CN103006491B - A kind of biological skin care dispelling growth striae and preparation method thereof - Google Patents
A kind of biological skin care dispelling growth striae and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of biological skin care dispelling growth striae, wherein said goods include bionic nano microsphere, Lauryldimonium Hydroxypropyl base hydrolytic collagen, pantothenic acid, asiaticoside, Aloe extraction solution, surfactant, oil, adjuvant, water, oligopeptide-1, palmityl tripeptides-1, silantriol, N-palmityl hydroxyproline cetyl and ubiquinone。The biological skin care dispelling growth striae of the present invention can eliminate the striae gravidarum of skin surface effectively, and human body is had no side effect, and has skin whitening, strengthens skin brightness, and skin keeps the advantages such as moistening and elasticity。The preparation method that the invention also discloses this biological skin care reagent dispelling growth striae, the method adopts emulsion process above-mentioned various component emulsifyings to be formed。The method is simple and practical, and the whole course of processing does not destroy the activity of active component。
Description
Technical field
The present invention relates to a kind of biological skin care dispelling growth striae and its preparation method, specifically, relate to a kind of biological skin care for striae gravidarum and preparation method thereof。
Background technology
It is known that waveform decorative pattern different in size all can occur in the abdominal part of the women of later stage of pregnancy, after childbirth, these decorative patterns, after progressively fading, still can leave some cicatrix line-transect stricture of vaginas, and medico is referred to as " striae gravidarum ", and it is the one of growth striae。Striae gravidarum produce self body constitution reason existing and the reason of self antenatal maintenance, also have genetic cause。Though the anemia of pregnant woman having 70%～90% can produce striae gravidarum, if but strengthen antenatal maintenance, then can greatly reduce the probability that striae gravidarum produces, at least the influence degree of striae gravidarum can be minimised。
At present, striae gravidarum frost product is various on the market, people by adding olive oil, some Chinese medicine, natural plant extracts or biological preparation in cosmetics, the biological activity utilizing them adjusts metabolism and the physiological structure of skin, plays the newborn effect such as striae gravidarum, anti-pigmentation of minimizing to a certain extent。These cosmetics are cream, emulsion form mostly, and effect is general, and the striae gravidarum that particularly time is longer, effect is not fairly obvious。This is because skin surface has one layer of horny layer, it is that active ingredient enters the internal natural cover for defense, and some little molecules can pass through hair follicle or corneocyte gap enters deep skin, but some macromole are just blocked in outside and can not enter deep skin。So that dispel, the effect of striae gravidarum is not as。For other growth striae, currently also there is no reasonable medicine。
Therefore, in the urgent need to a kind of biological skin care dispelling growth striae that can effectively eliminate striae gravidarum, the problem bad to solve the current effect dispelling growth striae。
Summary of the invention
The technical problem to be solved is to solve to dispel in reality the problem that the effect of growth striae is bad, it is provided that a kind of new biological skin care dispelling growth striae, can effectively arrive inside human body skin, dispels growth striae preferably。
For achieving the above object, the present invention adopts following technical scheme: a kind of biological skin care dispelling growth striae, wherein, the described biological skin care dispelling growth striae includes the system based on water, and the system of described water includes the component of following portions by weight:
Bionic nano microsphere 0.5-10 part
Lauryldimonium Hydroxypropyl base hydrolytic collagen 1-5 part
Pantothenic acid 0.5-5 part
Asiaticoside 1-3 part
Aloe extraction solution 1-5 part
Surfactant 1-5 part
Oil 5-15 part
Adjuvant 0.5-15 part
Water 50-75 part；
Wherein in the described biological skin care dispelling growth striae, described based on the following components also comprising therapeutically effective amount in the system of water:
Oligopeptide-1
Palmityl tripeptides-1
Silantriol
N-palmityl hydroxyproline cetyl, and
Ubiquinone。
In one embodiment of the invention, the parts by weight of each component of the biological skin care dispelling growth striae of the described system based on water are:
Bionic nano microsphere 1-8 part
Lauryldimonium Hydroxypropyl base hydrolytic collagen 2-4 part
Pantothenic acid 1-4 part
Asiaticoside 2-3 part
Aloe extraction solution 2-4 part
Surfactant 2-4 part
Oil 6-10 part
Adjuvant 0.6-10 part
Water 55-70 part；
In one embodiment of the invention, the Specific amounts of the described component based on the effective dose contained in the system of water is:
Oligopeptide-1500IU/ml-10000IU/ml；
Palmityl tripeptides-1500IU/ml-10000IU/ml；
Silantriol 10 × 10-5-5×10-4Weight portion；
N-palmityl hydroxyproline cetyl 3 × 10-4-5×10-4Weight portion；And
Ubiquinone 1 × 10-4-10×10-4Weight portion。
In one embodiment of the invention, described based on the Specific amounts of the component of effective dose in the system of water it is:
Oligopeptide-12000IU/ml-5000IU/ml；
Palmityl tripeptides-12000IU/ml-5000IU/ml；
Silantriol 8.2 × 10-5-2.46×10-4Weight portion；
N-palmityl hydroxyproline cetyl 1.16 × 10-4-3.48×10-4Weight portion；And
Ubiquinone 2 × 10-4-7.5×10-4Weight portion。
In the biological skin care dispelling growth striae of the present invention, described bionic nano microsphere be by any one in water, palmityl Hydroxyproyl Trimethyl ammonium amylopectin/glycerin crosspolymers, phenoxyethanol hydrolecithin, methyl hydroxybenzoate, butyl hydroxybenzoate, ethyl hydroxybenzoate, propyl hydroxybenzoate or its two or more be prepared from。
In the biological skin care dispelling growth striae of the present invention, one or more in isopropyl myristate, spermol, Jojoba oil, caprylic/capric triglyceride, wheat germ oil hydrogenation, tocopherol, Fructus oleae europaeae fruit oil of described grease separation。
In the biological skin care dispelling growth striae of the present invention, described surfactant is sucrose stearate。
In the biological skin care dispelling growth striae of the present invention, described adjuvant is selected from one or more in amino acid humectant, trehalose, essence, preservative。
In the biological skin care dispelling growth striae of the present invention, described water is deionized water。
Further, the preparation method that the present invention also provides for a kind of aforesaid biological skin care dispelling growth striae, described method comprises the following steps:
Weigh oligopeptide-1, bionic nano microsphere, palmityl tripeptides-1 by weight ratio, and at room temperature Homogeneous phase mixing, form additive A；
Surfactant, oil are at room temperature mixed, is again heated to 75-85 DEG C, form oil phase；
Asiaticoside, Lauryldimonium Hydroxypropyl base hydrolytic collagen, Aloe extraction solution, pantothenic acid, adjuvant being mixed with deionized water, and be again heated to 75-85 DEG C, form aqueous phase, wherein said adjuvant does not contain essence and preservative；
Described oil phase and aqueous phase being added in the emulsifying pot of also evacuation of preheating, beat homogenizing 3-4 minute, stopping is stirred after beating homogenizing and is cooled to 50 DEG C；
Add additive A, ubiquinone, silantriol, N-palmityl hydroxyproline cetyl, essence and preservative, stir 30-35 minute, be cooled to after 36-40 DEG C and form the described biological skin care goods dispelling growth striae。
In one embodiment, the vacuum of described evacuation is 0.05MPa, and the rotating speed of stirring is 50rpm。
The preparation method of the biological skin care dispelling growth striae of the present invention is simple, and the whole course of processing does not destroy the activity of active component。
Beneficial effects of the present invention is embodied in: the present invention utilizes bionic nano Microspheres Technique to be encapsulated oligopeptide-1, palmityl tripeptides-1, prevent oligopeptide-1, palmityl tripeptides-1 from inactivating, pro-skin nano-encapsulated, improve the permeability of skin, arrive rapidly skin nexine, form nutrient bank, slow releasing function makes active component uniformly discharge, synergistic activity, and reduce stimulation, solve the impermeable problem of product well。Specifically, the present invention utilizes Nano microsphere to provide one effective delivery system, and specific aim is carried, and infiltrates through skin nexine, protection, synergistic activity composition, reduces stimulation, reduces allergy。Owing to the impacts such as general Nano microsphere receptor 1 activity substrate concentration, pH value are big, the situation of microsphere aggregation easily occurs, the Nano microsphere that the present invention selects is per se with positive charge, mutually exclusive, therefore, bionic nano microsphere can quite stable, the active ingredient that bionic nano microsphere is encapsulated also can stablize, effectively arrive and play a role inside skin。Therefore in the biological skin care dispelling growth striae made, oligopeptide-1 and palmityl tripeptides-1 are encapsulated in bionic nano microsphere well, and the skin nexine of people can be infiltrated through preferably, with repairing growth stricture of vagina better, consolidation skin。
And asiaticoside has promotion Wound Healing；Lauryldimonium Hydroxypropyl base hydrolytic collagen has the skin that compacts, and repairs the effect of microgroove；Aloe extraction solution has speckle dispelling, anti-acne, skin whitening, strengthens skin brightness, and skin keeps moistening and elastic；Silantriol, N-palmityl hydroxyproline cetyl repair the effect of little scar, growth striae；Palmityl tripeptides-1 has the effect of the skin that compacts；Pantothenic acid tool manufactures antibody function；Ubiquinone has crease-resistant effect；Oligopeptide-1 has reparation collagen fiber and elastic fiber, repairing growth stricture of vagina, the effect of the skin that compacts。Therefore, the biological skin care dispelling growth striae of the present invention can eliminate growth striae effectively, to human non-toxic's side effect, it is easy to promotes and is suitable for。
Detailed description of the invention
Below in conjunction with specific embodiment, principles of the invention and feature being described, example is served only for explaining the present invention, is not intended to limit the scope of the present invention。
In this article, term " growth striae " refers to several the irregular stripeds occurred on human body, including striae gravidarum, because of the striped etc. caused of losing weight。The goods of the present invention are all effective to these growth striae, can eliminate growth striae or prevent the generation of these growth striae。
The biological skin care dispelling growth striae of the present invention includes bionic nano microsphere, Lauryldimonium Hydroxypropyl base hydrolytic collagen, pantothenic acid, asiaticoside, Aloe extraction solution, surfactant, oil, adjuvant, water, oligopeptide-1, palmityl tripeptides-1, silantriol, N-palmityl hydroxyproline cetyl and ubiquinone。After the hEGF receptor (EGFR) of oligopeptide-1 (hEGF) with special cross-cell membrane surface combines, have stimulated the activity of tyrosine kinase in EGFR complex, by the autophosphorylation effect of EGFR complex, quick information transfer network is formed in cell, a series of biochemical reactions of activator protein enzyme and phosphate etc., promote internal Ca2+、K+With sugar etc. low-molecular material enter (Active transport) in cell in a large number, glycolysis amount increases, RNA and protein synthesis increase, after effect a period of time, EGFR complex starts to promote that DNA synthesizes, and thus tend to the division of the various kinds of cell such as stimulating endothelial cell, mononuclear cell, propagation and differentiation, so as to migrate to wound site, acceleration starts wound tissue's regeneration, repairs and the outer interstitial formation of born of the same parents。On the other hand, hEGF can increase other Endogenous Growth Factors, promotes hydroxyproline synthesis, regulates collagenase and the synthesis of collagen, secretion and precipitation, regulate collagen degradation, make collagen fiber arrange in a linear fashion, strengthen wound surface anti-tensile degree, repairs wound。Research shows, in epidermis, in, the cell of outer 3 germinal layers all have EGFR to exist。The normal cells such as the horn cell of people, confluent monolayer cells and fibrocyte all have specific EGFR。The dermal fibroblasts of people has 4 × 105Individual～10 × 105Individual EGFR binding site, this absorbs hEGF for human skin cell theoretically provides foundation。This effect has other targeting (that is: target cell is epithelial cell, endotheliocyte and fibroblast etc.) and real-time。
After supplementing rhEGF, regenerative cell quickly generates, and the quick keratinization of senile cell comes off, and total cellular score is greatly increased, and ruptures, and collagen fiber and the elastic fiber of degeneration are repaired, the problem effectively solving striae gravidarum lines。
Under the effect of rhEGF, the cell of differentiation and maturation is inverse is divided into stem cell。Stem cell, when reaching a certain amount of, is formed on " stem cell island ", accelerates the generation of new cell。" stem cell island " has higher propagation, differentiation capability, the fresh cells that it is continuously generated constitutes new cell mass, thus changing the ratio of new old cell in skin, reduce the mean age of skin, skin is made to be in the younger state of consolidation all the time, effectively solve the cutis laxa problem of striae gravidarum, improve the striae gravidarum of skin。
In the present invention, cosmetics that the described biological skin care dispelling growth striae can be separately formed or astringent, can also be that the present invention mixes with pharmaceutically acceptable excipient and/or carrier, making the pharmaceutical composition reagent of external, the form of reagent can be emulsifiable paste, ointment, emulsion, gel or astringent。
In one embodiment of the invention, described bionic nano microsphere is to be prepared from by any one in water, palmityl Hydroxyproyl Trimethyl ammonium amylopectin/glycerin crosspolymers, phenoxyethanol hydrolecithin, methyl hydroxybenzoate, butyl hydroxybenzoate, ethyl hydroxybenzoate, propyl hydroxybenzoate or two or more material therein。
In one embodiment of the invention, one or more in isopropyl myristate, spermol, Jojoba oil, caprylic/capric triglyceride, wheat germ oil hydrogenation, tocopherol, Fructus oleae europaeae fruit oil of described grease separation。It should be appreciated by those skilled in the art, it would however also be possible to employ other oil, as long as the oil used has identical similar function。
In one embodiment of the invention, described surfactant is sucrose stearate。Certainly, surfactant can also other material, as long as the purpose of the present invention can be realized。
In another embodiment of the present invention, described adjuvant selected from amino acid humectant, trehalose, essence, preservative one or more。
In yet another embodiment of the present invention, described water is deionized water。
It is all commercially available that all reagent used herein (includes reagent mentioned above), and content used herein refers to the every kind of component specification according to the product bought, by the pure amount of substance that calculated reality contains。Therefore amount used below is all referring to the pure amount of component, and the amount directly directly taken from reagent bottle (bag) during non-purchase。
By the description of following specific embodiment, those skilled in the art can more easily understand the present invention and advantage thereof and benefit。
Embodiment 1
A kind of biological skin care dispelling growth striae, it includes the system based on water, and the system of described water includes the component of following portions by weight:
Bionic nano microsphere 0.5 part
Lauryldimonium Hydroxypropyl base hydrolytic collagen 1 part
0.5 part of pantothenic acid
Asiaticoside 1 part
Aloe extraction solution 1 part
1 part of surfactant
Oil 5 parts
Adjuvant 0.5 part
50 parts of water；
Wherein in the described biological skin care dispelling growth striae, described based on the following components also comprising therapeutically effective amount in the system of water:
Oligopeptide-1500IU/ml；
Palmityl tripeptides-1500IU/ml；
Silantriol 10 × 10-5Weight portion；
N-palmityl hydroxyproline cetyl 3 × 10-4Weight portion；And
Ubiquinone 1 × 10-4Weight portion。
The preparation method of the above-mentioned biological skin care dispelling growth striae is as follows:
Each component above-mentioned is weighed by above-mentioned proportioning, standby；
By oligopeptide-1, bionic nano microsphere, palmityl tripeptides-1, and at room temperature Homogeneous phase mixing, form additive A；
Surfactant, oil are at room temperature mixed in the oil phase pot of emulsifying pot group, is again heated to 75-85 DEG C, form oil phase；It is preferred that described temperature is 78-80 DEG C；More preferably, described temperature is 80 DEG C, and now reaction effect is best；
Asiaticoside, Lauryldimonium Hydroxypropyl base hydrolytic collagen, Aloe extraction solution, pantothenic acid, adjuvant are added with deionized water in the aqueous phase pot of emulsifying pot group and mix, and it is again heated to 75-85 DEG C, forming aqueous phase, wherein said adjuvant does not contain essence and preservative；It is preferred that described temperature is 78-80 DEG C；More preferably, described temperature is 80 DEG C, and now reaction effect is best；
Preheating emulsifying pot is to 75-85 DEG C, it is preferred that, preheating emulsifying pot is to 78-80 DEG C；More preferably, preheating emulsifying pot is to 80 DEG C。
Emulsifying pot being evacuated to about 0.05MPa, and described oil phase and aqueous phase is added in the emulsifying pot of preheating, beat homogenizing 3 minutes, stopping is stirred after beating homogenizing and is cooled to 50 DEG C；Wherein, stir speed (S.S.) is about 50rpm；
Then, add additive A, ubiquinone, silantriol, N-palmityl hydroxyproline cetyl, essence and preservative, stir about 30 minutes, be cooled to after 36-40 DEG C and form the described biological skin care goods dispelling growth striae。Preferably cool the temperature to 38 DEG C, obtain preferably goods。
Being observed under-5 DEG C ,-15 DEG C, 40 DEG C conditions by the above-mentioned prepared biological skin care dispelling growth striae, mastic is fine and smooth, and without oil-water separation phenomenon, outward appearance is without significant change。
Being taken by the above-mentioned prepared biological skin care dispelling growth striae puts in several Clear glass bottles and jars in right amount, seals and is placed on 40 DEG C ,-15 DEG C, stands 24 hours。It is shown that after dispelling the biological skin care recovery room temperature of growth striae, mastic is without oil-water separation phenomenon, fine and smooth, glossy, illustrates that this dispels the good stability of the biological skin care of growth striae。
Embodiment 2
A kind of biological skin care dispelling growth striae, it includes the system based on water, and the system of described water includes the component of following portions by weight:
Bionic nano microsphere 1 part
Lauryldimonium Hydroxypropyl base hydrolytic collagen 2 parts
1 part of pantothenic acid
Asiaticoside 2 parts
Aloe extraction solution 2 parts
2 parts of surfactant
Oil 6 parts
Adjuvant 0.6 part
55 parts of water；
Wherein in the described biological skin care dispelling growth striae, described based on the system of water also comprises following components:
Oligopeptide-12000IU/ml；
Palmityl tripeptides-12000IU/ml；
Silantriol 8.2 × 10-5Weight portion；
N-palmityl hydroxyproline cetyl 1.16 × 10-4Weight portion；And
Ubiquinone 2 × 10-4Weight portion。
Method described in previous embodiment 1 is prepared and obtains the biological skin care dispelling growth striae described in embodiment 2。
Being observed under-5 DEG C ,-15 DEG C, 40 DEG C conditions by the above-mentioned prepared biological skin care dispelling growth striae, mastic is fine and smooth, and without oil-water separation phenomenon, outward appearance is without significant change。
Being taken by the above-mentioned prepared biological skin care dispelling growth striae puts in several Clear glass bottles and jars in right amount, seals and is placed on 40 DEG C ,-15 DEG C, stands 24 hours。It is shown that after dispelling the biological skin care recovery room temperature of growth striae, mastic is without oil-water separation phenomenon, fine and smooth, glossy, illustrates that this dispels the good stability of the biological skin care of growth striae。
Embodiment 3
A kind of biological skin care dispelling growth striae, it includes the system based on water, and the system of described water includes the component of following portions by weight:
Bionic nano microsphere 10 parts
Lauryldimonium Hydroxypropyl base hydrolytic collagen 5 parts
5 parts of pantothenic acid
Asiaticoside 3 parts
Aloe extraction solution 5 parts
5 parts of surfactant
Oil 15 parts
Adjuvant 15 parts
75 parts of water；
Wherein in the described biological skin care dispelling growth striae, described based on the system of water also comprises following components:
Oligopeptide-15000IU/ml；
Palmityl tripeptides-15000IU/ml；
Silantriol 2.46 × 10-4Weight portion；
N-palmityl hydroxyproline cetyl 3.84 × 10-4Weight portion；And
Ubiquinone 7.5 × 10-4Weight portion。
Method described in previous embodiment 1 is prepared and obtains the biological skin care dispelling growth striae described in embodiment 3。
Being observed under-5 DEG C ,-15 DEG C, 40 DEG C conditions by the above-mentioned prepared biological skin care dispelling growth striae, mastic is fine and smooth, and without oil-water separation phenomenon, outward appearance is without significant change。
Being taken by the above-mentioned prepared biological skin care dispelling growth striae puts in several Clear glass bottles and jars in right amount, seals and is placed on 40 DEG C ,-15 DEG C, stands 24 hours。It is shown that after dispelling the biological skin care recovery room temperature of growth striae, mastic is without oil-water separation phenomenon, fine and smooth, glossy, illustrates that this dispels the good stability of the biological skin care of growth striae。
Embodiment 4
A kind of biological skin care dispelling growth striae, it includes the system based on water, and the system of described water includes the component of following portions by weight:
Bionic nano microsphere 1 part
Lauryldimonium Hydroxypropyl base hydrolytic collagen 2 parts
1 part of pantothenic acid
Asiaticoside 2 parts
Aloe extraction solution 2 parts
2 parts of surfactant
Oil 6 parts
Adjuvant 0.6 part
55 parts of water；
Wherein in the described biological skin care dispelling growth striae, described based on the system of water also comprises following components:
Oligopeptide-110000IU/ml；
Palmityl tripeptides-110000IU/ml；
Silantriol 5 × 10-4Weight portion；
N-palmityl hydroxyproline cetyl 5 × 10-4Weight portion；And
Ubidecarenone × 10-4Weight portion。
Method described in previous embodiment 1 is prepared and obtains the biological skin care dispelling growth striae described in embodiment 4。
Being observed under-5 DEG C ,-15 DEG C, 40 DEG C conditions by the above-mentioned prepared biological skin care dispelling growth striae, mastic is fine and smooth, and without oil-water separation phenomenon, outward appearance is without significant change。
Being taken by the above-mentioned prepared biological skin care dispelling growth striae puts in several Clear glass bottles and jars in right amount, seals and is placed on 40 DEG C ,-15 DEG C, stands 24 hours。It is shown that after dispelling the biological skin care recovery room temperature of growth striae, mastic is without oil-water separation phenomenon, fine and smooth, glossy, illustrates that this dispels the good stability of the biological skin care of growth striae。
Embodiment 5 effect contrast test
The biological skin care dispelling growth striae previous embodiment made carries out biological effect contrast test:
(1) contrast agent is commercially available striae gravidarum frost and blank emollient cream；
(2) test crowd: pregnant woman 30 people, wherein, 21 people are that first time is conceived, and 9 people were for giving birth to a child；
(3) test method: by random for Primiparous time-pregnant women average mark A, B, C tri-groups per capita, had pregnant woman's stochastic averagina of childbearing history to distribute in A, B, C are tri-groups。Test material within three month, is begun to use from pregnancy, A group striae gravidarum of the present invention frost, B group commercially available striae gravidarum frost, C group blank emollient cream, every day is with once, being applied in abdominal part, until the childbirth later moon。
Result of the test such as table 1 below and table 2:
Table 1
Table 1 is the situation contrast that after the women of Primiparous time-pregnant uses trial target, striae gravidarum occurs。
Table 2
Table 2 is the situation contrast that after having the women of conceived history to use trial target, striae gravidarum occurs。
From table 1 and table 2 it is known that no matter for the women of Primiparous time-pregnant or the women having conceived history, after the biological skin care dispelling growth striae using the present invention, the striae gravidarum of women is all had greatly improved。
More than simply contrast test is done in the experiment of striae gravidarum, also other growth striae has been carried out contrast test simultaneously, for instance, because of the growth striae that fat-reducing is subsequently formed, result of the test shows, the present invention dispels the biological skin care of growth striae can dispel these growth striae too。Therefore, the biological skin care dispelling growth striae of the present invention is applicable to all of growth striae。
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all within the spirit and principles in the present invention, any amendment of making, equivalent replacement, improvement etc., should be included within protection scope of the present invention。
Claims (8)
1. the biological skin care dispelling growth striae, it is characterised in that the described biological skin care dispelling growth striae includes the system based on water, and the system of described water includes the component of following portions by weight:
Bionic nano microsphere 0.5-10 part
Lauryldimonium Hydroxypropyl base hydrolytic collagen 1-5 part
Pantothenic acid 0.5-5 part
Asiaticoside 1-3 part
Aloe extraction solution 1-5 part
Surfactant 1-5 part
Oil 5-15 part
Adjuvant 0.5-15 part
Water 50-75 part；
Wherein in the described biological skin care dispelling growth striae, described based on the following components also comprising therapeutically effective amount in the system of water:
Oligopeptide-1
Palmityl tripeptides-1
Silantriol
N-palmityl hydroxyproline cetyl, and
Ubiquinone；
Described bionic nano microsphere is to be prepared from by its in water, palmityl Hydroxyproyl Trimethyl ammonium amylopectin/glycerin crosspolymers, phenoxyethanol hydrolecithin, methyl hydroxybenzoate, butyl hydroxybenzoate, ethyl hydroxybenzoate, propyl hydroxybenzoate is two or more；Described adjuvant is selected from one or more in amino acid humectant, trehalose, essence, preservative。
2. dispel the biological skin care of growth striae as claimed in claim 1, it is characterised in that the parts by weight of each component of the biological skin care dispelling growth striae of the described system based on water are:
Bionic nano microsphere 1-8 part
Lauryldimonium Hydroxypropyl base hydrolytic collagen 2-4 part
Pantothenic acid 1-4 part
Asiaticoside 2-3 part
Aloe extraction solution 2-4 part
Surfactant 2-4 part
Oil 6-10 part
Adjuvant 0.6-10 part
Water 55-70 part。
3. dispel the biological skin care of growth striae as claimed in claim 1 or 2, it is characterised in that the Specific amounts of the described component based on the therapeutically effective amount contained in the system of water is:
Oligopeptide-1500IU/ml-10000IU/ml；
Palmityl tripeptides-1500IU/ml-10000IU/ml；
Silantriol 10 × 10-5-5×10-4Weight portion；
N-palmityl hydroxyproline cetyl 3 × 10-4-5×10-4Weight portion；And
Ubiquinone 1 × 10-4-10×10-4Weight portion。
4. dispel the biological skin care of growth striae as claimed in claim 1 or 2, it is characterised in that: one or more in isopropyl myristate, spermol, Jojoba oil, caprylic/capric triglyceride, wheat germ oil hydrogenation, tocopherol, Fructus oleae europaeae fruit oil of described grease separation。
5. dispel the biological skin care of growth striae as claimed in claim 1 or 2, it is characterised in that: described surfactant is sucrose stearate。
6. dispel the biological skin care of growth striae as claimed in claim 1 or 2, it is characterised in that: described water is deionized water。
7. the preparation method of the biological skin care dispelling growth striae as claimed in claim 1, it is characterised in that described method comprises the following steps:
Weigh oligopeptide-1, bionic nano microsphere, palmityl tripeptides-1 by weight ratio, and at room temperature Homogeneous phase mixing, form additive A；
Surfactant, oil are at room temperature mixed, is again heated to 75-85 DEG C, form oil phase；
Asiaticoside, Lauryldimonium Hydroxypropyl base hydrolytic collagen, Aloe extraction solution, pantothenic acid, adjuvant being mixed with water, and be again heated to 75-85 DEG C, form aqueous phase, wherein said adjuvant does not contain essence and preservative；
Described oil phase and aqueous phase being added in the emulsifying pot of also evacuation of preheating, beat homogenizing 3-4 minute, stopping is stirred after beating homogenizing and is cooled to 50 DEG C；
Add additive A, ubiquinone, silantriol, N-palmityl hydroxyproline cetyl, essence and preservative, stir 30-35 minute, be cooled to after 36-40 DEG C and form the described biological skin care dispelling growth striae。
8. method as claimed in claim 7, it is characterised in that the vacuum of described evacuation is 0.05MPa, and the rotating speed of stirring is 50rpm。
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| CN103340813B (en) * | 2013-06-27 | 2014-07-30 | 安婕妤化妆品科技股份有限公司 | Collagenic skin care emulsion, and preparation method and application thereof |
| CN104546606B (en) * | 2014-12-26 | 2017-12-29 | 青蛙王子(中国)日化有限公司 | A kind of oil-in-water is dispelled striae of pregnancy frost and preparation method thereof |
| CN105902477B (en) * | 2016-04-27 | 2018-11-02 | 深圳市容大生物技术有限公司 | The comprehensive biological agent and preparation method thereof for improving eye vigor |
| CN106344435A (en) * | 2016-08-26 | 2017-01-25 | 吉安市御美丽健康产业股份有限公司 | Skin protection cream capable of eliminating striae gravidarum |
| CN106511171A (en) * | 2016-12-06 | 2017-03-22 | 广州聚禅现代农业研究院有限公司 | Amaranth polysaccharide-containing beautifying lotion |
| CN106580925B (en) * | 2016-12-21 | 2019-02-22 | 郑州大学 | A kind of preparation method and applications of artificial cell nanocapsule carrier |
| CN107837316A (en) * | 2017-11-20 | 2018-03-27 | 冯君玉 | A kind of striae of pregnancy repairs liquid, preparation method and applications |
| CN108175740B (en) * | 2018-01-29 | 2020-11-10 | 广东袋鼠妈妈生物科技有限公司 | Repair cream with effects of effectively preventing and removing striae gravidarum and preparation method thereof |
| CN110013447B (en) * | 2019-03-13 | 2022-08-05 | 广州雅纯化妆品制造有限公司 | Cream for removing striae gravidarum and preparation method thereof |
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| CN101536967A (en) * | 2009-04-22 | 2009-09-23 | 烟台新时代健康产业日化有限公司 | New use of green plum blossom extraction method and green plum blossom anti-aging skin cream |
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| JP2008526963A (en) * | 2005-01-14 | 2008-07-24 | リポ ケミカルズ インコーポレイテッド | Compositions and methods for treating overpigmented skin |
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