CN103005463A - Low molecular collagen oral enteric microcapsule, preparation method thereof, and health drink - Google Patents
Low molecular collagen oral enteric microcapsule, preparation method thereof, and health drink Download PDFInfo
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- CN103005463A CN103005463A CN2012105264416A CN201210526441A CN103005463A CN 103005463 A CN103005463 A CN 103005463A CN 2012105264416 A CN2012105264416 A CN 2012105264416A CN 201210526441 A CN201210526441 A CN 201210526441A CN 103005463 A CN103005463 A CN 103005463A
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Abstract
The invention provides a low molecular collagen oral enteric microcapsule, a preparation method thereof, and a health drink, and belongs to the field of food. The low molecular collagen oral enteric microcapsule comprises health-care components which are of a health-care efficacy amount, and auxiliary material, wherein the health-care components are composed of low molecular collagen, and the low molecular collagen is collagen with the molecular weight of 500 to 1000 Da; and the auxiliary material comprises one or more of the following food annexing solidifying agents: gelatin, alginic acid or sodium salt thereof, ethyl cellulose, polyamino acid, and/or polylactic acid- polyethyleneglycol periodic copolymer. The low molecular collagen oral enteric microcapsule and the combination drink thereof are easy to carry, are improved in flavor, are not insoluble in the stomach but enteric, and are good in storage stability.
Description
Technical field
The present invention relates to low molecular collagen oral enteric microcapsules and preparation method thereof and the health drink of field of food.
Background technology
To be collagenous fibres have better water miscible protein, an English formal name used at school Collagen through what obtain behind the Partial digestion to collagen.Be present in widely in the skin, bone, muscle, cartilage, joint, hair, eye tissue of human body, play triple anti-aging effects of support, reparation, protection.Collagen mainly is distributed in the mammiferous connective tissue, is the main matter basis of these connective tissues.Have 1st/3rd in the human body protein, collagen, nearly 3 kilograms collagen in the human body of growing up has very important effect, and collagen can be kept intercellular elasticity, increases the elastic force of skin and makes it smooth; Promote cell metabolism, keep fit, delay senility; Promote the precipitation of calcium in bone, effectively prevent osteoporosis etc.With advancing age, the loss that collagen can be gradually.So delay senility must replenishing collagen.Can come replenishing collagen by the oral modes such as the food of collagen, direct hypodermic injection, oral low molecular collagen peptide that contain.
At present, commercially available collagen product is conventional tablet and capsule substantially, and gastric mucosa is had some excitants; Bioavilability is low, carries the shortcomings such as inconvenience.Based on the problems referred to above, we are incorporated into field of food with the microcapsules technology of field of medicaments maturation, to hang down molecular collagen has made and has been beneficial in vivo absorption, the oral enteric microcapsules that meet user's compliance, and with the form of combination product, for the consumer provides portable, easily use, have the pleasing beverage products of the low molecular collagen of health-care components.
Summary of the invention
The problem that invention will solve
The purpose of this invention is to provide a kind of low molecular collagen oral enteric microcapsules and preparation method thereof.
Another object of the present invention is to provide a kind of preparation method of low molecular collagen oral enteric microcapsules combined health drink, the method is simple, be easy to produce.
For the scheme of dealing with problems
The objective of the invention is to be achieved through the following technical solutions:
An embodiment of the invention relate to, a kind of low molecular collagen oral enteric microcapsules, it is characterized in that, its health component and auxiliary material by the health-care efficacy amount is made, wherein said health component is comprised of low molecular collagen, and described low molecular collagen is that molecular weight is the collagen of 500-1000Da; Described auxiliary material comprises that food additive adds curing agent, and it is selected from gelatin, alginic acid or its sodium salt, ethyl cellulose, polyaminoacid and/or the polylactic acid-polyethylene glycol block copolymer one or more; The preparation method of described microcapsules comprises, be selected from gelatin, alginic acid or its sodium salt, ethyl cellulose, polyaminoacid and/or the polylactic acid-polyethylene glycol block copolymer one or more and form capsule material solution by being dissolved in the aqueous solution described, described low molecular collagen is added in the capsule material solution, then add the curing agent solution by adding the gained mixed solution to food additive, and be cured as micelle, micelle is dry.
An embodiment of the invention relate to, and a kind of method for preparing described low molecular collagen oral enteric microcapsules comprises the steps:
1) will be selected from gelatin, alginic acid or its sodium salt, ethyl cellulose, polyaminoacid and/or the polylactic acid-polyethylene glycol block copolymer one or more and be added to the water, and leave standstill to it and dissolve fully, make capsule material solution;
2) described low molecular collagen is added in the capsule material solution, stir it is dissolved fully, leave standstill or ultrasonic, obtain mixed solution;
3) described mixed solution being splashed into concentration is that 10%～36% food additive adds and solidifies in the agent solution, stirs and is cured as micelle, all drips off rear curing, separates micelle, washing;
4) with described micelle at 45 ℃～50 ℃ dry dry micelles.
In a preferred embodiment of the present invention, described low molecular collagen is 1:1～6:1 with one or more the mass ratio that is selected from gelatin, alginic acid or its sodium salt, ethyl cellulose, polyaminoacid and/or the polylactic acid-polyethylene glycol block copolymer, preferred 4:1.
In a preferred embodiment of the present invention, the mass ratio that is selected from one or more and water in gelatin, alginic acid or its sodium salt, ethyl cellulose, polyaminoacid and/or the polylactic acid-polyethylene glycol block copolymer in the described capsule material solution is 1:60～1:40, and the mass ratio that preferred described capsule material solution is sodium alginate and water is the mixture of 1:60～1:40.
In a preferred embodiment of the present invention, it is characterized in that, it is 10%～36% that described food additive adds curing agent solution concentration, preferred 15%-36%.
In a preferred embodiment of the present invention, it is characterized in that, it is calcium chloride that described food additive adds curing agent.
In a preferred embodiment of the present invention, the concentration of described capsule material solution is 1.6%～3.5%, preferred 2%～3.5%.
In a preferred embodiment of the present invention, the particle diameter of described low molecular collagen microcapsules is less than 1.5mm.
An embodiment of the invention relate to, the solid health-care beverage that described low molecular collagen oral enteric microcapsules are made, it is characterized in that, described solid health-care beverage is formed for the raw material configuration of calculating based on the weight of water by following consumption: low molecular collagen oral enteric microcapsules 5～10g, purified water 100-200ml, fruity flavor 0.1-0.5%, and vitamin C 0.01-0.2%; Described fruity flavor is one or more that are selected from orange flavor, grapefruit flavor, peach flavor and/or the apple aroma, its preparation technology is as follows: get low molecular collagen oral enteric microcapsules, fruity flavor and vitamin C and add stirring and dissolving in the purified water, the granulation subpackage, and get final product.
An embodiment of the invention relate to; the health-care liquid beverage that described low molecular collagen oral enteric microcapsules are made; it is characterized in that; described health-care liquid beverage is formed for the raw material configuration of calculating based on the weight of water by following consumption: low molecular collagen oral enteric microcapsules 5-10g; taurine 0.05-0.1%; vitamin C 0.5-1.0%; Juice 0.5-2.5%; with purified water 500ml; its preparation technology is as follows: add successively vitamin C; taurine; with Juice in purified water; after refiltering sterilization, add low molecular collagen oral enteric microcapsules packing, and get final product.
An embodiment of the invention relate to, described low molecular collagen beverage, it is characterized in that, described low molecular collagen beverage is formed for the raw material configuration of calculating based on the weight of water by following consumption: low molecular collagen oral enteric microcapsules 5-10g, and liquid; Described liquid comprises taurine 0.005-0.01%, vitamin C 0.005-0.1%, Juice 0.05-0.25%, and purified water 50ml; Its preparation technology is as follows: add successively vitamin C, taurine and Juice in purified water, refilter sterilization after, form the beverage solvent, be combined into low molecular collagen beverage combination product with low molecular collagen oral enteric microcapsules, and get final product.
In an embodiment of the invention, described low molecular collagen is, low molecular collagen known in the art, and for example molecular weight is the collagen of 500-1000Da, includes but not limited to Isin glue collagen.
In this article, " health-care efficacy amount " or " health care effective dose " refers to cause the dosage of health-care efficacy or health-care effect or health care effect, perhaps refers to cause the content of health-care efficacy or health-care effect or health care effect.Preferably, " health-care efficacy amount " or " health care effective dose " includes but not limited to that described low molecular collagen and one or more the mass ratio that is selected from gelatin, alginic acid or its sodium salt, ethyl cellulose, polyaminoacid and/or the polylactic acid-polyethylene glycol block copolymer are 1:1～6:1.
An embodiment of the invention relate to, and described microcapsules are prepared with hardening process in the liquid, and its average grain diameter mainly is distributed in 0.05～2.0mm less than 1.5mm.
By the analysis of physical and chemical property to low molecular collagen, many experiments is observed, preferably take the sodium alginate natural polysaccharide carbohydrate gel shaped, stable, that security all reaches the health food requirement as the capsule material, adopt phase separation method, in the mixture of low molecular collagen and capsule material, add another cure-crosslinking agent the solubility of capsule material is reduced and condense upon capsule-core around, encystation in liquid phase.This method is simple to operate, and the gel particle size range is easily controlled, and can improve the local flavor of low molecular collagen, and simultaneously, security is good, is convenient to produce.
The effect of invention
This technique main feature is: increase low molecular collagen load capacity, improve bioavilability, the load capacity of functional components improves, and is insoluble in gastric juice, complete in the enteron aisle stripping, thereby increases health care degree of absorbing.
Oral enteric microcapsules technology among the present invention can adopt the coating method that hardens in the liquid, includes but not limited to: phase separation method, interfacial polymerization, spray drying process etc.
Description of drawings
Fig. 1 shows that oral enteric microcapsules of the present invention do not dissolve in gastric juice.
Fig. 2 shows that oral enteric microcapsules of the present invention dissolve in intestinal juice.
The specific embodiment
Following examples mainly are be used to further specifying the present invention, rather than limit the scope of the invention.
Material and source: low molecular collagen is that molecular weight is the collagen of 500-1000, includes but not limited to Isin glue collagen.
Embodiment 1: the screening of sodium alginate concentration scope
Low molecular collagen oral enteric microcapsules prescription sees Table 1:
Table 1. hangs down molecular collagen oral enteric microcapsules formula table
Wherein, the fish scale that described low molecular collagen is Tilapia mossambica, fish-skin are primary raw material, and it is with being dissolved by trichloroacetic acid of enzymatic isolation method production, the mean molecule quantity food-grade hydrolysis Isin glue collagen product at 500-1000Da.
Preparation technology: the sodium alginate that takes by weighing weight percent concentration by upper table prescription adds in the purified water and dissolves, leave standstill to it and dissolve fully, the low molecular collagen powder that slowly adds formula ratio, stirring and dissolving, leave standstill rear ultrasonic processing, remove bubble, it is in 10% the calcium chloride salt solution that the above-mentioned low molecular collagen mixed solution of sodium alginate for preparing is splashed into concentration, constantly stir and be solidified into micelle, whole low molecular collagen sodium alginate solns drip off rear crosslinked 10min, separate micelle, after purified water is cleaned, 45～50 ℃ of dryings 3 hours, get product.
The prescription 1 of above-mentioned preparation～prescription 8 low molecular collagen microcapsules reaction raffinate are poured into and measured volume in the graduated cylinder, again with biuret method mensuration protein solubility C known in the art.According to formula: envelop rate E=(G-CV)/G * 100% computational envelope rate.The low molecular collagen total amount that G representative adds in the formula, the amount of entrapped low molecular collagen not during CV representative preparation microcapsules; Simultaneously, observe and record shape and its roundness of enteric microcapsule, the particle diameter computing formula is D=∑ DI/n.The average grain diameter of the low molecular collagen microcapsules micelle of employing slide measure mensuration gained is less than 1.5mm.
Embodiment 2: the screening of low molecular collagen concentration range
Low molecular collagen oral enteric microcapsules prescription sees Table 2:
Table 2. hangs down molecular collagen oral enteric microcapsules formula table
| The prescription number | 1 | 2 | 3 | 4 | 5 | 6 |
| Low molecular collagen | 125g | 250g | 375g | 500g | 625g | 750g |
| Sodium alginate | 125g | 125g | 125g | 125g | 125g | 125g |
| Calcium chloride | 10% | 10% | 10% | 10% | 10% | 10% |
| Crosslinking temperature | 25℃ | 25℃ | 25℃ | 25℃ | 25℃ | 25℃ |
| Crosslinking time | 10min | 10min | 10min | 10min | 10min | 10min |
| Purified water | 5000ml | 5000ml | 5000ml | 5000ml | 5000ml | 5000ml |
| The microcapsules outward appearance | Spherical | Spherical | Spherical | Spherical | Spherical | Spherical |
| Envelop rate (%) | 67.4 | 80.6 | 83.4 | 85.4 | 85.3 | 85.0 |
Preparation technology: the sodium alginate that takes by weighing formula ratio by upper table prescription, add the purified water dissolving, leave standstill to it and dissolve fully, ratio by weight 1:1～6:1 takes by weighing low molecular collagen powder, slowly add in the sodium alginate soln, stirring and dissolving, leave standstill rear ultrasonic processing, remove bubble, it is in 10% the calcium salt soln that the above-mentioned low molecular collagen sodium alginate soln for preparing is splashed into concentration, constantly stir and be solidified into micelle, whole low molecular collagen sodium alginate solns drip off rear crosslinked 10min, separate micelle, after purified water is cleaned, 45～50 ℃ of dryings 3 hours, get product.From envelop rate trend, fill a prescription 4 effective optimization formula 4.
The prescription 1 of above-mentioned preparation～prescription 6 low molecular collagen microcapsules reaction raffinate are poured into and measured volume in the graduated cylinder, again with biuret method mensuration protein solubility C known in the art.According to formula: envelop rate E=(G-CV)/G * 100% computational envelope rate.The low molecular collagen total amount that G representative adds in the formula, the amount of entrapped low molecular collagen not during CV representative preparation microcapsules; Simultaneously, observe and record shape and its roundness of enteric microcapsule, the particle diameter computing formula is D=∑ DI/n, and the average grain diameter of the low molecular collagen microcapsules micelle of employing slide measure mensuration gained is less than 1.5mm.
Embodiment 3: the screening of calcium chloride concentration scope
Low molecular collagen oral enteric microcapsules prescription sees Table 3:
Table 3. hangs down molecular collagen oral enteric microcapsules formula table
Preparation technology: the sodium alginate that takes by weighing formula ratio by upper table prescription, ratio by weight 1:40 adds the purified water dissolving, leave standstill to it and dissolve fully, take by weighing the low molecular collagen powder of formula ratio, slowly add in the sodium alginate soln, stirring and dissolving, leave standstill rear ultrasonic processing, remove bubble, the above-mentioned low molecular collagen sodium alginate soln for preparing is splashed into to the calcium salt soln of variable concentrations, constantly stir and be solidified into micelle, whole low molecular collagen sodium alginate solns drip off rear crosslinked 10min, separate micelle, after purified water is cleaned, 45～50 ℃ of dryings 3 hours, get product.
The prescription 1 of above-mentioned preparation～prescription 8 low molecular collagen microcapsules reaction raffinate are poured into and measured volume in the graduated cylinder, again with biuret method mensuration protein solubility C known in the art.According to formula: envelop rate E=(G-CV)/G * 100% computational envelope rate.The low molecular collagen total amount that G representative adds in the formula, the amount of entrapped low molecular collagen not during CV representative preparation microcapsules; Simultaneously, observe and record shape and its roundness of enteric microcapsule, the particle diameter computing formula is D=∑ DI/n, and the average grain diameter of the low molecular collagen microcapsules micelle of employing slide measure mensuration gained is less than 1.5mm.
Embodiment 4: the screening of calcium chloride concentration scope
Low molecular collagen oral enteric microcapsules prescription sees Table 4:
Table 4. hangs down molecular collagen oral enteric microcapsules formula table
Preparation technology: the sodium alginate that takes by weighing formula ratio by upper table prescription, ratio by weight 1:50 adds the purified water dissolving, leave standstill to it and dissolve fully, take by weighing the low molecular collagen powder of formula ratio, slowly add in the sodium alginate soln, stirring and dissolving, leave standstill rear ultrasonic processing, remove bubble, the above-mentioned low molecular collagen sodium alginate soln for preparing is splashed into to the calcium salt soln of variable concentrations, constantly stir and be solidified into micelle, whole low molecular collagen sodium alginate solns drip off rear crosslinked 10min, separate micelle, after purified water is cleaned, 45～50 ℃ of dryings 3 hours, get product.
The prescription 1 of above-mentioned preparation～prescription 8 low molecular collagen microcapsules reaction raffinate are poured into and measured volume in the graduated cylinder, again with biuret method mensuration protein solubility C known in the art.According to formula: envelop rate E=(G-CV)/G * 100% computational envelope rate.The low molecular collagen total amount that G representative adds in the formula, the amount of entrapped low molecular collagen not during CV representative preparation microcapsules; Simultaneously, observe and record shape and its roundness of enteric microcapsule, the particle diameter computing formula is D=∑ DI/n, and the average grain diameter of the low molecular collagen microcapsules micelle of employing slide measure mensuration gained is less than 1.5mm.
Embodiment 5: the screening of calcium chloride concentration scope
Low molecular collagen oral enteric microcapsules prescription sees Table 5: table 5. hangs down molecular collagen oral enteric microcapsules formula table
Preparation technology: the sodium alginate that takes by weighing formula ratio by upper table prescription, ratio by weight 1:60 adds the purified water dissolving, leave standstill to it and dissolve fully, take by weighing the low molecular collagen powder of formula ratio, slowly add in the sodium alginate soln, stirring and dissolving, leave standstill rear ultrasonic processing, remove bubble, the above-mentioned low molecular collagen sodium alginate soln for preparing is splashed into to the calcium salt soln of variable concentrations, constantly stir and be solidified into micelle, whole low molecular collagen sodium alginate solns drip off rear crosslinked 10min, separate micelle, after purified water is cleaned, 45～50 ℃ of dryings 3 hours, get product.
The prescription 1 of above-mentioned preparation～prescription 8 low molecular collagen microcapsules reaction raffinate are poured into and measured volume in the graduated cylinder, again with biuret method mensuration protein solubility C known in the art.According to formula: envelop rate E=(G-CV)/G * 100% computational envelope rate.The low molecular collagen total amount that G representative adds in the formula, the amount of entrapped low molecular collagen not during CV representative preparation microcapsules; Simultaneously, observe and record shape and its roundness of enteric microcapsule, the particle diameter computing formula is D=∑ DI/n, and the average grain diameter of the low molecular collagen microcapsules micelle of employing slide measure mensuration gained is less than 1.5mm.
The present invention in conjunction with the embodiments the result of study of 1～embodiment 5 determine crosslinking agent calcium chloride preferred concentration 15%～36%, sodium alginate concentration in 1.6%～3.5% scope, the low better rounding of molecular collagen micelle outward appearance.
Embodiment 6: low molecular collagen oral enteric microcapsules formula components
Low molecular collagen oral enteric microcapsules formula components sees Table 6:
Table 6. hangs down molecular collagen oral enteric microcapsules formula components table
| Formula components | 1 | 2 | 3 | 4 | 5 |
| Low molecular collagen | 500g | 500g | 500g | 500g | 500g |
| Calcium chloride | 15% | 15% | 15% | 15% | 15% |
| Sodium alginate | 125g | ? | ? | ? | ? |
| Gelatin | ? | 125g | ? | ? | ? |
| Ethyl cellulose | ? | ? | 125g | ? | ? |
| Polyaminoacid | ? | ? | ? | 125g | ? |
| Polylactic acid-polyethylene glycol block copolymer | ? | ? | ? | ? | 125g |
| Crosslinking temperature | 25℃ | 25℃ | 25℃ | 25℃ | 25℃ |
| Crosslinking time | 10min | 10min | 10min | 10min | 10min |
| Purified water | 5000ml | 5000ml | 5000ml | 5000ml | 5000ml |
| The microcapsules outward appearance | Spherical | Spherical | Spherical | Spherical | Spherical |
| Average envelop rate (%) | 80.4 | 80.0 | 76.0 | 80.0 | 80.2 |
The present invention in conjunction with the embodiments 6 results of study determines spherical, the better rounding of the low molecular collagen protomere outward appearance that obtains take gelatin, ethyl cellulose, polyaminoacid and polylactic acid-polyethylene glycol block copolymer as the capsule material, and average grain diameter is less than 100 μ m.Consider, the sodium alginate molecule is a kind of natural polysaccharide that sea-tangle is extracted, have pharmaceutical preparation, required stability, dissolubility, viscosity and the security of health food auxiliary material, food rank sodium alginate easily obtains, biologically has good compatibility, sodium alginate is nontoxic, and the whole world approximately produces 30000 tons every year now, and wherein 30% is used for food industry.Therefore, preferably use sodium alginate.
Embodiment 7: the preparation of low molecular collagen oral enteric microcapsules solid beverage.
The low molecular collagen enteric microcapsule 50-100g of prescription 4 preparations among the embodiment 1, purified water 1000-2000ml, fruity flavor 0.1-0.5%, and vitamin C 0.01-0.2% calculate based on the weight of water;
Preparation process: get low molecular collagen enteric microcapsule, fruity flavor and vitamin C and add stirring and dissolving in the purified water, drying, the granulation subpackage, and get final product.
Embodiment 8: the preparation of low molecular collagen oral enteric microcapsules liquid beverage.
The low molecular collagen microcapsules 50-100gg of prescription 4 preparations among the embodiment 1, purified water 5000ml, taurine 0.05-0.1%, Juice 0.5-2.5%, and vitamin C 0.5-1.0% calculate based on the weight of water;
Preparation process: add successively vitamin C, taurine and Juice in purified water, refilter sterilization after, add low molecular collagen packing, and get final product.
Embodiment 9: low molecular collagen beverage preparation
Embodiment 7 low molecular collagen oral enteric microcapsules solid beverages a (containing low molecular collagen capsulae enterosolubilis 5-10g) a with liquid beverage (purified water 50ml, taurine 0.005-0.01%, vitamin C 0.005-0.1% and Juice be an amount of 0.05-0.25% to taste, calculates based on the weight of water) portion is assembled into low molecular collagen beverage combination product.
Embodiment 10: extracorporeal releasing test.
Adopt low molecular collagen oral enteric microcapsules solid beverage, embodiment 9 preparations of embodiment 8 preparations low molecular collagen oral enteric microcapsules liquid beverage and embodiment 2 low molecular collagen oral enteric microcapsules, hang down the molecular collagen beverage and carry out extracorporeal releasing experiment, the results are shown in Table 7 and table 8.Test procedure is as follows:
With reference to " Chinese pharmacopoeia version in 2010 prepare respectively simulated gastric fluid (get watery hydrochloric acid 16.4ml, add water approximately 800ml and pepsin 10g, after shaking up, thin up becomes 1000ml, and get final product), simulated intestinal fluid (phosphate buffer that namely contains pancreatin, pH6.8).Equal an amount of microcapsules add respectively in the simulated gastric fluid and simulated intestinal fluid of disintegration tester, observe micro-capsule situation of change in the medium, and behind 2h, get in simulated gastric fluid, the simulated intestinal fluid micro-capsule and observe its mode of appearance, get appropriate amount of fluid and adopt biuret method known in the art to measure protein solubility C.
Table 7
Table 8
Claims (11)
1. one kind low molecular collagen oral enteric microcapsules is characterized in that, its health component and auxiliary material by the health-care efficacy amount is made, wherein
Described health component is comprised of low molecular collagen, and described low molecular collagen is that molecular weight is the collagen of 500-1000Da;
Described auxiliary material comprises that food additive adds curing agent, and it is selected from gelatin, alginic acid or its sodium salt, ethyl cellulose, polyaminoacid and/or the polylactic acid-polyethylene glycol block copolymer one or more;
The preparation method of described microcapsules comprises, be selected from gelatin, alginic acid or its sodium salt, ethyl cellulose, polyaminoacid and/or the polylactic acid-polyethylene glycol block copolymer one or more and form capsule material solution by being dissolved in the aqueous solution described, described low molecular collagen is added in the capsule material solution, then add the curing agent solution by adding the gained mixed solution to food additive, and be cured as micelle, micelle is dry.
2. a method for preparing low molecular collagen oral enteric microcapsules according to claim 1 comprises the steps:
1) will be selected from gelatin, alginic acid or its sodium salt, ethyl cellulose, polyaminoacid and/or the polylactic acid-polyethylene glycol block copolymer one or more and be added to the water, and leave standstill to it and dissolve fully, make capsule material solution;
2) described low molecular collagen is added in the capsule material solution, stir it is dissolved fully, leave standstill or ultrasonic, obtain mixed solution;
3) described mixed solution being splashed into concentration is that 10%～36% food additive adds and solidifies in the agent solution, stirs and is cured as micelle, all drips off rear curing, separates micelle, washing;
4) with described micelle at 45 ℃～50 ℃ dry dry micelles.
3. low molecular collagen oral enteric microcapsules according to claim 1 or preparation method according to claim 2, it is characterized in that, described low molecular collagen is 1:1～6:1 with one or more the mass ratio that is selected from gelatin, alginic acid or its sodium salt, ethyl cellulose, polyaminoacid and/or the polylactic acid-polyethylene glycol block copolymer, preferred 4:1.
4. low molecular collagen oral enteric microcapsules according to claim 1 or preparation method according to claim 2, it is characterized in that, the mass ratio that is selected from one or more and water in gelatin, alginic acid or its sodium salt, ethyl cellulose, polyaminoacid and/or the polylactic acid-polyethylene glycol block copolymer in the described capsule material solution is 1:60～1:40, and the mass ratio that preferred described capsule material solution is sodium alginate and water is the mixture of 1:60～1:40.
5. low molecular collagen oral enteric microcapsules according to claim 1 or preparation method according to claim 2 is characterized in that, it is 10%～36% that described food additive adds curing agent solution concentration, preferred 15%-36%.
6. low molecular collagen oral enteric microcapsules according to claim 1 or preparation method according to claim 2 is characterized in that, it is calcium chloride that described food additive adds curing agent.
7. low molecular collagen oral enteric microcapsules according to claim 1 or preparation method according to claim 2 is characterized in that, the concentration of described capsule material solution is 1.6%～3.5%, preferred 2%～3.5%.
8. low molecular collagen oral enteric microcapsules according to claim 1 or preparation method according to claim 2 is characterized in that, the particle diameter of described low molecular collagen microcapsules is less than 1.5mm.
9. solid health-care beverage of making according to the described low molecular collagen oral enteric microcapsules of aforementioned each claim, it is characterized in that, described solid health-care beverage is formed for the raw material configuration of calculating based on the weight of water by following consumption: low molecular collagen oral enteric microcapsules 5～10g, purified water 100-200ml, fruity flavor 0.1-0.5%, and vitamin C 0.01-0.2%; Described fruity flavor is one or more that are selected from orange flavor, grapefruit flavor, peach flavor and/or the apple aroma, its preparation technology is as follows: get low molecular collagen oral enteric microcapsules, fruity flavor and vitamin C and add stirring and dissolving in the purified water, drying, the granulation subpackage, and get final product.
10. health-care liquid beverage of making according to the described low molecular collagen oral enteric microcapsules of aforementioned each claim; it is characterized in that; described health-care liquid beverage is formed for the raw material configuration of calculating based on the weight of water by following consumption: low molecular collagen oral enteric microcapsules 5-10g; taurine 0.05-0.1%; vitamin C 0.5-1.0%; Juice 0.5-2.5%; with purified water 500ml; its preparation technology is as follows: add successively vitamin C; taurine; with Juice in purified water; after refiltering sterilization; add low molecular collagen oral enteric microcapsules packing, and get final product.
11. one kind according to the described low molecular collagen beverage of aforementioned each claim, it is characterized in that, described low molecular collagen beverage is formed for the raw material configuration of calculating based on the weight of water by following consumption: low molecular collagen oral enteric microcapsules 5-10g, and liquid; Described liquid comprises taurine 0.005-0.01%, vitamin C 0.005-0.1%, Juice 0.05-0.25%, and purified water 50ml; Its preparation technology is as follows: add successively vitamin C, taurine and Juice in purified water, refilter sterilization after, form the beverage solvent, be combined into low molecular collagen beverage combination product with low molecular collagen oral enteric microcapsules, and get final product.
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| CN108112835A (en) * | 2017-12-19 | 2018-06-05 | 山东禹王生态食业有限公司 | A kind of double protein capsule beverage and preparation method thereof |
| CN111228239A (en) * | 2020-01-13 | 2020-06-05 | 厦门金达威生物科技有限公司 | PH sensitive type gel microcapsule and preparation method thereof |
| CN115176845A (en) * | 2022-08-06 | 2022-10-14 | 山东悠乐滋生物科技有限公司 | Fermentation preparation process of phycocyanin coconut-flavor sucrose-free yoghurt powder |
| CN115606716A (en) * | 2022-09-30 | 2023-01-17 | 广东越群生物科技股份有限公司 | Microcapsule fry feed free of starch and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1969889A (en) * | 2006-12-04 | 2007-05-30 | 济南赛拜斯生物工程有限公司 | Enteric-coated multilayer encapsulated probiotic microcapsule and preparation method thereof |
| CN102429891A (en) * | 2011-12-13 | 2012-05-02 | 河南科技大学 | Method for preparing low-molecular-weight sheep bone collagen polypeptide calcium chelate microcapsules |
| CN102764426A (en) * | 2012-07-30 | 2012-11-07 | 福建卫生职业技术学院 | Scorpion venom protein polypeptide colon-targeted preparation and preparation method thereof |
-
2012
- 2012-12-07 CN CN2012105264416A patent/CN103005463A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1969889A (en) * | 2006-12-04 | 2007-05-30 | 济南赛拜斯生物工程有限公司 | Enteric-coated multilayer encapsulated probiotic microcapsule and preparation method thereof |
| CN102429891A (en) * | 2011-12-13 | 2012-05-02 | 河南科技大学 | Method for preparing low-molecular-weight sheep bone collagen polypeptide calcium chelate microcapsules |
| CN102764426A (en) * | 2012-07-30 | 2012-11-07 | 福建卫生职业技术学院 | Scorpion venom protein polypeptide colon-targeted preparation and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 刘翔等: "胶原三肽果汁饮料配方工艺设计", 《中国食品工业》 * |
| 吴克刚，柴向华: "《食品微胶囊技术》", 31 July 2006, 中国轻工业出版社 * |
| 张守庆: "重组抗菌肽海藻酸钠微囊制备与体外释放特征研究", 《海洋科学》 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103689739A (en) * | 2013-12-11 | 2014-04-02 | 杭州佳禾食品有限公司 | Fruity drink capsule and preparation method thereof |
| CN103689739B (en) * | 2013-12-11 | 2015-06-10 | 杭州佳禾食品有限公司 | Fruity drink capsule and preparation method thereof |
| CN107619441A (en) * | 2017-10-19 | 2018-01-23 | 中国水产科学研究院黄海水产研究所 | A kind of preparation method and application of collagen peptide chelating calcium microballoon |
| CN107619441B (en) * | 2017-10-19 | 2021-05-11 | 中国水产科学研究院黄海水产研究所 | Preparation method and application of collagen peptide chelated calcium microspheres |
| CN108112835A (en) * | 2017-12-19 | 2018-06-05 | 山东禹王生态食业有限公司 | A kind of double protein capsule beverage and preparation method thereof |
| CN108112835B (en) * | 2017-12-19 | 2021-12-14 | 山东禹王生态食业有限公司 | Double-protein capsule beverage and preparation method thereof |
| CN111228239A (en) * | 2020-01-13 | 2020-06-05 | 厦门金达威生物科技有限公司 | PH sensitive type gel microcapsule and preparation method thereof |
| CN111228239B (en) * | 2020-01-13 | 2022-04-22 | 厦门金达威生物科技有限公司 | PH sensitive type gel microcapsule and preparation method thereof |
| CN115176845A (en) * | 2022-08-06 | 2022-10-14 | 山东悠乐滋生物科技有限公司 | Fermentation preparation process of phycocyanin coconut-flavor sucrose-free yoghurt powder |
| CN115606716A (en) * | 2022-09-30 | 2023-01-17 | 广东越群生物科技股份有限公司 | Microcapsule fry feed free of starch and preparation method thereof |
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