CN102988465A - Process for low-temperature extracting kudzu root flavanone and kudzu root starch from kudzu root - Google Patents
Process for low-temperature extracting kudzu root flavanone and kudzu root starch from kudzu root Download PDFInfo
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- CN102988465A CN102988465A CN201210408613XA CN201210408613A CN102988465A CN 102988465 A CN102988465 A CN 102988465A CN 201210408613X A CN201210408613X A CN 201210408613XA CN 201210408613 A CN201210408613 A CN 201210408613A CN 102988465 A CN102988465 A CN 102988465A
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- radix puerariae
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Abstract
The invention relates to a process for low-temperature extracting kudzu root flavanone and kudzu root starch from kudzu root. According to the process, kudzu or pueraria thomsonii benth developing for 2-5 years is washed, sliced, dried and crushed into pueraria powders, then edible alcohol with a certain concentration is added into the pueraria powders, the mixture is heated and extracted supersonically and subsequently filtered under heating to obtain pueraria extract and filter residues; and the pueraria extract is subjected to vacuum distillation and drying to obtain kudzu root flavanone extract, the filter residues are ground by adding water, screened and subjected to centrifugal separation, and precipates are dried and crushed to obtain kudzu root powder. The raw materials selected by the process have rich resources and high content of kudzu root flavanone, and suitable for scale production requirements; according to the process, the technology of firstly supersonically extracting kudzu root flavanone and subsequently preparing kudzu root powder by centrifugal separation improves the comprehensive utilization value of kudzu root; the process adopts edible alcohol and purified water as the extraction solvent, the recovery is convenient, and simultaneously nontoxic and harmful products are guaranteed; and the process is simple and has short production period, and can be used for large-scale industrial production.
Description
Technical field
The present invention relates to a kind of method of from plant, extracting active substance, be specifically related to a kind of method of from Radix Puerariae, extracting Radix Puerariae total flavones and Radix Puerariae starch.
Background technology
Radix Puerariae is the tuber of leguminous plant Pueraria, is rich in Radix Puerariae starch and Radix Puerariae flavone class material, be traditional Chinese medicine be again health food.Radix Puerariae China distribute wide, output is high, aboundresources, and Pueraria lobota is the rank vegetation, accommodative ability of environment is strong, is can sustainable development and the plant resources of utilization.
In recent years Radix Puerariae cultivated area development is very fast, but research and comprehensive utilization to Radix Puerariae still are in the junior stage, existing Radix Puerariae processing technique, perhaps focus on the extraction of Amylum Puerariae Radicis, perhaps focus on the extraction of Radix Puerariae total flavones, can extract continuously Radix Puerariae starch, Radix Puerariae total flavones although also mention, but specific aim is not strong, extraction efficiency is not high, economic benefit is also lower simultaneously, in a word, lacks suitable extraction Radix Puerariae starch and the technique of Radix Puerariae total flavones.And it is high to plant in the Radix Puerariae in 1 year content of starch, suitable preparation Amylum Puerariae Radicis, but Radix Puerariae flavone content is lower than 0.5%.Radix Puerariae flavone content is higher in the Wild Pueraria, but content of starch is low, and output is limited, collects difficulty.More than two kinds of raw materials all can not adapt to the requirement of industrial-scale production.Planting season, Radix Puerariae flavone and Radix Puerariae starch content were all higher at the Radix Puerariae of 2-5, were fit to carry out the comprehensive extraction of industrialization and application.
Chinese patent application number is that " with the process of metal nano membrance separation comprehensively extracting pueraria starch, flavonoid medicine " patent of invention of 021279661 provides the method for a kind of comprehensively extracting pueraria powder and Radix Puerariae flavone class medicine, the ultrafiltration membrane technique that the method adopts, the Amylum Puerariae Radicis separation efficiency is low, and a large amount of Radix Puerariae flavones is because being extracted in the crude fibre that is present in the Radix Puerariae epidermis, extract of poor benefitsly, be not suitable for large-scale production.
Chinese patent application number is 200910250993.7 " technique of high efficiency extraction Radix Puerariae starch and Radix Puerariae total isoflavone ", the method that provides is to extract first Radix Puerariae starch, then in the Radix Puerariae slag, extract Radix Puerariae flavone, because Radix Puerariae flavone can be partly dissolved in water with frustrating to grind in the standby process of slurry in the Radix Puerariae fragmentation, along with waste liquid flows out, reduced the extraction ratio of Radix Puerariae flavone, comprehensive benefit is not high.Chinese patent application number is 201010555037.2 " process of a kind of synchronous production Radix Puerariae starch, Radix Puerariae flavone ", the method that provides is that first defibrination is isolated Radix Puerariae starch, then the Radix Puerariae residue is used for extracting Radix Puerariae flavone, increased simultaneously the technique of from waste water, extracting flavone, but the wastewater flow rate that the preparation Radix Puerariae starch produces is large and Radix Puerariae flavone content is very low, and intractability is large, and expense is high, the extraction benefit is relatively poor, is not suitable with suitability for industrialized production.Chinese patent application number is 03124754.7 " Radix Puerariae simultaneous extraction Radix Puerariae starch, pueraria polysaccharide, Radix Puerariae isoflavone technique ", the method that provides is to separate Radix Puerariae starch behind Radix Puerariae defibrination, the enzymolysis, then solution is concentrated, precipitate with ethanol obtains pueraria polysaccharide, Radix Puerariae isoflavone, but the defibrination process need adds a large amount of water, the solution concentration time is long, and power consumption is large, and puerarin is slightly soluble in water, the effective ingredient rate of transform is not high, can not satisfy industrialization production requirements.
Chinese patent application number is 201010136218.1 " process of a kind of comprehensive production Radix Puerariae flavone, puerarin and Radix Puerariae starch ", and the method that provides is to adopt microwave auxiliary extraction Radix Puerariae flavone, separating starch in filtering residue.The method Radix Puerariae flavone extraction ratio is high; but extraction temperature reaches 80 ℃; and pass through microwave heating; local temperature can be higher; and the gelatinization point of Radix Puerariae starch is 65-70 ℃; therefore can destroy the structure of starch, the productive rate of minimizing starch in extracting the Radix Puerariae total flavones process, the temperature difference is larger in the large-scale production, and starch gelatinization can cause separation difficulty, the low inferior problem of productive rate.
Summary of the invention
The objective of the invention is for above-mentioned present situation, aim to provide the process of Radix Puerariae total flavones and Radix Puerariae starch in the extract at low temperature Radix Puerariae that a kind of preparation technology is simple, production cost is low, extraction ratio with short production cycle, product is high, the purpose of realization extract at low temperature Radix Puerariae total flavones and Radix Puerariae starch from Radix Puerariae, and extraction ratio that can two kinds of products of Effective Raise.
The invention provides the process of Radix Puerariae total flavones and Radix Puerariae starch in a kind of extract at low temperature Radix Puerariae, concrete steps are as follows:
(1) Radix Puerariae is cleaned section, carry out drying, pulverize, obtain powder of Radix Puerariae;
Described Radix Puerariae is the Pachyrhizua angulatus of Wild Pueraria or trophophase 2-5;
(2) the resulting powder of Radix Puerariae of step (1) is joined in the supersound extraction device, adding concentration of volume percent is the edible ethanol of 30-80%, is heated to 30-60 ℃, the ultrasonic extraction 10-100 of proportion 20-80Hz minute again, filtered while hot namely gets Radix Puerariae extracting solution and filtering residue;
The solid-to-liquid ratio of powder of Radix Puerariae and edible ethanol is 1g:5-20ml;
(3) the Radix Puerariae extracting solution elder generation distilling under reduced pressure recovered alcohol that step (2) is obtained is distinguished the flavor of without alcohol to residual liquid, with the residual liquid drying, obtains extract product of general flavone of kudzuvine root again;
(4) gained filtering residue in the step (2) being added water, to frustrate pulverizing broken, crosses first the yawing sieve fiber is removed, and filtrate is adopted centrifugalize, will precipitate the oven dry pulverizing and namely get Radix Puerariae starch.
The present invention compared with prior art has following features:
1, the Radix Puerariae of selecting is the Pachyrhizua angulatus of Wild Pueraria or trophophase 2-5, and Radix Puerariae total flavones content is high, and raw material supply is sufficient, has good comprehensive utilization value, can adapt to the large-scale production requirement;
2, adopt first supersound extraction Radix Puerariae total flavones, rear centrifugalize to prepare the Radix Puerariae starch technology, elder generation's supersound extraction Radix Puerariae total flavones, improved extraction efficiency, reduced the extraction temperature, avoided the gelatinizing of Radix Puerariae starch, rear centrifugalize prepares Radix Puerariae starch, has reached the purpose of comprehensive utilization Radix Puerariae, has improved the comprehensive utilization value of Radix Puerariae;
3, adopt edible ethanol and pure water as extracting solvent, the convenient recycling guarantees that simultaneously product is nontoxic.
The specific embodiment
The present invention obtains powder of Radix Puerariae with the clean section of Radix Puerariae, drying, pulverizing, adds certain density edible ethanol, and heating is filtered after the employing ultrasonic extraction and obtained Radix Puerariae extracting solution and filtering residue; Radix Puerariae extracting solution elder generation distilling under reduced pressure recovered alcohol, again that residual liquid is dry, obtain extract product of general flavone of kudzuvine root; Filtering residue adds water, and to frustrate pulverizing broken, and the rear centrifugalize of sieving will precipitate oven dry and pulverize and namely get Radix Puerariae starch.The Radix Puerariae extracting solution concentrate drying
The residual liquid drying means is vacuum drying, spray drying or lyophilization.
The Radix Puerariae that the present invention selects is the Pachyrhizua angulatus of Wild Pueraria or trophophase 2-5, and because Radix Puerariae total flavones content in the Pachyrhizua angulatus of growing in a year is low, content of starch is high, does not extract the value of Radix Puerariae flavone, can not adapt to the requirement of large-scale production.
Below in conjunction with embodiment in detail the present invention is described in detail.
Embodiment one:
(1) is that the Pachyrhizua angulatus in 2 years is cleaned chip drying with the 5Kg trophophase, pulverizes, obtain powder of Radix Puerariae 2Kg;
(2) the powder of Radix Puerariae 1Kg that obtains is joined in the supersound extraction device, add 80%vol edible ethanol 10L, be heated to 40 ℃, the supersound extraction 60 minutes of proportion 26Hz again, filtered while hot namely gets Radix Puerariae extracting solution and filtering residue;
(3) the Radix Puerariae extracting solution elder generation that step (2) is obtained is vacuum distillation method distilling under reduced pressure recovered alcohol routinely, distinguishes the flavor of without alcohol to residual liquid, again with the residual liquid spray drying, obtains extract product of general flavone of kudzuvine root 78.4g;
(4) gained filtering residue in the step (2) being added water, to frustrate pulverizing broken, crosses first the yawing sieve fiber is removed, and filtrate is adopted centrifugalize, will precipitate the oven dry pulverizing and namely get Radix Puerariae starch 252.6g.
Embodiment two:
(1) is that the Pachyrhizua angulatus in 3 years is cleaned chip drying with the 5Kg trophophase, pulverizes, obtain powder of Radix Puerariae 2.3Kg;
(2) the powder of Radix Puerariae 1Kg that obtains is joined in the supersound extraction device, add 70%vol edible ethanol 20L, be heated to 30 ℃, the supersound extraction 100 minutes of proportion 20Hz again, filtered while hot namely gets Radix Puerariae extracting solution and filtering residue;
(3) the Radix Puerariae extracting solution elder generation that step (2) is obtained is vacuum distillation method distilling under reduced pressure recovered alcohol routinely, distinguishes the flavor of without alcohol to residual liquid, again with the residual liquid lyophilization, obtains extract product of general flavone of kudzuvine root 68.6g;
(4) gained filtering residue in the step (2) being added water, to frustrate pulverizing broken, crosses first the yawing sieve fiber is removed, and filtrate is adopted centrifugalize, will precipitate the oven dry pulverizing and namely get Radix Puerariae starch 213.5g.
Embodiment three:
(1) 5Kg jin Herba Gelsemii Elegantis is cleaned chip drying, pulverize, obtain 3 kilograms of powder of Radix Puerariae;
(2) the powder of Radix Puerariae 1Kg that obtains is joined in the supersound extraction device, add 30%vol edible ethanol 15L, be heated to 60 ℃, the supersound extraction 60 minutes of proportion 80Hz again, filtered while hot namely gets Radix Puerariae extracting solution and filtering residue;
(3) the Radix Puerariae extracting solution elder generation that step (2) is obtained is vacuum distillation method distilling under reduced pressure recovered alcohol routinely, distinguishes the flavor of without alcohol to residual liquid, residual liquid is put into the vacuum drying oven vacuum drying again, obtains extract product of general flavone of kudzuvine root 81.2g;
(4) gained filtering residue in the step (2) being added water, to frustrate pulverizing broken, crosses first the yawing sieve fiber is removed, and filtrate is adopted centrifugalize, will precipitate the oven dry pulverizing and namely get Radix Puerariae starch 126.1g.
Embodiment four:
(1) is that the Pachyrhizua angulatus in 5 years is cleaned chip drying with the 5Kg trophophase, pulverizes, obtain powder of Radix Puerariae 2.6Kg;
(2) the powder of Radix Puerariae 1Kg that obtains is joined in the supersound extraction device, add 80%vol edible ethanol 5L, be heated to 30 ℃, the supersound extraction 100 minutes of proportion 20Hz again, filtered while hot namely gets Radix Puerariae extracting solution and filtering residue;
(3) ethanol is received by the Radix Puerariae extracting solution elder generation that step (2) is obtained routinely vacuum distillation method distilling under reduced pressure, distinguishes the flavor of without alcohol to residual liquid, again with the residual liquid spray drying, obtains extract product of general flavone of kudzuvine root 77.5g;
(4) gained filtering residue in the step (2) being added water, to frustrate pulverizing broken, crosses first the yawing sieve fiber is removed, and filtrate is adopted centrifugalize, will precipitate the oven dry pulverizing and namely get Radix Puerariae starch 141.6g.
Embodiment five:
(1) is that the Pachyrhizua angulatus in 4 years is cleaned chip drying with the 5Kg trophophase, pulverizes, obtain powder of Radix Puerariae 2.5Kg jin;
(2) the powder of Radix Puerariae 1Kg that obtains is joined in the supersound extraction device, add 50%vol edible ethanol 10L, be heated to 60 ℃, the supersound extraction 10 minutes of proportion 70Hz again, filtered while hot namely gets Radix Puerariae extracting solution and filtering residue;
(3) the Radix Puerariae extracting solution elder generation that step (2) is obtained is vacuum distillation method distilling under reduced pressure recovered alcohol routinely, distinguishes the flavor of without alcohol to residual liquid, again with the residual liquid spray drying, obtains extract product of general flavone of kudzuvine root 73.6g;
(4) gained filtering residue in the step (2) being added water, to frustrate pulverizing broken, crosses first the yawing sieve fiber is removed, and filtrate is adopted centrifugalize, will precipitate the oven dry pulverizing and namely get Radix Puerariae starch 159.4g.
Claims (2)
1. the process of Radix Puerariae total flavones and Radix Puerariae starch in the extract at low temperature Radix Puerariae is characterized in that concrete steps are as follows:
(1) Radix Puerariae is cleaned section, carry out drying, pulverize, obtain powder of Radix Puerariae;
Described Radix Puerariae is the Pachyrhizua angulatus of Wild Pueraria or trophophase 2-5;
(2) the resulting powder of Radix Puerariae of step (1) is joined in the supersound extraction device, adding concentration of volume percent is the edible ethanol of 30-80%, is heated to 30-60 ℃, the ultrasonic extraction 10-100 of proportion 20-80Hz minute again, filtered while hot namely gets Radix Puerariae extracting solution and filtering residue;
The solid-to-liquid ratio of powder of Radix Puerariae and edible ethanol is 1g:5-20ml;
(3) the Radix Puerariae extracting solution elder generation distilling under reduced pressure recovered alcohol that step (2) is obtained is distinguished the flavor of without alcohol to residual liquid, with the residual liquid drying, obtains extract product of general flavone of kudzuvine root again;
(4) gained filtering residue in the step (2) being added water, to frustrate pulverizing broken, crosses first the yawing sieve fiber is removed, and filtrate is adopted centrifugalize, will precipitate the oven dry pulverizing and namely get Radix Puerariae starch.
2. the process of Radix Puerariae total flavones and Radix Puerariae starch in a kind of extract at low temperature Radix Puerariae according to claim 1 is characterized in that the residual liquid drying means after the distilling under reduced pressure of Radix Puerariae extracting solution elder generation is vacuum drying, spray drying or lyophilization.
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Cited By (5)
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| CN103224862A (en) * | 2013-04-09 | 2013-07-31 | 随州市二月风食品有限公司 | Pueraria rice wine and preparation method thereof |
| CN103554276A (en) * | 2013-10-15 | 2014-02-05 | 温天文 | Technological process for extracting starch, cellulose and general flavone in root of kudzu vine by use of organic membrane |
| CN105168326A (en) * | 2015-06-24 | 2015-12-23 | 黄红林 | Radix puerariae extract preparation method |
| CN107568735A (en) * | 2017-11-06 | 2018-01-12 | 德兴市宋氏葛业有限公司 | A kind of preparation method of superminiature kudzuvine root starch |
| CN108685061A (en) * | 2017-04-12 | 2018-10-23 | 西南大学 | A kind of pueraria lobata ultramicro whole powder and the composition comprising it and application |
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| CN101805410A (en) * | 2010-03-29 | 2010-08-18 | 武汉俩发科技有限公司 | Technological method for comprehensively producing pueraria flavonid, puerarin and arrowroot starch |
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| CN102357114A (en) * | 2007-08-07 | 2012-02-22 | 北京北大维信生物科技有限公司 | Application of Chinese herbal medicine kudzu root extracts in preparation of weight-losing lipid-lowering medicines or medicines with lipase activity inhibition effect |
| CN101805410A (en) * | 2010-03-29 | 2010-08-18 | 武汉俩发科技有限公司 | Technological method for comprehensively producing pueraria flavonid, puerarin and arrowroot starch |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103224862A (en) * | 2013-04-09 | 2013-07-31 | 随州市二月风食品有限公司 | Pueraria rice wine and preparation method thereof |
| CN103224862B (en) * | 2013-04-09 | 2015-06-17 | 随州市二月风食品有限公司 | Pueraria rice wine and preparation method thereof |
| CN103554276A (en) * | 2013-10-15 | 2014-02-05 | 温天文 | Technological process for extracting starch, cellulose and general flavone in root of kudzu vine by use of organic membrane |
| CN105168326A (en) * | 2015-06-24 | 2015-12-23 | 黄红林 | Radix puerariae extract preparation method |
| CN108685061A (en) * | 2017-04-12 | 2018-10-23 | 西南大学 | A kind of pueraria lobata ultramicro whole powder and the composition comprising it and application |
| CN107568735A (en) * | 2017-11-06 | 2018-01-12 | 德兴市宋氏葛业有限公司 | A kind of preparation method of superminiature kudzuvine root starch |
| CN107568735B (en) * | 2017-11-06 | 2021-02-26 | 德兴市宋氏葛业有限公司 | Preparation method of ultramicro kudzu vine powder |
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Application publication date: 20130327 |