CN103039962B - A kind of Semen Ziziphi Spinosae oil soft capsule and preparation method thereof - Google Patents
A kind of Semen Ziziphi Spinosae oil soft capsule and preparation method thereof Download PDFInfo
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- CN103039962B CN103039962B CN201110311800.1A CN201110311800A CN103039962B CN 103039962 B CN103039962 B CN 103039962B CN 201110311800 A CN201110311800 A CN 201110311800A CN 103039962 B CN103039962 B CN 103039962B
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- 210000000582 Semen Anatomy 0.000 title claims abstract description 114
- 239000007901 soft capsule Substances 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 108010010803 Gelatin Proteins 0.000 claims description 27
- 229920000159 gelatin Polymers 0.000 claims description 27
- 239000008273 gelatin Substances 0.000 claims description 27
- 235000019322 gelatine Nutrition 0.000 claims description 27
- 235000011852 gelatine desserts Nutrition 0.000 claims description 27
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 27
- 239000000463 material Substances 0.000 claims description 22
- 239000003292 glue Substances 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 230000000576 supplementary Effects 0.000 claims description 8
- 230000000694 effects Effects 0.000 abstract description 9
- 238000005516 engineering process Methods 0.000 abstract description 2
- 230000003860 sleep quality Effects 0.000 abstract description 2
- 239000003921 oil Substances 0.000 description 103
- 230000002159 abnormal effect Effects 0.000 description 30
- 230000035943 smell Effects 0.000 description 30
- OYHQOLUKZRVURQ-IXWMQOLASA-N Linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 10
- 239000002253 acid Substances 0.000 description 8
- 150000002978 peroxides Chemical class 0.000 description 8
- 239000000796 flavoring agent Substances 0.000 description 7
- 235000019634 flavors Nutrition 0.000 description 7
- 239000002994 raw material Substances 0.000 description 7
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N Oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 5
- 235000020778 linoleic acid Nutrition 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 239000002775 capsule Substances 0.000 description 4
- 238000009795 derivation Methods 0.000 description 4
- 235000013402 health food Nutrition 0.000 description 4
- DTOSIQBPPRVQHS-PDBXOOCHSA-N α-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 4
- 206010013980 Dyssomnias Diseases 0.000 description 3
- 206010040984 Sleep disease Diseases 0.000 description 3
- 231100000486 side effect Toxicity 0.000 description 3
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 3
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 3
- 241000700199 Cavia porcellus Species 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 206010022437 Insomnia Diseases 0.000 description 2
- 229960004488 Linolenic Acid Drugs 0.000 description 2
- 239000005642 Oleic acid Substances 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 230000001058 adult Effects 0.000 description 2
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- -1 linolenic acid Chemical class 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 238000007493 shaping process Methods 0.000 description 2
- QGJZLNKBHJESQX-WRJNVHMXSA-N (1R,5aR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid Chemical compound C1CC(O)C(C)(C)C2CCC3(C)[C@]4(C)CCC5(C(O)=O)CC[C@@H](C(=C)C)C5C4CCC3C21C QGJZLNKBHJESQX-WRJNVHMXSA-N 0.000 description 1
- CNNRPFQICPFDPO-UHFFFAOYSA-N 1-Octacosanol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCO CNNRPFQICPFDPO-UHFFFAOYSA-N 0.000 description 1
- 229960002666 1-octacosanol Drugs 0.000 description 1
- HLLSOEKIMZEGFV-UHFFFAOYSA-N 4-(dibutylsulfamoyl)benzoic acid Chemical compound CCCCN(CCCC)S(=O)(=O)C1=CC=C(C(O)=O)C=C1 HLLSOEKIMZEGFV-UHFFFAOYSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 208000003455 Anaphylaxis Diseases 0.000 description 1
- QGJZLNKBHJESQX-FZFNOLFKSA-N Betulinic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C QGJZLNKBHJESQX-FZFNOLFKSA-N 0.000 description 1
- 230000036912 Bioavailability Effects 0.000 description 1
- 210000004369 Blood Anatomy 0.000 description 1
- 210000004907 Glands Anatomy 0.000 description 1
- 206010023683 Lagophthalmos Diseases 0.000 description 1
- 210000004185 Liver Anatomy 0.000 description 1
- 210000004072 Lung Anatomy 0.000 description 1
- 229960003987 Melatonin Drugs 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 210000001672 Ovary Anatomy 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 210000000952 Spleen Anatomy 0.000 description 1
- 210000001541 Thymus Gland Anatomy 0.000 description 1
- 210000004291 Uterus Anatomy 0.000 description 1
- 210000001215 Vagina Anatomy 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001154 acute Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 230000003064 anti-oxidating Effects 0.000 description 1
- 230000000680 avirulence Effects 0.000 description 1
- 230000035514 bioavailability Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 231100000160 chronic toxicity Toxicity 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 235000004626 essential fatty acids Nutrition 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 235000001497 healthy food Nutrition 0.000 description 1
- 230000002489 hematologic Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000009114 investigational therapy Methods 0.000 description 1
- 230000003522 irritant Effects 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
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- 229960004232 linoleic acid Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 230000003505 mutagenic Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000000050 nutritive Effects 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
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- 230000035790 physiological processes and functions Effects 0.000 description 1
- OZAIFHULBGXAKX-UHFFFAOYSA-N precursor Substances N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 230000004799 sedative–hypnotic effect Effects 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000002557 soporific Effects 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 231100000456 subacute toxicity Toxicity 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 210000001519 tissues Anatomy 0.000 description 1
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- 230000002588 toxic Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000002110 toxicologic Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 230000002936 tranquilizing Effects 0.000 description 1
- 230000001228 trophic Effects 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
Abstract
The invention provides a kind of Semen Ziziphi Spinosae oil soft capsule and preparation method thereof.Semen Ziziphi Spinosae oil soft capsule of the present invention uses Semen Ziziphi Spinosae oil to be prepared from through Modern preparations technology, proves through animal function and human feeding trial, has improvement sleep, improves the effect of sleep quality.
Description
Technical field
The present invention relates to a kind of Semen Ziziphi Spinosae oil soft capsule and preparation method thereof, belong to health food and manufacture field.
Background technology
Due to the continuous quickening of people's rhythm of life, competition, operating pressure is continuously increased, and society is aged
The reasons such as change, make the number suffering from sleep disorder be continuously increased.According to World Health Organization (WHO), 14 national investigation are found: 27%
People have sleeping problems, the adult of about 1/3 the most once by insomnia tormented.Wherein the insomnia incidence rate of the U.S. reaches
32-50%, Britain is 10-14%, and West Germany is 15%, and Japan is 20%, and France is 30%.The Sleep questionnaire result of China shows: at present
China insomniac there are about 1.5 hundred million, and dyssomnia person is up to 300,000,000 people, wherein more than 200,000,000 lives in city.In adult, there are about
50% experience having dyssomnia, and working woman more has the people of up to 80% perplexed by dyssomnia, by this in middle-aged and elderly people
That perplexs is the most quite a lot.Evidence suggests: sleep disorder may result in degeneration or the disappearance of human body own physiological function, finally leads
Cause the generation of various physiological decease.Therefore, the most effectively prevent and treat sleep disorder and become the 21 century mankind and pursue Gao Pin
One of obstacle of matter healthy living.Meanwhile, progressively strengthen and people's nothing to high-quality healthy living along with people's care concepts
Limit is pursued, and sleep market necessarily will become huge fresh combatants of 21 century health-product market.
At present, market is improved the research of sleep and much concentrate on Western medicine such as melatonin and the aspect such as stable, although tool
There is certain effect, but long-term taking can produce certain dependency and side effect.Semen Ziziphi Spinosae is the health food of integration of edible and medicinal herbs
Raw material, document is recorded has the effect improving sleep, is processed into and has the health food improving sleep function, not only eats
Safe and reliable, and effect is notable；Not there is side effect simultaneously, do not have toleration.
Semen Ziziphi Spinosae oil is by the Semen Ziziphi Spinosae oil and fat product that to be raw material make through squeezing, the working procedure processing such as refined.Medical science now
Research proves, Semen Ziziphi Spinosae oil has inhibitory action to mice nervus centralis, and mice tranquilizing soporific is had good curative effect, and time long
Between use there is no toleration, meanwhile, this central inhibitory action does not interferes with the memory function of mice, on the contrary, strengthens little on the contrary
The memory function of Mus, clinical long-time clothes do not have toxicity, and without mutagenic action, also document shows, unsaturated in Semen Ziziphi Spinosae oil
Fatty acid has obvious sedative-hypnotic effect to mice, and a lot of document shows: rich in oleic acid, sub-oil in Semen Ziziphi Spinosae oil
Acid, the unsaturated fatty acid such as linolenic acid, these unsaturated fatty acids exist, can be converted in vivo endogenous sleep derivation material or
Person can promote endogenous sleep derivation substance release, thus improves sleep quality.
Summary of the invention
It is an object of the invention to provide a kind of Semen Ziziphi Spinosae oil soft capsule and preparation method thereof.
Semen Ziziphi Spinosae oil soft capsule of the present invention is made up of the supplementary material of following weight ratio:
Semen Ziziphi Spinosae oil 95-99.8 Semen Tritici aestivi germ oil 0.2-5.
It is preferably:
Semen Ziziphi Spinosae oil 95 Semen Tritici aestivi germ oil 5.
Or it is preferably:
Semen Ziziphi Spinosae oil 99.8 Semen Tritici aestivi germ oil 0.2.
Or it is preferably:
Semen Ziziphi Spinosae oil 99 Semen Tritici aestivi germ oil 1.
Or it is preferably:
Semen Ziziphi Spinosae oil 98 Semen Tritici aestivi germ oil 2.
Or it is preferably:
Semen Ziziphi Spinosae oil 98.5 Semen Tritici aestivi germ oil 1.5.
Or it is preferably:
Semen Ziziphi Spinosae oil 99.5 Semen Tritici aestivi germ oil 0.5.
Present invention also offers the preparation method of this Semen Ziziphi Spinosae oil soft capsule, steps of the method are:
A) proportionally weigh Semen Ziziphi Spinosae oil and Semen Tritici aestivi germ oil, mix homogeneously, obtain mixed material；
B) according to gelatin 38-46 weight portion, water 34-42 weight portion, the ratio of glycerol 16-24 weight portion, 60-70 DEG C of change
Glue, obtains gelatin solution；
C) step a) gained mixed material is encapsulated as soft capsule with the gelatin solution of step b) gained.
It is preferably:
A) proportionally weigh Semen Ziziphi Spinosae oil and Semen Tritici aestivi germ oil, mix homogeneously, obtain mixed material；
B) according to gelatin 42 weight portion, water 38 weight portion, the ratio of glycerol 20 weight portion, change glue at 65 DEG C, obtain gelatin solution；
C) step a) gained mixed material is encapsulated as soft capsule with the gelatin solution of step b) gained.
Semen Ziziphi Spinosae oil belongs to oleic acid, linoleic acid oils and fats, and its linoleic acid content is up to 50%, higher than Oleum Arachidis hypogaeae semen (25%),
Olive pulls the Oleic Linoleic quasi-greases such as oil (10 %) and Oleum Camelliae (15%), linoleic acid as the essential fatty acid of human body,
Playing very important effect in terms of Human Physiology, it is that human cell tissue and parathyrine synthesize the precursor that can not lack, tool
There is very important trophic function.In addition, possibly together with a series of other biological active ingredients in Semen Ziziphi Spinosae, as sterol, three
Terpenoid such as betulin and betulic acid, Semen Ziziphi Spinosae Saponin etc., modern pharmacology research display: contain in Semen Ziziphi Spinosae oil
Various plants fatty acid can be converted into endogenous sleep derivation material in vivo or endogenous sleep derivation material can be promoted to release
Put, there is regulation S sleep, the effect of induced physiological sleep, take for a long time and have no its toleration, simultaneously and have no secondary
Effect report, additionally, Semen Ziziphi Spinosae oil itself is again to be formed by refined in pure natural plant, without any side effects to human body.Cause
This can be as novel improvement sleep assistant health product.
Semen Ziziphi Spinosae oil soft capsule of the present invention has the characteristics that and advantage:
In terms of feed preparation process, use cold-squeezing to extract and obtain, extract overall process and do not use organic solvent, it is to avoid
Organic solvent residual problem, the quality preservation of oil is pure, and safety is high, does not destroy the unsaturated fatty acids such as linoleic acid simultaneously
Nutritional labeling, nutritive value is higher.
In terms of prescription compatibility, Semen Ziziphi Spinosae oil is oiliness raw material, easily aoxidizes, raw containing abundant dimension in Semen Tritici aestivi germ oil
The multiple lifes such as element E, linoleic acid, linolenic acid, octacosanol and multiple physiologically active component, have anti-antioxidation, slow down aging
Reason activity, the two compatibility uses, can extend the shelf-life of product, simultaneously both at oils product, has good intersolubility,
Not stratified, not suspendible, it is easy to preparations shaping.
For confirming the stable of Semen Tritici aestivi germ oil and antioxidation, contrived experiment is provided with 6 different Semen Tritici aestivi germ oils and adds
Enter amount, different samples are carried out trimestral accelerated stability test experiment, investigates the color of Semen Ziziphi Spinosae oil, transparency, gas
Taste, flavour, acid value, 6 indexs of peroxide value.
1. prepared by sample: self-control Semen Ziziphi Spinosae oil, 6 parts, is separately added into different amounts of wheat germ oil: 0%, 0.2%, 0.5%, 1.0%,
1.5%, 2.0%.
2. accelerated stability test: by 6 parts of Semen Ziziphi Spinosae oil, in temperature 40 DEG C ± 2 DEG C, the condition of relative humidity 75% ± 5%
Lower placement 3 months, at 0 month, 1 month, 2 months, 3 months intervals, periodic inspection indices.The results are shown in Table 1-6.
Table 1 is not added with Semen Tritici aestivi germ oil
| Standing time | 0 month | January | February | March |
| Color | Yellowish-brown oily | Yellowish-brown oily | Yellowish-brown oily | Yellowish-brown oily |
| Clarity | Transparent | Transparent | Transparent | Transparent |
| Abnormal smells from the patient | There is the intrinsic abnormal smells from the patient of Semen Ziziphi Spinosae oil | There is the intrinsic abnormal smells from the patient of Semen Ziziphi Spinosae oil | There is the intrinsic abnormal smells from the patient of Semen Ziziphi Spinosae oil | There is the intrinsic abnormal smells from the patient of Semen Ziziphi Spinosae oil |
| Flavour | Tasteless, free from extraneous odour | Tasteless, free from extraneous odour | Tasteless, free from extraneous odour | Tasteless, free from extraneous odour |
| Acid value | 16.48 | 18.45 | 19.05 | 19.06 |
| Peroxide value | 4.06 | 4.12 | 4.20 | 4.21 |
Table 2 adds 0.2% Semen Tritici aestivi germ oil
| Standing time | 0 month | January | February | March |
| Color | Yellowish-brown oily | Yellowish-brown oily | Yellowish-brown oily | Yellowish-brown oily |
| Clarity | Transparent | Transparent | Transparent | Transparent |
| Abnormal smells from the patient | There is the intrinsic abnormal smells from the patient of Semen Ziziphi Spinosae oil | There is the intrinsic abnormal smells from the patient of Semen Ziziphi Spinosae oil | There is the intrinsic abnormal smells from the patient of Semen Ziziphi Spinosae oil | There is the intrinsic abnormal smells from the patient of Semen Ziziphi Spinosae oil |
| Flavour | Tasteless, free from extraneous odour | Tasteless, free from extraneous odour | Tasteless, free from extraneous odour | Tasteless, free from extraneous odour |
| Acid value | 16.48 | 18.01 | 18.36 | 18.38 |
| Peroxide value | 4.06 | 4.11 | 4.15 | 4.15 |
Table 3 adds 0.5% Semen Tritici aestivi germ oil
| Standing time | 0 month | January | February | March |
| Color | Yellowish-brown oily | Yellowish-brown oily | Yellowish-brown oily | Yellowish-brown oily |
| Clarity | Transparent | Transparent | Transparent | Transparent |
| Abnormal smells from the patient | There is the intrinsic abnormal smells from the patient of Semen Ziziphi Spinosae oil | There is the intrinsic abnormal smells from the patient of Semen Ziziphi Spinosae oil | There is the intrinsic abnormal smells from the patient of Semen Ziziphi Spinosae oil | There is the intrinsic abnormal smells from the patient of Semen Ziziphi Spinosae oil |
| Flavour | Tasteless, free from extraneous odour | Tasteless, free from extraneous odour | Tasteless, free from extraneous odour | Tasteless, free from extraneous odour |
| Acid value | 16.48 | 17.86 | 18.08 | 18.13 |
| Peroxide value | 4.06 | 4.06 | 4.09 | 4.10 |
Table 4 adds 1.0% Semen Tritici aestivi germ oil
| Standing time | 0 month | January | February | March |
| Color | Yellowish-brown oily | Yellowish-brown oily | Yellowish-brown oily | Yellowish-brown oily |
| Clarity | Transparent | Transparent | Transparent | Transparent |
| Abnormal smells from the patient | There is the intrinsic abnormal smells from the patient of Semen Ziziphi Spinosae oil | There is the intrinsic abnormal smells from the patient of Semen Ziziphi Spinosae oil | There is the intrinsic abnormal smells from the patient of Semen Ziziphi Spinosae oil | There is the intrinsic abnormal smells from the patient of Semen Ziziphi Spinosae oil |
| Flavour | Tasteless, free from extraneous odour | Tasteless, free from extraneous odour | Tasteless, free from extraneous odour | Tasteless, free from extraneous odour |
| Acid value | 16.48 | 16.93 | 17.41 | 17.45 |
| Peroxide value | 4.06 | 4.04 | 4.07 | 4.09 |
Table 5 adds 1.5% Semen Tritici aestivi germ oil
| Standing time | 0 month | January | February | March |
| Color | Yellowish-brown oily | Yellowish-brown oily | Yellowish-brown oily | Yellowish-brown oily |
| Clarity | Transparent | Transparent | Transparent | Transparent |
| Abnormal smells from the patient | There is the intrinsic abnormal smells from the patient of Semen Ziziphi Spinosae oil | There is the intrinsic abnormal smells from the patient of Semen Ziziphi Spinosae oil | There is the intrinsic abnormal smells from the patient of Semen Ziziphi Spinosae oil | There is the intrinsic abnormal smells from the patient of Semen Ziziphi Spinosae oil |
| Flavour | Tasteless, free from extraneous odour | Tasteless, free from extraneous odour | Tasteless, free from extraneous odour | Tasteless, free from extraneous odour |
| Acid value | 16.53 | 17.12 | 17.15 | 17.18 |
| Peroxide value | 4.06 | 4.05 | 4.06 | 4.06 |
Table 6 adds 2.0% Semen Tritici aestivi germ oil
| Standing time | 0 month | January | February | March |
| Color | Yellowish-brown oily | Yellowish-brown oily | Yellowish-brown oily | Yellowish-brown oily |
| Clarity | Transparent | Transparent | Transparent | Transparent |
| Abnormal smells from the patient | There is the intrinsic abnormal smells from the patient of Semen Ziziphi Spinosae oil | There is the intrinsic abnormal smells from the patient of Semen Ziziphi Spinosae oil | There is the intrinsic abnormal smells from the patient of Semen Ziziphi Spinosae oil | There is the intrinsic abnormal smells from the patient of Semen Ziziphi Spinosae oil |
| Flavour | Tasteless, free from extraneous odour | Tasteless, free from extraneous odour | Tasteless, free from extraneous odour | Tasteless, free from extraneous odour |
| Acid value | 16.53 | 17.10 | 17.10 | 17.15 |
| Peroxide value | 4.06 | 4.06 | 4.07 | 4.06 |
3. interpretation of result: investigated by accelerated stability test, after adding Semen Tritici aestivi germ oil, soft capsule content stablizes
Property significantly improve (face shaping change is little, but acid value and peroxide value reduce, and illustrate to be difficult to become sour, stability raising), add
Entering amount is that 1.5% and 2.0% difference is inconspicuous.
In terms of preparation process, this product primary raw material, based on the oily matter of liquid, uses advanced soft capsule bag
Encapsulation technique, it is ensured that the stability of content, improves its bioavailability, and good looking appearance, it is easy to carry, the side of taking simultaneously
Just.
Semen Ziziphi Spinosae oil raw material Semen Ziziphi Spinosae (parched) is that " notice that Ministry of Public Health manages about further specification healthy food material " (is defended
Method prison sends out [2002] No. 51) in the kind recorded of adnexa 1, belong to " being food and the article of medicine ".Use as food,
Its safety is higher.
In Modern Literature, the safety to Semen Ziziphi Spinosae oil is studied, and result shows: big mice is not all surveyed by Semen Ziziphi Spinosae oil
Go out LD50, rabbit skin irritation test has no acute toxic reaction.The body weight of rat, hematological examination, blood biochemical analysis check nothing
Significant difference, the heart of rat, liver, spleen, lung, ' translate, ' organ perusal such as the upper gland of brother, thymus, pungent ball, uterus, ovary and
Pathological section light microscopy checking, does not all find obvious pathological change.Guinea pig skin, lagophthalmos eyeball and vagina topical application, have no obvious
Irritant reaction.Guinea pig skin has no anaphylaxis.Conclude that clinical practice Semen Ziziphi Spinosae oil avirulence.
Belonging to sum up, the kind of raw material selected by this formula and consumption meet the relevant regulations of health food, this product formula section
Learning, without incompatibility, selected raw material type and consumption per day meet relevant regulations, and meanwhile, this product proves it is also peace through toxicological test
Complete, human body will not be produced any acute, subacute and chronic toxicity.
Detailed description of the invention
Following embodiment is for illustrating the preparation of Semen Ziziphi Spinosae oil soft capsule of the present invention, but it can not be to the model of the present invention
Enclose any restriction of composition.
Embodiment 1
Supplementary material ratio:
Semen Ziziphi Spinosae oil 9500g Semen Tritici aestivi germ oil 500g.
Preparation method:
A) proportionally weigh Semen Ziziphi Spinosae oil and Semen Tritici aestivi germ oil, mix homogeneously, obtain mixed material；
B) according to gelatin 3800g, water 4200g, the ratio of glycerol 2400g, change glue at 60 DEG C, obtain gelatin solution；
C) step a) gained mixed material is encapsulated as soft capsule with the gelatin solution of step b) gained, prepare 1.26 ten thousand soft
Capsule.
Embodiment 2
Supplementary material ratio:
Semen Ziziphi Spinosae oil 9800g Semen Tritici aestivi germ oil 200g.
Preparation method:
A) proportionally weigh Semen Ziziphi Spinosae oil and Semen Tritici aestivi germ oil, mix homogeneously, obtain mixed material；
B) according to gelatin 4600g, water 3400g, the ratio of glycerol 1600g, change glue at 70 DEG C, obtain gelatin solution；
C) step a) gained mixed material is encapsulated as soft capsule with the gelatin solution of step b) gained, obtains 1.25 ten thousand flexible glues
Capsule.
Embodiment 3
Supplementary material ratio:
Semen Ziziphi Spinosae oil 9850g Semen Tritici aestivi germ oil 150g.
Preparation method:
A) proportionally weigh Semen Ziziphi Spinosae oil and Semen Tritici aestivi germ oil, mix homogeneously, obtain mixed material；
B) according to gelatin 4200g, water 3800g, the ratio of glycerol 2000g, change glue at 65 DEG C, obtain gelatin solution；
C) step a) gained mixed material is encapsulated as soft capsule with the gelatin solution of step b) gained, obtains 1.28 ten thousand flexible glues
Capsule.
Embodiment 4
Supplementary material ratio:
Semen Ziziphi Spinosae oil 9900g Semen Tritici aestivi germ oil 100g.
Preparation method:
A) proportionally weigh Semen Ziziphi Spinosae oil and Semen Tritici aestivi germ oil, mix homogeneously, obtain mixed material；
B) according to gelatin 4000g, water 4000g, the ratio of glycerol 2000g, change glue at 68 DEG C, obtain gelatin solution；
C) step a) gained mixed material is encapsulated as soft capsule with the gelatin solution of step b) gained, obtains 1.26 ten thousand flexible glues
Capsule.
Embodiment 5
Supplementary material ratio:
Semen Ziziphi Spinosae oil 9950g Semen Tritici aestivi germ oil 150g.
Preparation method:
A) proportionally weigh Semen Ziziphi Spinosae oil and Semen Tritici aestivi germ oil, mix homogeneously, obtain mixed material；
B) according to gelatin 4400g, water 3800g, the ratio of glycerol 1600g, change glue at 62 DEG C, obtain gelatin solution；
C) step a) gained mixed material is encapsulated as soft capsule with the gelatin solution of step b) gained, obtains soft capsule 1.27 ten thousand
Grain.
Embodiment 6
Supplementary material ratio:
Semen Ziziphi Spinosae oil 9980g Semen Tritici aestivi germ oil 20g.
Preparation method:
A) proportionally weigh Semen Ziziphi Spinosae oil and Semen Tritici aestivi germ oil, mix homogeneously, obtain mixed material；
B) according to gelatin 4000g, water 4200g, the ratio of glycerol 1800g, change glue at 66 DEG C, obtain gelatin solution；
C) step a) gained mixed material is encapsulated as soft capsule with the gelatin solution of step b) gained, obtains 1.24 ten thousand flexible glues
Capsule.
Claims (1)
1. a Semen Ziziphi Spinosae oil soft capsule, it is characterised in that be made up of the supplementary material of following weight ratio:
Semen Ziziphi Spinosae oil 98.5 Semen Tritici aestivi germ oil 1.5,
The preparation method of described Semen Ziziphi Spinosae oil soft capsule, is made up of the following step:
A) proportionally weigh Semen Ziziphi Spinosae oil and Semen Tritici aestivi germ oil, mix homogeneously, obtain mixed material；
B) according to gelatin 42 weight portion, water 38 weight portion, the ratio of glycerol 20 weight portion, change glue at 65 DEG C, obtain gelatin solution；
C) step a) gained mixed material is encapsulated as soft capsule with the gelatin solution of step b) gained.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110311800.1A CN103039962B (en) | 2011-10-15 | A kind of Semen Ziziphi Spinosae oil soft capsule and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110311800.1A CN103039962B (en) | 2011-10-15 | A kind of Semen Ziziphi Spinosae oil soft capsule and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103039962A CN103039962A (en) | 2013-04-17 |
| CN103039962B true CN103039962B (en) | 2016-12-14 |
Family
ID=
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1491693A (en) * | 2003-09-10 | 2004-04-28 | 西安交通大学 | Extraction of wild jujube seed oil and preparation of soft capsule and function on central nervous system |
| CN101518581A (en) * | 2009-04-08 | 2009-09-02 | 延安大学 | Compound gardenia oil soft capsule and method for preparing same |
| CN102228249A (en) * | 2011-07-07 | 2011-11-02 | 合肥工业大学 | Method for manufacturing wheat germ oil microcapsule |
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1491693A (en) * | 2003-09-10 | 2004-04-28 | 西安交通大学 | Extraction of wild jujube seed oil and preparation of soft capsule and function on central nervous system |
| CN101518581A (en) * | 2009-04-08 | 2009-09-02 | 延安大学 | Compound gardenia oil soft capsule and method for preparing same |
| CN102228249A (en) * | 2011-07-07 | 2011-11-02 | 合肥工业大学 | Method for manufacturing wheat germ oil microcapsule |
Non-Patent Citations (1)
| Title |
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| 小麦胚芽及其脂类和蛋白质的研究现状;曲艺，等;《食品加工》;20090131(第1期);第32-35页 * |
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Effective date of registration: 20221010 Address after: 050035 no.238 Tianshan Street, high tech Zone, Shijiazhuang City, Hebei Province Patentee after: Yiling Health Technology Co.,Ltd. Address before: 102600 17 Tianfu street, Daxing biomedical industry base, Zhongguancun Science and Technology Park, Daxing District, Beijing Patentee before: BEIJING YILING PHARMACEUTICAL Co.,Ltd. |