CN103041451A - Activatable medical percutaneous injection filler based on laser - Google Patents
Activatable medical percutaneous injection filler based on laser Download PDFInfo
- Publication number
- CN103041451A CN103041451A CN 201310007824 CN201310007824A CN103041451A CN 103041451 A CN103041451 A CN 103041451A CN 201310007824 CN201310007824 CN 201310007824 CN 201310007824 A CN201310007824 A CN 201310007824A CN 103041451 A CN103041451 A CN 103041451A
- Authority
- CN
- China
- Prior art keywords
- laser
- filler
- hyaluronic acid
- injection
- special particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Abstract
The invention discloses an activatable medical percutaneous injection filler based on laser, which mainly comprises crosslinked hyaluronic acid, and a special particle component with good tissue compatibility, wherein special particles are mixed into the crosslinked hyaluronic acid filler, and are 50-100 micrometers in particle size. The action time of the filler by single injection can be prolonged to be multiple times than before by the action of the laser.
Description
Technical field
The present invention relates to a kind of medical filler, especially relate to a kind of activated injection of skin formula filler based on laser.
Background technology
The injection filler is one of present international beautifying skin field Noninvasive therapy method the most commonly used, its advantage is wrinkle (such as nasolabial fold), the tissue depression (such as Acne Scar or tear groove) at rapidly filling face or other position, and expand tissue volume and make it plentiful (such as rich lip or augmentation rhinoplasty) etc., so injection is filled and is in recent years become the fastest project of present beauty treatment fields growth rate.The kind of medical injection formula filler is a lot, comprises collagen protein, hyaluronic acid, gelatin, silica gel and autologous fat etc.But wherein hyaluronic acid has outstanding histocompatibility, almost without sensitization and the characteristic such as viscoelasticity preferably, becomes gradually the preferred material of injection of skin formula filler.Hyaluronic acid (Hyaluromic acid, HA) be a kind of natural linear polysaccharide composition that extensively is present in the zooblast epimatrix, be connected with β 1-4 key with β 1-3 by the glucuronic acid ammonia of being connected with N acetyl and connect that the polyanion disaccharide unit formed consisted of, be the important component that forms connective tissue, synovial fluid and other soft tissues such as skin, good histocompatibility is arranged.Hyaluronic acid does not have antigenic specificity between different kinds or tissue, the probability that therefore produces allergy or immunogenic response is very low.It has been found that in all vertebratess and as " biomembrane " of antibacterial and plays a role.Because hyaluronic acid has special physics and biochemical characteristic in normal structure, so that it becomes a kind of desirable structural composites.When hyaluronic acid was melted in the aqueous solution, the carboxyl that it is adjacent and N acetyl group can form hydrogen bond, and this characteristic can make it keep the rigidity of conformation and in conjunction with moisture.1 gram hyaluronic acid at most can be in conjunction with 6 premium on currency.The half-life of natural hyaluronic acid in tissue only has 1 to 2 day time, is water and carbon dioxide by the enzymatic degradation in the liver subsequently.As effective corium filler, 1 to 2 day time is inadequate, needs the longer retention time of organizing.The hyaluronic acid of initial suitability for industrialized production is extracted by cockscomb, adopted afterwards the streptococcus equi fermentative Production, natural hyaluronic acid can form larger, more stable molecule through after crosslinked, not only kept the filling characteristics such as same histocompatibility and viscoelasticity, and retention time is also longer in tissue.The retention time of different hyaluronic acid injection filleies in skin of having been ratified by FDA at present is about 4-8 month and do not wait.
Most injection filleies all can be within a certain period of time by tissue institute degraded and absorbed at present, wanting to obtain stable cosmetic result just needs regular repeated multiple times injection, as uses hyaluronic patient to need again to inject to keep curative effect after about 8 months.So not only increase patient's cost, and increased the misery of patient infusion.Up to now, not yet find in the prior art to prolong the filler injection method of action time.
Summary of the invention
Goal of the invention: the object of the invention is to overcome the deficiency of existing hyaluronic acid injection filler, a kind of activated medical skin injection filler based on laser is provided, thereby can prolongs the action time of a shot.
Technical scheme: a kind of activated medical skin injection filler based on laser is mainly become to be grouped into by crosslinked hyaluronic acid and the good special particles of histocompatibility; Described special particles is incorporated in the crosslinked hyaluronic acid filler, and the particle diameter of special particles is 50 μ m-100 μ m.
Described special particles has different optical absorption characteristics, can be smashed fully under the laser action of absorption peak wavelength corresponding to special particles, and fragment can be engulfed and be transported in the regional nodes.
Beneficial effect: compared with prior art, the activated medical skin injection filler based on laser provided by the invention, can extend to original several times the action time of shot filler under the effect of laser.
Description of drawings
Fig. 1 is the experiment flow figure of the embodiment of the invention; Wherein (1)-(7) expression is based on the mechanism of the activated medical skin injection filler of laser.
The specific embodiment
Below in conjunction with specific embodiment, further illustrate the present invention, should understand these embodiment only is used for explanation the present invention and is not used in and limits the scope of the invention, after having read the present invention, those skilled in the art all fall within the application's claims limited range to the modification of the various equivalent form of values of the present invention.
The laser skin care also is the very fast treatment means of in recent years beautifying skin field development, it mainly is that machinery (optoacoustic) effect by laser and/or photo-thermal effect produce stimulation to the stromal cells such as fibroblast in the corium, thereby start the process of injury repairing, fibroblast is subject to activating the newborn collagen protein of rear generation and other extracellular matrix composition, reach and fill tiny wrinkle, increase the effect of dermis thickness and capacity.By introducing some exogenous material, can increase the absorption to specific wavelength laser, thereby strengthen intradermal inflammatory reaction, further increase the output of matter composition between collagen protein etc.Under the selective photothermolysis of specific laser, change after only having these exogenous material absorbing laser energy, and very little to the damage of normal surrounding tissue, cell, so inflammatory reaction also is limited in around the exogenous granule, and can not cause excessive tissue injury.
The present invention combines the mechanism of laser skin care and injection filler, be achieved through the following technical solutions, in crosslinked hyaluronic acid filler, mix special particles, the histocompatibility of these microgranules is good, and (common 50 μ m-100 μ m) are of moderate size, neither can be engulfed digestion by the phagocyte in the dermal tissue and be transported in the regional nodes, thus the characteristic such as the not too large viscosity that affects filler and viscoelasticity again.In addition, these microgranules have different optical absorption characteristics, can be smashed fully under the laser action of absorption peak wavelength corresponding to microgranule, and fragment can be engulfed and be transported in the regional nodes.The agent of intradermal injection fillers is (6-8 month) by after a while, the hyaluronic acid composition is sponged by degradable substantially, only leave over the absorbed microgranule of lower those energy in area for treatment, under the Q-switch laser irradiation of using the wavelength that can smash microgranule, microgranule is fragmentated by explosion, in explosion, can excite circumgranular inflammatory reaction, activate various inflammatory cells, produce inflammatory factor and chemotactic factor, start the injury repairing process, intradermal fibroblast is subject to activation and can produces a large amount of I types and III collagen type in this process, be equivalent to produce from the agent of body endogenous filling in situ and continue to play a role at therapentic part, so can " activate " filler, make it to continue to produce " filling " effect, and all microgranules will be eliminated in the final filler.Just need this moment to consider to inject next time.
Embodiment 1:
Fig. 1 is the mechanism based on the activated medical skin injection filler of laser.Present embodiment mixes two kinds of microgranules, but can mix more kinds of microgranules in the implementation process of the present invention, and it is more to mix kind, and the prolongation effect of filler is better, as long as use the laser that can smash each microgranule respective wavelength fully just can.
(1) in crosslinked hyaluronic acid filler, mixes two kinds of special microgranules (triangle microgranule and square microgranule), the histocompatibility of these microgranules is good, and (particle diameter is 50 μ m-100 μ m) is of moderate size, neither can be engulfed digestion by the phagocyte in the dermal tissue and be transported in the regional nodes, thus the characteristic such as the not too large viscosity that affects filler and viscoelasticity again.In addition, two kinds of microgranules have different optical absorption characteristics, under the laser action of corresponding absorption peak wavelength, can be smashed fully, wherein the triangle microgranule can be that the red laser of 622-770nm smashes by wavelength, the square microgranule can be that the green laser of 455-492nm smashes by wavelength, and fragment can be engulfed and be transported in the regional nodes.
The hyaluronic acid filler that (2) will infiltrate two kinds of special particles is injected in intradermal.
(3) agent of intradermal injection fillers is by after a while (6-8 month), and the hyaluronic acid composition is sponged by degradable substantially, only leaves over lower those absorbed triangle microgranule of energy and square microgranules in area for treatment.
(4) under the red laser irradiation, the triangle microgranule is fragmentated by explosion, in explosion, can excite circumgranular inflammatory reaction, activate various inflammatory cells, produce inflammatory factor and chemotactic factor, start the injury repairing process, intradermal fibroblast is subject to activation and can produces a large amount of I types and III collagen type in this process, is equivalent to produce from the agent of body endogenous filling in situ and continues to play a role at therapentic part.
(5) the triangle microgranule is eliminated, only remaining square microgranule.
(6) pass through 6-8 month again, after new life's collagen protein is degraded and absorbed, can select green laser again to shine injected area, excite corresponding square microgranule explosion, " activation " filler continues to produce " filling " effect so again.
(7) all microgranules are eliminated in the final filler.Just need this moment to consider to inject next time.
Claims (2)
1. activated medical skin injection filler based on laser is characterized in that: mainly become to be grouped into by crosslinked hyaluronic acid and the good special particles of histocompatibility; Described special particles is incorporated in the crosslinked hyaluronic acid filler, and the particle diameter of special particles is 50 μ m-100 μ m.
2. the activated medical skin injection filler based on laser as claimed in claim 1, it is characterized in that: described special particles has different optical absorption characteristics, can be smashed fully under the laser action of absorption peak wavelength corresponding to special particles, fragment can be engulfed and be transported in the regional nodes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201310007824 CN103041451A (en) | 2013-01-09 | 2013-01-09 | Activatable medical percutaneous injection filler based on laser |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201310007824 CN103041451A (en) | 2013-01-09 | 2013-01-09 | Activatable medical percutaneous injection filler based on laser |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103041451A true CN103041451A (en) | 2013-04-17 |
Family
ID=48054458
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201310007824 Pending CN103041451A (en) | 2013-01-09 | 2013-01-09 | Activatable medical percutaneous injection filler based on laser |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103041451A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104815398A (en) * | 2015-05-25 | 2015-08-05 | 成都凤磐生物科技有限公司 | Photorejuvenation system combined with microneedle sticker |
| CN106421897A (en) * | 2016-10-26 | 2017-02-22 | 曹京敏 | Human body soft tissue filling agent and preparation method thereof and specialized pulverizer |
-
2013
- 2013-01-09 CN CN 201310007824 patent/CN103041451A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104815398A (en) * | 2015-05-25 | 2015-08-05 | 成都凤磐生物科技有限公司 | Photorejuvenation system combined with microneedle sticker |
| CN104815398B (en) * | 2015-05-25 | 2017-10-17 | 成都凤磐生物科技有限公司 | With reference to the photon delicate skin system of microneedle patch |
| CN106421897A (en) * | 2016-10-26 | 2017-02-22 | 曹京敏 | Human body soft tissue filling agent and preparation method thereof and specialized pulverizer |
| CN106421897B (en) * | 2016-10-26 | 2022-04-19 | 曹京敏 | Human soft tissue filler, preparation method thereof and special pulverizer |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI716365B (en) | Injectable dermal filler composition, a kit comprising the same, a method for preparing the same, and a use thereof | |
| KR101296754B1 (en) | A Hydrogel Composition For Transdermal Administration of Drug | |
| JP4532602B2 (en) | Dermal filler composition | |
| CN102229705B (en) | Collagen temperature-sensitive hydrogel and preparation method thereof | |
| CN101842084B (en) | Microparticles comprising PCL and uses thereof | |
| ES2637202T3 (en) | Hyaluronic acid based formulations | |
| CN111840638B (en) | Preparation method of crosslinked hyaluronic acid filler for injection | |
| CN110964215B (en) | Preparation method of L-polylactic acid and cross-linked hyaluronic acid composite gel for injection and obtained product | |
| CN103341216B (en) | Scar-removing repairing material and preparation method thereof | |
| JP2010511454A (en) | Hyaluronic acid gel for intradermal injection | |
| CA2794017C (en) | Dermal filler composition comprising cross-linked dextran having a molecular weight of 30,000 to 100,000 | |
| CN103622864A (en) | Multifunctional aloe gel and preparation method thereof | |
| CN110559489A (en) | Injection filler | |
| CN110812253A (en) | Hyaluronic acid gel for water light injection and use method thereof | |
| Ioelovich | Nanocellulose—Fabrication, structure, properties, and application in the area of care and cure | |
| CN108478453A (en) | Hyaluronic acid face mask liquid and preparation method thereof | |
| KR101967153B1 (en) | The material composition of the filler improving wrinkles, atrophic scars and other skin deficits | |
| CN103041451A (en) | Activatable medical percutaneous injection filler based on laser | |
| CN114904049A (en) | Polycaprolactone microsphere gel containing hyaluronic acid and collagen and preparation method thereof | |
| CN103131029A (en) | Collagen covalent cross-linking hydrogel and preparation method thereof | |
| ITAN20110138A1 (en) | SYNTHESIS OF A MULTIFASIC INJECTABLE GEL BASED ON FREE AND RETICULATED MONOFASIC HYALURONIC ACID AND BIPHASIC HYALURONIC ACID ASSOCIATED WITH HYDROXYAPATITIS WITH INHIBITOR OF IALURONIDASE MICROINCAPSULATE. | |
| CN203090278U (en) | Laser skin hairdressing system based on filler | |
| CN109846808A (en) | Crystallite injection liquid cosmetics, preparation method and skin makeup rifle with spot-removing function | |
| CN115024991B (en) | Anti-aging composition and preparation method and application thereof | |
| Morganti | 37 Chitin Nanofibrils and Their Derivatives as Cosmeceuticals |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130417 |