CN103027788B - Preparation method of absorbable medical dressing - Google Patents
Preparation method of absorbable medical dressing Download PDFInfo
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- CN103027788B CN103027788B CN201310003806.1A CN201310003806A CN103027788B CN 103027788 B CN103027788 B CN 103027788B CN 201310003806 A CN201310003806 A CN 201310003806A CN 103027788 B CN103027788 B CN 103027788B
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Abstract
The invention provides an absorbable medical dressing. The absorbable medical dressing comprises an elastic backing and a polymeric matrix layer arranged on the backing, wherein the backing comprises at least one of polyurethane, hyaluronic acid, hyaluronate, absorbable aliphatic polyester and polyhydroxy butyric acid; the polymeric matrix layer comprises at least one of polyacrylic acid, alginic acid, chitosan, water-soluble polyamide, chitosan derivative, polylysine and cellulose derivative; a medicine layer is arranged on the polymeric matrix layer; and the medicine layer comprises at least one of collagen, fibrinogen, growth factor and antibiotic. A preparation method of the absorbable medical dressing comprises the following steps: (1) preparing a polymeric matrix aqueous solution; (2) injecting the prepared polymeric matrix aqueous solution into a mould; (3) freezing the polymeric matrix aqueous solution in the mould; (4) lyophilizing the frozen polymeric matrix aqueous solution; and (5) postprocessing polymeric matrix sponge to prepare the absorbable medical dressing.
Description
Technical field
The present invention relates to a kind of dressing and preparation method thereof, spy is standby is a kind of absorbability medical dressing and preparation method thereof.
Background technology
Wound is the serious problems of harm humans health, according to World Health Organization's trauma care guide, the whole world every day have 16000 people because of wound lethal, and because wound to cause medical expense be up to 16% of all global medical expenses, wherein create in the wounded, have 1/3 be because of the relevant multiple organs failure of losing blood and lose blood lethal.If can stop blooding timely and effectively, to saving wounded's life, stablize traumatic condition, for successive treatment creates conditions very important.And dressing is as hemostatic material, refer to the covering that covers on wound, has protective effect, can assist Bleeding control, to protect from infection and absorb secretions, bleeding-stopping dressing has great significance for timely hemostasis.Meanwhile, hemostasis in art, reduce lose blood, keep visual area clear, prevent vital tissue damage, guarantee that operation safety and postoperative wound healing etc. are all significant.
Traditional bleeding-stopping dressing is generally by adding bioactive molecule, as thrombin and the former albumen of fiber, improve the anthemorrhagic performance of dressing, but the manufacturing cost of this class dressing is higher, and keeps the specific activity of such bioactive molecule more difficult.Existing bleeding-stopping dressing is a kind of chitosan derivatives after polyacrylic acid modified, main performance is that water absorption is very excellent, but polyacrylic biological safety does not get the nod so far, the chitosan sthptic sponge having on market is to take the mandruka that chitosan and gelatin be main component, its humid stability is very poor, the wound that is easy to ooze out at a large amount of blood dissolves, and cannot bring into play coagulant property.
Summary of the invention
In order to solve the deficiencies in the prior art, the invention provides a kind of safe and reliable, absorbability medical dressing that humid stability is good and preparation method thereof.
The technical solution adopted for the present invention to solve the technical problems is:
A kind of absorbability medical dressing, comprise and there is elastic backing and be arranged on the polymer matrix layer on backing, described backing is by polyurethane, hyaluronic acid, hyaluronate, at least one composition in absorbability aliphatic polyester or poly butyric, polymer matrix layer is by polyacrylic acid, alginic acid, chitosan, water soluble polyamide, chitosan derivatives, at least one composition in polylysine or cellulose derivative, in polymer matrix layer, be provided with medicine layer, described medicine layer is by collagen protein, Fibrinogen, at least one composition in somatomedin or antibiotic.
As such scheme preferably, described backing is poly butyric material, poly butyric material has good thermoplasticity, and can be degradable be in vivo carbon dioxide.
Described polymer matrix layer is comprised of chitosan, and chitosan has the biologic activity such as hemostatic bacteriostatic, and is Biodegradable material, can be degradable in vivo.
A preparation method for absorbability medical dressing as above, comprises the following steps:
(1) produce polymeric matrix aqueous solution: choose polymeric matrix, polymeric matrix is polyacrylic acid, alginic acid, chitosan, water soluble polyamide, chitosan derivatives, at least one in polylysine or cellulose derivative, the polymeric matrix that utilization is chosen is prepared polymeric matrix aqueous solution, in polymeric matrix aqueous solution, add acidic materials and medicine, in the polymeric matrix aqueous solution making, the concentration of polymeric matrix is 0.1%～2.5%, the concentration of acidic materials is 0.5%～5%, acidic materials are glutamic acid, lactic acid, hydrochloric acid, any one in acetic acid or glycolic, the mass ratio of medicine and polymeric matrix is 1:1000～1:10000,
(2) prepared polymeric matrix aqueous solution is injected to mould: the length for the mould of polymeric matrix aqueous solution injection molding is 60～70cm, width is 9～21cm, described mould has 3 chambers, and the height of chamber is 0.05～0.2cm, and width is 2～6cm;
(3) to the polymeric matrix aqueous solution in mould, carry out freezing: the mould that polymeric matrix aqueous solution is housed is inserted to freeze dryer cryodesiccation chamber, described refrigerating process includes four steps, the first step is hygral equilibrium process, in hygral equilibrium process, temperature is 20～25 ℃, and equilibration time is 2～5h; Second step is temperature-fall period, is cooled to 2～10 ℃, and keeps the temperature 20～60min of 2～10 ℃ with the rate of temperature fall of 0.3～1.0 ℃/min; The 3rd step is cooling deferring procedure, and the rate of temperature fall continuation cooling with 0.3～1.0 ℃/min, when cooling temperature reaches-5 ℃, need to keep the of short duration stage of rising again, and the temperature of rising again is-3～0 ℃, and the retention time is 3～5min; The 4th step is for continuing temperature-fall period, with the rate of temperature fall of 0.3～1.0 ℃/min, continues to be cooled to-40 ℃, and at-40 ℃ of freezing 30～60min.After freezing completing, obtain refrigeration material;
(4) refrigeration material is carried out to lyophilizing: negative pressure be in the environment of-80～-20KPa to refrigeration material lyophilizing, lyophilizing includes four steps, the first step is the stage of being rapidly heated, temperature is rapidly heated to 0 ℃ by cryogenic temperature, the heating-up time is 20～50min; Second step is delayed phase, and temperature remains on 0 ℃, and be 400～600min time delay; The 3rd step is for continuing the stage of being rapidly heated, and temperature is rapidly heated to 35～40 ℃ by 0 ℃, and the heating-up time is 20～50min; The 4th step is for continuing delayed phase, and temperature remains on 35～40 ℃ of intensification temperature, and be 1000～2000min time delay; After lyophilizing completes, obtain polymeric matrix sponge;
(5) polymeric matrix sponge is carried out to post processing, make absorbability medical dressing: described post processing comprises three steps, the first step is the densification stage, utilize hot melt by polymeric matrix sponge and backing laminating, then take hot plate compression method, make polymeric matrix sponge and backing bonding, the temperature that hot plate compression method is selected is 75～85 ℃, moulding pressure is 0.5～0.6MPa, and the thickness of resulting polymers substrate sponge is 0.6～10mm, and density is 0.1～0.5g/m
3; Second step is pretreatment stage, and by polymeric matrix sponge and backing baking, bake out temperature is 75～80 ℃, and drying time is 0.25～0.5h.The processing stage that the 3rd step being softening, adopt softening machine that polymeric matrix sponge and backing are softened, make absorbability medical dressing, the Gurley hardness number of resulting polymers substrate sponge is 2000～10000.
As such scheme preferably, described polymeric matrix is that molecular weight is the chitosan of 150～300Qian Dao Er, the deacetylation of chitosan is 80%～95%.
In step (1), need polymeric matrix aqueous solution to carry out vacuum deaerator in the preparation process of polymeric matrix aqueous solution, the pressure of vacuum deaerator is-8 * 10
5～-3 * 10
5pa, the deaeration time is 5～30min.
The beneficial effect that the present invention has than prior art is: absorbability medical dressing provided by the invention and preparation method thereof, adopt polymeric matrix that absorbability is good as polymer matrix layer, and in polymer matrix layer, be provided with carrier layer, carrier layer is the ingredients with healing property, safety and the curative effect of dressing have been improved, and by techniques such as freezing, lyophilizing, densification, pretreatment and softening processing, change the hardness of dressing, improved the humid stability of dressing.
The specific embodiment
Below in conjunction with embodiment, the invention will be further described.
In the present embodiment 1, first produce polymeric matrix aqueous solution: the chitosan 455g that chooses molecular weight Wei300 thousand Dao Er, the deacetylation of chitosan is 95%, the chitosan that utilization is chosen is prepared chitosan aqueous solution, in chitosan aqueous solution, add acetic acid and 0.4g collagen protein, in the chitosan aqueous solution making, the concentration of chitosan is 2.3%, and the concentration of acetic acid is 4%, in chitosan aqueous solution preparation process, need chitosan aqueous solution to carry out vacuum deaerator, deaeration pressure is-3 * 10
5pa, the deaeration time is 5min;
Secondly prepared polymeric matrix aqueous solution is injected to mould: the length for the mould of polymeric matrix aqueous solution injection molding is 60～70cm, width is 9～21cm, described mould has 3 chambers, and the height of chamber is 0.05～0.2cm, and width is 2～6cm;
Then the chitosan aqueous solution in mould is carried out freezing: the mould that chitosan aqueous solution is housed is inserted to freeze dryer cryodesiccation chamber, described refrigerating process includes four steps, the first step is hygral equilibrium process, and in hygral equilibrium process, temperature is preferably 25 ℃, and equilibration time is preferably 5h; Second step is temperature-fall period, is cooled to 2 ℃, and keeps the temperature 60min of 2 ℃ with the rate of temperature fall of 0.5 ℃/min; The 3rd step is cooling deferring procedure, and the rate of temperature fall continuation cooling with 0.5 ℃/min, when cooling temperature reaches-5 ℃, need to keep the of short duration stage of rising again, and the temperature of rising again is-3 ℃, and the retention time is 5min; The 4th step is for continuing temperature-fall period, with the rate of temperature fall of 0.5 ℃/min, continues to be cooled to-40 ℃, and at-40 ℃ of freezing 30min.After freezing completing, obtain refrigeration material;
Then refrigeration material is carried out to lyophilizing: in the environment that is-80KPa in negative pressure,, to refrigeration material lyophilizing, lyophilizing includes four steps, and the first step is the stage of being rapidly heated, and temperature is rapidly heated to 0 ℃ by cryogenic temperature, and the heating-up time is 50min; Second step is delayed phase, and temperature remains on 0 ℃, and be 600min time delay; The 3rd step is for continuing the stage of being rapidly heated, and temperature is rapidly heated to 40 ℃ by 0 ℃, and the heating-up time is 40min; The 4th step is for continuing delayed phase, and temperature remains on 40 ℃ of intensification temperature, and be 2000min time delay; After lyophilizing completes, obtain chitosan sponge;
Next step carries out post processing by chitosan sponge: described post processing comprises three steps, the first step is the densification stage, utilize hot melt by chitosan sponge and backing laminating, take again hot plate compression method, make polymeric matrix sponge and backing bonding, the temperature that hot plate compression method is selected is 80 ℃, and moulding pressure is 0.5MPa, the thickness of gained chitosan sponge is 10mm, and density is 0.1g/m
3; Second step is pretreatment stage, takes baking, and bake out temperature is 80 ℃, and drying time is 0.5h.The processing stage that the 3rd step being softening, adopt softening machine that polymeric matrix sponge and backing are softened, make absorbability medical dressing, the Gurley hardness number of gained chitosan sponge is 4000.
Then the dressing assembling is cut, encapsulate and use the sterilizing of 19kGy gamma ray.
In the present embodiment 2, first produce polymeric matrix aqueous solution: the chitosan 455g that chooses molecular weight Wei150 thousand Dao Er, the deacetylation of chitosan is 85%, the chitosan that utilization is chosen is prepared chitosan aqueous solution, in chitosan aqueous solution, add acetic acid and 0.4g somatomedin, in the chitosan aqueous solution making, the concentration of chitosan is 0.1%, and the concentration of acetic acid is 0.8%, in chitosan aqueous solution preparation process, need chitosan aqueous solution to carry out vacuum deaerator, deaeration pressure is-8 * 10
5pa, the deaeration time is 30min;
Secondly prepared polymeric matrix aqueous solution is injected to mould: the length for the mould of polymeric matrix aqueous solution injection molding is 60～70cm, width is 9～21cm, described mould has 3 chambers, and the height of chamber is 0.05～0.2cm, and width is 2～6cm;
Then the chitosan aqueous solution in mould is carried out freezing: the mould that chitosan aqueous solution is housed is inserted to freeze dryer cryodesiccation chamber, described refrigerating process includes four steps, the first step is hygral equilibrium process, and in hygral equilibrium process, temperature is preferably 20 ℃, and equilibration time is preferably 2h; Second step is temperature-fall period, is cooled to 10 ℃, and keeps the temperature 20min of 10 ℃ with the rate of temperature fall of 0.3 ℃/min; The 3rd step is cooling deferring procedure, and the rate of temperature fall continuation cooling with 0.3 ℃/min, when cooling temperature reaches-5 ℃, need to keep the of short duration stage of rising again, and the temperature of rising again is 0 ℃, and the retention time is 3min; The 4th step is for continuing temperature-fall period, with the rate of temperature fall of 0.3 ℃/min, continues to be cooled to-40 ℃, and at-40 ℃ of freezing 50min.After freezing completing, obtain refrigeration material;
Then refrigeration material is carried out to lyophilizing: in the environment that is-20KPa in negative pressure,, to refrigeration material lyophilizing, lyophilizing includes four steps, and the first step is the stage of being rapidly heated, and temperature is rapidly heated to 0 ℃ by cryogenic temperature, and the heating-up time is 20min; Second step is delayed phase, and temperature remains on 0 ℃, and be 400min time delay; The 3rd step is for continuing the stage of being rapidly heated, and temperature is rapidly heated to 40 ℃ by 0 ℃, and the heating-up time is 20min; The 4th step is for continuing delayed phase, and temperature remains on 40 ℃ of intensification temperature, and be 1300min time delay; After lyophilizing completes, obtain chitosan sponge;
Next step carries out post processing by chitosan sponge: described post processing comprises three steps, described post processing comprises three steps, the first step is the densification stage, utilize hot melt by polymeric matrix sponge and backing laminating, then take hot plate compression method, make polymeric matrix sponge and backing bonding, the temperature that hot plate compression method is selected is 75 ℃, moulding pressure is 0.6MPa, and the thickness of gained chitosan sponge is 0.6mm, and density is 0.3g/m
3; Second step is pretreatment stage, takes baking, and bake out temperature is 75 ℃, and drying time is 0.25h.The processing stage that the 3rd step being softening, adopt softening machine that polymeric matrix sponge and backing are softened, make absorbability medical dressing, the Gurley hardness number of gained chitosan sponge is 2000.
Then the dressing assembling is cut, encapsulate and use the sterilizing of 15kGy gamma ray.
In the present embodiment 3, first produce polymeric matrix aqueous solution: the chitosan 455g that chooses molecular weight Wei200 thousand Dao Er, the deacetylation of chitosan is 90%, the chitosan that utilization is chosen is prepared chitosan aqueous solution, in chitosan aqueous solution, add acetic acid and 0.04g Fibrinogen, in the chitosan aqueous solution making, the concentration of chitosan is 1%, and the concentration of acetic acid is 2%, in chitosan aqueous solution preparation process, need chitosan aqueous solution to carry out vacuum deaerator, deaeration pressure is-5 * 10
5pa, the deaeration time is 20min;
Secondly prepared polymeric matrix aqueous solution is injected to mould: the length for the mould of polymeric matrix aqueous solution injection molding is 60～70cm, width is 9～21cm, described mould has 3 chambers, and the height of chamber is 0.05～0.2cm, and width is 2～6cm;
Then the chitosan aqueous solution in mould is carried out freezing: the mould that chitosan aqueous solution is housed is inserted to freeze dryer cryodesiccation chamber, described refrigerating process includes four steps, the first step is hygral equilibrium process, and in hygral equilibrium process, temperature is preferably 22 ℃, and equilibration time is preferably 3h; Second step is temperature-fall period, is cooled to 5 ℃, and keeps the temperature 40min of 5 ℃ with the rate of temperature fall of 0.4 ℃/min; The 3rd step is cooling deferring procedure, and the rate of temperature fall continuation cooling with 0.4 ℃/min, when cooling temperature reaches-5 ℃, need to keep the of short duration stage of rising again, and the temperature of rising again is-2 ℃, and the retention time is 4min; The 4th step is for continuing temperature-fall period, with the rate of temperature fall of 0.4 ℃/min, continues to be cooled to-40 ℃, and at-40 ℃ of freezing 60min.After freezing completing, obtain refrigeration material;
Then refrigeration material is carried out to lyophilizing: in the environment that is-50KPa in negative pressure,, to refrigeration material lyophilizing, lyophilizing includes four steps, and the first step is the stage of being rapidly heated, and temperature is rapidly heated to 0 ℃ by cryogenic temperature, and the heating-up time is 30min; Second step is delayed phase, and temperature remains on 0 ℃, and be 500min time delay; The 3rd step is for continuing the stage of being rapidly heated, and temperature is rapidly heated to 40 ℃ by 0 ℃, and the heating-up time is 30min; The 4th step is for continuing delayed phase, and temperature remains on 40 ℃ of intensification temperature, and be 1600min time delay; After lyophilizing completes, obtain chitosan sponge;
Next step carries out post processing by chitosan sponge: described post processing comprises three steps, described post processing comprises three steps, the first step is the densification stage, utilize hot melt by polymeric matrix sponge and backing laminating, then take hot plate compression method, make polymeric matrix sponge and backing bonding, the temperature that hot plate compression method is selected is 85 ℃, moulding pressure is 0.6MPa, and the thickness of gained chitosan sponge is 0.8mm, and density is 0.2g/m
3; Second step is pretreatment stage, takes baking, and bake out temperature is 78 ℃, and drying time is 0.4h.The processing stage that the 3rd step being softening, adopt softening machine that polymeric matrix sponge and backing are softened, make absorbability medical dressing, the Gurley hardness number of gained chitosan sponge is 3000.
Then the dressing assembling is cut, encapsulate and use the sterilizing of 17kGy gamma ray.
Claims (3)
1. a preparation method for absorbability medical dressing, is characterized in that comprising the following steps:
(1) produce polymeric matrix aqueous solution: choose polymeric matrix, polymeric matrix is polyacrylic acid, alginic acid, chitosan, water soluble polyamide, chitosan derivatives, at least one in polylysine or cellulose derivative, the polymeric matrix that utilization is chosen is prepared polymeric matrix aqueous solution, in polymeric matrix aqueous solution, add acidic materials and medicine, in the polymeric matrix aqueous solution making, the concentration of polymeric matrix is 0.1%～2.5%, the concentration of acidic materials is 0.5%～5%, acidic materials are glutamic acid, lactic acid, hydrochloric acid, any one in acetic acid or glycolic, the mass ratio of medicine and polymeric matrix is 1:1000～1:10000,
(2) prepared polymeric matrix aqueous solution is injected to mould: the length for the mould of polymeric matrix aqueous solution injection molding is 60～70cm, width is 9～21cm, described mould has 3 chambers, and the height of chamber is 0.05～0.2cm, and width is 2～6cm;
(3) to the polymeric matrix aqueous solution in mould, carry out freezing: the mould that polymeric matrix aqueous solution is housed is inserted to freeze dryer cryodesiccation chamber, described freezing process includes four steps, the first step is hygral equilibrium process, in hygral equilibrium process, temperature is 20～25 ℃, and equilibration time is 2～5h; Second step is temperature-fall period, is cooled to 2～10 ℃, and keeps the temperature 20～60min of 2～10 ℃ with the rate of temperature fall of 0.3～1.0 ℃/min; The 3rd step is cooling deferring procedure, and the rate of temperature fall continuation cooling with 0.3～1.0 ℃/min, when cooling temperature reaches-5 ℃, need to keep the of short duration stage of rising again, and the temperature of rising again is-3～0 ℃, and the retention time is 3～5min; The 4th step is for continuing temperature-fall period, continues to be cooled to-40 ℃, and at-40 ℃ of freezing 30～60min, after freezing completing, obtain refrigeration material with the rate of temperature fall of 0.3～1.0 ℃/min;
(4) refrigeration material is carried out to lyophilizing: negative pressure be in the environment of-80～-20KPa to refrigeration material lyophilizing, lyophilizing includes four steps, the first step is the stage of being rapidly heated, temperature is rapidly heated to 0 ℃ by cryogenic temperature, the heating-up time is 20～50min; Second step is delayed phase, and temperature remains on 0 ℃, and be 400～600min time delay; The 3rd step is for continuing the stage of being rapidly heated, and temperature is rapidly heated to 35～40 ℃ by 0 ℃, and the heating-up time is 20～50min; The 4th step is for continuing delayed phase, and temperature remains on 35～40 ℃ of intensification temperature, and be 1000～2000min time delay; After lyophilizing completes, obtain polymeric matrix sponge;
(5) polymeric matrix sponge is carried out to post processing, make absorbability medical dressing: described post processing comprises three steps, the first step is the densification stage, utilize hot melt by polymeric matrix sponge and backing laminating, then take hot plate compression method, make polymeric matrix sponge and backing bonding, the temperature that hot plate compression method is selected is 75～85 ℃, moulding pressure is 0.5～0.6MPa, and the thickness of resulting polymers substrate sponge is 0.6～10mm, and density is 0.1～0.5g/m
3, second step is pretreatment stage, by polymeric matrix sponge and backing baking, bake out temperature is 75～80 ℃, drying time is 0.25～0.5h, the processing stage that the 3rd step being softening, adopt softening machine that polymeric matrix sponge and backing are softened, make absorbability medical dressing, the Gurley hardness number of resulting polymers substrate sponge is 2000～10000, the absorbability medical dressing making, comprise and there is elastic backing and be arranged on the polymer matrix layer on backing, described backing is by polyurethane, hyaluronic acid, hyaluronate, at least one composition in absorbability aliphatic polyester or poly butyric, polymer matrix layer is by polyacrylic acid, alginic acid, chitosan, water soluble polyamide, chitosan derivatives, the lyophilizing sponge of at least one composition in polylysine or cellulose derivative, in polymer matrix layer, be provided with medicine layer, described medicine layer is by collagen protein, Fibrinogen, at least one composition in somatomedin or antibiotic.
2. preparation method according to claim 1, is characterized in that: described polymeric matrix is that molecular weight is the chitosan of 150～300Qian Dao Er, and the deacetylation of chitosan is 80%～95%.
3. preparation method according to claim 1, is characterized in that: in step (1), need polymeric matrix aqueous solution to carry out vacuum deaerator in the preparation process of polymeric matrix aqueous solution, the pressure of vacuum deaerator is-8 * 10
5～3 * 10
5pa, the deaeration time is 5～30min.
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| CN103623454B (en) * | 2013-11-28 | 2015-04-22 | 北京健康广济贸易有限公司 | High-permeability film dressing |
| CN104497348B (en) * | 2014-12-31 | 2018-10-26 | 武汉奥绿新生物科技股份有限公司 | A kind of submissiveization Processes and apparatus of poly- polysaccharide freeze-drying sponge dressing |
| CN106139230A (en) * | 2015-04-21 | 2016-11-23 | 胡庆柳 | One has bioactive medical dressing and preparation method thereof |
| CN109289078B (en) * | 2018-11-02 | 2020-06-19 | 广东药科大学 | Long-acting antibacterial band-aid |
| CN111671975A (en) * | 2020-07-01 | 2020-09-18 | 江南大学 | Composite artificial skin material for repairing skin injury |
| CN115626982B (en) * | 2022-11-02 | 2024-03-08 | 中山大学 | Nitrogen-oxygen free radical modified lysine-based polyester amide polymer and preparation method and application thereof |
| CN116726241B (en) * | 2023-08-11 | 2023-10-20 | 江苏亨瑞生物医药科技有限公司 | Collagen hemostatic and antibacterial dressing and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1095916A (en) * | 1993-03-22 | 1994-12-07 | 布里斯托尔-迈尔斯斯奎布公司 | Polymer is made the wound dressing of bottom |
| CN100379463C (en) * | 2002-12-19 | 2008-04-09 | 3M创新有限公司 | Absorbent medical articles |
| CN101801322A (en) * | 2007-09-28 | 2010-08-11 | 日绊株式会社 | Patch material |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2920163Y (en) * | 2006-04-20 | 2007-07-11 | 中山大学附属第二医院 | Nanometer hemostatic plaster |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1095916A (en) * | 1993-03-22 | 1994-12-07 | 布里斯托尔-迈尔斯斯奎布公司 | Polymer is made the wound dressing of bottom |
| CN100379463C (en) * | 2002-12-19 | 2008-04-09 | 3M创新有限公司 | Absorbent medical articles |
| CN101801322A (en) * | 2007-09-28 | 2010-08-11 | 日绊株式会社 | Patch material |
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Address after: 430074 A-406, Wuhan international business center, Optics Valley Road, Hubei, China Patentee after: Wuhan Olympic Green new biological Polytron Technologies Inc Address before: 430074 A-406, Wuhan international business center, Optics Valley Road, Hubei, China Patentee before: WUHAN GREENOVO BIOTECHNOLOGY CO., LTD. |