CN102977023B - A kind of (-)-meptazinol phenyl urethan-L-(+)-tartrate type III crystal - Google Patents
A kind of (-)-meptazinol phenyl urethan-L-(+)-tartrate type III crystal Download PDFInfo
- Publication number
- CN102977023B CN102977023B CN201210473829.4A CN201210473829A CN102977023B CN 102977023 B CN102977023 B CN 102977023B CN 201210473829 A CN201210473829 A CN 201210473829A CN 102977023 B CN102977023 B CN 102977023B
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- China
- Prior art keywords
- type iii
- tartrate
- phenyl urethan
- iii crystal
- meptazinol phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 239000013078 crystal Substances 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 claims abstract description 11
- 238000000634 powder X-ray diffraction Methods 0.000 claims abstract description 6
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims description 10
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 4
- 238000009413 insulation Methods 0.000 claims description 4
- 229940095064 tartrate Drugs 0.000 claims description 4
- 239000011549 crystallization solution Substances 0.000 claims 2
- 238000012360 testing method Methods 0.000 description 4
- 238000001757 thermogravimetry curve Methods 0.000 description 4
- FEWJPZIEWOKRBE-JCYAYHJZSA-L L-tartrate(2-) Chemical compound [O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O FEWJPZIEWOKRBE-JCYAYHJZSA-L 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002329 infrared spectrum Methods 0.000 description 3
- 206010013786 Dry skin Diseases 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000012065 filter cake Substances 0.000 description 2
- 238000002386 leaching Methods 0.000 description 2
- 229960000365 meptazinol Drugs 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- JLICHNCFTLFZJN-OAHLLOKOSA-N 3-[(3s)-3-ethyl-1-methylazepan-3-yl]phenol Chemical compound C=1C=CC(O)=CC=1[C@]1(CC)CCCCN(C)C1 JLICHNCFTLFZJN-OAHLLOKOSA-N 0.000 description 1
- 206010048650 Cholinesterase inhibition Diseases 0.000 description 1
- 206010012289 Dementia Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 229940000406 drug candidate Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210473829.4A CN102977023B (en) | 2012-11-09 | 2012-11-09 | A kind of (-)-meptazinol phenyl urethan-L-(+)-tartrate type III crystal |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210473829.4A CN102977023B (en) | 2012-11-09 | 2012-11-09 | A kind of (-)-meptazinol phenyl urethan-L-(+)-tartrate type III crystal |
Publications (2)
Publication Number | Publication Date |
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CN102977023A CN102977023A (en) | 2013-03-20 |
CN102977023B true CN102977023B (en) | 2015-09-02 |
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CN201210473829.4A Expired - Fee Related CN102977023B (en) | 2012-11-09 | 2012-11-09 | A kind of (-)-meptazinol phenyl urethan-L-(+)-tartrate type III crystal |
Country Status (1)
Country | Link |
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CN (1) | CN102977023B (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1850804A (en) * | 2006-03-31 | 2006-10-25 | 复旦大学 | Optical-purity meptazinol orits salts, and preparing method |
CN101020661A (en) * | 2007-03-19 | 2007-08-22 | 复旦大学 | (-)-meptazinol carbamate derivative and/or its salt and their prepn and use |
-
2012
- 2012-11-09 CN CN201210473829.4A patent/CN102977023B/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1850804A (en) * | 2006-03-31 | 2006-10-25 | 复旦大学 | Optical-purity meptazinol orits salts, and preparing method |
CN101020661A (en) * | 2007-03-19 | 2007-08-22 | 复旦大学 | (-)-meptazinol carbamate derivative and/or its salt and their prepn and use |
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Publication number | Publication date |
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CN102977023A (en) | 2013-03-20 |
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ASS | Succession or assignment of patent right |
Owner name: WEIHAI DISU PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: DISHA PHARMACEUTICAL GROUP SHANDONG DISHA PHARMACEUTICAL CO., LTD. WEIHAI DISU PHARMACEUTICAL CO., LTD. WEIHAI WEITAI PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO., LTD. Effective date: 20150716 |
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C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20150716 Address after: 264205 No. 1 South Qingdao Road, Weihai economic and Technological Development Zone, Shandong, China Applicant after: Disha Pharmaceutical Industry Group Corp., Ltd. Applicant after: Weihai Disu Pharmaceutical Co., Ltd. Address before: 264205 No. 1 South Qingdao Road, Weihai economic and technological development, Shandong Applicant before: Disha Pharmaceutical Industry Group Corp., Ltd. Applicant before: Disha Pharmaceutical Group Shandong Disha Pharmaceutical Co., Ltd. Applicant before: Weihai Disu Pharmaceutical Co., Ltd. Applicant before: Weihai Weitai Medical Technology Development Co., Ltd. |
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C14 | Grant of patent or utility model | ||
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CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150902 Termination date: 20181109 |