CN102986722A - Sterilizing composition containing simeconazole and chloropiperidine ester - Google Patents
Sterilizing composition containing simeconazole and chloropiperidine ester Download PDFInfo
- Publication number
- CN102986722A CN102986722A CN2012104775804A CN201210477580A CN102986722A CN 102986722 A CN102986722 A CN 102986722A CN 2012104775804 A CN2012104775804 A CN 2012104775804A CN 201210477580 A CN201210477580 A CN 201210477580A CN 102986722 A CN102986722 A CN 102986722A
- Authority
- CN
- China
- Prior art keywords
- simeconazoles
- ester
- bacterium ester
- chlorine nalidixic
- nalidixic bacterium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a sterilizing composition containing simeconazole and chloropiperidine ester. The sterilizing composition is prepared by compounding effective components, namely, simeconazole and chloropiperidine ester which are on the mass ratio of (1-80):(40-1); the total mass of the simeconazole and chloropiperidine ester in the preparation is of 1-80% based on the total mass of the whole preparation; and the rest components are the agromedical allowable and acceptable auxiliary components. The sterilizing composition provided by the invention can be prepared in pesticide formulation like missible oil, suspoemulsion, wettable powder, water dispersible granule, emulsion in water and microemulsion. The sterilizing composition containing simeconazole and chloropiperidine ester can be used for effectively preventing and treating a plurality of diseases caused by ascomycetes, basidiomycetes and fungi imperfecti, and has excellent effects of preventing various powdery mildews, cladosporium cucumerinum, rust diseases, damping off, banded sclerotial blight, rice blast, false smut, apple rust and watermelon anthracnose.
Description
Technical field
The present invention relates to the agriculture chemical compounding technical field, be specifically related to a kind of bactericidal composition that contains simeconazoles and chlorine nalidixic bacterium ester.
Background technology
Simeconazoles system Japan three common companies (now are three common A, company) in siliceous three series bactericidal agent of exploitation in 1991, it is the deep and remote pure biosynthesis inhibitor of a kind of ergot, destroy and stop the biosynthesis of the cell membrane important composition composition ergosterol of germ, cause cell membrane not form, make germ dead.Because absorption in having well, therefore can be promptly by plant absorbing, and in conducted inside; Have good protection and therapeutic activity.Can effectively prevent and treat disease due to numerous sac fungis, basidiomycetes and the imperfect fungus, especially all kinds of powdery mildews, scab, rust, damping off, banded sclerotial blight etc. be had excellent preventive effect.The chemistry of simeconazoles is called (R, S)-2-(4 fluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-trimethyl silicane propane-2-alcohol, and its chemical structural formula is
Chlorine nalidixic bacterium ester is the methoxy acrylic bactericide with independent intellectual property right that Shenyang Chemical Engineering Inst develops, chemical name N-methoxyl group-N-[2-[[(3,5,6-trichloropyridine-2-yl) oxygen] methyl] phenyl] methyl carbamate.Chlorine nalidixic bacterium ester is a kind of high-efficiency broad spectrum low toxicity bactericide, have prevention and therapeutic action, the multiple diseases such as the wheat powdery mildew that caused by sac fungi, basidiomycetes and imperfect fungus, rice blast, false smut, cucurbits powdery mildew, tomato powdery mildew, apple rust, watermelon anthrax, flowers powdery mildew are shown excellent control efficiency, during using, the field has no adverse effects to supplying to study the thing growth, to non-target organism and Environmental security.
Using chemical agent is the most effectively means of controlling plant diseases.But long-term use single chemical bactericide continuously high dose, cause easily the problems such as residual, the environmental pollution of medicament and anti-pesticide resistance fungi development.Reasonably chemical bactericide is composite or be mixed and have the expansion fungicidal spectrum, improve control efficiency, prolong the optimum period for applying fertilizer, reduce dosage, reduce poisoning, reduce residual, delay Antifungal resistance and the positive characteristics such as drug-fast generation and development, bactericide compounded is the most one of the effective method that addresses the above problem.Exploitation new product bactericide price is constantly soaring, and by contrast, exploitation is efficient with research, low toxicity, low-residual composite be mixed have small investment, the lead time is short and be subject to domestic and international attention, the numerous and confused dynamics that develops that strengthens.We filter out simeconazoles and chlorine nalidixic bacterium ester and carry out compositely on the basis of lab screening and field trial, have obvious synergistic effect.And about the composite bactericidal composition of simeconazoles and chlorine nalidixic bacterium ester and use and there is no at present the people and reported.
Summary of the invention
Based on above situation, the object of the invention is to provide a kind of new and effective pesticide sterilizing composite.Can effectively prevent and treat disease due to numerous sac fungis, basidiomycetes and the imperfect fungus, all kinds of powdery mildews, scab, rust, damping off, banded sclerotial blight, rice blast, false smut, apple rust, watermelon anthrax etc. are had excellent preventive effect.
Technical scheme of the present invention realizes by following measures:
A kind of bactericidal composition that contains simeconazoles and chlorine nalidixic bacterium ester, two yuan of the active ingredient simeconazoles of this bactericidal composition and chlorine nalidixic bacterium esters are composite, and all the other are auxiliary element.The mass ratio of active ingredient simeconazoles and chlorine nalidixic bacterium ester is 1～80: 40～1 in the wherein said Pesticidal combination, described bactericidal composition of the present invention is through the toxicity test experimental verification, the mass ratio of simeconazoles and chlorine nalidixic bacterium ester is 1～50: 20～1 o'clock, and synergistic effect is better.
The formulations of pesticide that described bactericidal composition of the present invention can be prepared are missible oil, suspending agent, wetting powder, water dispersible granules, aqueous emulsion, microemulsion.Wherein active ingredient simeconazoles and the chlorine nalidixic bacterium ester gross mass in preparation accounts for 1%～80% of the whole quality of the pharmaceutical preparations, when wherein accounting for 5%-55%, and toxicity and the residual preferably balance that reaches, cost is also lower.
The specific embodiments of the formulations of pesticide that bactericidal composition of the present invention is mixed with is as follows:
Described bactericidal composition is cream preparation, and the mass fraction of component is: simeconazoles 1～80; 1～40 part of chlorine nalidixic bacterium ester; 10～30 parts of conventional emulsifiers; 20～50 parts of conventional solvents; 1～5 part of conventional synergist.The concrete production stage of this cream preparation adds emulsifier, the synergist rear oily liquids that becomes transparent and homogeneous that stirs after dissolving fully in the solvent again for first active ingredient simeconazoles and chlorine nalidixic bacterium ester being added, can namely can be made into the cream preparation of the present composition.
Described bactericidal composition is suspending agent, and the mass fraction of component is: 1～80 part of simeconazoles; 1～40 part of chlorine nalidixic bacterium ester; 5～20 parts of dispersants; 1～5 part of antifreezing agent; 0.1～2 part of thickener; 0.1～0.8 part of defoamer; 0～10 part of penetrating agent; 0.1～5 part of pH value conditioning agent; Water, surplus.The concrete production stage of this suspending agent is for mixing other auxiliary agents first, mix through high speed shear, add active ingredient simeconazoles and chlorine nalidixic bacterium ester, abrading-ball is 2～3 hours in ball crusher, make a diameter all below 5mm, namely can be made into the suspending agent preparation of the present composition.
Described bactericidal composition is wetting powder, and the mass fraction of component is: 1～80 part of simeconazoles; 1～40 part of chlorine nalidixic bacterium ester; 3～10 parts of dispersants; 1～5 part of wetting agent; Filler, surplus.The concrete production stage of this wetting powder is: by above-mentioned prescription the active ingredient simeconazoles is mixed with chlorine nalidixic bacterium ester and dispersant, wetting agent and filler, uniform stirring in stirred tank, behind airslide disintegrating mill, mixing, namely can be made into the wetting powder of the present composition.
Described bactericidal composition is water dispersible granules, and the mass fraction of component is: 1～80 part of simeconazoles; 1～40 part of chlorine nalidixic bacterium ester; 3～10 parts of dispersants; 1～10 part of wetting agent; 1～5 part of disintegrant; The filler surplus.The concrete production stage of this water dispersible granules is: by above-mentioned prescription active ingredient simeconazoles and chlorine nalidixic bacterium ester and dispersant, wetting agent, disintegrant and filler are mixed, pulverize with micro jet, through mediating, then add and carry out granulation, drying, screening in the fluidized bed prilling dryer by sample analysis, namely can be made into the water dispersible granules of the present composition.
Described bactericidal composition is aqueous emulsion, and the mass fraction of component is: 1～80 part of simeconazoles; 1～40 part of chlorine nalidixic bacterium ester; 3～30 parts of emulsifier; 5～15 parts of solvents; 2～15 parts of stabilizing agents; 1～5 part of antifreezing agent; 0.1～8 part of defoamer; 0.2～2 part of thickener; Water surplus.The concrete production stage of this aqueous emulsion is: at first simeconazoles and chlorine nalidixic bacterium ester, solvent and emulsifier, cosolvent are added together, make and be dissolved into uniform oil phase; With part water, antifreeze, other the insecticides adjuvant such as antimicrobial mixes into uniform water; When the reactor high speed stirs, oil phase is added water, slowly add water until reach the phase inversion point, open clipper and carry out high speed shear, and add remaining water, shear approximately half an hour, form the aqueous emulsion of oil-in-water type, namely can be made into the aqueous emulsion of the present composition.
Described bactericidal composition is microemulsion, and the mass fraction of component is: 1～80 part of simeconazoles, 1～40 part of chlorine nalidixic bacterium ester, 10～30 parts of emulsifier, 1～8 part of antifreezing agent, 0.5～10 part of stabilizing agent, 20～50 parts of conventional solvent cosolvents.Simeconazoles and chlorine nalidixic bacterium ester are dissolved fully with cosolvent, add again other compositions such as emulsifier, antifreezing agent stabilizing agent, evenly mix, add at last entry, can be made into microemulsion after fully stirring.
Wherein above-described emulsifier is selected from calcium dodecyl benzene sulfonate and aliphatic acid polyethenoxy ether, the alkylphenol polyoxyethylene sulfosuccinate, styrylphenol polyoxyethylene ether, polyoxyethylene nonylphenol ether, castor oil polyoxyethylene ether, aliphatic acid polyethenoxy base ester, any or more than one any mixtures than forming in the polyoxyethylene aliphatic alcohol ether.
Described solvent is dimethylbenzene or biodiesel, toluene, and diesel oil, methyl alcohol, ethanol, n-butanol, isopropyl alcohol, turpentine oil, solvent naphtha, dimethyl formamide, dimethyl sulfoxide (DMSO), one or more in the water equal solvent are arbitrarily than the mixture that forms.
Described dispersant is selected from polycarboxylate, lignosulfonates, alkylphenol polyoxyethylene methyl ether condensate sulfate, the alkylsulfonate calcium salt, the naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol polyoxyethylene, polyoxyethylene carboxylate, aliphatic amine polyoxyethylene ether, one or more in the fatty acid glyceride APEO.
Described wetting agent is selected from lauryl sodium sulfate, calcium dodecyl benzene sulfonate, and Nekal BX, moistening bleeding agent F, alkylbenzenesulfonate polyoxyethylene triphen is phosphenylic acid salt dimly, spaonin powder, silkworm excrement, one or more in the soapberry powder.
Described disintegrant is selected from bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, one or more in the sodium bicarbonate.
Described thickener is selected from xanthans, carboxymethyl cellulose, carboxyethyl cellulose, methylcellulose, Magnesiumaluminumsilicate, in the polyvinyl alcohol one or more.
Described stabilizing agent is selected from sodium citrate, a kind of in the resorcinol.
Described antifreezing agent is selected from ethylene glycol, propane diols, one or more in the glycerine.
Described defoamer is selected from silicone oil, silicone compound, C
10-20The saturated fat acid compounds, C
8-10One or more of fatty alcohol.
Described filler is selected from kaolin, diatomite, bentonite, attapulgite, white carbon, starch, one or more in the precipitated calcium carbonate.
The composite bactericide of the present invention take simeconazoles and chlorine nalidixic bacterium ester as active ingredient has obvious synergistic effect, delays the drug-fast generation in key, and reduced to become to produce cost and use cost, can be used for the improvement of resistance disease.Can effectively prevent and treat disease due to numerous sac fungis, basidiomycetes and the imperfect fungus, all kinds of powdery mildews, scab, rust, damping off, banded sclerotial blight, rice blast, false smut, apple rust, watermelon anthrax etc. are had excellent preventive effect.
Embodiment
For making technical scheme of the present invention, purpose and advantage are clearer, and the present invention describes with following specific embodiment, but the present invention is not limited to these examples.The mode that effect experiment of the present invention adopts indoor biometrics and field trial to combine, if no special instructions, the ratio of below mentioning all is ratio of quality and the number of copies.
Embodiment: the different proportioning co-toxicity experiments from chlorine nalidixic bacterium ester of simeconazoles.
1.1 reagent agent
The former medicine of 95 % simeconazoles, the former medicine of 95% chlorine nalidixic bacterium ester, above-mentioned former medicine provides by research and development department of extra large rel medicine company limited company.
1.2 test target
Never executed simeconazoles and chlorine nalidixic bacterium ester and cucumber of the same type from Shouguang, Shandong and gather potted plantly and separate, for the examination cucumber variety: Chang Chun Mi Ci.
1.3 test method
1.3.1 medicament preparation
Use first the former medicine of acetone solution, according to the result of preliminary experiment two an amount of former medicines are made into 5 different proportionings, with acetone each is processed that to be diluted to respectively 5 concentration gradients stand-by again, the ratio of 5 different proportioning active ingredients from chlorine nalidixic bacterium ester of simeconazoles is respectively 36:16; 39:13; 42:10; 45:7; 48:4.
In pot for growing seedlings, place the greenhouse to cultivate susceptible cucumber variety Chang Chun Mi Ci cultivation, plant grows to three to four leaf after dates, gathers the blade of identical leaf age, is used for cultivation and the mensuration of powdery mildew of cucumber bacterium.
1.3.2 the cultivation of powdery mildew of cucumber bacterium and the preparation of spore suspension
The powdery mildew of cucumber bacterium adopts the plants method to cultivate under 20 ℃, the condition of 12h alternation of light and darkness, and per 30 d turn culture 1 time.With the conidium on the sterile water wash-out incidence of leaf, being mixed with spore concentration is l * 10 during inoculation
6The suspension of individual/mL.
1.3.3 strains tested sensitivity testing
Adopt leaf dish moisturizing method to carry out toxicity test.First the blade that gathers is prepared into the leaf dish that diameter is 1.5cm, mixing at random, place respectively the series concentration liquid that configures to soak lh, 50 leaf dishes of each concentration, test is with the blank that is treated to of adding medicine not, after soaking end, leaf faces up and puts on the wetting blotting paper of identical liquor strength, liquid on the leaf dish is blotted, the spore suspension l0L for preparing is inoculated in leaf dish central authorities, after room temperature is placed 5 min, places under 20 ℃, the condition of 1 2h alternation of light and darkness and cultivate, measure the onset area on the leaf dish behind the 10d, calculate EC
50
On the basis of preliminary experiment, respectively single dose simeconazoles and chlorine nalidixic bacterium ester are carried out toxicity test in order to upper method, the two EC
50Value is respectively 5.61 ㎎/l and 1.37 ㎎/l
The percentage that accounts for the leaf disc area according to lesion area is divided sick level
0 grade: anosis;
1 grade: the sorus area accounts for below 5% of whole leaf area;
3 grades: the sorus area accounts for below the 6%-10% of whole leaf area;
5 grades: the sorus area accounts for below the 11%-20% of whole leaf area;
7 grades: the sorus area accounts for below the 21%-50% of whole leaf area;
9 grades: the sorus area accounts for more than 50% of whole leaf area;
1.3.4 mixture toxicity test and interpretation of result
Carry out the toxicity test of mixture according to mixed ratio with single dose toxicity test method.
If contrast lethality＜5% is not proofreaied and correct, the contrast lethality by formula 2 is proofreaied and correct between 5%-20%, the contrast lethality〉20%, test need be reformed.
Take the logarithm value of drug concentration (mg/L) as independent variable x, take the probability value of corrected mortality as dependent variable y, set up respectively the virulence regression equation formula, adopt DPS software to calculate the LC of single dose and each proportioning mixture
50Calculate co-toxicity coefficient (CTC) according to the abundant method of Sun Yun.Co-toxicity coefficient CTC, computing formula is as follows: (take simeconazoles as the standard medicament, its toxicity index is 100):
The LC of the toxicity index of chlorine nalidixic bacterium ester (TI)=simeconazoles
50The LC of/chlorine nalidixic bacterium ester
50* 100
The LC of the true toxicity index (ATI) of M=simeconazoles
50The LC of/M
50* 100
The TI of the TI of the theoretical toxicity index (TTI) of M=simeconazoles * P simeconazoles+chlorine nalidixic bacterium ester * P chlorine nalidixic bacterium ester
The TTI of the ATI/M of the co-toxicity coefficient of M (CTC)=M * 100
In the formula:
M is simeconazoles and the mixture of the different proportionings of chlorine nalidixic bacterium ester
The P simeconazoles is simeconazoles shared ratio in mixture
The P chlorine nalidixic bacterium ester is chlorine nalidixic bacterium ester shared ratio in mixture
2.1 toxicity test result
Table 1 simeconazoles and chlorine nalidixic bacterium ester are to the toxicity test of powdery mildew of cucumber
| Process title | Proportioning | Virulence regression equation (Y=a+bX) | The correlation coefficient r value | LC 50（mg/L） | Co-toxicity coefficient (CTC) |
| Simeconazoles | _____ | Y=3.5694X+2.3267 | 0.9894 | 5.61 | _______ |
| Chlorine nalidixic bacterium ester | _____ | Y=3.6964X+4.4946 | 0.9882 | 1.37 | _______ |
| Simeconazoles: chlorine nalidixic bacterium ester | 36：16 | Y=3.7374X+3.9754 | 0.9892 | 1.88 | 152.49 |
| Simeconazoles: chlorine nalidixic bacterium ester | 39：13 | Y=3.4694X+4.0731 | 0.9914 | 1.85 | 170.82 |
| Simeconazoles: chlorine nalidixic bacterium ester | 42：10 | Y=3.7432X+4.0088 | 0.9891 | 1.84 | 191.06 |
| Simeconazoles: chlorine nalidixic bacterium ester | 45：7 | Y=3.7963X+3.6412 | 0.9884 | 2.28 | 173.56 |
| Simeconazoles: chlorine nalidixic bacterium ester | 48：4 | Y=3.9423X+3.2372 | 0.9901 | 2.80 | 161.77 |
As can be seen from the table, the result of the test of different proportion proportioning shows, is 36:16 in the active ingredient ratio; 39:13; 42:10; 45:7; When 48:4 dilutes respectively, all show stronger synergistic effect, wherein take simeconazoles and chlorine nalidixic bacterium ester as 42:10 the time synergistic effect best, its co-toxicity coefficient is 191.06.Suggestion is carried out further field control effectiveness test to suitable proportion 42:10 left and right sides mixture preparation, to estimate its field practical application effect.
3, the experimental result of field trial control wheat powdery mildew, rice blast
3.1 field trial control wheat powdery mildew
3.1.1 basic condition experimental field
Experimental field be located at Henan, select the medium wheat paddock of occurring degree for experimental field, soil fertility is medium, and irrigation and drainage are convenient.Dispenser weather in April on the same day 1 is clear to cloudy, 11 ℃ of mean temperature of air, relative moisture 81%, 2～3 grades of southerlies; April 11 was fine, 18.2 ℃ of mean temperature of air, relative moisture 60%, 2～3 grades of southerlies.
3.1.2 spraying time and method
At the 1st medicine of wheat powdery mildew their early stage (April 1) spray, (April 11) spray medicine second time sprays 2 times altogether behind the 10d.(operating pressure 0.2～0.3MPa), 750L carries out foliar spray according to the per hectare amount of liquid medicine to adopt the 3WBS-16 knapsack sprayer.
3.1.3 pilot survey and data are processed
Investigation state of an illness radix before the medicine, test is investigated 3 times altogether, i.e. disease index investigation before the medicine, preventive effect investigation in 10 days behind the 1st medicine, 10 days and preventive effect investigation in 20 days behind 2 medicines.
3.1.4 drug effect computational methods
Sick leaf rate (the %)=sick number of sheets/investigate total number of sheets * 100
Disease index=∑ (the sick numbers of sheets at different levels * relative level numerical value)/(investigating total number of sheets * 9) * 100
Control efficiency (%)=(disease index behind disease index before the 1-(blank district medicine * treatment region medicine)/(disease index before disease index behind the blank district medicine * treatment region medicine)) * 100
3.1.5 poisoning investigation method
Whether continuous 7d range estimation medicament has poisoning to crop after the dispenser.
3.1.6 experimental result and analysis
Table 2 is respectively organized the test effect that test medicine is processed the control wheat powdery mildew
Interpretation of result:
As shown in Table 2,52% simeconazoles chlorine nalidixic bacterium ester is more remarkable with the effect of 42:10 proportioning control wheat powdery mildew, behind the medicine 10 days for the first time, for the second time 10 days and 20 days preventive effects 94.35% the highest, 93.02% and 90.69% behind the medicine, and the effect of complex preparation significantly is better than two kinds of single doses, not only significantly improve the effect for wheat powdery mildew, and further prolonged its lasting period.
4.1 field trial is measured the control efficiency to rice blast
4.1.1 application method
Altogether dispenser twice of test, check plot spray equivalent clear water.When making up a prescription, after with a small amount of water medicament fully being dissolved first, add suitable quantity of water again and carry out the all-out atomizing processing, even spraying sprays emphatically rice strain middle and lower part.All adopting power driven sprayer, operating pressure during the spray medicine is 2.0～2.3 kg/cm
2, shower nozzle aperture 1.2 mm.The residential quarter spouting liquid is used by 675 liters/hectare, and liquid is sprayed application to the positive and negative two sides of crop leaf uniformly.
4.1.2 investigation method
4.1.2.1 leaf pest investigation method
Experimental field be located at the rice in Hunan field, the field of selecting the more consistent leaf seasonal febrile diseases of growing way their early stage is for experimental field, and middle fertility is well-managed.
Every residential quarter is got 4 points at random, the whole blades of five strains during investigation, and a situation arises for the statistics disease.
Every leaf records total number of sheets, the sick number of sheets at different levels by the percentage classification that scab accounts for leaf area, calculates the blade incidence of disease, disease index, refers to comparison with the contrast disease, calculates relative control effect.
Severity Scaling standard (take blade as unit)
Sick level victimization state
0 grade: on the blade without scab;
1 grade: scab is syringe needle shape size foxiness;
2 grades: slightly large brown point;
3 grades: circular to oval-shaped grey scab, edge brown, 1 ~ 2 millimeter of scab diameter;
4 grades: typical spindle scab, long 1 ~ 2 centimetre, usually be confined between 2 veins, the area of causing harm is no more than 2% of blade area;
5 grades: typical spindle scab, the area of causing harm is no more than 10% of leaf area;
6 grades: typical spindle scab, the area 10.1 ~ 25% of causing harm;
7 grades: typical spindle scab, the area 25.1 ~ 50% of causing harm;
8 grades: typical spindle scab, the area 50.1 ~ 75% of causing harm;
9 grades: full leaf is withered.
Panicle blast disease tassel yield Assessment for classification standard:
Sick level victimization state
0 grade: anosis;
1 grade: disease tassel yield is lower than 1 ~ 5%;
3 grades: disease tassel yield is lower than 5.1 ~ 10%;
5 grades: disease tassel yield is lower than 10.1 ~ 25%;
7 grades: disease tassel yield is lower than 25.1 ~ 50%;
9 grades: disease tassel yield is lower than 50.1 ~ 100%.
4.1.3 control time and number of times
Leaf pest control times
In the rice tillering intermediary and later stages, leaf blast in rice enters their early stage investigation, investigation disease index before the medicine, and 7 each investigation were once observed its lasting effect in 15 days behind the secondary medicine behind first and second time medicine, investigated altogether 4 times.
Neck pest control times
In paddy stage of yellow ripeness, to investigate after neck seasonal febrile diseases feelings are stable, check is once after the week.
Test is investigated 4 times altogether, i.e. disease index investigation before the medicine, preventive effect investigation in 7 days behind the 1st medicine, 7 days and preventive effect investigation in 15 days behind 2 medicines.
4.1.4 drug effect computational methods
Sick leaf rate (the %)=sick number of sheets/investigate total number of sheets * 100
Disease index=∑ (the sick numbers of sheets at different levels * relative level numerical value)/(investigating total number of sheets * 9) * 100
Control efficiency (%)=(disease index behind disease index before the 1-(blank district medicine * treatment region medicine)/(disease index before disease index behind the blank district medicine * treatment region medicine)) * 100
4.1.5 poisoning investigation method
Whether continuous 7d range estimation medicament has poisoning to crop after the dispenser.
4.1.6 result of the test and analysis
Each effect of processing the control rice blast sees Table 3
Each processes the effect of control rice blast table 3
Interpretation of result:
As can be seen from Table 3,52% simeconazoles chlorine nalidixic bacterium ester is remarkable with the effect of 42:10 proportioning control rice blast.Its quick-acting and lasting effect are all relatively good, and be especially outstanding with lasting effect.Complex preparation significantly is better than effect under the low concentration consumption in control efficiency under the consumption of high concentration.According to the field range estimation, in the test dose scope, plant growth is normal, and the poisoning phenomenon to paddy rice does not all appear in each treatment agent, illustrates that it is safe to paddy rice.
In sum, the present invention is the bactericidal composition that contains simeconazoles and chlorine nalidixic bacterium ester, powdery mildew of cucumber, wheat powdery mildew, rice blast etc. all had preferably effect, and it is to the target crop safety, compare with single dose, bactericidal composition of the present invention has the advantage that quick-acting is good, the lasting period is long, is difficult for producing poisoning, so research and development of the present invention and popularization are of great significance social tool.
Claims (5)
1. bactericidal composition that contains simeconazoles and chlorine nalidixic bacterium ester, it is characterized in that: the active ingredient of this bactericidal composition is that simeconazoles and two yuan of chlorine nalidixic bacterium esters are composite, and wherein the mass ratio of active ingredient azoles bacterium ester and chlorine nalidixic bacterium ester is 1～80: 40～1.
2. bactericidal composition according to claim 1, it is characterized in that: the quality optimization ratio of simeconazoles and chlorine nalidixic bacterium ester is 1～50: 20～1.
3. bactericidal composition according to claim 1, it is characterized in that: simeconazoles and chlorine nalidixic bacterium ester account for 1%～80% of the whole quality of the pharmaceutical preparations.
4. bactericidal composition according to claim 3, it is characterized in that: simeconazoles and chlorine nalidixic bacterium ester account for 5%～55% of the whole quality of the pharmaceutical preparations.
5. according to claim 1 and 2 or 3 or 4 described bactericidal compositions, it is characterized in that: the formulations of pesticide that this bactericidal composition can be prepared into are missible oil, suspending agent, wetting powder, water dispersible granules, aqueous emulsion, microemulsion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104775804A CN102986722A (en) | 2012-11-22 | 2012-11-22 | Sterilizing composition containing simeconazole and chloropiperidine ester |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104775804A CN102986722A (en) | 2012-11-22 | 2012-11-22 | Sterilizing composition containing simeconazole and chloropiperidine ester |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102986722A true CN102986722A (en) | 2013-03-27 |
Family
ID=47916210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012104775804A Pending CN102986722A (en) | 2012-11-22 | 2012-11-22 | Sterilizing composition containing simeconazole and chloropiperidine ester |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102986722A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103563969A (en) * | 2012-07-31 | 2014-02-12 | 江苏丰源种业有限公司 | Sterilization composition for preventing and treating plant diseases |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003026421A1 (en) * | 2001-09-27 | 2003-04-03 | Monsanto Technology, Llc | Fungicidal compositions and their applications in agriculture |
| CN101427684A (en) * | 2007-11-08 | 2009-05-13 | 中国中化集团公司 | Fungicide composition containing chlorine nalidixic bacterium ester and triazole bactericides |
| JP2009143953A (en) * | 2009-02-17 | 2009-07-02 | Mitsui Chemicals Agro Inc | Stabilized agrochemical powder composition |
-
2012
- 2012-11-22 CN CN2012104775804A patent/CN102986722A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003026421A1 (en) * | 2001-09-27 | 2003-04-03 | Monsanto Technology, Llc | Fungicidal compositions and their applications in agriculture |
| CN101427684A (en) * | 2007-11-08 | 2009-05-13 | 中国中化集团公司 | Fungicide composition containing chlorine nalidixic bacterium ester and triazole bactericides |
| JP2009143953A (en) * | 2009-02-17 | 2009-07-02 | Mitsui Chemicals Agro Inc | Stabilized agrochemical powder composition |
Non-Patent Citations (1)
| Title |
|---|
| 程志明等: "杀菌剂硅氟唑的开发沿革", 《世界农药》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103563969A (en) * | 2012-07-31 | 2014-02-12 | 江苏丰源种业有限公司 | Sterilization composition for preventing and treating plant diseases |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103719120A (en) | Sterilization composition containing pyraclostrobin and boscalid | |
| CN104585181A (en) | Fungicidal composition containing fluxapyroxad and prothioconazole | |
| CN103081913A (en) | Sterilization composition containing boscalid and kresoxim-methyl | |
| CN103355308A (en) | Sterilization composition containing prothioconazole and boscalid | |
| CN105475317A (en) | Sterilization combination containing efficient metalaxyl-M and cymoxanil | |
| CN103141493A (en) | Bactericidal composition containing difenoconazole and benthiavalicarb-isopropyl | |
| CN102960349A (en) | Germicide composition containing pyraoxystrobin and tiadinil | |
| CN102986722A (en) | Sterilizing composition containing simeconazole and chloropiperidine ester | |
| CN103070176A (en) | Sterilizing composition containing prothioconazole and syp-1620 | |
| CN103503879A (en) | Sterilization composition containing prothioconazole and bupirimate | |
| CN103081942A (en) | Sterilizing composition containing pyraoxystrobin and simeconazole | |
| CN102960351A (en) | Antiseptic composition containing enestroburin and SYP-7017 | |
| CN103004820A (en) | Sterilization composition containing pyraclostrobin and nitrapyrin bacteria ester | |
| CN104126593A (en) | Sterilization composition containing ametoctradin and fluopyram | |
| CN104521984A (en) | Bactericidal composition containing SYP-Z048 and hexaconazole | |
| CN103300009A (en) | Sterilization composition with coumoxystrobin and penconazole | |
| CN103081943A (en) | Bactericidal composition containing simeconazole and JS399-19 | |
| CN105104386A (en) | Sterilization composition containing hymexazol and fludioxonil | |
| CN104585183A (en) | Fungicidal composition containing SYP-Z048 and enestroburin | |
| CN103004860A (en) | Sterilization composition containing simeconazole and bupirimate | |
| CN102948422A (en) | Sterilization composition containing pyraoxystrobin and pyrimethanil | |
| CN103081924A (en) | Sterilizing composition containing enestroburin and tiadinil | |
| CN104542620A (en) | Fungicide composition containing SYP-Z048 and fludioxonil | |
| CN103798244A (en) | Bactericidal composition containing cyflufenamid and flutriafol | |
| CN104054733A (en) | Sterilization combination containing meptyldinocap and pyrametostrobin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130327 |
|
| WD01 | Invention patent application deemed withdrawn after publication |