CN102961449A - Hui medicine collunarium tincture for treating cerebrovascular disease and preparation method thereof - Google Patents
Hui medicine collunarium tincture for treating cerebrovascular disease and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Hui medicine collunarium tincture for treating cerebrovascular disease and a preparation method thereof. The Hui medicine collunarium tincture is prepared by respectively cleaning, drying and crushing colocynth, rhizome corydalis and mint, sieving by a 80-mesh sieve, sterilizing by ultraviolet, mixing with 95 % ethanol, immersing for 3 to 5 days, filtering to get a supernatant, diluting by distilled water to prepare the 20 % ethanol extract collunarium tincture theoretically containing 10-15 % of drug. Active ingredients of the Hui medicine collunarium tincture can rapidly pass through the blood cerebral barrier, directly reach a disease position, improve ischemic and hypoxic brain tissues, and activate bodies' capability of self restoration, thereby achieving effects of eliminating or alleviating condition and treating. Clinical trials show that the effect is significant.
Description
Technical field
The invention belongs to go back to the pharmaceutical preparations technology field, particularly relate to a kind of time medical collunarium tincture that is used for the treatment of cerebrovascular disease and preparation method thereof.
Background technology
Cerebrovascular disease is commonly encountered diseases clinically, and one of frequently-occurring disease has the characteristics of high disability rate, high relapse rate, high mortality.Cause cerebrovascular obstruction, tissue ischemia, anoxia owing to a variety of causes causes cerebrovascular and hemodynamic variation, and occur take cerebrovascular disease as main clinical manifestation.Research data show [Dong Wenli. the estimation of apoplexy financial burden [J]. the China Health career management, 1999,15 (5): 243-245.]: in the cause of death of city, cerebrovascular disease holds pride of place, cardiovascular disease accounts for the 3rd, and it occurs mainly relevant with hypertension, pathoglycemia, blood fat disorder, smoking, the factor such as drink.
Modern Clinics comprises the artery and vein thrombolytic, anticoagulant, anti-platelet aggregation, the application of neuroprotective, mild hypothermia therapy and neural stem cells transplantation etc. at Therapeutic Method commonly used aspect the treatment cerebrovascular disease.But these Therapeutic Method are favourable fraud is arranged also, at first, cause easily cerebral edema behind the operative treatment, and cause and infect; Secondly, because the existence of blood brain barrier causes medicine fine arrival focus not bring into play therapeutical effect, the while medicine can cause the infringement of other organs; The high medical expense of modern technologies also is the problem that the treatment primary disease exists, and has brought serious burden for patient's body and mind.Therefore seek a kind of low price, the Therapeutic Method of determined curative effect is medical circles' problem demanding prompt solutions.
China Hui ethnic group medicine is an important member in the Chinese traditional medicine extended family, China Hui ethnic group medicine not only has long and brilliant history, more have the opinion of science to administer opinion and abundant treatment experience, have distinct traditional ethnic minority medicine feature [Jia Menghui, etc." Huihui Formularies " treatment brain is disease oral pills side medicine analysis [J]. Ningxia Medical University's journal, 2011,33 (4): 301-303.].Aspect encephalopathy prevents and treats, Hui ethnic group's medicine have the theoretical system of leading and science and abundant treatment experience [Jia Menghui, etc." Huihui Formularies " control brain is dosage form and the medicine law analysis [J] of disease. Ningxia Medical University's journal, 2011,33 (2): 103-104.] and, time medicine is particularly good at and uses nasal drop control cerebrovascular disease.
Summary of the invention
The present invention uses on the experiential basis of nasal drop treatment cerebrovascular disease in a large number in summary " Huihui Formularies " just, kind and pharmacological action according to its high frequency time medication, chosen one group of medical collunarium tincture that returns that is used for the treatment of cerebrovascular disease, this collunarium tincture passes through nasal mucosa medicine administration, make the medicine can be without the first pass effect of liver stomach and pass through rapidly blood brain barrier, through sick institute, improve the hypoxic-ischemic situation of cerebral tissue, activate the self-repairing capability of body, thereby reach the effect of elimination or mitigate the disease and treatment.
Another object of the present invention provides the preparation method of above-mentioned time medical collunarium tincture.
The technical solution adopted in the present invention is:
A kind of medical collunarium tincture that returns that is used for the treatment of cerebrovascular disease is characterized in that its raw material prescription is:
Coloquintida 1～3 weight portion;
Rhizoma Corydalis 1～2 weight portion;
Herba Menthae 1 weight portion.
The described preparation method of returning medical collunarium tincture that is used for the treatment of cerebrovascular disease, its technical process is: pulverous coloquintida, Rhizoma Corydalis and Herba Menthae are joined in 95% ethanol, mix homogeneously is got supernatant after the immersion, make in theory 95% ethanol extract of pastille 50～70%.
Add distilled water in 95% ethanol extract of pastille 50～70% in theory, making in theory, 20% ethanol extract of pastille 10～15% is back medical collunarium tincture.
The granularity of above-mentioned pulverous coloquintida, Rhizoma Corydalis and Herba Menthae was 80 mesh sieves.
Above-mentioned coloquintida, Rhizoma Corydalis and Herba Menthae are cleaned respectively before pulverizing and dry.
Above-mentioned soak time is 3-5 days.
Medication theoretical foundation of the present invention is:
1. coloquintida
Coloquintida, " Huihui Formularies " is called that husky black fan is rare in us, Sha Hahan answer in and in Sha Hamu seldom answers, be the transliteration of Arabic, have another name called colocynth, be the dry mature fruit of Cucurbitaceae Citrullus plant amedica Citrullus colocynthis (L) Schrad.Be the high frequency time medication in the treatment cerebrovascular side.Main product north African, the Central Asia and various countries, West Asia, China recent years is introduced outstanding kind from states such as north African, the Central Asia and is manually planted in Xinjiang, and other areas are without cultivation.Coloquintida is not only the world Islam clinical conventional crude drugs in various countries, and the uighur medicine of China is used colocynth treatment disease has had about millennial history.The Uygur nationality and the Hui ethnic group all are the Mohammedan nationalitys of faith, and two ethnomedicine theories all are to develop on the basis that has absorbed ancient Arabic medical science.Return the medical knowledge opinion and think that coloquintida property is xeothermic, for secondary is done, level Four heat has dispeling the wind, the matter body fluid of subsiding a swelling, eliminate the phlegm, and removes unusual lymphatic temperament, opens the brain resistance, and the pain relieving of religion gas is attacked and rushed down dampness, eliminates the effects such as jaundice; Cure mainly raw property or lymphatic temperament disease, cold head disease is such as headache, migraine, feeling of fullness in the head, paralysis, epilepsy, toothache, otalgia, forgetful, dizzy, be that diligent happy venom flees to block in organs such as brain, stomach, intestinal in eye etc. and unnecessary pathogenic body fluid, various edema, habitual constipation, jaundice, hepatopathy, hematopathy and diabetes.Existing literature of ancient book is investigated, and this medicine appears in " the doctor's allusion quotation " that the Song dynasty shown by Central Asia people's Avicenna the earliest.Modern study shows, contains colocynthin 0.6%～2% in the coloquintida fruit, Cucurbitacin B, E, K, and citrullol, d-coloquintida elements etc. are in the sarcocarp still fatty oily 1%～1.3%; Seed fatty oily 15%～17%.Cucurbitacine is the highly oxidized tetracyclic triterpenoid of a class, has found so far kind more than 40, and wherein the most frequently used person is Cucurbitacin B (Cucurbitacin B), be proved have antiinflammatory, the multiple biological activity such as antitumor, anti-chemocarcinogenesis.In vivo and in vitro shows, Cucurbitacin B can inhibition tumor cell propagation and induced its apoptosis, for multiple human tumor cell stronger growth inhibited effect is arranged.Zhang Meixia etc. studies show that, Cucurbitacin B is by suppressing the propagation of breast cancer cell, cause that S phase and G2/M phase block, induce Apoptosis of Breast Cancer, thereby bring into play Graft Versus Tumor.Cucurbitacin B also has the effect of good anti-hepatitis, obviously reduces alanine aminotransferase, in the control experiment to the experimental rat chronic hepatic injury, can obviously increase hepatic glycogen and accumulate, stops hepatic cell fattydegeneration and obviously suppress hepatic fibroplasia; Zoopery shows has the existence of prolongation effect to the tumor animal; Biological basic species and resin-like thing have strong catharsis effect; Get an amount of coloquintida, suck the nostril facial paralysis but make the snuffing agent with an amount of Fructus Canarii albi fry soup.
In summary, coloquintida can reach detumescence, the matter of eliminating the phlegm body fluid, remove unusual lymphatic temperament by its xeothermic property, opens the brain resistance, and the pain relieving of religion gas makes brain through unobstructed, and four liquid are in harmonious proportion; Again in conjunction with finding after our literature research to existing research coloquintida, coloquintida treatment brain is that the mechanism of action of disease may be to intervene cytokine by the synergy of the chemical compounds such as its contained colocynthin, Cucurbitacin B, E, K, citrullol and d-coloquintida element, and reaching the treatment brain is disease.
2. Rhizoma Corydalis
Rhizoma Corydalis has another name called Rhizoma Corydalis, Rhizoma Corydalis, is Papaveraceae Corydalis herbaceos perennial, is called in " Huihui Formularies ": " thorn of becoming estranged ", " Sanguinaria canadensis " are the high frequency time medication in the treatment cerebrovascular side.Be the quality goods of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, especially be world-famous for the effect of pain relieving.Li Shizhen (1518-1593 A.D.) is concluded Rhizoma Corydalis in Compendium of Material Medica have " invigorating blood circulation promoting the circulation of QI, pain relieving, diuresis " four large effects, and praise highly Rhizoma Corydalis " stagnation of QI in the energy promoting the circulation of blood, stasis in the gas is so specially control up and down all pains of the whole body ".
Studies confirm that, separablely in the Rhizoma Corydalis go out 15 kinds of alkaloids, wherein Corydaline, second element, ugly element, the last of the ten Heavenly stems, element all had analgesic activity, and is especially remarkable with analgesia, the sedation of tetrahydropalmatine.It is a kind of Tetrahydropalmatine, with berberine be the molecular structure of same type.With barbiturate synergism is arranged, can resist again the central excitation effect of amfetamine and caffeine.Tetrahydropalmatine also has the effect of anti-5-HT.Rhizoma Corydalis second element also can make thyroid weight increase.Dehydrogenation Rhizoma Corydalis first element can increase coronary flow and Nutritional myocardium blood flow, prevents myocardial ischemia.Experiment is proof also, and corydaline, Tetrahydropalmatine have analgesic activity, and Tetrahydropalmatine analgesia index is higher.Tetrahydropalmatine can both suppress cerebral cortex and infracortical electrical activity, and is especially comparatively responsive with motor cortex.
3. Herba Menthae
Dry aerial parts for labiate Herba Menthae Mentha haplocalyx Briq..Be referred to as " spreading grey fore-telling " in " Huihui Formularies ", be the high frequency time medication in the treatment cerebrovascular side." medicineization justice " carries: " Herba Menthae, acrid in the mouth can fall apart, and is cool in nature and clear, and the meeting of tonneau six sun is first, the benefaction women's head-ornaments." " Bencao Tujing " have: " wind that cures the wound, wind syndrome of the head, the lattice of being open to the custom, children's's wind saliva." clearly put down in writing Herba Menthae and have dispelling wind and heat pathogens, the clear sharp head's effect.
Herba Menthae mainly contains multiple volatile oil component, accounts for 1.3～2%.Main component is menthol (Menthol), content about 77～78%, secondly be menthone (Menthone), content is 8～12%, also contains acetic acid peppermint ester (Menthyl acetate), camphene (Camphene), limonene (Limonene), isomenthone (Isomenthone), pinene (Pinene) piperitenone (Menthenone), resin and a small amount of tannin, rosmarinic acid (Rosmarinicacid).Still contain in addition the multiple free amino acids such as threonine (threonine), alanine, glutamic acid, agedoite, also have multiple flavone compound.
The pharmacological research proof of Herba Menthae has positive effect to the central nervous system: can promote mice movable by dose dependent, it promotes mice movable, may be relevant with dopamine.Zoopery shows that menthol has protective effect to brain.Apple mint oil and oleum menthae piperitae all have central inhibitory action, can obviously prolong the length of one's sleep that pentobarbital sodium is induced, and menthol has a certain amount of effect relationship to the central inhibitory action of pentobarbital.Secondly, Herba Menthae can also promote the effect of Transdermal absorption: foreign study shows that menthol can significantly promote the effect of acetaminophen Transdermal absorption, and triamcinolone acetonide is had remarkable promotion Absorption, the bioavailability of Radix Bupleuri is increased, can significantly promote the Transdermal absorption of acetaminophen.The effect of this promotion Transdermal absorption may be because menthol passes through the transdermal penetration ability of the structural change medicine of change Stratum corneum lipids.
The present invention will adopt above-mentioned medical material prescription to make back doctor's collunarium tincture, reach the purpose for the treatment of cardiovascular and cerebrovascular disease by nose-blood brain barrier.Its theoretical foundation is:
The present invention is theoretical according to the pathology of internal organs, meridians and body constitution physiological theory, " natural disposition decays " and the body constitution such as " cold, hot, dry are wet " of returning medicine " brain system all kinds of diseases and ailments ", " brain the master take in ", " brain unite hundred arteries and veins " and " limbs, four liquid ", morbidity, " correspondence between man and universe " reach " coordinating inside and outside " to control theoretical with the control of rehabilitation principle, as to pay attention to fragrant section expectorant, blood stasis dispelling refreshment product for opinion be time medical traditional theories such as clinical application characteristic medication sight.Think that people's various motions and sensation all had under one's command by brain, namely if there is not total feel effect of brain, the people just can not have vision, audition, olfactory sensation and even brothers' motion to large brain-capacity " Directorate-General DG its close close ".The imbalance and four property, four liquid distribute in vivo, cause that expectorant is turbid, through the brain network, the brain body is stranded by evil stagnation of blood stasis, must not QI and blood moisten foster in brain, weak to having under one's command of hundred arteries and veins, body key, consciousness and motion, and send out, consciousness obstructed for abnormal state of mind, body key and (or) syndrome caused by wind pathogen disease among the dyskinesia etc.
Modern medicine is thought: the key by the Drug therapy cerebrovascular disease is that can medicine pass through blood brain barrier.Modern anatomy thinks that nasal cavity olfactory region mucosa is positioned at superior nasal concha and corresponding nasal septum, and the regio olfactoria is the above and corresponding part of nasal septum in superior nasal concha plane, includes bipolar olfactory cell, sustenticular cell, basal cell and a small amount of villus cell.The nervi olfactory surface is wrapped in unique Olfactory Ensheathing Cells In Vitro, and Olfactory Ensheathing Cells In Vitro is a kind of glial cell of specific type, has the double properties of Schwann cell and star spongiocyte, follows the nervi olfactory aixs cylinder to enter the central nervous system by peripheral nervous system.This unique anatomical features is that nose administration sees through the physiological foundation that blood brain barrier enters cranium.
Returning medicine payes attention to using aromatics to be rich in the Drug therapy cerebrovascular disease of volatile ingredient, modern pharmacological research proves, the selected coloquintida of the present invention, Rhizoma Corydalis and Herba Menthae are rich in volatile ingredient, very easily by blood brain barrier, so can effectively treat the cerebrovascular disease of series.
Medical collunarium tincture is used for the treatment of the clinical trial process of cerebrovascular disease to the below for the present invention returns:
Return medical collunarium tincture treatment cerebral infarction sequela 54 examples
1 clinical data
1.1 case source
All cases all are diagnosed as Cerebral Infarction Patients from the department of Chinese medicine outpatient service of First People's Hospital, Yinchuan City and in-patient department, and the course of disease is more than 6 months, totally 108 examples.Be divided at random treatment group and matched group, every group of 54 examples.52～78 years old treatment group age, 63.8 years old mean age; The course of disease 9 months to 11 years, 2 infraction person's 8 examples wherein, 1 person's 46 example; 56～75 years old matched group age, 64.3 years old mean age, the course of disease 6 months to 10 years, 2 infraction person's 9 examples wherein, 1 person's 45 example.Epidemiological Analysis by statistics, two groups at age of onset, the course of disease and morbidity number of times difference not statistically significant (P〉0.05), has comparability.
1.2 diagnostic criteria
Write " Chinese acute ischemic cerebral apoplexy diagnosis and treatment guide 2010 " (2010) that group is formulated with reference to neurological branch of Chinese Medical Association cerebrovascular group acute ischemic cerebral apoplexy diagnosis and treatment guide.
1.3 inclusive criteria
1. Acute onset; 2. focal neurologic impairment, minority is comprehensive neurologic impairment; 3. sings and symptoms is more than lasting a few hours; 4. brain CT or MRI Cerebral hemorrhage and other pathological changes; 5. brain CT or MRI have a responsibility for the infarction focus; 6. after falling ill 6 months
[1]
2 Therapeutic Method
2.1 two groups all give basic symptomatic treatment: quiet activating blood and removing stasis drug; Conventional body needle treatment, routine needling Baihui, wind pond, shoulder Yu, shoulder Liao, arm Er, Wai Guan, connected valleys, Huantiao, fengshi, tsu san li, the cave such as punching too.
2.2 treatment group adds on the basis of the above with of the present invention time medical collunarium tincture.
Operational approach: patient's dorsal position, the doctor cleans nasal cavity with cotton swab, splashes into each 2 of medicinal liquids in the bilateral nostril, and forefinger maintains static spiral applying light 2～3 seconds, makes medicinal liquid fully pass through Nasal Mucosa Absorption.
2.3 the course for the treatment of: all are treated 1 time on the equal 1st, 1 course for the treatment of on the 7th, treat altogether 4 courses for the treatment of.
3 observation of curative effect
3.1 criterion of therapeutical effect is with reference to the 4th curative effect determinate standard that the cerebrovascular disease academic conference is passed through in the whole nation.According to apoplexy Clinical Nerve Function Deficiency marking scales, consciousness, horizontal gaze function, facial muscle, language, upper and lower extremities muscular strength, hand muscle power and walking ability before and after the patient treatment are marked, best result 45 minutes, minimum minute 0 minute, adopt the nimodipine method: [integration * 100% before (integration after integration before the treatment-treatment)/treatment] is expressed as a percentage.
Be almost recovered: the functional impairment scoring reduces 90%～100%, and disability degree is 0 grade;
Marked improvement: the functional impairment scoring reduces 46%～89%, and disability degree is 1～3 grade;
Progressive: the functional impairment scoring reduces 18%～45%;
Unchanged: the functional impairment scoring reduces or is increased in 18%;
Worsen: the functional impairment scoring is increased in more than 18%.
3.2 therapeutic outcome
Neurological deficits score comparison before and after the table 1 liang group patient treatment ((minute,
Annotate: with front relatively #P＜005 for the treatment of, * P＜001
Two groups of patient's curative effects compare (example) after 4 weeks of table 2 treatment
After around two groups of treatments, according to neurological impairment is marked, the treatment group total effective rate reaches 92.59%, and the matched group total effective rate reaches 83.33%, two groups of effective percentage differences have statistical significance (P＜0.05), show that the treatment group curative effect obviously is better than matched group.
4 discuss
Cerebral infarction claims again cerebral infarction, is nervous system common disease, and is higher because of its fatality rate that disables, and has a strong impact on human health and quality of life, so clinical to try to explore effective Therapeutic Method imperative.
China's Hui ethnic group medicine is aspect the preventing and treating of disease at brain, has made larger contribution.Send as an envoy to the Western Regions when opening the Silk Road as far back as the Han dynasty from Zhang Qian, and Western Regions medicine just imports China continually into, a great deal of medicine is wherein arranged from Arab countries.Hui ethnic group medicine is kind in incense drug treatment brain disease, theoretical closely related with its " brain unite hundred arteries and veins ", " brain idea will and motion ".My institute's department of Chinese medicine is as the state key training---return medical encephalopathy training, keep blazing new trails in a pioneering spirit clinically, invented time medical collunarium tincture, treatment by cerebral infarction sequela is observed, and the treatment group total effective rate 93.75% as a result, and matched group is 78.12%, two groups of total effective rate differences have statistical significance (P＜0.05), prompting the present invention treats cerebral infarction sequela can obviously improve the neurological recovery, improves life in patients, and curative effect is determined.
Modern pharmacology research is thought, the incense drug that relates in Hui ethnic group's medicine contains volatile oil, resin and natural gum etc. more, has strong fragrance, the via intranasal application administration is a kind of new way to the brain delivering medicament, and because blood brain barrier is stronger 5000 times than cerebrospinal flrid-brain barrier effect, therefore can reach the purpose of brain targeting by the most weak cerebrospinal fluid of barrier action-brain barrier.This theory is enough to provide foundation for nasal-cavity administration targeted therapy central nervous system disease.As seen the collunarium tincture is as one of effective external treatment of returning medical national characters treatment cerebrovascular disease, and clinic is further promoted.
The specific embodiment
Embodiment 1
Prepare raw material according to the following weight proportioning: coloquintida 3KG, Rhizoma Corydalis 2KG, Herba Menthae 1KG.
Preparation method:
At first coloquintida, Rhizoma Corydalis, Herba Menthae are cleaned respectively, oven dry is pulverized, and crosses 80 mesh sieves, makes medicamental pulverata, through the ultraviolet radiation sterilization, seals for subsequent use.
Take by weighing in proportion coloquintida, Rhizoma Corydalis and Herba Menthae powder, amount to 100g in the measuring cup of 250ml, add the ethanol of 200ml95%, repeatedly shake mixedly, soak 72h, leaching supernatant 100ml makes in theory 95% ethanol extract of pastille 50%.
Get above-mentioned cleaner liquid 100ml in the measuring cup of 500ml, add distilled water 375ml, shake up, produce in theory 20% ethanol extract of pastille 10.53%, be the medical collunarium tincture of this time.
Embodiment 2
Prepare raw material according to the following weight proportioning: coloquintida 1KG, Rhizoma Corydalis 1KG, Herba Menthae 1KG.
Preparation method:
At first coloquintida, Rhizoma Corydalis, Herba Menthae are cleaned respectively, oven dry is pulverized, and crosses 80 mesh sieves, makes medicamental pulverata, through the ultraviolet radiation sterilization, seals for subsequent use.
Take by weighing in proportion coloquintida, Rhizoma Corydalis and Herba Menthae powder, amount to 100g in the measuring cup of 250ml, add the ethanol of 200ml95%, repeatedly shake mixedly, soak 72h, leaching supernatant 100ml makes in theory 95% ethanol extract of pastille 50%.
Get above-mentioned cleaner liquid 100ml in the measuring cup of 500ml, add distilled water 375ml, shake up, produce in theory 20% ethanol extract of pastille 10.53%, be the medical collunarium tincture of this time.
Embodiment 3
Prepare raw material according to the following weight proportioning: coloquintida 2KG, Rhizoma Corydalis 1KG, Herba Menthae 1KG.
Preparation method:
At first coloquintida, Rhizoma Corydalis, Herba Menthae are cleaned respectively, oven dry is pulverized, and crosses 80 mesh sieves, makes medicamental pulverata, through the ultraviolet radiation sterilization, seals for subsequent use.
Take by weighing in proportion coloquintida, Rhizoma Corydalis and Herba Menthae powder, amount to 100g in the measuring cup of 250ml, add the ethanol of 200ml95%, repeatedly shake mixedly, soak 72h, leaching supernatant 100ml makes in theory 95% ethanol extract of pastille 50%.
Get above-mentioned cleaner liquid 100ml in the measuring cup of 500ml, add distilled water 375ml, shake up, produce in theory 20% ethanol extract of pastille 10.53%, be the medical collunarium tincture of this time.
Embodiment 4
Prepare raw material according to the following weight proportioning: coloquintida 1KG, Rhizoma Corydalis 2KG, Herba Menthae 1KG.
Preparation method:
At first coloquintida, Rhizoma Corydalis, Herba Menthae are cleaned respectively, oven dry is pulverized, and crosses 80 mesh sieves, makes medicamental pulverata, through the ultraviolet radiation sterilization, seals for subsequent use.
Take by weighing in proportion coloquintida, Rhizoma Corydalis and Herba Menthae powder, amount to 100g in the measuring cup of 250ml, add the ethanol of 178ml95%, repeatedly shake mixedly, soak 96h, leaching supernatant 100ml makes in theory 95% ethanol extract of pastille 56%.
Get above-mentioned cleaner liquid 100ml in the measuring cup of 500ml, add distilled water 375ml, shake up, produce in theory 20% ethanol extract of pastille 12%, be the medical collunarium tincture of this time.
Embodiment 5
Prepare raw material according to the following weight proportioning: coloquintida 3KG, Rhizoma Corydalis 2KG, Herba Menthae 1KG.
Preparation method:
At first coloquintida, Rhizoma Corydalis, Herba Menthae are cleaned respectively, oven dry is pulverized, and crosses 80 mesh sieves, makes medicamental pulverata, through the ultraviolet radiation sterilization, seals for subsequent use.
Take by weighing in proportion coloquintida, Rhizoma Corydalis and Herba Menthae powder, amount to 100g in the measuring cup of 250ml, add the ethanol of 150ml95%, repeatedly shake mixedly, soak 120h, leaching supernatant 100ml makes in theory 95% ethanol extract of pastille 67%.
Get above-mentioned cleaner liquid 100ml in the measuring cup of 500ml, add distilled water 375ml, shake up, produce in theory 20% ethanol extract of pastille 14%, be the medical collunarium tincture of this time.
Embodiment 6
Prepare raw material according to the following weight proportioning: coloquintida 2KG, Rhizoma Corydalis 1KG, Herba Menthae 1KG.
Preparation method:
At first coloquintida, Rhizoma Corydalis, Herba Menthae are cleaned respectively, oven dry is pulverized, and crosses 80 mesh sieves, makes medicamental pulverata, through the ultraviolet radiation sterilization, seals for subsequent use.
Take by weighing in proportion coloquintida, Rhizoma Corydalis and Herba Menthae powder, amount to 100g in the measuring cup of 250ml, add the ethanol of 142ml95%, repeatedly shake mixedly, soak 72h, leaching supernatant 100ml makes in theory 95% ethanol extract of pastille 70%.
Get above-mentioned cleaner liquid 100ml in the measuring cup of 500ml, add distilled water 375ml, shake up, produce in theory 20% ethanol extract of pastille 15%, be the medical collunarium tincture of this time.
Claims (6)
1. medical collunarium tincture that returns that is used for the treatment of cerebrovascular disease is characterized in that its raw material prescription is:
Coloquintida 1～3 weight portion;
Rhizoma Corydalis 1～2 weight portion;
Herba Menthae 1 weight portion.
2. preparation method of returning medical collunarium tincture that is used for the treatment of cerebrovascular disease as claimed in claim 1, its technical process is: pulverous coloquintida, Rhizoma Corydalis and Herba Menthae are joined in 95% ethanol, mix homogeneously, get supernatant after the immersion, make in theory 95% ethanol extract of pastille 50～70%.
3. according to the preparation method of returning medical collunarium tincture that is used for the treatment of cerebrovascular disease claimed in claim 2, it is characterized in that: add distilled water in 95% ethanol extract of pastille 50～70% in theory, making in theory, 20% ethanol extract of pastille 10～15% is back medical collunarium tincture.
4. according to the preparation method of returning medical collunarium tincture that is used for the treatment of cerebrovascular disease claimed in claim 2, it is characterized in that: the granularity of above-mentioned pulverous coloquintida, Rhizoma Corydalis and Herba Menthae was 80 mesh sieves.
5. according to claim 2 or the 4 described preparation methoies of returning medical collunarium tincture that are used for the treatment of cerebrovascular disease, it is characterized in that: above-mentioned coloquintida, Rhizoma Corydalis and Herba Menthae are cleaned respectively before pulverizing and dry.
6. according to the preparation method of returning medical collunarium tincture that is used for the treatment of cerebrovascular disease claimed in claim 2, it is characterized in that: above-mentioned soak time is 3-5 days.
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Application publication date: 20130313 |