CN102973925A - Preparation method of composition for promoting wound healing - Google Patents
Preparation method of composition for promoting wound healing Download PDFInfo
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- CN102973925A CN102973925A CN2012104889542A CN201210488954A CN102973925A CN 102973925 A CN102973925 A CN 102973925A CN 2012104889542 A CN2012104889542 A CN 2012104889542A CN 201210488954 A CN201210488954 A CN 201210488954A CN 102973925 A CN102973925 A CN 102973925A
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Abstract
The invention provides a preparation method of a composition for promoting wound healing. The preparation method comprises the following steps of: (1) dissolving 0.5 to 2.5 percent of chlorhexidine acetate and 1 to 3.5 percent of prednisolone acetate in 5 to 15 percent of sterile water; (2) adding 2 to 5 percent of dodecyl dimethyl benzyl ammonium chloride and 0.05 to 0.3 percent of vascular endothelial growth factor, and uniformly stirring; and (3) filling ointment base till 100 percent, and sufficiently and uniformly stirring to obtain a finished product. According to the composition prepared by the method, the time of wound healing can be remarkably shortened, and the scar width can be effectively reduced.
Description
Technical field
This relates to a kind of method that promotes the compositions of wound healing.
Background technology
Wound healing is the process that tissue integrity is recovered.But wound healing occurs in three differences overlapping stage, i.e. inflammation phase, multiplicative stage and regeneration stage.Many factors can affect the healing of wound greatly.Hinder the major reason of wound healing when wherein antibacterial infects.Antibacterial can make inflammation phase prolong, and suppresses epithelium formation, wound contraction and collagen deposition.Wound healing tends to follow the excessive accumulation of collagen protein, causes occurring cicatrix, and is greatly cutaneous attractive in appearance.
Summary of the invention
The object of the present invention is to provide the preparation method of the compositions that promotes wound healing, prepared group of compositions can infect, promote blood vessel hyperplasia and reduce cicatrization by the establishment antibacterial.
The compositions of promotion wound healing of the present invention is comprised of the component of following percentage by weight:
| Chlorhexidine acetate | 0.5-2.5% |
| Prednisolone acetate | 1-3.5% |
| Dodecyl dimethyl benzyl ammonium chloride | 2-5% |
| VEGF | 0.05-0.3% |
| Sterilized water | 5-15% |
| Surplus is ointment base. | ? |
The preparation method of the compositions of promotion wound healing of the present invention may further comprise the steps:
(1) 0.5-2.5% chlorhexidine acetate and 1-3.5% prednisolone acetate are dissolved in the 5-15% sterilized water;
(2) add 2-5% dodecyl dimethyl benzyl ammonium chloride and 0.05-0.3% VEGF, stir;
(2) add ointment base and complement to 100%, stir, get product.
The specific embodiment
Below in conjunction with embodiment the present invention is described in further detail.But the invention is not restricted to given example.
Embodiment 1
The compositions of the promotion wound healing of present embodiment is comprised of the component of following percentage by weight:
| Chlorhexidine acetate | 0.5% |
| Prednisolone acetate | 1% |
| Dodecyl dimethyl benzyl ammonium chloride | 2% |
| VEGF | 0.05% |
| Sterilized water | 5% |
| Surplus is ointment base. | ? |
The preparation method of the compositions of the promotion wound healing of present embodiment may further comprise the steps:
(1) 0.5% chlorhexidine acetate and 1% prednisolone acetate are dissolved in 5% sterilized water;
(2) add 2% dodecyl dimethyl benzyl ammonium chloride and 0.05% VEGF, stir;
(2) add ointment base and complement to 100%, stir, get product.
Embodiment 2
The compositions of the promotion wound healing of present embodiment is comprised of the component of following percentage by weight:
| Chlorhexidine acetate | 1.5% |
| Prednisolone acetate | 2% |
| Dodecyl dimethyl benzyl ammonium chloride | 3% |
| VEGF | 0.2% |
| Sterilized water | 8% |
| Surplus is ointment base. | ? |
The preparation method of the compositions of the promotion wound healing of present embodiment may further comprise the steps:
(1) 1.5% chlorhexidine acetate and 2% prednisolone acetate are dissolved in 8% sterilized water;
(2) add 3% dodecyl dimethyl benzyl ammonium chloride and 0.2% VEGF, stir;
(3) add ointment base and complement to 100%, stir, get product.
Embodiment 3
The chemosterilant of present embodiment is comprised of the component of following percentage by weight:
| Chlorhexidine acetate | 2.5% |
| Prednisolone acetate | 3.5% |
| Dodecyl dimethyl benzyl ammonium chloride | 5.0% |
| VEGF | 0.3% |
| Sterilized water | 15% |
| Surplus is ointment base. | ? |
The preparation method of the compositions of the promotion wound healing of present embodiment may further comprise the steps:
(1) 2.5% chlorhexidine acetate and 3.5% prednisolone acetate are dissolved in 15% sterilized water;
(2) add 5.0% dodecyl dimethyl benzyl ammonium chloride and 0.3% VEGF, stir;
(3) add ointment base and complement to 100%, stir, get product.
During use, the compositions of the promotion wound healing that the present invention is made is applied on the wound equably, uses every day 3 times.Estimate wound healing by measurement wound closure degree and cicatrix width in mice.Compare with matched group, the compositions of the promotion wound healing that the present invention makes has significantly shortened wound healing time and has effectively reduced the cicatrix width.
Claims (2)
1. a preparation method that promotes the compositions of wound healing is characterized in that, may further comprise the steps:
(1) 0.5-2.5% chlorhexidine acetate and 1-3.5% prednisolone acetate are dissolved in the 5-15% sterilized water;
(2) add 2-5% dodecyl dimethyl benzyl ammonium chloride and 0.05-0.3% VEGF, stir;
(3) add ointment base and complement to 100%, stir, get product.
2. the preparation method of compositions as claimed in claim 1 is characterized in that, may further comprise the steps:
(1) 1.5% chlorhexidine acetate and 2% prednisolone acetate are dissolved in 8% sterilized water;
(2) add 3% dodecyl dimethyl benzyl ammonium chloride and 0.2% VEGF, stir;
(3) add ointment base and complement to 100%, stir, get product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104889542A CN102973925A (en) | 2012-11-27 | 2012-11-27 | Preparation method of composition for promoting wound healing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104889542A CN102973925A (en) | 2012-11-27 | 2012-11-27 | Preparation method of composition for promoting wound healing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102973925A true CN102973925A (en) | 2013-03-20 |
Family
ID=47848460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012104889542A Pending CN102973925A (en) | 2012-11-27 | 2012-11-27 | Preparation method of composition for promoting wound healing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102973925A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10610499B2 (en) * | 2016-05-06 | 2020-04-07 | SaCSh Corp. | Ophthalmic compositions |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101232898A (en) * | 2005-06-17 | 2008-07-30 | 健泰科生物技术公司 | Use of VEGF for wound healing |
-
2012
- 2012-11-27 CN CN2012104889542A patent/CN102973925A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101232898A (en) * | 2005-06-17 | 2008-07-30 | 健泰科生物技术公司 | Use of VEGF for wound healing |
Non-Patent Citations (1)
| Title |
|---|
| B.YADUVANSHI ET AL.: "Evaluation of Wound Healing Potential of Topical Formulation of Leaf Juice of Tridax Procumbens L. in Mice", 《INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10610499B2 (en) * | 2016-05-06 | 2020-04-07 | SaCSh Corp. | Ophthalmic compositions |
| US10632083B2 (en) | 2016-05-06 | 2020-04-28 | SaCSh Corp. | Ophthalmic compositions |
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Application publication date: 20130320 |