CN103006693A - Double-vitamin calcium carbonate composition - Google Patents
Double-vitamin calcium carbonate composition Download PDFInfo
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- CN103006693A CN103006693A CN2013100061157A CN201310006115A CN103006693A CN 103006693 A CN103006693 A CN 103006693A CN 2013100061157 A CN2013100061157 A CN 2013100061157A CN 201310006115 A CN201310006115 A CN 201310006115A CN 103006693 A CN103006693 A CN 103006693A
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Abstract
The invention relates to a double-vitamin calcium carbonate composition belonging to the technical field of medicine. The composition comprises the following active components: 300-3500 parts by weight of calcium carbonate, 0.1-60 parts by weight of vitamin K and 0.001-0.1 part by weight of vitamin D. According to the invention, because of the scientific formula, calcium can be effectively supplemented; and the double-vitamin calcium carbonate composition is safe and convenient to take.
Description
Technical field
The present invention relates to medical technical field, be specifically related to a kind of two-dimentional calcium carbonate composition.
Background technology
Calcium is the maximum a kind of inorganic salt of people's in-vivo content, the content of calcium accounts for the 0.5%-2.0% of human body weight in the normal human, wherein 99% calcium is present among skeleton and the tooth, 1% calcium great majority are ionic condition and are present in soft tissue, extracellular fluid and the blood, are keeping dynamic equilibrium with skeleton.Calcium has the normal reaction of keeping nerve, muscle, regulates heartbeat and keeps heart alternately to shrink continuously and diastole, keeps contraction and the neururgic transmission isoreactivity of muscle.China resident could ensure better that the resident is healthy because the dietary habit problem totally need to generally suit to replenish the calcium.Solve now the problem of replenishing the calcium, the general intake that increases calcium and the absorption rate that improves calcium of adopting.At present, calcium supplementing product is more, and the prescription too complex that wherein has also relates to additional various nutrient elements, and effect of supplemented calcium is not obvious; Some calcium supplementing product doses are too large, and are difficult for being absorbed by the body, and cause effect of supplemented calcium relatively poor; Some calcium supplementing products also exist the problems such as side effect is large.Therefore, it is obvious how developmental research goes out a kind of effect of supplemented calcium, and the calcium supplementing product of taking safe ready becomes a technical problem of being badly in need of solution.
Summary of the invention
The purpose of this invention is to provide the two-dimentional calcium carbonate composition that a kind of effect of supplemented calcium is obvious, take safe ready.
The technical solution used in the present invention is a kind of two-dimentional calcium carbonate composition, and described compositions active component is: calcium carbonate 300～3500 weight portions, vitamin K 0.1～60 weight portion, vitamin D 0.001～0.1 weight portion.
As preferably, described compositions active component is: calcium carbonate 500～3200 weight portions, vitamin K1～30 weight portions, vitamin D 0.005～0.05 weight portion.
As preferably, described compositions active component is: calcium carbonate 1000～2500 weight portions, vitamin K5～25 weight portions, vitamin D 0.008～0.02 weight portion.
As preferably, described compositions also contains at pharmaceutically acceptable correctives or disintegrating agent.
As preferably, described compositions is tablet, capsule or granule.
As preferably, described tablet is conventional tablet, Film coated tablets or chewable tablet.
As preferably, described vitamin K is selected from vitamin K
1, vitamin K
2, vitamin K
3Or vitamin K
4In a kind of and any mixture.
As preferably, described vitamin D is selected from vitamin D
2Or vitamin D
3In a kind of and composition thereof.
Beneficial effect of the present invention is: (1) scientific formulation of the present invention is reasonable, and calcium carbonate provides the calcium source for body; Vitamin D can improve body to the absorption of calcium, promote bone growth and calcification, promote tooth sound, can also muscle strength reinforcing, thereby can prevent Falls in Old People, reduce risk of bone fracture; Vitamin K can be regulated the deposition of calcium in bone matrix, can promote the reconstruction of bone and the mobilization of calcium.The three is used in conjunction with each other, and body is absorbed more abundant to calcium carbonate, and can be on the skeleton effectively under the deposition, thereby effectively increases bone density, reduces risk of bone fracture.(2) the present invention is owing to filling a prescription rationally, and when reaching the increase bone density, dose obviously reduces, and therefore can avoid many discomforts that series products causes because the long-term, high-dose use is replenished the calcium, such as gastric mucosa damage, Calculus of digestive duct and urinary tract infringement etc.(3) the present invention is owing to adding an amount of vitamin K, thereby greatly reduce the consumption of taking vitamin D every day, avoided owing to taking the problem of many discomforts such as inflammatory eye that megavitamin D causes, skin pruritus, vomiting, diarrhoea every day, having overcome when replenishing the calcium calcium source needs the auxiliary of megavitamin D, could allow body calcium absorption be reached the technical barrier of effect of supplemented calcium.(4) the present invention uses by short-term, can effectively treat because osteoporosis and the rickets that calcium deficiency causes is safe and reliable through routine clinical verifications up to a hundred, has no side effect.
For confirming effectiveness of the present invention, the spy does following contrast test:
The present invention compares with the preparation that only has calcium carbonate and vitamin D to make, and is reaching under the prerequisite of identical effect of supplemented calcium, and dose can reduce 1/3; And under the prerequisite of same dose, the effect of replenishing the calcium can improve 3 times.
The present invention adopts the preparation of embodiment one in addition, estimates according to Ministry of Public Health " health food check and assessment technique standard ", and evaluation result sees Table 1.
Experimental technique: 60 of the SPF level female sd inbred rats of getting body weight and be 220-260g, with normal feedstuff adaptability feed after seven days, according to body weight, be divided at random following six groups: three dosage groups of sham operated rats, model control group, the embodiment of the invention one and high dose calcium carbonate control group, 10 of every treated animals.Sham operated rats operation: with 3% pentobarbital sodium intraperitoneal anesthesia, under strict sterile working, get lumbar vertebra by the dorsal part two incision enter the abdominal cavity, extract a little mesostenium after, the layer-by-layer suture otch carefully stops blooding; Three dosage groups of model control group, the embodiment of the invention one and the operation of high dose calcium carbonate control group, anesthesia is the same, under strict sterile working, get the other dorsal part two incision of lumbar vertebra, enter the abdominal cavity dorsal part, after the complete excision bilateral ovaries, the layer-by-layer suture otch carefully stops blooding.Postoperative three days, sham operated rats and model control group are with the distilled water gavage; Three dosage groups of the present invention, be 200mg/kgbw group, 400mg/kgbw group, 800mg/kgbw group (be equivalent to respectively human intaking amount 40mg/kg.bw group 5,10 and 20 times), the sample liquid gavage (preparation of gavage liquid: get respectively 2g of the present invention, 4g, 8g with preparation, adding distil water is settled to 100ml, is mixed with the sample liquid of 200mg/kgbw, 400mg/kgbw, 800mg/kgbw); High dose group calcium carbonate control group per os pours into the calcium carbonate of 224mg/kgbw, and this dosage is equivalent to high dose group level of the present invention.All animal gavage amounts are 10ml/kgbw, and once a day, continuously gavage is 90 days, weigh weekly and adjust the gavage amount by body weight.Test last femoral artery sacrificed by exsanguination animal, take out the right side femur, in 105 ℃ of baking ovens, roasting to constant weight, the weighing bone is heavy.Adopt DPX-L dual energy X-ray absorptiometry instrument to measure fl bone density (g/cm
2), its concrete assay method is to scan whole fl with DPX-L dual energy X-ray absorptiometry instrument, represents this bone bone density with the average bone density of bone.Adopt the right femur calcium content of atomic absorption spectroscopy determination.
Table 1 is on the impact of rat bone density and calcium content of bone
| Group | Number of animals | Fl bone density (g/cm2) | Right bone calcium content of femur (mg/g) |
| Sham operated rats | 10 | 0.2251±0.0072 | 186.14±10.11 |
| Model control group | 10 | 0.2024±0.0074 | 185.82±14.31 |
| The high dose calcium carbonate control group | 10 | 0.2185±0.0104 | 187.11±10.94 |
| 200mg/kg.bw group | 10 | 0.2232±0.0106 | 193.41±8.67 |
| 400mg/kg.bw group | 10 | 0.2158±0.0107 | 195.98±16.22 |
| 800mg/kg.bw group | 10 | 0.2148±0.0107 | 196.84±19.66 |
By as seen from Table 1, bone density, the calcium content of bone of three dosage groups of the present invention are compared model control group, and there were significant differences, illustrate that the present invention has replenishing the calcium, increases the effect of bone density.
The specific embodiment
For making those skilled in the art understand in detail production technology of the present invention and technique effect, the below further introduces application of the present invention and technique effect with concrete production instance.
Embodiment one: the preparation of granule
Take by weighing calcium carbonate 750g, vitamin K
12g, vitamin K
32g, vitamin K
42g, vitamin D
23mg, vitamin D
3Then 2mg and sucrose 2244g are 95% dissolve with ethanol vitamin K with 40ml concentration
1, vitamin K
3, vitamin K
4, vitamin D
2, vitamin D
3, add again the dilution of 350ml purified water, get wetting agent for subsequent use.Behind calcium carbonate and sucrose mix homogeneously, with gained wetting agent soft material processed, granulate, under 50 ℃ condition, carry out drying, granulate, packing namely gets described granule.
Embodiment two: the preparation of granule
Take by weighing calcium carbonate 1500g, vitamin K
112g, vitamin D
2Then 5mg and sucrose 1488g are 95% dissolve with ethanol vitamin K with 30ml concentration
1, vitamin D
2, add again the dilution of 250ml purified water, get wetting agent for subsequent use.With calcium carbonate and sucrose mix homogeneously, with gained wetting agent soft material processed, granulate, under 40 ℃ condition, carry out drying, granulate, packing namely gets described granule.
Embodiment three: the preparation of tablet
Take by weighing calcium carbonate 750g, vitamin K
212g, vitamin D
3Then 5mg, microcrystalline Cellulose 100g and carboxymethylstach sodium 20g are 95% dissolve with ethanol vitamin K with 35ml concentration
2, vitamin D
3, add again the dilution of 200ml purified water, get wetting agent for subsequent use.With calcium carbonate, microcrystalline Cellulose and carboxymethylstach sodium mix homogeneously, with gained wetting agent soft material processed, granulate, under 50 ℃ condition, carry out drying, granulate adds magnesium stearate 2.5g mixing, and tabletting namely gets described conventional tablet.
Embodiment four: the preparation of film coated tablet
Take by weighing calcium carbonate 750g, vitamin K
312g, vitamin D
2Then 5mg, microcrystalline Cellulose 100g and carboxymethylstach sodium 20g are 95% dissolve with ethanol vitamin K with 40ml concentration
3And vitamin D
2, add again the dilution of 180ml purified water, get wetting agent for subsequent use.With calcium carbonate, microcrystalline Cellulose and carboxymethylstach sodium mix homogeneously, with gained wetting agent soft material processed, granulate, under 60 ℃ condition, carry out drying, granulate adds magnesium stearate 2.5g mixing, tabletting, take by weighing again routinely coating operation of hypromellose 85g and Pulvis Talci 15g, namely get described film coated tablet.
Embodiment five: the preparation of chewable tablet
Take by weighing calcium carbonate 750g, vitamin K
22g, vitamin K
32g, vitamin K
42g, vitamin D
3Then 5mg and sucrose 100g are 95% dissolve with ethanol vitamin K with 40ml concentration
2, vitamin K
3, vitamin K
4And vitamin D
3, add again the dilution of 150ml purified water, get wetting agent for subsequent use.With calcium carbonate and sucrose mix homogeneously, with gained wetting agent soft material processed, granulate, under 60 ℃ condition, carry out drying, granulate adds micropowder silica gel 30g mixing, and tabletting namely gets described chewable tablet.
Embodiment six: the preparation of chewable tablet
Take by weighing calcium carbonate 750g, vitamin K
34g, vitamin K
42g, vitamin D
2Then 5mg, lactose 100g and mannitol 100g are 95% dissolve with ethanol vitamin K with 30ml concentration
3, vitamin K
4And vitamin D
2, add again the dilution of 200ml purified water, get wetting agent for subsequent use.With calcium carbonate, lactose and mannitol mix homogeneously, with gained wetting agent soft material processed, granulate, under 50 ℃ condition, carry out drying, granulate adds micropowder silica gel 30g mixing, and tabletting namely gets described chewable tablet.
Embodiment seven: the preparation of capsule
Take by weighing calcium carbonate 750g, vitamin K
14g, vitamin K
22g, vitamin D
3Then 5mg is 95% dissolve with ethanol vitamin K with 30ml concentration
1, vitamin K
2And vitamin D
3, add again the dilution of 200ml purified water, get wetting agent for subsequent use.Calcium carbonate with gained wetting agent soft material processed, is granulated, carry out drying under 50 ℃ condition, granulate adds magnesium stearate 2.5g mixing, uses the Capsules filling, namely gets described capsule.
Claims (8)
1. a two-dimentional calcium carbonate composition is characterized in that described compositions active component is: calcium carbonate 300～3500 weight portions, vitamin K 0.1～60 weight portion, vitamin D 0.001～0.1 weight portion.
2. a kind of two-dimentional calcium carbonate composition according to claim 1 is characterized in that described compositions active component is: calcium carbonate 500～3200 weight portions, vitamin K1～30 weight portions, vitamin D 0.005～0.05 weight portion.
3. a kind of two-dimentional calcium carbonate composition according to claim 1 is characterized in that described compositions active component is: calcium carbonate 1000～2500 weight portions, vitamin K5～25 weight portions, vitamin D 0.008～0.02 weight portion.
4. each described a kind of two-dimentional calcium carbonate composition is characterized in that described compositions also contains at pharmaceutically acceptable correctives or disintegrating agent according to claim 1-3.
5. each described a kind of two-dimentional calcium carbonate composition is characterized in that described compositions is tablet, capsule or granule according to claim 1-3.
6. a kind of two-dimentional calcium carbonate composition according to claim 5 is characterized in that described tablet is conventional tablet, Film coated tablets or chewable tablet.
7. each described a kind of two-dimentional calcium carbonate composition is characterized in that described vitamin K is selected from vitamin K according to claim 1-3
1, vitamin K
2, vitamin K
3Or vitamin K
4In a kind of and any mixture.
8. each described a kind of two-dimentional calcium carbonate composition is characterized in that described vitamin D is selected from vitamin D according to claim 1-3
2Or vitamin D
3In a kind of and composition thereof.
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|---|---|---|---|
| CN2013100061157A CN103006693A (en) | 2013-01-08 | 2013-01-08 | Double-vitamin calcium carbonate composition |
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|---|---|---|---|
| CN2013100061157A CN103006693A (en) | 2013-01-08 | 2013-01-08 | Double-vitamin calcium carbonate composition |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104705658A (en) * | 2015-04-09 | 2015-06-17 | 四川健之源科技有限公司 | Health food with bone density improving function |
| CN107375221A (en) * | 2017-07-12 | 2017-11-24 | 广州富诺健康科技股份有限公司 | One kind contains farnoquinone calcium tablet and preparation method thereof |
| CN108478595A (en) * | 2018-05-01 | 2018-09-04 | 王康俊 | A kind of pharmaceutical composition containing calcium carbonate, vitamine D3, farnoquinone |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE1016055A7 (en) * | 2004-05-25 | 2006-02-07 | Psaltopoulos Emmanuel | Sugar confection such as candy or chocolate is made with sufficient calcium and vitamins D and K to meet a person's daily requirements |
| BE1016895A6 (en) * | 2005-12-16 | 2007-09-04 | Psaltopoulos Emmanuel | Calcium composition, useful to prevent/treat osteoporosis and articular cartilage calcification, comprises optionally elementary calcium in the form e.g. of calcium carbonate or calcium citrate, and vitamins e.g. vitamin-D3, vitamin-K3 |
| CN101416894A (en) * | 2008-11-27 | 2009-04-29 | 清华大学 | Operation robot needle-insertion positioning device under magnetic sensor environment |
-
2013
- 2013-01-08 CN CN2013100061157A patent/CN103006693A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE1016055A7 (en) * | 2004-05-25 | 2006-02-07 | Psaltopoulos Emmanuel | Sugar confection such as candy or chocolate is made with sufficient calcium and vitamins D and K to meet a person's daily requirements |
| BE1016895A6 (en) * | 2005-12-16 | 2007-09-04 | Psaltopoulos Emmanuel | Calcium composition, useful to prevent/treat osteoporosis and articular cartilage calcification, comprises optionally elementary calcium in the form e.g. of calcium carbonate or calcium citrate, and vitamins e.g. vitamin-D3, vitamin-K3 |
| CN101416894A (en) * | 2008-11-27 | 2009-04-29 | 清华大学 | Operation robot needle-insertion positioning device under magnetic sensor environment |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104705658A (en) * | 2015-04-09 | 2015-06-17 | 四川健之源科技有限公司 | Health food with bone density improving function |
| CN104705658B (en) * | 2015-04-09 | 2017-04-19 | 四川健之源科技有限公司 | Health food with bone density improving function |
| CN107375221A (en) * | 2017-07-12 | 2017-11-24 | 广州富诺健康科技股份有限公司 | One kind contains farnoquinone calcium tablet and preparation method thereof |
| CN108478595A (en) * | 2018-05-01 | 2018-09-04 | 王康俊 | A kind of pharmaceutical composition containing calcium carbonate, vitamine D3, farnoquinone |
| CN108478595B (en) * | 2018-05-01 | 2021-07-02 | 海南施宝生物科技有限公司 | A pharmaceutical composition containing calcium carbonate, vitamin D3, and vitamin K2 |
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Application publication date: 20130403 |