8A patent/CN103048248B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2410267C (en) * | 2000-05-31 | 2006-01-03 | Zinoviy Dmitrievich Khomynets | Operation mode of an oil well pumping unit for well development and device for performing said operation mode |
| CN1961980A (en) * | 2002-01-04 | 2007-05-16 | 德卡产品有限公司 | Loading mechanism for infusion pump |
| CN2699286Y (en) * | 2004-05-12 | 2005-05-11 | 严衍禄 | Optical range and sample volume adjustable solid sampling pool |
| FR2874079B1 (en) * | 2004-08-06 | 2008-07-18 | Francis Pelissier | THERMOCHEMICAL CEMENT TREATMENT MACHINE |
| CN201514365U (en) * | 2009-10-29 | 2010-06-23 | 艾丹 | Bubble-free diffusion cell |
| CN102606816A (en) * | 2012-03-06 | 2012-07-25 | 白黎明 | Movable joint type flow limiting device |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103299961A (en) * | 2013-05-31 | 2013-09-18 | 江苏省血吸虫病防治研究所 | Device and method for in-vitro preparation of schistosomulum |
| CN103299961B (en) * | 2013-05-31 | 2015-08-12 | 江苏省血吸虫病防治研究所 | A kind of external device and method preparing schistosomulum |
| CN104345013A (en) * | 2013-07-29 | 2015-02-11 | 北京大学 | Experimental device for nuclide migration study under high temperature condition |
| CN104422634A (en) * | 2013-08-22 | 2015-03-18 | 中国科学院大连化学物理研究所 | Method for characterization of polyelectrolyte plate hydrogel or hydrogel film density |
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| Publication number | Publication date |
|---|---|
| CN103048248B (en) | 2015-08-26 |
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