CN102949416B - A kind of pharmaceutical composition and preparation method thereof for improving gastrointestinal function - Google Patents
A kind of pharmaceutical composition and preparation method thereof for improving gastrointestinal function Download PDFInfo
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- CN102949416B CN102949416B CN201210481455.0A CN201210481455A CN102949416B CN 102949416 B CN102949416 B CN 102949416B CN 201210481455 A CN201210481455 A CN 201210481455A CN 102949416 B CN102949416 B CN 102949416B
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Abstract
The present invention discloses a kind of pharmaceutical composition and preparation method thereof for improving gastrointestinal function, the ingredient and its weight proportion which contains are as follows: 20 parts of Lactobacillus rhamnosus, 30 parts of Yue Shi lactobacillus, 30 parts of Bifidobacterium, 15 parts of Lactobacillus casei.Pharmaceutical composition of the invention is a kind of using integration of drinking and medicinal herbs raw material as the health product capsule of component, pharmaceutical composition of the invention is expected to can reach the effect of improving gastrointestinal function, using Lactobacillus rhamnosus, Yue Shi lactobacillus, Bifidobacterium, Lactobacillus casei as primary raw material, it is process using scientific and reasonable production technology, this product definite functions, it is quality controllable, take safety.The preparation method of pharmaceutical composition of the invention is simple, and conventional equipment can prepare completion.
Description
Technical field
The invention belongs to health product technology fields, are related to a kind of pharmaceutical composition of health care product, especially a kind of for changing
The pharmaceutical composition and preparation method thereof of kind gastrointestinal function.
Background technique
Exploitation pharmaceutical combination product is expected to reach improvement gastrointestinal tract healthcare function.This product is with Lactobacillus rhamnosus, Yue Shi
Lactobacillus, Bifidobacterium, Lactobacillus casei are primary raw material, according to gastrointestinal tract mechanism, using scientific and reasonable production work
Skill is process, this product definite functions, quality controllable, takes safety.
Functional disturbances of gastrointestinal tract is also known as Gastrointestinal neurosis or functional disturbances of gastrointestinal tract, there is the background of mental element, with stomach more
It based on intestinal movement dysfunction, and without organic disease basis in terms of pathological anatomy, therefore does not include other systems disease yet
Functional disturbances of gastrointestinal tract caused by disease.Clinical manifestation mainly gastrointestinal tract be related to feed and in terms of it is abnormal, also often
It is laxed with insomnia, anxiety, attention, amnesia, neuroticism, the other functions symptom such as headache.Functional disturbances of gastrointestinal tract
Fairly common, in the neurosis of various internal organs, the morbidity number highest of gastrointestinal tract is more common in person between twenty and fifty.
Summary of the invention
The purpose of the present invention is intended to provide a kind of pharmaceutical composition and preparation method thereof for improving gastrointestinal function, should
Pharmaceutical composition is a kind of health product capsule based on integration of drinking and medicinal herbs raw material, and this product is with Yue Shi lactobacillus, Bifidobacterium
Monarch drug in a prescription, assistant are assimilated with Lactobacillus rhamnosus, Lactobacillus casei, four kinds of ingredient synergistic effects, Gastrointestinal motility adjustment, enhancing stomach
Ability and stomach and intestine resistance reach the healthcare function for improving gastrointestinal tract.
The technical scheme is that designing a kind of for improving the pharmaceutical composition of gastrointestinal function, it is characterised in that
The ingredient and its weight proportion that it contains are as follows: 3 parts of Lactobacillus rhamnosus, 30 parts of Yue Shi lactobacillus, 20 parts of Bifidobacterium, cheese cream
15 parts of bacillus.
It is described a kind of for improving the preparation method of the pharmaceutical composition of gastrointestinal function, it is characterised in that it includes following
Step:
1) weigh raw material by following weight ratios: 20 parts of Lactobacillus rhamnosus, 30 parts of Yue Shi lactobacillus, 30 parts of Bifidobacterium,
15 parts of Lactobacillus casei；
2) above-mentioned raw materials are weighed, 10 parts of DEXTROSE ANHYDROUSs are added, cross 80 meshes, ingredient；
3) ingredient of step 2 is fitted into mixing machine and is uniformly mixed, it is spare；
4) by said mixture, upper capsule filling machine is filled；
5) inner packing；
6) outer packing, product inspection, storage.
The invention has the advantages that the Yue Shi lactobacillus in the present invention can maintain the normal microecological balance of gastrointestinal tract, inhibit
The invasion and infection of pathogen enhance immunity of organisms, especially have very strong bacteriostasis to Escherichia coli and Salmonella enteritidis；
Bifidobacterium is the most beneficial flora of enteral, has adjustment function of intestinal canal disorder effect.It can safeguard that enteron aisle normal bacteria flora is flat
Weighing apparatus, inhibits the growth of pathogen, prevents constipation, diarrhea and gastrointestinal disorders etc. can also synthesize vitamin, amino acid in enteron aisle
Absorption with raising body to calcium ion；It enhances human immunity, it is antitumor.The one kind of Lactobacillus casei as probiotics, energy
Enough be resistant to organism defense mechanism, into human body after can in enteron aisle large number of viable, play adjust intestinal flora balance, promote
The effects of being absorbed into human consumption.The adjustable microecological balance of Lactobacillus rhamnosus, enhancing host intestine resistance, prevention and
It treats diarrhea, eliminate allergy, there is the effect of certain fungistatic effect and booster immunization system, can maintain healthy intestinal flora.
Each raw material plays a role to improvement gastrointestinal tract all in terms of different, and Yue Shi lactobacillus, Bifidobacterium are to improve stomach
It is movable to play the role of adjusting stomach and intestine for the primary raw material of function of intestinal canal；Assistant with Lactobacillus rhamnosus, Lactobacillus casei, control by auxiliary
Treat the weak indigestion of WeiDongLi Capsule, the gastrointestinal diseases such as diarrhea constipation.This formula can not only improve gastrointestinal function, moreover it is possible to enhance machine
Body immunity has auxiliary therapeutic action to other diseases.
Pharmaceutical composition of the invention is main with Yue Shi lactobacillus, Bifidobacterium, Lactobacillus rhamnosus, Lactobacillus casei
Raw material, for a health care product of gastrointestinal dysfunction crowd exploitation.This product using Yue Shi lactobacillus, Bifidobacterium as monarch drug in a prescription,
Assistant is enhanced gastrointestinal tract resistance, is increased and be immunized, reached and change with Lactobacillus rhamnosus, Lactobacillus casei, four kinds of ingredient synergistic effects
The healthcare function of kind gastrointestinal tract.No dependence.
Specific embodiment
The present invention is further explained in the light of specific embodiments, but not as limitation of the present invention.This reality
Applying does not have the part described in detail in example be using the prior art and professional standard or known approaches.
Embodiment 1
The pharmaceutical composition provided by the invention is using made of following steps:
1) weigh raw material by following weight ratios: 20 parts of Lactobacillus rhamnosus, 30 parts of Yue Shi lactobacillus, 30 parts of Bifidobacterium,
15 parts of Lactobacillus casei；
2) above-mentioned raw materials are weighed, 10 parts of DEXTROSE ANHYDROUSs are added, cross 80 meshes, ingredient；
3) ingredient of step 2 is fitted into mixing machine and is uniformly mixed, it is spare；
4) by said mixture, upper capsule filling machine is filled；
5) inner packing；
6) outer packing, product inspection, storage.
The embodiment of the present invention 1 is used to improve the clinic of pharmaceutical composition (capsule) the treatment gastrointestinal dysfunction of gastrointestinal function
Observation
1 data and method
1.1 general information
Selection outpatient service voluntarily receives gastroenteritis patient 80 for the treatment of, male 30, women 50, is randomly divided into treatment group
1, treatment group 2, treatment group 3 and control group, every group 20；Each group patient age symptom is constituted without significant difference, disease time
Longest 10 years, most short June.It is comparable (P > 0.05).
1.2 treatment method
Treatment group's Primary Care is consistent, and control group is not taken medicine.The embodiment of the present invention 1 for the treatment of group 1, three times a day, once
One, 3 months as a treatment course.Yichun medicine company lactobacillin tablet for the treatment of group 2, one time 1-2 times gram (based on lactein), one day
3 times；Treatment group 3 with Beijing Shouchuan hall board stomach pacify liquid, three times a day, one time one.
2 results
2.1 curative effect determinate standard
Cure: clinical symptoms and sign disappear, and tongue vein is normal, stomach and the saturating ulcer surface healing of duodenum barium；It is effective: symptom
It is clearly better, lesion morphology tissue makes moderate progress；Effective: symptom improves, lesion morphology, and histology improves or obvious change
Change；Invalid: symptom member improves or aggravates, and lesion morphology histology is the same or still develops.
2.2 treatment results
| It cures | It is effective | Effectively | In vain | It is efficient | |
| Control | 20 | 0 | |||
| Treatment group 1 | 8 | 6 | 4 | 2 | 90% |
| Treatment group 2 | 7 | 5 | 5 | 3 | 85% |
| Treatment group 3 | 6 | 6 | 3 | 3 | 85% |
3 discuss
Chinese medicine thinks that the pathogenesis of gastrointestinal disorders disease mainly includes caused by spleen, stomach, large intestine, Small Intestine are not normal
The difference interpretation of the cause, onset and process of an illness such as fever and chills, actual situation, phlegm-blood stasis and qi and blood, imbalance of yin and yang.Essence is because in human body dysfunction of spleen and stomach and internal organs
Balance is broken, so that caused by gastrointestinal tract is greatly reduced the defence capability of disease.It is combined using pure Chinese medicine and promotes human body certainly
Body combined immune power, and by adjusting the microcirculation of gastrointestinal tract and surrounding organ, gastrointestinal bacterial flora balance is adjusted, gastrointestinal tract is improved
Environment reaches healing purpose.It is reliably effective to further relate to prescription belonging to embodiment 1 in the invention.
Claims (1)
1. a kind of for improving the preparation method of the pharmaceutical composition of gastrointestinal function, it the following steps are included:
1) weigh raw material by following weight ratios: 20 parts of Lactobacillus rhamnosus, 30 parts of Bifidobacterium, does 30 parts of Yue Shi lactobacillus
15 parts of Lactobacillus paracasei；
2) above-mentioned raw materials are weighed, 10 parts of DEXTROSE ANHYDROUSs are added, cross 80 meshes, ingredient；
3) ingredient of step 2 is fitted into mixing machine and is uniformly mixed, it is spare；
4) by said mixture, upper capsule filling machine is filled；
5) inner packing；
6) outer packing, product inspection, storage.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210481455.0A CN102949416B (en) | 2012-11-23 | 2012-11-23 | A kind of pharmaceutical composition and preparation method thereof for improving gastrointestinal function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210481455.0A CN102949416B (en) | 2012-11-23 | 2012-11-23 | A kind of pharmaceutical composition and preparation method thereof for improving gastrointestinal function |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102949416A CN102949416A (en) | 2013-03-06 |
| CN102949416B true CN102949416B (en) | 2018-12-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210481455.0A Active CN102949416B (en) | 2012-11-23 | 2012-11-23 | A kind of pharmaceutical composition and preparation method thereof for improving gastrointestinal function |
Country Status (1)
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114717129B (en) * | 2021-08-23 | 2023-11-21 | 青岛蔚蓝生物股份有限公司 | Lactobacillus rhamnosus and application thereof in preventing and relieving constipation symptoms |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102256610A (en) * | 2008-12-18 | 2011-11-23 | 伯拉考成像股份公司 | Probiotic formulations |
| CN102762216A (en) * | 2009-05-11 | 2012-10-31 | 雀巢产品技术援助有限公司 | Complete liquid nutrition for children at the age of 1-10 years comprising probiotics |
-
2012
- 2012-11-23 CN CN201210481455.0A patent/CN102949416B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102256610A (en) * | 2008-12-18 | 2011-11-23 | 伯拉考成像股份公司 | Probiotic formulations |
| CN102762216A (en) * | 2009-05-11 | 2012-10-31 | 雀巢产品技术援助有限公司 | Complete liquid nutrition for children at the age of 1-10 years comprising probiotics |
Non-Patent Citations (2)
| Title |
|---|
| 双歧杆菌、乳杆菌制剂在食品工业中的研究现状与展望;张莉滟等;《中国微生态学杂志》;20020228;第14卷(第1期);第50-51页 * |
| 国内外益生菌制品发展现状;杜鹏等;《食品科学》;20040531;第25卷(第5期);第194-198页 * |
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| CN102949416A (en) | 2013-03-06 |
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| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information |
Inventor after: Li Qiufei Inventor after: Tang Yonghong Inventor after: Qian Bo Inventor after: Gao Xiang Inventor after: Mou Xiao Inventor before: Tang Yonghong Inventor before: Qian Bo |
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| COR | Change of bibliographic data | ||
| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Address after: 710075 B601 studio, 1 gazelle Valley, C District, 69 Jinhua Road, Xi'an High-tech Zone, Shaanxi Applicant after: Xi'an Tyco pharmaceuticals Polytron Technologies Inc Address before: 710077 1-10502B, modern business center, No. 2 zhang85 Road, hi tech Zone, Xi'an, Shaanxi Applicant before: Taikomed Consulting Ltd. |
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