CN103021249B - Heating carbon dioxide simulating abdominal cavity experimental box - Google Patents
Heating carbon dioxide simulating abdominal cavity experimental box Download PDFInfo
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- CN103021249B CN103021249B CN201210591209.0A CN201210591209A CN103021249B CN 103021249 B CN103021249 B CN 103021249B CN 201210591209 A CN201210591209 A CN 201210591209A CN 103021249 B CN103021249 B CN 103021249B
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Abstract
The invention relates to the technical field of medical experiment devices, in particular to a heating carbon dioxide simulating abdominal cavity experimental box which comprises a box body, a temperature humidity sensor, a heating plate, a fan, a temperature humidity controller, a universal bearing, a humidifying device and a camera. The box body is provided with a containing passage for containing an experimental animal, a sealing film capable of being sutured is mounted at the inner end of the containing passage, exhaust holes are arranged below the outer end of the containing passage, and an oxygen pipe is arranged above the outer end of the containing passage. The experimental animal with the head facing outwards and the chest and the back hermetically sutured is fixedly placed in the containing passage, the exhaust holes arranged below the outer end of the containing passage exhaust leaked CO2 to prevent accumulation, and the oxygen pipe arranged above the outer end of the containing passage can provide oxygen for the experimental animal to guarantee the experimental animal to be alive during experiment. The heating carbon dioxide simulating abdominal cavity experimental box can help an experiment operator to stretch into a laparoscope operating instrument through Trocar in the universal bearing to perform experimental operations similar to laparoscopic surgeries to the experimental animal.
Description
Technical field
The present invention relates to medical experiment device technique field, particularly relate to a kind of heating carbon dioxide simulation abdominal cavity experimental box.
Background technology
Since this advanced technology of laparoscope is introduced, the Minimally Invasive Surgical Technology being representative with it general outer, woman's products, uropoiesis, chest outward and the every field such as shaping be used widely, minimally invasive surgery just develops at a speed unheard of before, and is acknowledged as one of main flow direction of 21st century surgery development.Along with the range of application of laparoscopic surgery expands, be included in application in the Diagnosis and Treat of malignant tumour and increase, also occurred new problem, be exactly with CO thereupon
2for occurring under the condition of pneumoperitoneum medium that tumor growth is accelerated, easily recur and stab the problems such as mouth tumor planting transfer.Clinical own through having there is many malignant abdominal tumors CO
2find the report of tumour cell diffusion and puncturing hole metastases after the laparoscopy of pneumoperitoneum, make CO
2whether pneumoperitoneum is exactly the focus that oneself that promote the factor of malignant tumour propagation and transfer becomes research at present, in addition, and heating CO
2on the impact of malignant tumour propagation and transfer how pneumoperitoneum? can be as favourable in the late tumor patient of peritoneal perfusion sample to abdominal metastas? medical circle waits in expectation and has a complete assessment to laparoscope in the feasibility of malignant tumour diagnosis and treatment and security.For this reason, scholars select transplanted tumor animal model and Cell culture invitro Discussion on Technology celioscope pneumoperitoneum on malignant tumour propagation and the impact of transfer, analyze the mechanism that it is possible.Scholars study different CO
2pressure and pneumoperitoneum time and temperature humidity on malignant tumour propagation with shift the impact and concrete mechanism thereof that produce.But due to the factor of ethics, be difficult to that whole process is carried out to tumor patient and observe, repeatedly can not carry out traumatic examination, more can not carry out the experiment of aggressive contrastive at human body.Therefore, both at home and abroad by means of Ex vivo animal model, by building immunized mice tumor model, then build CO
2pneumoperitoneum or heating CO
2pneumoperitoneum model, thus explore CO
2pneumoperitoneum or heating CO
2pneumoperitoneum, on malignant tumour propagation and the impact of transfer, instructs clinical.
Due to the reason such as expense, modelling, little animal used as test, especially nude mice, carry out the important animal used as test of oncology research beyond doubt.But, in current experimental provision, experimental design or experimentation, due to little animal used as test body volume and abdominal cavity less, the laparoscopic surgery operation of similar human abdominal cavity cannot be carried out,, or in experimentation, animal used as test cannot survive, and cannot obtain similar human abdominal cavity, ideal CO
2pneumoperitoneum or heating CO
2pneumoperitoneum experimental situation, cannot carry out the toy experiment at body or live body.
Summary of the invention
The object of the invention is to for existing damp and hot CO
2the deficiency that pneumoperitoneum experimental provision exists does further improvement to it, designs in similar human abdominal cavity and carries out heating CO
2laparoscopic surgery operates same or analogous abdominal cavity environment, is applied to zoopery, provides simulation heating CO
2the live body in abdominal cavity/at body zoopery environment, ensure that animal used as test survives in experimentation.Facilitate observation experiment, and the heating carbon dioxide simulation abdominal cavity experimental box of similar laparoscopic surgery sample experimental implementation is carried out to animal used as test.
A kind of heating carbon dioxide simulation abdominal cavity experimental box, comprise casing, be arranged at the Temperature Humidity Sensor in casing, heating plate, fan and temperature and humidity controller, also include damping device and be positioned at the camera of casing, escape pipe and siphunculus is respectively arranged with in the two sides of casing, siphunculus is communicated with the gas outlet of damping device, described casing is provided with the holding channel for accommodating animal used as test, the inner of this holding channel extends to the cavity in casing, the outer end of this holding channel extends to the outside of described casing, the inner of holding channel is equiped with diaphragm seal, the outer end of holding channel is provided with vent port or oxygen supplying tube, the sidewall of described casing is equiped with universal bearing.
Wherein, described casing comprises lagging casing, heat-insulation layer and the sealant that ecto-entad sets gradually, described heating plate is evenly attached at the inwall of sealant, described fan is installed on the inner side of heating plate, described temperature and humidity controller is positioned at lagging casing, and the inside of described sealant is provided with Temperature Humidity Sensor.
Wherein, described damping device is installed on the inner side of described lagging casing.
Wherein, described sealant is equiped with the transparent cover plate that can open and close.
Wherein, described holding channel cylindrically.
Wherein, described escape pipe is equiped with operation valve.
Wherein, described casing is equiped with Universal pipe, and the inner of this Universal pipe extend into the inside of casing, and described camera is fixed at the inner of this Universal pipe.
Wherein, the inside of described sealant is provided with ultraviolet germicidal lamp.
Wherein, the madial wall of described sealant is provided with two bearings, and the two ends of described ultraviolet germicidal lamp are individually fixed in two bearings.
Beneficial effect of the present invention is: the invention provides heating carbon dioxide simulation abdominal cavity experimental box, in experimentation, allow the health of animal through the middle part of diaphragm seal, and the chest and back fur of animal and diaphragm seal are sewed up, then animal is fixed in holding channel, outwardly, the inner of diaphragm seal and holding channel, towards box house, is finally connected and sealed and namely completes the preliminary work of simulated experiment the head of animal by health.The vent port arranged below holding channel outer end discharges the CO spilt
2gas is in case gather, and the oxygen hose arranged above holding channel outer end can be animal used as test and provides oxygen, and box house is built in similar human abdominal cavity and carried out heating CO
2laparoscopic surgery operates same or analogous abdominal cavity environment, and is applied to zoopery, provides simulation heating CO
2the live body in abdominal cavity/at body zoopery environment, ensure that animal used as test survives in experimentation, experiment effect is good.Camera is equiped with in casing of the present invention, production position and the direction of camera is controlled by peripheral operation universal bearing, camera is observed, recorded information, experimental implementation person is helped to stretch into celioscope operating apparatus by the Trocar being fixed on universal bearing, similar laparoscopic surgery sample experimental implementation is carried out to animal used as test, practical.
Accompanying drawing explanation
Fig. 1 is perspective view of the present invention.
Fig. 2 is left TV structure schematic diagram of the present invention.
Fig. 3 is the sectional structure schematic diagram in A-A cross section in Fig. 2.
Embodiment
For the ease of the understanding of those skilled in the art, below in conjunction with embodiment and accompanying drawing, the present invention is further illustrated, and the content that embodiment is mentioned not is limitation of the invention.
As shown in Figure 1 to Figure 3, a kind of heating carbon dioxide simulation abdominal cavity experimental box, comprise casing 1, be arranged at the Temperature Humidity Sensor 2 in casing 1, heating plate 3, fan 4 and temperature and humidity controller 5, also include damping device 6 and be positioned at the camera 18 of casing 1, escape pipe 14 and siphunculus 15 is respectively arranged with in the two sides of casing 1, siphunculus 15 is communicated with the gas outlet of damping device 6, described casing 1 is provided with the holding channel 7 for accommodating animal used as test, the inner of this holding channel 7 extends to the cavity in casing 1, the outer end of this holding channel 7 extends to the outside of described casing 1, the inner of holding channel 7 is equiped with diaphragm seal 8, the outer end of holding channel 7 is provided with vent port 9, the sidewall of described casing 1 is equiped with universal bearing 21.
For mouse simulated experiment, in the experimentation of reality, allow the health of mouse through the middle part of diaphragm seal 8, and the fur of mouse chest and back and diaphragm seal 8 are sewed up, then mouse is fixed in holding channel 7, outwardly, health is inner towards casing 1 for the head of mouse, and namely be finally connected and sealed with the inner of holding channel 7 by diaphragm seal 8 completes the preliminary work of simulated experiment.The vent port arranged below holding channel outer end discharges the CO spilt
2gas is in case gather, and the oxygen hose arranged above holding channel outer end can be mouse and provides oxygen, and box house is built in similar human abdominal cavity and carried out heating CO
2laparoscopic surgery operates same or analogous abdominal cavity environment, and is applied to experiment on mice, provides simulation heating CO
2the live body in abdominal cavity/at body experiment on mice environment, ensure that mouse survives in experimentation, experiment effect is better.
Trochar (Trocar) enters into casing 1 through universal bearing 21, due to the setting of universal bearing 21, trochar (Trocar) can arbitrarily movement in casing 1, and in the contact position of trochar and universal bearing 21, there is good sealing effect, be convenient to experimenter and the operation of class laparoscopic surgery is carried out to the mouse abdominal cavity in casing 1.Be preferred embodiment universal bearing 21 be two, facilitate right-hand man to operate chain two trochars (Trocar) respectively simultaneously.
Camera 18 is equiped with in casing 1 of the present invention, production position and the direction of camera 18 is controlled by peripheral operation universal bearing 17, camera is observed, recorded information, help experimental implementation person to stretch into celioscope operating apparatus by the Trocar being fixed on universal bearing, similar laparoscopic surgery sample experimental implementation is carried out to animal used as test., practical.
The described casing 1 of the present embodiment comprises lagging casing 10, heat-insulation layer 11 and the sealant 12 that ecto-entad sets gradually, described heating plate 3 is evenly attached at the inwall of sealant 12, described fan 4 is installed on the inner side of heating plate 3, described temperature and humidity controller 5 is positioned at lagging casing 10, and the inside of described sealant 12 is provided with Temperature Humidity Sensor 2.
In use, outside CO
2gas enters damping device 6 inside via the air intake opening that lagging casing 10 is preset and carries out moistening process, the CO after humidification
2then gas enter into sealant 12 by the gas outlet of damping device 6, under the heating plate 3 in sealant 12 and the effect of fan 4, and the CO in casing 1
2the mixing of gas uniform, and the state reaching a kind of constant temperature and humidity.Simultaneously by the CO in Temperature Humidity Sensor 2 pairs of casings 1
2the humiture of gas carries out real-time monitoring, and then is is effectively regulated and controled by the humiture in the 5 pairs of casings 1 of the temperature and humidity controller on lagging casing 10, makes the CO in casing 1
2humiture reaches default level, and effectively improves the homogeneity of the temperature and humidity in sealant 12, damp and hot CO
2the experimental situation that pneumoperitoneum experimental provision provides is more solid.
The described damping device 6 of the present embodiment is installed on the inner side of described lagging casing 10.And the air intake opening of damping device 6 is connected with the air intake opening that lagging casing 10 is preset by pipeline, substantially increases described damp and hot CO
2the structural compactness of pneumoperitoneum experimental provision, humidifying effect is better.
The described sealant 12 of the present embodiment is equiped with the transparent cover plate 13 that can open and close.In the process used, Real Time Observation can be carried out to the experimental status in sealant 12 by this transparent cover plate 13, be convenient to the process understanding experiment in time.
Cylindrically, so that mouse to be positioned over the inside of holding channel 7, the connection sealing simultaneously between diaphragm seal 8 and this cylindric holding channel 7 is better for the described holding channel 7 of the present embodiment.
The described escape pipe 14 of the present embodiment is equiped with operation valve 16, to described damp and hot CO
2gas in pneumoperitoneum experimental provision carries out flow regulation, convenient control.
The described casing 1 of the present embodiment is equiped with Universal pipe 17, and the inner of this Universal pipe 17 extend into the inside of casing 1, and described camera 18 is fixed at the inner of this Universal pipe 17.Experimenter controls production position and the direction of camera 18 by peripheral operation universal bearing 17, camera is observed, recorded information, help experimental implementation person to stretch into celioscope operating apparatus by the Trocar being located in Universal pipe 17, similar laparoscopic surgery sample experimental implementation is carried out to animal used as test.
The inside of the described sealant 12 of the present embodiment is provided with ultraviolet germicidal lamp 19.The madial wall of concrete described sealant 12 is provided with two bearings 20, and the two ends of described ultraviolet germicidal lamp 19 are individually fixed in two bearings 20.Ultraviolet germicidal lamp 19 is fixed on the madial wall of sealant 12 by two bearings 20, and this device when needed can to the CO in casing 1
2gas and other experimental subjectss are carried out effective sterilization and disinfect.
Above-described embodiment is the present invention's preferably implementation, and in addition, the present invention can also realize by alternate manner, and any apparent replacement is all within protection scope of the present invention without departing from the inventive concept of the premise.
Claims (9)
1. heat carbon dioxide simulation abdominal cavity experimental box, comprise casing (1), temperature and humidity controller (5), be arranged at the Temperature Humidity Sensor (2) in casing (1), heating plate (3) and fan (4), it is characterized in that: also comprise damping device (6) and be positioned at the camera (18) of casing (1), escape pipe (14) and siphunculus (15) is respectively arranged with in the two sides of casing (1), siphunculus (15) is communicated with the gas outlet of damping device (6), described casing (1) is provided with the holding channel (7) for accommodating animal used as test, the inner of this holding channel (7) extends to the cavity in casing (1), the outer end of this holding channel (7) extends to the outside of described casing (1), the inner of holding channel (7) is equiped with diaphragm seal (8), the outer end of holding channel (7) is provided with vent port (9) and oxygen supplying tube, the sidewall of described casing (1) is equiped with universal bearing (21).
2. heating carbon dioxide simulation abdominal cavity experimental box according to claim 1, it is characterized in that: described casing (1) comprises lagging casing (10), heat-insulation layer (11) and the sealant (12) that ecto-entad sets gradually, described heating plate (3) is evenly attached at the inwall of sealant (12), described fan (4) is installed on the inner side of heating plate (3), described temperature and humidity controller (5) is positioned at lagging casing (10), and the inside of described sealant (12) is provided with Temperature Humidity Sensor (2).
3. heating carbon dioxide simulation abdominal cavity experimental box according to claim 2, is characterized in that: described damping device (6) is installed on the inner side of described lagging casing (10).
4. heating carbon dioxide simulation abdominal cavity experimental box according to claim 2, is characterized in that: described sealant (12) is equiped with the transparent cover plate (13) that can open and close.
5. heating carbon dioxide simulation abdominal cavity experimental box according to claim 1, is characterized in that: described holding channel (7) cylindrically.
6. heating carbon dioxide simulation abdominal cavity experimental box according to claim 1, is characterized in that: described escape pipe (14) is equiped with operation valve (16).
7. heating carbon dioxide simulation abdominal cavity experimental box according to claim 1, it is characterized in that: described casing (1) is equiped with Universal pipe (17), the inner of this Universal pipe (17) extend into the inside of casing (1), and described camera (18) is fixed at the inner of this Universal pipe (17).
8. heating carbon dioxide simulation abdominal cavity experimental box according to claim 1, is characterized in that: the inside of described sealant (12) is provided with ultraviolet germicidal lamp (19).
9. heating carbon dioxide simulation abdominal cavity experimental box according to claim 8, it is characterized in that: the madial wall of described sealant (12) is provided with two bearings (20), the two ends of described ultraviolet germicidal lamp (19) are individually fixed in two bearings (20).
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210591209.0A CN103021249B (en) | 2012-12-31 | 2012-12-31 | Heating carbon dioxide simulating abdominal cavity experimental box |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210591209.0A CN103021249B (en) | 2012-12-31 | 2012-12-31 | Heating carbon dioxide simulating abdominal cavity experimental box |
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| CN103021249A CN103021249A (en) | 2013-04-03 |
| CN103021249B true CN103021249B (en) | 2015-02-04 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB2591779B (en) * | 2020-02-06 | 2021-12-29 | S Haval Sagar | A system for simulation training of extra corporeal life support therapies |
| CN111751067A (en) * | 2020-05-29 | 2020-10-09 | 重庆银河试验仪器有限公司 | Three combined test case length test piece vibration test structure |
| CN113229156A (en) * | 2021-05-08 | 2021-08-10 | 中国人民解放军军事科学院军事医学研究院 | Animal hypoxia-sensitive individual screening device |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994001154A1 (en) * | 1992-07-07 | 1994-01-20 | Andronic Devices, Ltd. | Apparatus and method for improved insufflation |
| CN1967626A (en) * | 2006-11-14 | 2007-05-23 | 上海交通大学医学院附属瑞金医院 | An experiment device to simulate body hyperthermia CO2 pneumoperitoneum |
| CN202036455U (en) * | 2011-01-25 | 2011-11-16 | 中国人民解放军第四军医大学 | Experimental device for rat respiratory tract obstruction model |
| CN203204912U (en) * | 2012-12-31 | 2013-09-18 | 东莞市人民医院 | Heating carbon dioxide abdomen simulation experiment box |
-
2012
- 2012-12-31 CN CN201210591209.0A patent/CN103021249B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994001154A1 (en) * | 1992-07-07 | 1994-01-20 | Andronic Devices, Ltd. | Apparatus and method for improved insufflation |
| CN1967626A (en) * | 2006-11-14 | 2007-05-23 | 上海交通大学医学院附属瑞金医院 | An experiment device to simulate body hyperthermia CO2 pneumoperitoneum |
| CN202036455U (en) * | 2011-01-25 | 2011-11-16 | 中国人民解放军第四军医大学 | Experimental device for rat respiratory tract obstruction model |
| CN203204912U (en) * | 2012-12-31 | 2013-09-18 | 东莞市人民医院 | Heating carbon dioxide abdomen simulation experiment box |
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| CN103021249A (en) | 2013-04-03 |
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Granted publication date: 20150204 Termination date: 20171231 |